Ignacio Vazquez-Garcia
@ignaciovazquez.bsky.social
Assistant Professor @ Massachusetts General Hospital | Harvard Medical School | Broad Institute
https://vazquezgarcialab.mgh.harvard.edu/
https://vazquezgarcialab.mgh.harvard.edu/
Pinned
New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)
Reposted by Ignacio Vazquez-Garcia
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Ignacio Vazquez-Garcia
Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...
www.nature.com
July 17, 2025 at 8:24 AM
Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team
Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process?
In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion.
www.nature.com/articles/s41...
In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion.
www.nature.com/articles/s41...
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...
www.nature.com
September 3, 2025 at 1:58 PM
Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process?
In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion.
www.nature.com/articles/s41...
In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion.
www.nature.com/articles/s41...
Reposted by Ignacio Vazquez-Garcia
We have two #postdoc positions open to join my team at @ebi.embl.org in beautiful Cambridge!
We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇
We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇
Postdoctoral Fellow
Your group The Cortes-Ciriano group studies the mutational processes and mechanisms of genome instability underpinning tumourigenesis, immune escape, and drug response through the analysis of high-thr...
embl.wd103.myworkdayjobs.com
April 4, 2025 at 11:37 AM
We have two #postdoc positions open to join my team at @ebi.embl.org in beautiful Cambridge!
We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇
We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇
Reposted by Ignacio Vazquez-Garcia
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The somatic mutation landscape of normal gastric epithelium - Nature
Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influen...
www.nature.com
March 20, 2025 at 2:59 PM
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)
January 7, 2025 at 5:18 AM
New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)
It was a treat to see the @OnesandToozePod live in New York last night. Timely dialogues on climate activism, the UN and cosmopolitanism. And Keynes, of course!
December 29, 2024 at 11:19 PM
It was a treat to see the @OnesandToozePod live in New York last night. Timely dialogues on climate activism, the UN and cosmopolitanism. And Keynes, of course!
Excited to share a commentary on emerging challenges in understanding and targeting cancer genome instability to improve patient outcomes:
https://bit.ly/3XoSstk
Thanks to @CD_AACR for the opportunity and to everyone else from the @AACR NextGen Stars Program who contributed!
https://bit.ly/3XoSstk
Thanks to @CD_AACR for the opportunity and to everyone else from the @AACR NextGen Stars Program who contributed!
December 29, 2024 at 11:19 PM
Excited to share a commentary on emerging challenges in understanding and targeting cancer genome instability to improve patient outcomes:
https://bit.ly/3XoSstk
Thanks to @CD_AACR for the opportunity and to everyone else from the @AACR NextGen Stars Program who contributed!
https://bit.ly/3XoSstk
Thanks to @CD_AACR for the opportunity and to everyone else from the @AACR NextGen Stars Program who contributed!
We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology!
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
December 29, 2024 at 11:19 PM
We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology!
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
Beautiful morning in San Diego! I am excited to present our latest work on genome instability in ovarian cancer. Looking forward to a fantastic session with @sajraparicio @McclellandLab @skimomiks (12:15-14:00 PT, Room 29 Conv...
December 29, 2024 at 11:24 PM
Beautiful morning in San Diego! I am excited to present our latest work on genome instability in ovarian cancer. Looking forward to a fantastic session with @sajraparicio @McclellandLab @skimomiks (12:15-14:00 PT, Room 29 Conv...
In Orlando this week for #AACR23! A great experience thus far presenting our recent work, meeting colleagues and hearing about the latest advances.
December 29, 2024 at 11:24 PM
In Orlando this week for #AACR23! A great experience thus far presenting our recent work, meeting colleagues and hearing about the latest advances.
To close out the year, I am incredibly delighted to share our latest work now published in @Nature.
We studied the impact of genomic instability on the tumor microenvironment and its role driving immune evasion in ovarian...
We studied the impact of genomic instability on the tumor microenvironment and its role driving immune evasion in ovarian...
December 29, 2024 at 11:29 PM
To close out the year, I am incredibly delighted to share our latest work now published in @Nature.
We studied the impact of genomic instability on the tumor microenvironment and its role driving immune evasion in ovarian...
We studied the impact of genomic instability on the tumor microenvironment and its role driving immune evasion in ovarian...
What an epic final full of so much suspense! Congratulations, Argentina! #FIFAWorldCup
December 29, 2024 at 11:34 PM
What an epic final full of so much suspense! Congratulations, Argentina! #FIFAWorldCup
Fabulous time with colleagues from across all the #CancerGrandChallenges teams in beautiful Barcelona.
December 29, 2024 at 11:34 PM
Fabulous time with colleagues from across all the #CancerGrandChallenges teams in beautiful Barcelona.
Wonderful morning meeting the Queen of Spain and Spanish colleagues in NYC to discuss the future of cancer research. Thanks to @ContraCancerEs @CasaReal @IC_NewYork @comunidadECUSA for hosting this event. #WorldCancerResearchDay
December 29, 2024 at 11:39 PM
Wonderful morning meeting the Queen of Spain and Spanish colleagues in NYC to discuss the future of cancer research. Thanks to @ContraCancerEs @CasaReal @IC_NewYork @comunidadECUSA for hosting this event. #WorldCancerResearchDay
#AACR22="/hashtag/AACR22" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#AACR22 minisymposium on single-cell and spatial profiling of tumor cells and the immune microenvironment, chaired by @IamLinghua and @SohrabShah
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
December 29, 2024 at 11:54 PM
#AACR22="/hashtag/AACR22" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#AACR22 minisymposium on single-cell and spatial profiling of tumor cells and the immune microenvironment, chaired by @IamLinghua and @SohrabShah
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
Proud and delighted to share our latest work on the impact of mutational processes on immune and malignant phenotypes in ovarian cancer.
https://www.biorxiv.org/content/10.1101/2021.08.24.454519v1
@sloan_kettering @CompOncMSK
@SohrabShah @DmitriyZamarin @fuhlitz
#singlecell...
https://www.biorxiv.org/content/10.1101/2021.08.24.454519v1
@sloan_kettering @CompOncMSK
@SohrabShah @DmitriyZamarin @fuhlitz
#singlecell...
Immune and malignant cell phenotypes of ovarian cancer ar...
High-grade serous ovarian cancer (HGSOC) is an archetypal...
www.biorxiv.org
December 30, 2024 at 12:15 AM
Proud and delighted to share our latest work on the impact of mutational processes on immune and malignant phenotypes in ovarian cancer.
https://www.biorxiv.org/content/10.1101/2021.08.24.454519v1
@sloan_kettering @CompOncMSK
@SohrabShah @DmitriyZamarin @fuhlitz
#singlecell...
https://www.biorxiv.org/content/10.1101/2021.08.24.454519v1
@sloan_kettering @CompOncMSK
@SohrabShah @DmitriyZamarin @fuhlitz
#singlecell...
Francisco Goya’s enlightened genius on display at The Met’s “Graphic Imagination”. #metmuseum #Goya275
December 30, 2024 at 12:20 AM
Francisco Goya’s enlightened genius on display at The Met’s “Graphic Imagination”. #metmuseum #Goya275
Vigil for the victims of police brutality. #BlackLivesMatter
December 30, 2024 at 12:20 AM
Vigil for the victims of police brutality. #BlackLivesMatter
This weekend I will be riding with Team @CompOncMSK at @Cycle4Survival. Every donation helps! All the funds raised will support rare cancer research at @sloan_kettering. You can donate here:
https://bit.ly/2vqfnM6
https://bit.ly/2vqfnM6
December 30, 2024 at 12:25 AM
This weekend I will be riding with Team @CompOncMSK at @Cycle4Survival. Every donation helps! All the funds raised will support rare cancer research at @sloan_kettering. You can donate here:
https://bit.ly/2vqfnM6
https://bit.ly/2vqfnM6
Superb work being presented today at the @sloan_kettering CMO Symposium. Come by the poster session to hear about the latest work we are doing between the @SohrabShah Lab and an incredible cross-disciplinary team of collaborators at MSK – 2:50-3:30pm at Zuckerman Research Center.
December 30, 2024 at 12:30 AM
Superb work being presented today at the @sloan_kettering CMO Symposium. Come by the poster session to hear about the latest work we are doing between the @SohrabShah Lab and an incredible cross-disciplinary team of collaborators at MSK – 2:50-3:30pm at Zuckerman Research Center.