Fabrizio Musacchio
@fabmusacchio.bsky.social
Hi 👋 I'm a postdoc in the #Neuroimmunology and #Imaging group at the @dzne.science Bonn 🧪🔬 Passionate about #ComputationalNeuroscience 🧠💻 and #NeuralModeling 🧮
🌍 fabriziomusacchio.com
👨💻 github.com/FabrizioMusacchio
🐘 sigmoid.social/@pixeltracker
🌍 fabriziomusacchio.com
👨💻 github.com/FabrizioMusacchio
🐘 sigmoid.social/@pixeltracker
Reposted by Fabrizio Musacchio
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
www.nature.com
November 13, 2025 at 1:08 PM
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Reposted by Fabrizio Musacchio
🗓️ Mark your calendars: the next #BernsteinConference will take place September 28 to October 1, 2026, in Frankfurt am Main!
Follow the link below to meet the first confirmed speakers. More to come!
👉 bernstein-network.de/bernstein-co...
#BernsteinNetwork #CompNeuro
Follow the link below to meet the first confirmed speakers. More to come!
👉 bernstein-network.de/bernstein-co...
#BernsteinNetwork #CompNeuro
November 13, 2025 at 8:00 AM
🗓️ Mark your calendars: the next #BernsteinConference will take place September 28 to October 1, 2026, in Frankfurt am Main!
Follow the link below to meet the first confirmed speakers. More to come!
👉 bernstein-network.de/bernstein-co...
#BernsteinNetwork #CompNeuro
Follow the link below to meet the first confirmed speakers. More to come!
👉 bernstein-network.de/bernstein-co...
#BernsteinNetwork #CompNeuro
Reposted by Fabrizio Musacchio
How “intelligent” is a slime mold? When it solves mazes, it might not be thinking:it’s obeying physics. Our new paper with
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social
November 12, 2025 at 4:17 AM
How “intelligent” is a slime mold? When it solves mazes, it might not be thinking:it’s obeying physics. Our new paper with
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social
@jordiplam.bsky.social shows how it follows a least action principle,letting physics do the job arxiv.org/pdf/2511.08531
@drmichaellevin.bsky.social @docteur-drey.bsky.social
In #Germany, a court ruled that #OpenAI violated #copyright law by using protected #songlyrics without permission. The court says that each time a copyrighted song is used, either for training or in an chat answer, OpenAI must pay a license fee to the artists.
🌍 www.tagesschau.de/wirtschaft/d...
🌍 www.tagesschau.de/wirtschaft/d...
Münchner Gericht: ChatGPT darf Liedtexte nicht ohne Lizenz nutzen
Im Streit um die Nutzung von Liedtexten - unter anderem von Herbert Grönemeyer - hat der ChatGPT-Betreiber OpenAI eine Niederlage gegen die GEMA hinnehmen müssen. Das Landgericht München sieht eine Ur...
www.tagesschau.de
November 12, 2025 at 9:50 AM
In #Germany, a court ruled that #OpenAI violated #copyright law by using protected #songlyrics without permission. The court says that each time a copyrighted song is used, either for training or in an chat answer, OpenAI must pay a license fee to the artists.
🌍 www.tagesschau.de/wirtschaft/d...
🌍 www.tagesschau.de/wirtschaft/d...
#arXiv will no longer accept #CcomputerScience review papers unless they’re already accepted elsewhere. The reason: too many low-quality and #AI-generated submissions.
🌍 https://www.nature.com/articles/d41586-025-03664-7
🌍 https://www.nature.com/articles/d41586-025-03664-7
November 12, 2025 at 9:26 AM
#arXiv will no longer accept #CcomputerScience review papers unless they’re already accepted elsewhere. The reason: too many low-quality and #AI-generated submissions.
🌍 https://www.nature.com/articles/d41586-025-03664-7
🌍 https://www.nature.com/articles/d41586-025-03664-7
Reposted by Fabrizio Musacchio
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
October 30, 2025 at 10:37 AM
I have a number of colleagues who think that LLMs will be very useful as individualized tutors.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
November 12, 2025 at 4:20 AM
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
Reposted by Fabrizio Musacchio
🧠 Microglia are the brain’s living sensors — extending and retracting their fine “feet” to shape synapses, sense activity, and repair tissue.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
November 11, 2025 at 3:56 PM
🧠 Microglia are the brain’s living sensors — extending and retracting their fine “feet” to shape synapses, sense activity, and repair tissue.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
Reposted by Fabrizio Musacchio
Latest from the lab: Laura Haetzel finds that excitatory transmission from auditory thalamus to tail of striatum is accompanied by a sparse inhibitory projection. This allows for state-dependent control of striatal output.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Inhibitory inputs from thalamus promote resilient spiking in tail of striatum
Neuroscience; Sensory neuroscience
www.cell.com
November 11, 2025 at 3:04 PM
Latest from the lab: Laura Haetzel finds that excitatory transmission from auditory thalamus to tail of striatum is accompanied by a sparse inhibitory projection. This allows for state-dependent control of striatal output.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Fabrizio Musacchio
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
November 10, 2025 at 6:14 PM
𝗜𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗮 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝗻𝗲𝘁𝘄𝗼𝗿𝗸?
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
In a sense yes, but does network science help us understand the brain as a complex system? Intriguing paper.
If anything the paper has 800+ refs!
#neuroskyence #complexsystems
doi.org/10.1016/j.pl...
Reposted by Fabrizio Musacchio
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
November 9, 2025 at 9:33 PM
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Reposted by Fabrizio Musacchio
All talks of the 2025 UCL #Neuropixels course are now available: www.youtube.com/playlist?lis...
For more information on the course see the website: www.ucl.ac.uk/neuropixels/...
And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋.
Happy Neuropixeling!
For more information on the course see the website: www.ucl.ac.uk/neuropixels/...
And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋.
Happy Neuropixeling!
2025 UCL Neuropixels Course - YouTube
Lectures at the 2025 UCL Neuropixels course (https://www.ucl.ac.uk/neuropixels/training/2025-neuropixels-course)
www.youtube.com
November 10, 2025 at 1:48 PM
All talks of the 2025 UCL #Neuropixels course are now available: www.youtube.com/playlist?lis...
For more information on the course see the website: www.ucl.ac.uk/neuropixels/...
And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋.
Happy Neuropixeling!
For more information on the course see the website: www.ucl.ac.uk/neuropixels/...
And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋.
Happy Neuropixeling!
Reposted by Fabrizio Musacchio
Flower Power: Cells induced by molybdenum disulphide nanoflowers to increase production of mitochondria to transfer to & repair damaged cells
📹 John Soukar et al @tamu.bsky.social in @pnas.org
➡️ bpod.org.uk/archive/2025...
📹 John Soukar et al @tamu.bsky.social in @pnas.org
➡️ bpod.org.uk/archive/2025...
November 9, 2025 at 10:38 AM
Flower Power: Cells induced by molybdenum disulphide nanoflowers to increase production of mitochondria to transfer to & repair damaged cells
📹 John Soukar et al @tamu.bsky.social in @pnas.org
➡️ bpod.org.uk/archive/2025...
📹 John Soukar et al @tamu.bsky.social in @pnas.org
➡️ bpod.org.uk/archive/2025...
Reposted by Fabrizio Musacchio
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
November 7, 2025 at 4:29 PM
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
Reposted by Fabrizio Musacchio
Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
November 7, 2025 at 2:40 PM
Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Reposted by Fabrizio Musacchio
🧠 How do emotion and memory shape behavior?
Join live webinar with Dr. Oliver Barnstedt @obarnstedt.bsky.social l & Dr. Anne Petzold @neuroadept.bsky.social(European Neuroscience Institute Göttingen)
🗓️ November 13th | 14:00 CET
👉 Clickto register: us02web.zoom.us/webinar/regi...
Join live webinar with Dr. Oliver Barnstedt @obarnstedt.bsky.social l & Dr. Anne Petzold @neuroadept.bsky.social(European Neuroscience Institute Göttingen)
🗓️ November 13th | 14:00 CET
👉 Clickto register: us02web.zoom.us/webinar/regi...
November 7, 2025 at 8:22 AM
🧠 How do emotion and memory shape behavior?
Join live webinar with Dr. Oliver Barnstedt @obarnstedt.bsky.social l & Dr. Anne Petzold @neuroadept.bsky.social(European Neuroscience Institute Göttingen)
🗓️ November 13th | 14:00 CET
👉 Clickto register: us02web.zoom.us/webinar/regi...
Join live webinar with Dr. Oliver Barnstedt @obarnstedt.bsky.social l & Dr. Anne Petzold @neuroadept.bsky.social(European Neuroscience Institute Göttingen)
🗓️ November 13th | 14:00 CET
👉 Clickto register: us02web.zoom.us/webinar/regi...
Reposted by Fabrizio Musacchio
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Fabrizio Musacchio
A tad late (announcements coming) but very happy to share the latest developments in my previous preprint!
Previously, we show that neural representations for control of movement are largely distinct following supervised or reinforcement learning. The latter most closely matches NHP recordings.
Previously, we show that neural representations for control of movement are largely distinct following supervised or reinforcement learning. The latter most closely matches NHP recordings.
Here’s our latest work at @glajoie.bsky.social and @mattperich.bsky.social ‘s labs! Excited to see this out.
We used a combination of neural recordings & modelling to show that RL yields neural dynamics closer to biology, with useful continual learning properties.
www.biorxiv.org/content/10.1...
We used a combination of neural recordings & modelling to show that RL yields neural dynamics closer to biology, with useful continual learning properties.
www.biorxiv.org/content/10.1...
Brain-like neural dynamics for behavioral control develop through reinforcement learning
During development, neural circuits are shaped continuously as we learn to control our bodies. The ultimate goal of this process is to produce neural dynamics that enable the rich repertoire of behavi...
www.biorxiv.org
November 6, 2025 at 2:10 AM
A tad late (announcements coming) but very happy to share the latest developments in my previous preprint!
Previously, we show that neural representations for control of movement are largely distinct following supervised or reinforcement learning. The latter most closely matches NHP recordings.
Previously, we show that neural representations for control of movement are largely distinct following supervised or reinforcement learning. The latter most closely matches NHP recordings.
Reposted by Fabrizio Musacchio
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 10:04 AM
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
Reposted by Fabrizio Musacchio
🌀🌀🌀New paper on the generation phases of Flow Matching arxiv.org/abs/2510.24830
Are FM & diffusion models nothing else than denoisers at every noise level?
In theory yes, *if trained optimally*. But in practice, do all noise level equally matter?
with @annegnx.bsky.social, S Martin & R Gribonval
Are FM & diffusion models nothing else than denoisers at every noise level?
In theory yes, *if trained optimally*. But in practice, do all noise level equally matter?
with @annegnx.bsky.social, S Martin & R Gribonval
November 5, 2025 at 9:03 AM
🌀🌀🌀New paper on the generation phases of Flow Matching arxiv.org/abs/2510.24830
Are FM & diffusion models nothing else than denoisers at every noise level?
In theory yes, *if trained optimally*. But in practice, do all noise level equally matter?
with @annegnx.bsky.social, S Martin & R Gribonval
Are FM & diffusion models nothing else than denoisers at every noise level?
In theory yes, *if trained optimally*. But in practice, do all noise level equally matter?
with @annegnx.bsky.social, S Martin & R Gribonval
Reposted by Fabrizio Musacchio
1/N
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
June 23, 2025 at 12:28 PM
1/N
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
Just came across #FPbase, a community-driven database for #fluorescent #proteins and #spectral properties 🌈 Very useful for selecting reporters, comparing #excitation/ #emission #spectra, planning multi-color #imaging 🔬, and avoiding spectral overlap:
🌍 https://www.fpbase.org/about/
#Microscopy 🧪
🌍 https://www.fpbase.org/about/
#Microscopy 🧪
November 5, 2025 at 3:29 PM
Just came across #FPbase, a community-driven database for #fluorescent #proteins and #spectral properties 🌈 Very useful for selecting reporters, comparing #excitation/ #emission #spectra, planning multi-color #imaging 🔬, and avoiding spectral overlap:
🌍 https://www.fpbase.org/about/
#Microscopy 🧪
🌍 https://www.fpbase.org/about/
#Microscopy 🧪
Reposted by Fabrizio Musacchio
Specialized structure of neural population codes in parietal cortex outputs
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specialized structure of neural population codes in parietal cortex outputs - Nature Neuroscience
Cortical neurons comprising an output pathway form a specialized population code that enhances the propagation of information to a downstream target, potentially improving the accuracy of decision-mak...
www.nature.com
November 5, 2025 at 2:13 PM
Specialized structure of neural population codes in parietal cortex outputs
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This Saturday is #OpenCampus 2025 at the @unicologne.bsky.social (open house):
⏰ Saturday, November 8, 2025, from 10 am to 3 pm
🌍 https://uni.koeln/Y7Y6J https://wisskomm.social/@UniKoeln/115491169819354059
⏰ Saturday, November 8, 2025, from 10 am to 3 pm
🌍 https://uni.koeln/Y7Y6J https://wisskomm.social/@UniKoeln/115491169819354059
November 4, 2025 at 9:15 PM
This Saturday is #OpenCampus 2025 at the @unicologne.bsky.social (open house):
⏰ Saturday, November 8, 2025, from 10 am to 3 pm
🌍 https://uni.koeln/Y7Y6J https://wisskomm.social/@UniKoeln/115491169819354059
⏰ Saturday, November 8, 2025, from 10 am to 3 pm
🌍 https://uni.koeln/Y7Y6J https://wisskomm.social/@UniKoeln/115491169819354059