Malcolm Campbell
@malcolmgcampbell.bsky.social
Postdoc in Uchida Lab, Harvard (dopamine, learning, circuit computation) | PhD in Giocomo lab, Stanford (grid cells, path integration, navigation) | NIH NIDA K99/R00 | Bridging theory and biology of animal learning and decision making
Pinned
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
Reposted by Malcolm Campbell
How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (@deisseroth.bsky.social)
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation
In novel environments, animals quickly learn to navigate, and position-correlated spatial representations rapidly emerge in both the retrosplenial cortex (RSC) and primary visual cortex (V1). However,...
doi.org
October 24, 2025 at 3:40 AM
How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (@deisseroth.bsky.social)
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Malcolm Campbell
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by Malcolm Campbell
Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.
A brief rundown...
www.nature.com/articles/s41...
A brief rundown...
www.nature.com/articles/s41...
A parabrachial hub for need-state control of enduring pain - Nature
Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.
www.nature.com
October 9, 2025 at 1:15 PM
Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.
A brief rundown...
www.nature.com/articles/s41...
A brief rundown...
www.nature.com/articles/s41...
Reposted by Malcolm Campbell
Had a blast writing about this new @currentbiology.bsky.social study from @leo-perrier.bsky.social, Lény Lego et al. on African striped mice
The paper: doi.org/10.1016/j.cu...
Dispatch with some context about why it's so cool: authors.elsevier.com/a/1luVG3QW8S...
#bioacoustics
#neuroskyence
The paper: doi.org/10.1016/j.cu...
Dispatch with some context about why it's so cool: authors.elsevier.com/a/1luVG3QW8S...
#bioacoustics
#neuroskyence
Ultrasonic signals support a large-scale communication landscape in wild mice. 👇 New paper by the ENES Bioacoustics Research Team in @currentbiology.bsky.social
authors.elsevier.com/a/1llMH3QW8S...
authors.elsevier.com/a/1llMH3QW8S...
authors.elsevier.com
October 6, 2025 at 6:37 PM
Had a blast writing about this new @currentbiology.bsky.social study from @leo-perrier.bsky.social, Lény Lego et al. on African striped mice
The paper: doi.org/10.1016/j.cu...
Dispatch with some context about why it's so cool: authors.elsevier.com/a/1luVG3QW8S...
#bioacoustics
#neuroskyence
The paper: doi.org/10.1016/j.cu...
Dispatch with some context about why it's so cool: authors.elsevier.com/a/1luVG3QW8S...
#bioacoustics
#neuroskyence
Reposted by Malcolm Campbell
Did you know that facial expressions reveal more than meets the eye? 🤯
Our new study shows that even a mouse's face 🐭 can reflect hidden neural computations🧠. Turns out, facial expressions are more than just emotions!
We're so excited to see this paper out @natneuro.nature.com 🎉
🔗: rdcu.be/eIQzO
Our new study shows that even a mouse's face 🐭 can reflect hidden neural computations🧠. Turns out, facial expressions are more than just emotions!
We're so excited to see this paper out @natneuro.nature.com 🎉
🔗: rdcu.be/eIQzO
Facial expressions in mice reveal latent cognitive variables and their neural correlates
Nature Neuroscience - The face reveals more than just emotion. Cazettes, Reato and colleagues show that subtle facial movements reveal hidden cognitive states, reflecting the brain’s ongoing...
rdcu.be
September 30, 2025 at 11:30 AM
Did you know that facial expressions reveal more than meets the eye? 🤯
Our new study shows that even a mouse's face 🐭 can reflect hidden neural computations🧠. Turns out, facial expressions are more than just emotions!
We're so excited to see this paper out @natneuro.nature.com 🎉
🔗: rdcu.be/eIQzO
Our new study shows that even a mouse's face 🐭 can reflect hidden neural computations🧠. Turns out, facial expressions are more than just emotions!
We're so excited to see this paper out @natneuro.nature.com 🎉
🔗: rdcu.be/eIQzO
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
September 19, 2025 at 1:05 PM
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
Our paper on foraging is now published in Neuron! Read it here:
www.cell.com/neuron/fullt...
This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!
www.cell.com/neuron/fullt...
This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics
Bukwich and Campbell et al. show that mice integrate elapsed time and reward intake,
scaled by a latent patience variable, to decide when to leave virtual “patches.” Frontal
cortex ramping activity ma...
www.cell.com
August 7, 2025 at 5:35 PM
Our paper on foraging is now published in Neuron! Read it here:
www.cell.com/neuron/fullt...
This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!
www.cell.com/neuron/fullt...
This project was co-led by Michael Bukwich (not on Bluesky) and me, with major contributions from all co-authors. Huge thanks to the whole team!