Jacob Smith
@jacobsmithsci.bsky.social
PI @UniBarcelona @IBUB_UB. https://sites.google.com/view/smithlab-ibub/home?authuser=0 Circadian clocks and inter-organ crosstalk.
Pinned
Circadian clock communication during homeostasis and ageing
Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...
rdcu.be
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
Reposted by Jacob Smith
🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu
Mechanobiology meets Nuclear Metabolism
www.nature.com/articles/s41...
Mechanobiology meets Nuclear Metabolism
www.nature.com/articles/s41...
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications
The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...
www.nature.com
July 30, 2025 at 10:03 AM
🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu
Mechanobiology meets Nuclear Metabolism
www.nature.com/articles/s41...
Mechanobiology meets Nuclear Metabolism
www.nature.com/articles/s41...
🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
Cancer-induced liver changes promote body wasting through secreted factors, with circadian
regulators and hepatokines being important contributors to cancer cachexia.
www.cell.com
July 22, 2025 at 5:29 PM
🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...
Part time (20h per week) technician/predoc position available in my lab at the University of Barcelona 🧬⏰ studying circadian rhythms & inter-organ crosstalk.
Starts 1st Sept 2025.
Contact via email link in website (sites.google.com/view/smithla...) for more info
#ScienceJobs #Barcelona #Circadian
Starts 1st Sept 2025.
Contact via email link in website (sites.google.com/view/smithla...) for more info
#ScienceJobs #Barcelona #Circadian
June 23, 2025 at 4:20 PM
Part time (20h per week) technician/predoc position available in my lab at the University of Barcelona 🧬⏰ studying circadian rhythms & inter-organ crosstalk.
Starts 1st Sept 2025.
Contact via email link in website (sites.google.com/view/smithla...) for more info
#ScienceJobs #Barcelona #Circadian
Starts 1st Sept 2025.
Contact via email link in website (sites.google.com/view/smithla...) for more info
#ScienceJobs #Barcelona #Circadian
🧪 Encouraging to see people standing up against tyranny and fascism in the US. The Trump administration’s anti-science and pro-war agenda isn’t just dangerous at home — it threatens progress and stability worldwide. Enough!
TODAY 6/14/25, we peacefully make our voices heard... NO KINGS!* 🇺🇸
*Also NO: CONVICTED FELONS/PATHOLOGICAL LIARS/DRAFT DODGERS/ADJUDICATED RAPISTS/SHORT-FINGERED VULGARIANS/MALIGNANT NARCISSISTS & ANYONE WHO INCITED AN INSURRECTION IN AN ATTEMPTED COUP AGAINST HIS OWN COUNTRY a/k/a TRAITORS ✊
*Also NO: CONVICTED FELONS/PATHOLOGICAL LIARS/DRAFT DODGERS/ADJUDICATED RAPISTS/SHORT-FINGERED VULGARIANS/MALIGNANT NARCISSISTS & ANYONE WHO INCITED AN INSURRECTION IN AN ATTEMPTED COUP AGAINST HIS OWN COUNTRY a/k/a TRAITORS ✊
June 14, 2025 at 9:20 AM
🧪 Encouraging to see people standing up against tyranny and fascism in the US. The Trump administration’s anti-science and pro-war agenda isn’t just dangerous at home — it threatens progress and stability worldwide. Enough!
Reposted by Jacob Smith
The failure of the National Academy of Sciences USA to make a clear and unequivocal statement about the disastrous Trump administration science policies — it lets all of us down and dooms them to eventual irrelevance.
US science is being wrecked, and its leadership is fighting the last war
Facing an extreme budget, the National Academies hosted an event that ignored it.
arstechnica.com
June 5, 2025 at 4:19 AM
The failure of the National Academy of Sciences USA to make a clear and unequivocal statement about the disastrous Trump administration science policies — it lets all of us down and dooms them to eventual irrelevance.
Reposted by Jacob Smith
US science folks: it's been really heartening to see all the Stand Up For Science posts. Thank you for showing the backbone and resolve that most institutions have lacked.
March 8, 2025 at 11:14 AM
US science folks: it's been really heartening to see all the Stand Up For Science posts. Thank you for showing the backbone and resolve that most institutions have lacked.
Great to see US scientists protesting in response to the insanity that is the US "government" right now. @standupforscience.bsky.social 🧪
Just finished our signs for @standupforscience.bsky.social 🧪
March 7, 2025 at 7:29 AM
Great to see US scientists protesting in response to the insanity that is the US "government" right now. @standupforscience.bsky.social 🧪
Reposted by Jacob Smith
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
Reposted by Jacob Smith
As we age, our circadian clock goes off-track, which may contribute to age-related diseases. A new review paper gets into the mechanisms and potential ways to prevent the decline www.nature.com/articles/s41...
January 5, 2025 at 6:08 PM
As we age, our circadian clock goes off-track, which may contribute to age-related diseases. A new review paper gets into the mechanisms and potential ways to prevent the decline www.nature.com/articles/s41...
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
Circadian clock communication during homeostasis and ageing
Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...
rdcu.be
January 3, 2025 at 12:00 PM
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
Wow, this is quite wild!
...and it doesn't end there: In a 2nd @biorxivpreprint.bsky.social that we posted back-to-back with @bjornschumacher.bsky.social‘s lab we show that in addition to affecting epigenetic inheritance, temperature perception controls genetic inheritance via transposons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Thermosensory neurons control genetic inheritance through regulation of germline transposons
Epigenetic inheritance can be influenced by environmental conditions and somatic inputs originating from different tissues. Such transgenerational inheritance is reversable as it does not lead to muta...
www.biorxiv.org
December 6, 2024 at 10:01 AM
Wow, this is quite wild!
Reposted by Jacob Smith
It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.
November 30, 2024 at 10:24 PM
It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.
Wow, this is cool. Non natural cis elements designed in silico that are more effective than natural
Machine-guided design of cell-type-targeting cis-regulatory elements
www.nature.com/articles/s41... @natureportfolio.bsky.social
www.nature.com/articles/s41... @natureportfolio.bsky.social
Machine-guided design of cell-type-targeting cis-regulatory elements - Nature
A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
www.nature.com
November 26, 2024 at 3:04 PM
Wow, this is cool. Non natural cis elements designed in silico that are more effective than natural
Reposted by Jacob Smith
If you just moved to BlueSky and interested in #chronobiology, find some of your community here!
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
November 25, 2024 at 4:33 PM
If you just moved to BlueSky and interested in #chronobiology, find some of your community here!
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Reposted by Jacob Smith
This month we published 2 MANUSCRIPTS in @natureportfolio.bsky.social , nature communication
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
November 22, 2024 at 5:00 AM
This month we published 2 MANUSCRIPTS in @natureportfolio.bsky.social , nature communication
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
1. Natalia Pardo discovers the role of nuclear MTHFD2 in centromere stability
2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response.
Nuclear Metabolism is on 🔥
Reposted by Jacob Smith
Optimist: The cup is half full
Pessimist: The cup is half empty
Molecular biologist: I forgot to add the primers to the cup
Pessimist: The cup is half empty
Molecular biologist: I forgot to add the primers to the cup
Optimist: The cup is half full
Pessimist: The cup is half empty
Chemist: WHAT THE HELL IS THIS UNLABELLED CUP WITH MYSTERY LIQUID??
Pessimist: The cup is half empty
Chemist: WHAT THE HELL IS THIS UNLABELLED CUP WITH MYSTERY LIQUID??
Optimist: The cup is half full
Pessimist: The cup is half empty
Historian: The cup is a product of a changing society, evidence of valued craftsmanship, technological development, taste, societal mores, and markers of class. George Washington drank from it.
Pessimist: The cup is half empty
Historian: The cup is a product of a changing society, evidence of valued craftsmanship, technological development, taste, societal mores, and markers of class. George Washington drank from it.
November 24, 2024 at 11:03 AM
Optimist: The cup is half full
Pessimist: The cup is half empty
Molecular biologist: I forgot to add the primers to the cup
Pessimist: The cup is half empty
Molecular biologist: I forgot to add the primers to the cup
Reposted by Jacob Smith
Hey @biorxivpreprint.bsky.social, I think you need to add another icon here 🦋
November 22, 2024 at 9:27 AM
Hey @biorxivpreprint.bsky.social, I think you need to add another icon here 🦋
🧪 Word cloud from papers to date. I'd say it sums up my research focus pretty well! (scholargoggler.com). Thanks to a post from @mojoshark.bsky.social for the idea
November 21, 2024 at 1:00 PM
🧪 Word cloud from papers to date. I'd say it sums up my research focus pretty well! (scholargoggler.com). Thanks to a post from @mojoshark.bsky.social for the idea
Reposted by Jacob Smith
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature
Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...
www.nature.com
November 21, 2024 at 11:48 AM
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jacob Smith
#UniBarcelona | 💙 Estrenem perfil en aquesta xarxa social i us animem a seguir-nos-hi!
📱 La #UniBarcelona ha deixat de publicar a X per marcar distàncies amb un espai on es fomenten missatges d’odi i prolifera la desinformació.
Llegeix el comunicat 👉 web.ub.edu/web/actualit...
📱 La #UniBarcelona ha deixat de publicar a X per marcar distàncies amb un espai on es fomenten missatges d’odi i prolifera la desinformació.
Llegeix el comunicat 👉 web.ub.edu/web/actualit...
November 20, 2024 at 2:19 PM
#UniBarcelona | 💙 Estrenem perfil en aquesta xarxa social i us animem a seguir-nos-hi!
📱 La #UniBarcelona ha deixat de publicar a X per marcar distàncies amb un espai on es fomenten missatges d’odi i prolifera la desinformació.
Llegeix el comunicat 👉 web.ub.edu/web/actualit...
📱 La #UniBarcelona ha deixat de publicar a X per marcar distàncies amb un espai on es fomenten missatges d’odi i prolifera la desinformació.
Llegeix el comunicat 👉 web.ub.edu/web/actualit...
It was great to speak at the Muscle, Exercise and Health symposium last week @InstitutCochin in Paris. A fantastic meeting! Thanks to the organisers and speakers- including keynotes Bente Pedersen, Helen Blau and Marco Sandri for amazing talks. #muscle #circadian #aging
First post here to report on the awesome talk by Helen Blau @stanfordpress.bsky.social on #muscle aging and rejuvenation possibilities during the @institutcochin annual symposium! @cnrs.bsky.social @inserm.bsky.social @université-paris cité !
November 18, 2024 at 11:11 AM
It was great to speak at the Muscle, Exercise and Health symposium last week @InstitutCochin in Paris. A fantastic meeting! Thanks to the organisers and speakers- including keynotes Bente Pedersen, Helen Blau and Marco Sandri for amazing talks. #muscle #circadian #aging
Reposted by Jacob Smith
The backbone of academia has always been ‘middle-class labs’ (as David Glanzman puts it): those medium-sized labs with reasonable funding and a dream of making a big discovery.
November 17, 2024 at 5:24 AM
The backbone of academia has always been ‘middle-class labs’ (as David Glanzman puts it): those medium-sized labs with reasonable funding and a dream of making a big discovery.
Agree 100%
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.
November 17, 2024 at 4:20 PM
Agree 100%
🧪 hopefully now this enters the science feed 😊
🧪 ⏰️ Are you looking to start a PhD? Interested in circadian rhythms & inter-organ crosstalk? Up for living in Barcelona? (who isnt?). If 3 yeses, get in touch via my website (link in bio).
Shares appreciated 🙏 #science
#circadian #interorgan #metabolism #liver #muscle #PhD #newPI
Shares appreciated 🙏 #science
#circadian #interorgan #metabolism #liver #muscle #PhD #newPI
November 16, 2024 at 11:03 PM
🧪 hopefully now this enters the science feed 😊