Irene Fernández Ugidos
@irenefu.bsky.social
Neuroscientist - Two-photon | cranial window | dendritic spine plasticity | neurovascular coupling - Postdoc @ Institute of Neuroscience in Alicante
Reposted by Irene Fernández Ugidos
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
September 19, 2025 at 1:05 PM
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
Reposted by Irene Fernández Ugidos
Latest from the lab. Fantastic work by talented Irene Fernández @irenefu.bsky.social Send us your feedback!
Preserved synaptic architecture but impaired ketamine-induced synaptic plasticity of layer 5 pyramidal neurons in the aged frontal cortex https://www.biorxiv.org/content/10.1101/2025.09.02.673642v1
September 8, 2025 at 5:47 AM
Latest from the lab. Fantastic work by talented Irene Fernández @irenefu.bsky.social Send us your feedback!
Reposted by Irene Fernández Ugidos
New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬
We found that psilocybin prolongs the neurovascular response, independent of neural activity.
This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️
We found that psilocybin prolongs the neurovascular response, independent of neural activity.
This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️
Excited to share our latest work is up on bioRxiv! Looking at capillary flow speed changes we show that psilocybin prolongs the neurovascular coupling response to a visual stimulus. 🍄🔬🧠🩸
@chris-schaffer.bsky.social @alexkwan.bsky.social @sn-lab.bsky.social
Preprint:
www.biorxiv.org/content/10.1...
@chris-schaffer.bsky.social @alexkwan.bsky.social @sn-lab.bsky.social
Preprint:
www.biorxiv.org/content/10.1...
August 1, 2025 at 5:30 PM
New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬
We found that psilocybin prolongs the neurovascular response, independent of neural activity.
This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️
We found that psilocybin prolongs the neurovascular response, independent of neural activity.
This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️
Reposted by Irene Fernández Ugidos
It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution - Communications Biology
Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.
www.nature.com
June 1, 2025 at 9:58 AM
It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Irene Fernández Ugidos
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS
Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to
stabilize key features of network activity, but whether these di...
www.pnas.org
May 31, 2025 at 3:19 PM
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Irene Fernández Ugidos
Check out the latest updates on Zach Plumley's @plumley.bsky.social project and give us feedback before we submit! Kudos to him and the rest of the team, including Irene Fernandez Ugidos @irenefu.bsky.social and Jennifer Calvo-Iglesias.
Estradiol treatment enhances neurovascular coupling independent of metabolic health status in a mouse model of menopause https://www.biorxiv.org/content/10.1101/2025.05.21.655189v1
May 27, 2025 at 11:59 PM
Check out the latest updates on Zach Plumley's @plumley.bsky.social project and give us feedback before we submit! Kudos to him and the rest of the team, including Irene Fernandez Ugidos @irenefu.bsky.social and Jennifer Calvo-Iglesias.
Reposted by Irene Fernández Ugidos
BREAKING: NSF has frozen all grant funding, as of yesterday. It's unclear when they will resume funding awards, or why the pause has been put in place. www.nature.com/articles/d41...
Exclusive: NSF stops awarding new grants and funding existing ones
US science funder also plans to screen grant applications for compliance with ‘agency priorities’.
www.nature.com
May 1, 2025 at 10:58 PM
BREAKING: NSF has frozen all grant funding, as of yesterday. It's unclear when they will resume funding awards, or why the pause has been put in place. www.nature.com/articles/d41...
Reposted by Irene Fernández Ugidos
📣 🇺🇸 and 🇨🇦 researchers! How about bringing your excellent research ideas to Europe? Learn more about the prestigious @erc.europa.eu grants in a webinar on May 6.
euraxess.ec.europa.eu/worldwide/no...
euraxess.ec.europa.eu/worldwide/no...
Info session: ERC grants for excellent frontier research
Join EURAXESS North America and MSKCC us for a webinar on the bottom-up grants available from the European Research Council, the premier European funding organization for excellent frontier research.
euraxess.ec.europa.eu
April 28, 2025 at 7:31 AM
📣 🇺🇸 and 🇨🇦 researchers! How about bringing your excellent research ideas to Europe? Learn more about the prestigious @erc.europa.eu grants in a webinar on May 6.
euraxess.ec.europa.eu/worldwide/no...
euraxess.ec.europa.eu/worldwide/no...
Reposted by Irene Fernández Ugidos
Now online! Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
Stress-induced depression-like behaviors are driven by a dynamic recurrent network involving neurons and astrocytes in the lateral habenula and norepinephrine release from neurons in the locus coeruleus in freely moving mice.
dlvr.it
April 24, 2025 at 10:38 PM
Now online! Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
Reposted by Irene Fernández Ugidos
Really nice paper demonstrating astrocytic control of amygdala-dependent fear memory!
Nature research paper: Psychedelic control of neuroimmune interactions governing fear
https://go.nature.com/4iriy7u
https://go.nature.com/4iriy7u
Psychedelic control of neuroimmune interactions governing fear - Nature
Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.
go.nature.com
April 23, 2025 at 4:21 PM
Really nice paper demonstrating astrocytic control of amygdala-dependent fear memory!
Reposted by Irene Fernández Ugidos
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
April 17, 2025 at 2:40 AM
Registration is open for a few more weeks but if you’re a trainee and want to be considered for one of the four talking slots please register before this weekend. We are selecting speakers on Monday.
www.eventbrite.ca/e/neural-cir...
www.eventbrite.ca/e/neural-cir...
Reposted by Irene Fernández Ugidos
Two-photon imaging of #GABA release in the inner plexiform layer of male and female mice retinae (8–16 weeks old) reveals over 40 different GABA-releasing neuron types 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina - Nature Neuroscience
GABA is the primary inhibitory neurotransmitter in the central nervous system. Using two-photon GABA imaging, Matsumoto et al. reveal over 40 GABA neuron types in the mouse retina, each uniquely filte...
www.nature.com
April 16, 2025 at 1:45 PM
Two-photon imaging of #GABA release in the inner plexiform layer of male and female mice retinae (8–16 weeks old) reveals over 40 different GABA-releasing neuron types 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Irene Fernández Ugidos
Organizing a #SfN25 nano is a great opportunity to network and connect with others in your field.
Register today! bit.ly/4jA3aXr
Register today! bit.ly/4jA3aXr
Want to organize a #SfN25 nanosymposium but not sure where to start?
Join this live webinar to review how to select a topic, identify and recruit others to join the nano, and develop a strong nano proposal.
Register now on Neuronline!
🔗 bit.ly/3R9rLGn
#NeuroSky
Join this live webinar to review how to select a topic, identify and recruit others to join the nano, and develop a strong nano proposal.
Register now on Neuronline!
🔗 bit.ly/3R9rLGn
#NeuroSky
April 14, 2025 at 4:55 PM
Organizing a #SfN25 nano is a great opportunity to network and connect with others in your field.
Register today! bit.ly/4jA3aXr
Register today! bit.ly/4jA3aXr
Reposted by Irene Fernández Ugidos
Bright and photostable yellow fluorescent proteins for extended imaging by François St-Pierre and team:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bright and photostable yellow fluorescent proteins for extended imaging - Nature Communications
Yellow fluorescent proteins (YFPs) photobleach rapidly, restricting microscopy experiments. Here, the authors report mGold2s and mGold2t, YFPs that extend imaging durations up to 25 times longer than ...
www.nature.com
April 7, 2025 at 12:50 PM
Bright and photostable yellow fluorescent proteins for extended imaging by François St-Pierre and team:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Irene Fernández Ugidos
Nature research paper: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors
https://go.nature.com/4lev255
https://go.nature.com/4lev255
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
go.nature.com
April 3, 2025 at 11:05 AM
Nature research paper: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors
https://go.nature.com/4lev255
https://go.nature.com/4lev255
Reposted by Irene Fernández Ugidos
We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
March 27, 2025 at 2:19 PM
We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Irene Fernández Ugidos
Recognizing excellence in neuroscience strengthens the entire field.
The 2025 SfN Awards and Prizes celebrate the researchers, educators, and mentors who drive neuroscience forward.
Nominate a colleague, friend, or peer by Thursday, May 8.
🔗 bit.ly/4iXFGLz
#Neurosky
The 2025 SfN Awards and Prizes celebrate the researchers, educators, and mentors who drive neuroscience forward.
Nominate a colleague, friend, or peer by Thursday, May 8.
🔗 bit.ly/4iXFGLz
#Neurosky
March 24, 2025 at 3:01 PM
Recognizing excellence in neuroscience strengthens the entire field.
The 2025 SfN Awards and Prizes celebrate the researchers, educators, and mentors who drive neuroscience forward.
Nominate a colleague, friend, or peer by Thursday, May 8.
🔗 bit.ly/4iXFGLz
#Neurosky
The 2025 SfN Awards and Prizes celebrate the researchers, educators, and mentors who drive neuroscience forward.
Nominate a colleague, friend, or peer by Thursday, May 8.
🔗 bit.ly/4iXFGLz
#Neurosky
Reposted by Irene Fernández Ugidos
Online now:
Single-cell spatial transcriptomic atlas of the whole mouse brain
Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters and genes, spatiotemporal dynamics of transcription factor regulons, and a gene-based parcellation framework, providing a comprehensive resource for brain architecture.
dlvr.it
March 24, 2025 at 12:35 PM
Online now:
Reposted by Irene Fernández Ugidos
Reposted by Irene Fernández Ugidos
Join Tim Spellman and #eNeuro Reviewing Editor Mark Laubach in the upcoming #ResearchInConversation webinar to discuss an innovative platform offering a new tool for neuroscience research w/ broad applications in translational neuroscience.
#NeuroSky
#NeuroSky
March 14, 2025 at 6:02 PM
Join Tim Spellman and #eNeuro Reviewing Editor Mark Laubach in the upcoming #ResearchInConversation webinar to discuss an innovative platform offering a new tool for neuroscience research w/ broad applications in translational neuroscience.
#NeuroSky
#NeuroSky
New in Bluesky! Interested in neuroscience, synaptic plasticity and dendritic spines 🔬Currently in Mostany Lab at Tulane working with two-photon and exciting plasticity projects. Ah, I also do ceramics 🏺
March 11, 2025 at 4:19 AM
New in Bluesky! Interested in neuroscience, synaptic plasticity and dendritic spines 🔬Currently in Mostany Lab at Tulane working with two-photon and exciting plasticity projects. Ah, I also do ceramics 🏺
Reposted by Irene Fernández Ugidos
A new target for promoting plasticity of dendritic spines can also ease fragile X traits in mice, a new study shows.
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/spectrum/tar...
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/spectrum/tar...
Targeting NMDA receptor subunit reverses fragile X traits in mice
The subunit acts as a “volume control” on signaling that shapes the density of dendritic spines, the new work suggests.
www.thetransmitter.org
March 6, 2025 at 2:41 PM
A new target for promoting plasticity of dendritic spines can also ease fragile X traits in mice, a new study shows.
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/spectrum/tar...
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/spectrum/tar...