Dr. Jesse Coker
@jcoker10.bsky.social
Chemical Biology Group Leader @ Cleveland Clinic Center for Therapeutics Discovery (C3TD). PhD from Structural Genomics Consortium @ University of Oxford. BS/BA University of Oklahoma. Julie's worse half. Thoughts are my own, not my employer’s.
Reposted by Dr. Jesse Coker
What's the role of MCL1 in chemoresistance?
A new preLight from @kanishka03.bsky.social highlighting a #preprint from Kylin Emhoff, @jcoker10.bsky.social & Jan Joseph Melenhorst challenging the concept that MCL1 promotes chemoresistance from the nucleus.
prelights.biologists.com/highlights/m...
A new preLight from @kanishka03.bsky.social highlighting a #preprint from Kylin Emhoff, @jcoker10.bsky.social & Jan Joseph Melenhorst challenging the concept that MCL1 promotes chemoresistance from the nucleus.
prelights.biologists.com/highlights/m...
MCL1 may not mediate chemoresistance - preLights
MCL1, an anti-apoptotic BCL-2 family protein, does not mediate chemotherapy resistance in cancer cells, which calls into question the role of MCL in therapy response.
prelights.biologists.com
September 11, 2025 at 3:32 PM
What's the role of MCL1 in chemoresistance?
A new preLight from @kanishka03.bsky.social highlighting a #preprint from Kylin Emhoff, @jcoker10.bsky.social & Jan Joseph Melenhorst challenging the concept that MCL1 promotes chemoresistance from the nucleus.
prelights.biologists.com/highlights/m...
A new preLight from @kanishka03.bsky.social highlighting a #preprint from Kylin Emhoff, @jcoker10.bsky.social & Jan Joseph Melenhorst challenging the concept that MCL1 promotes chemoresistance from the nucleus.
prelights.biologists.com/highlights/m...
Reposted by Dr. Jesse Coker
Reposted by Dr. Jesse Coker
The news across HHS today is awful, and the stated reasons behind it all are lies:
The Continuing Crisis, Part X: Reductions in Force, Gains in Centralized Power
www.science.org
April 1, 2025 at 4:10 PM
The news across HHS today is awful, and the stated reasons behind it all are lies:
Reposted by Dr. Jesse Coker
White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.
March 24, 2025 at 9:54 PM
White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.
Reposted by Dr. Jesse Coker
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
March 23, 2025 at 4:17 PM
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
Things remain exceedingly bleak but the first sunny, 70 degree day of 2025 is here and it is beautiful
March 14, 2025 at 8:00 PM
Things remain exceedingly bleak but the first sunny, 70 degree day of 2025 is here and it is beautiful
Reposted by Dr. Jesse Coker
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
go.nature.com
February 25, 2025 at 9:53 PM
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Reposted by Dr. Jesse Coker
I've read most of the analyses of the DOGE 2025 "receipts" site. This, from NPR, is the best I've read so far. Some of what they claim to have cut haven't been cut, other "cuts" will incur costs down the road.
NPR says DOGE has made $2B of cuts, not $55B.
www.npr.org/2025/02/19/n...
NPR says DOGE has made $2B of cuts, not $55B.
www.npr.org/2025/02/19/n...
DOGE released data about federal contract savings. It doesn't add up
A new government tracker claims DOGE has saved billions from ending federal contracts. But an NPR analysis of the data finds the claimed savings don't add up.
www.npr.org
February 20, 2025 at 5:25 AM
I've read most of the analyses of the DOGE 2025 "receipts" site. This, from NPR, is the best I've read so far. Some of what they claim to have cut haven't been cut, other "cuts" will incur costs down the road.
NPR says DOGE has made $2B of cuts, not $55B.
www.npr.org/2025/02/19/n...
NPR says DOGE has made $2B of cuts, not $55B.
www.npr.org/2025/02/19/n...
Reposted by Dr. Jesse Coker
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
February 8, 2025 at 1:43 PM
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
The Browns righteously deserve their ongoing punishment for abandoning Baker Mayfield
January 5, 2025 at 8:41 PM
The Browns righteously deserve their ongoing punishment for abandoning Baker Mayfield
I fell in love with basketball when I was eight because of LeBron. Tomorrow I turn 30 and he’s still doing this. Preposterous and wonderful.
December 26, 2024 at 3:37 AM
I fell in love with basketball when I was eight because of LeBron. Tomorrow I turn 30 and he’s still doing this. Preposterous and wonderful.
Reposted by Dr. Jesse Coker
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
December 9, 2024 at 11:19 PM
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
An all-time footballing legend and the greatest goalkeeper in the history of the USWNT #ThankYouAlyssa
Today, USWNT icon Alyssa Naeher hangs up her national team gloves. 115 caps, 2 World Cup titles, an Olympic Gold & Bronze medal, & the only goalkeeper in women’s soccer history to achieve a shutout in a World Cup Final & an Olympic gold medal game. You are one of a kind! ❤️⭐🥲
December 4, 2024 at 1:02 AM
An all-time footballing legend and the greatest goalkeeper in the history of the USWNT #ThankYouAlyssa
It might be cold and raining but it’s a beautiful day because City has been properly embarrassed at home 🔥
November 23, 2024 at 7:27 PM
It might be cold and raining but it’s a beautiful day because City has been properly embarrassed at home 🔥
Wicked goes so hard 🤯
November 23, 2024 at 2:18 AM
Wicked goes so hard 🤯
Reposted by Dr. Jesse Coker
Science has values, and they are inherently in opposition to political ideologies centered on the rejection of evidence, the promotion of scientific falsehoods, and that seek to undermine the institutions that support scientific inquiry. You don't get to pick!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Science is neither red nor blue
Long before the 5 November US presidential election, I had become ever more concerned that science has fallen victim to the same political divisiveness tearing at the seams of American society. This i...
www.science.org
November 21, 2024 at 10:06 PM
Science has values, and they are inherently in opposition to political ideologies centered on the rejection of evidence, the promotion of scientific falsehoods, and that seek to undermine the institutions that support scientific inquiry. You don't get to pick!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...