Janik Goltermann
@janikgoltermann.bsky.social
CBT therapist and postdoc at Charité Berlin working in neuroimaging psychiatry🧠 Topics: childhood maltreatment, neurobiology, depression and replicability / open science
Pinned
🧠Out now @natcomms.nature.com !
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
So excited to share the launch of a multi-disciplinary journal dedicated to replications and other meta research!🚀 It has been super interesting to be involved in this project and I can't wait for the first submissions!
replicationresearch.org
#openscience #neuroscience #metaresearch
replicationresearch.org
#openscience #neuroscience #metaresearch
October 10, 2025 at 9:42 AM
So excited to share the launch of a multi-disciplinary journal dedicated to replications and other meta research!🚀 It has been super interesting to be involved in this project and I can't wait for the first submissions!
replicationresearch.org
#openscience #neuroscience #metaresearch
replicationresearch.org
#openscience #neuroscience #metaresearch
What causal role do brain changes play in depression?
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!
#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!
#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
October 7, 2025 at 7:08 PM
What causal role do brain changes play in depression?
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!
#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!
#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
Reposted by Janik Goltermann
🔍 Have we solved the replication crisis?
Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.
📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)
#OpenScience #neuroskyence #academicsky
[1/3]
Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.
📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)
#OpenScience #neuroskyence #academicsky
[1/3]
September 30, 2025 at 10:08 AM
🔍 Have we solved the replication crisis?
Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.
📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)
#OpenScience #neuroskyence #academicsky
[1/3]
Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.
📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)
#OpenScience #neuroskyence #academicsky
[1/3]
Reposted by Janik Goltermann
Can brain organoids become conscious? A new paper argues it’s unlikely with today’s tech, but urges ethical debate as research advances.
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
Facing the possibility of consciousness in human brain organoids
The authors challenge recent claims that the emergence of consciousness in human brain
organoids (HBOs) remains implausible in the near term. Drawing on neuroscientific
evidence, developmental paralle...
www.cell.com
September 27, 2025 at 8:27 AM
Can brain organoids become conscious? A new paper argues it’s unlikely with today’s tech, but urges ethical debate as research advances.
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
Reposted by Janik Goltermann
The overlapping genetic architecture of psychiatric disorders and cortical brain structure
https://www.newsbeep.com/ie/35167/
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article PubMed …
https://www.newsbeep.com/ie/35167/
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article PubMed …
The overlapping genetic architecture of psychiatric disorders and cortical brain structure - Ireland News Beep
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007).
www.newsbeep.com
September 21, 2025 at 9:00 PM
The overlapping genetic architecture of psychiatric disorders and cortical brain structure
https://www.newsbeep.com/ie/35167/
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article PubMed …
https://www.newsbeep.com/ie/35167/
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article PubMed …
Reposted by Janik Goltermann
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com
September 17, 2025 at 8:12 PM
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Reposted by Janik Goltermann
🧠 The #MICrONS project just released the most detailed brain map ever—82K neurons, 523M synapses, all open for exploration. Dive in thanks to #BossDB: github.com/aplbrain/bos...
#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
April 17, 2025 at 1:21 PM
🧠 The #MICrONS project just released the most detailed brain map ever—82K neurons, 523M synapses, all open for exploration. Dive in thanks to #BossDB: github.com/aplbrain/bos...
#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
Reposted by Janik Goltermann
NEW Journal Article: "The Economic Impact of Open #Science: A Scoping Review" https://www.infodocket.com/2025/09/17/journal-article-the-economic-impact-of-open-science-a-scoping-review/ #OpenScience #os #oa #oss #ofd
September 17, 2025 at 12:08 PM
NEW Journal Article: "The Economic Impact of Open #Science: A Scoping Review" https://www.infodocket.com/2025/09/17/journal-article-the-economic-impact-of-open-science-a-scoping-review/ #OpenScience #os #oa #oss #ofd
Reposted by Janik Goltermann
📣 Attending #ICON2025?
Don’t miss this symposium today at 13:45!
Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"
#openscience #neuroskyence
Don’t miss this symposium today at 13:45!
Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"
#openscience #neuroskyence
This is the line-up 👇We‘ll cover recent result from #EEGManyLabs & #EEGManyPipelines as well as ongoing projects from @scone-neuro.bsky.social and @igor-dgps.bsky.social ! Join us tomorrow at #ICON2025 - 13:45 in room Boavista!
September 17, 2025 at 7:05 AM
📣 Attending #ICON2025?
Don’t miss this symposium today at 13:45!
Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"
#openscience #neuroskyence
Don’t miss this symposium today at 13:45!
Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"
#openscience #neuroskyence
Reposted by Janik Goltermann
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | bioRxiv www.biorxiv.org/content/10.1...
September 11, 2025 at 1:47 AM
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | bioRxiv www.biorxiv.org/content/10.1...
Reposted by Janik Goltermann
What prevents suicide in #bipolar disorder?
Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182
Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/
#psychiatry
Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182
Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/
#psychiatry
September 16, 2025 at 12:01 PM
What prevents suicide in #bipolar disorder?
Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182
Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/
#psychiatry
Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182
Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/
#psychiatry
Reposted by Janik Goltermann
Strategies for effective coding agent usage - the latest in my Better Code, Better Science series russpoldrack.substack.com/p/strategies...
Strategies for effective coding agent usage
Better Code, Better Science: Chapter 5, Part 4
russpoldrack.substack.com
September 16, 2025 at 3:48 PM
Strategies for effective coding agent usage - the latest in my Better Code, Better Science series russpoldrack.substack.com/p/strategies...
Reposted by Janik Goltermann
🚨 New paper in @npp-journal.bsky.social! We combined data from 3 studies (including an SSRI RCT) to explore how endocannabinoids relate to anxiety & treatment response in kids + teens. Team science w/ Jeanne Barcelona, Jeffrey Strawn & more!
www.nature.com/articles/s41...
@wsuthinklab.bsky.social
www.nature.com/articles/s41...
@wsuthinklab.bsky.social
Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors - Neuropsychopharmacology
Neuropsychopharmacology - Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors
www.nature.com
June 30, 2025 at 4:50 PM
🚨 New paper in @npp-journal.bsky.social! We combined data from 3 studies (including an SSRI RCT) to explore how endocannabinoids relate to anxiety & treatment response in kids + teens. Team science w/ Jeanne Barcelona, Jeffrey Strawn & more!
www.nature.com/articles/s41...
@wsuthinklab.bsky.social
www.nature.com/articles/s41...
@wsuthinklab.bsky.social
Reposted by Janik Goltermann
Happy to share our recent work attempting to better understand the impact of early life maternal separation on locus coeruleus function. Super proud of first author (the now Dr.) Chayla Vazquez. She brought this idea when she joined in… March 2020… and she carried it through these rough few years!
#ThisWeekInNPP
Early life stress profoundly impacts the 🧠 & can result in negative affective behaviors well into adulthood
Here, maternal separation stress produced dysregulated noradrenergic activity in the locus coeruleus (LC) across the lifespan, disrupting LC regulation of coping strategies
Early life stress profoundly impacts the 🧠 & can result in negative affective behaviors well into adulthood
Here, maternal separation stress produced dysregulated noradrenergic activity in the locus coeruleus (LC) across the lifespan, disrupting LC regulation of coping strategies
Maternal separation disrupts noradrenergic control of adult coping behaviors - Neuropsychopharmacology
Neuropsychopharmacology - Maternal separation disrupts noradrenergic control of adult coping behaviors
www.nature.com
September 12, 2025 at 7:56 PM
Happy to share our recent work attempting to better understand the impact of early life maternal separation on locus coeruleus function. Super proud of first author (the now Dr.) Chayla Vazquez. She brought this idea when she joined in… March 2020… and she carried it through these rough few years!
Reposted by Janik Goltermann
Just a friendly reminder to check who owns the preprint servers that you are using and to choose a non-commercial one: en.wikipedia.org/wiki/List_of...
May 13, 2025 at 8:02 AM
Just a friendly reminder to check who owns the preprint servers that you are using and to choose a non-commercial one: en.wikipedia.org/wiki/List_of...
🧠Out now @natcomms.nature.com !
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
September 16, 2025 at 4:21 PM
🧠Out now @natcomms.nature.com !
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
Reposted by Janik Goltermann
Looking for a 3-year 100% postdoc position at the intersection of mental health, neuroimaging and biological markers? Come join our team: short.sg/j/59191808
Postdoktorandin / Postdoktorand / PostDoc – Klinik für Psychiatrie, Psychosomatik und Psychotherapie
Postdoktorandin / Postdoktorand / PostDoc – Klinik für Psychiatrie, Psychosomatik und Psychotherapie
short.sg
September 5, 2025 at 3:02 PM
Looking for a 3-year 100% postdoc position at the intersection of mental health, neuroimaging and biological markers? Come join our team: short.sg/j/59191808
Reposted by Janik Goltermann
🧠 #DecisionMaking isn’t confined to single hubs but distributed across the #brain, incl. #sensory, #motor & #reward areas. Data of >600,000 neurons, 279 regions, 139 mice 🐭 across 12 labs 💪 from this extraordinary study show how #cognitive processes emerge from #brainwide #dynamics.
#Neuroscience 🧪
#Neuroscience 🧪
Sad day for peope who still believe brain areas are the primary organizational units of function in the brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A brain-wide map of neural activity during complex behaviour - Nature
The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...
www.nature.com
September 4, 2025 at 2:40 PM
🧠 #DecisionMaking isn’t confined to single hubs but distributed across the #brain, incl. #sensory, #motor & #reward areas. Data of >600,000 neurons, 279 regions, 139 mice 🐭 across 12 labs 💪 from this extraordinary study show how #cognitive processes emerge from #brainwide #dynamics.
#Neuroscience 🧪
#Neuroscience 🧪
Reposted by Janik Goltermann
At the FORRT Replication Hub, our mission is to support researchers who want to replicate previous findings. We have now published a big new component with which we want to fulfill this mission: An open access handbook for reproduction and replication studies: forrt.org/replication_...
September 3, 2025 at 6:54 AM
At the FORRT Replication Hub, our mission is to support researchers who want to replicate previous findings. We have now published a big new component with which we want to fulfill this mission: An open access handbook for reproduction and replication studies: forrt.org/replication_...
Reposted by Janik Goltermann
New preprint...and this one is truly EPIC 🚨.
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
August 30, 2025 at 8:30 AM
New preprint...and this one is truly EPIC 🚨.
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Reposted by Janik Goltermann
The lateral prefrontal cortex 🧠— which we think of as critical for goal driven behavior + is a target for psychiatric treatments— is fundamentally different in individuals relative to the group averages we’ve often studied.
👇see preprint and thread, led by Zach Ladwig
#neuroskyence #PsychSciSky
👇see preprint and thread, led by Zach Ladwig
#neuroskyence #PsychSciSky
August 14, 2025 at 3:16 PM
The lateral prefrontal cortex 🧠— which we think of as critical for goal driven behavior + is a target for psychiatric treatments— is fundamentally different in individuals relative to the group averages we’ve often studied.
👇see preprint and thread, led by Zach Ladwig
#neuroskyence #PsychSciSky
👇see preprint and thread, led by Zach Ladwig
#neuroskyence #PsychSciSky
🧠 Help shape a new MRI analysis toolbox for transparent, reproducible & replicable voxel-wise analyses!
📝 5–10 min anonymous survey on community needs/features: trap-survey.uni-muenster.de/index.php/93...
Please share!🔄
#Neuroimaging #OpenScience #Replicability #Neuroscience @traplabms.bsky.social
📝 5–10 min anonymous survey on community needs/features: trap-survey.uni-muenster.de/index.php/93...
Please share!🔄
#Neuroimaging #OpenScience #Replicability #Neuroscience @traplabms.bsky.social
Survey Open Science MRI Toolbox
trap-survey.uni-muenster.de
August 13, 2025 at 9:50 AM
🧠 Help shape a new MRI analysis toolbox for transparent, reproducible & replicable voxel-wise analyses!
📝 5–10 min anonymous survey on community needs/features: trap-survey.uni-muenster.de/index.php/93...
Please share!🔄
#Neuroimaging #OpenScience #Replicability #Neuroscience @traplabms.bsky.social
📝 5–10 min anonymous survey on community needs/features: trap-survey.uni-muenster.de/index.php/93...
Please share!🔄
#Neuroimaging #OpenScience #Replicability #Neuroscience @traplabms.bsky.social
Reposted by Janik Goltermann
🚀Making Replications Count Hackathon - in-person🚀
3 days. 2 open tools. 1 goal: make replication studies impossible to ignore
📅22–24 Oct 2025 | Münster, Germany ✈️Travel & accommodation covered (UKRI-funded)
Find out more below 👇
#OpenScience #Metascience #Replication #Hackathon #CodingForScience
3 days. 2 open tools. 1 goal: make replication studies impossible to ignore
📅22–24 Oct 2025 | Münster, Germany ✈️Travel & accommodation covered (UKRI-funded)
Find out more below 👇
#OpenScience #Metascience #Replication #Hackathon #CodingForScience
August 11, 2025 at 12:17 PM
🚀Making Replications Count Hackathon - in-person🚀
3 days. 2 open tools. 1 goal: make replication studies impossible to ignore
📅22–24 Oct 2025 | Münster, Germany ✈️Travel & accommodation covered (UKRI-funded)
Find out more below 👇
#OpenScience #Metascience #Replication #Hackathon #CodingForScience
3 days. 2 open tools. 1 goal: make replication studies impossible to ignore
📅22–24 Oct 2025 | Münster, Germany ✈️Travel & accommodation covered (UKRI-funded)
Find out more below 👇
#OpenScience #Metascience #Replication #Hackathon #CodingForScience
Reposted by Janik Goltermann
🧪 98% researchers value publishing null/negative results—yet <20% actually submit them.
🗑️ ~€26B wasted in Europe from duplicating unpublished null data
📢 Editors: make space for null results. Make it visible. Science needs it. #OpenScience #ResearchIntegrity #NullResults
🗑️ ~€26B wasted in Europe from duplicating unpublished null data
📢 Editors: make space for null results. Make it visible. Science needs it. #OpenScience #ResearchIntegrity #NullResults
August 10, 2025 at 10:51 AM
🧪 98% researchers value publishing null/negative results—yet <20% actually submit them.
🗑️ ~€26B wasted in Europe from duplicating unpublished null data
📢 Editors: make space for null results. Make it visible. Science needs it. #OpenScience #ResearchIntegrity #NullResults
🗑️ ~€26B wasted in Europe from duplicating unpublished null data
📢 Editors: make space for null results. Make it visible. Science needs it. #OpenScience #ResearchIntegrity #NullResults
Reposted by Janik Goltermann
"Experts cannot unambiguously decide if a failure to attain the same results evidences a failure to replicate the original results or a violation of the ceteris paribus assumption between the original and its direct replication."
Open Access: doi.org/10.1007/s108...
Open Access: doi.org/10.1007/s108...
August 7, 2025 at 9:51 PM
"Experts cannot unambiguously decide if a failure to attain the same results evidences a failure to replicate the original results or a violation of the ceteris paribus assumption between the original and its direct replication."
Open Access: doi.org/10.1007/s108...
Open Access: doi.org/10.1007/s108...