Ignacio Vazquez-Garcia
@ignaciovazquez.bsky.social
Assistant Professor @ Massachusetts General Hospital | Harvard Medical School | Broad Institute
https://vazquezgarcialab.mgh.harvard.edu/
https://vazquezgarcialab.mgh.harvard.edu/
How do WGD tumors tolerate instability and evade immune sensing? WGD alters cell state: it delays G1/S, represses STING and IFN signaling, and decouples immune activation from chromosomal chaos despite abundant cytosolic DNA from ruptured micronuclei. [6/13]
September 3, 2025 at 1:58 PM
How do WGD tumors tolerate instability and evade immune sensing? WGD alters cell state: it delays G1/S, represses STING and IFN signaling, and decouples immune activation from chromosomal chaos despite abundant cytosolic DNA from ruptured micronuclei. [6/13]
Despite elevated chromosomal instability, WGD-high tumors exhibit tolerance to progressive karyotypic disruption, favoring gradual, post-WGD copy number losses. This supports a model where WGD promotes diversification via genomic remodeling. [5/13]
September 3, 2025 at 1:58 PM
Despite elevated chromosomal instability, WGD-high tumors exhibit tolerance to progressive karyotypic disruption, favoring gradual, post-WGD copy number losses. This supports a model where WGD promotes diversification via genomic remodeling. [5/13]
WGD was linked to elevated chromosomal instability: copy number alterations, missegregations, and ruptured micronuclei. We quantified these rates at single-cell resolution, using scWGS + phylogenetic analysis and multiplexed IF + deep learning-based image segmentation. [4/13]
September 3, 2025 at 1:58 PM
WGD was linked to elevated chromosomal instability: copy number alterations, missegregations, and ruptured micronuclei. We quantified these rates at single-cell resolution, using scWGS + phylogenetic analysis and multiplexed IF + deep learning-based image segmentation. [4/13]
We found that WGD is not a static or historical event. Nearly all tumors exhibited mixtures of 0×, 1×, and 2× WGD cells. Several tumors showed parallel WGD events in distinct subclones, while others displayed the emergence of new WGD clones late in evolution. [3/13]
September 3, 2025 at 1:58 PM
We found that WGD is not a static or historical event. Nearly all tumors exhibited mixtures of 0×, 1×, and 2× WGD cells. Several tumors showed parallel WGD events in distinct subclones, while others displayed the emergence of new WGD clones late in evolution. [3/13]
To answer this, we generated single-cell whole-genome sequencing (scWGS) data from >30,000 tumor cells across 41 patients with high-grade serous ovarian cancer (HGSOC). We integrated this with multiplexed immunofluorescence (IF) and single-cell RNA-seq data. [2/13]
September 3, 2025 at 1:58 PM
To answer this, we generated single-cell whole-genome sequencing (scWGS) data from >30,000 tumor cells across 41 patients with high-grade serous ovarian cancer (HGSOC). We integrated this with multiplexed immunofluorescence (IF) and single-cell RNA-seq data. [2/13]
New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)
January 7, 2025 at 5:18 AM
New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)
It was a treat to see the @OnesandToozePod live in New York last night. Timely dialogues on climate activism, the UN and cosmopolitanism. And Keynes, of course!
December 29, 2024 at 11:19 PM
It was a treat to see the @OnesandToozePod live in New York last night. Timely dialogues on climate activism, the UN and cosmopolitanism. And Keynes, of course!
We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology!
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
December 29, 2024 at 11:19 PM
We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology!
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
We have a fantastic program lined up! A few spots left. Register now!
🔥 GRS: June 8-9 (early career)🔥
https://dir.lat/O0TlRc
🔥 GRC: June 9-14 (main...
Beautiful morning in San Diego! I am excited to present our latest work on genome instability in ovarian cancer. Looking forward to a fantastic session with @sajraparicio @McclellandLab @skimomiks (12:15-14:00 PT, Room 29 Conv...
December 29, 2024 at 11:24 PM
Beautiful morning in San Diego! I am excited to present our latest work on genome instability in ovarian cancer. Looking forward to a fantastic session with @sajraparicio @McclellandLab @skimomiks (12:15-14:00 PT, Room 29 Conv...
Lots of familiar faces at the reception last night!
December 29, 2024 at 11:29 PM
Lots of familiar faces at the reception last night!
In Orlando this week for #AACR23! A great experience thus far presenting our recent work, meeting colleagues and hearing about the latest advances.
December 29, 2024 at 11:24 PM
In Orlando this week for #AACR23! A great experience thus far presenting our recent work, meeting colleagues and hearing about the latest advances.
Fabulous time with colleagues from across all the #CancerGrandChallenges teams in beautiful Barcelona.
December 29, 2024 at 11:34 PM
Fabulous time with colleagues from across all the #CancerGrandChallenges teams in beautiful Barcelona.
Wonderful morning meeting the Queen of Spain and Spanish colleagues in NYC to discuss the future of cancer research. Thanks to @ContraCancerEs @CasaReal @IC_NewYork @comunidadECUSA for hosting this event. #WorldCancerResearchDay
December 29, 2024 at 11:39 PM
Wonderful morning meeting the Queen of Spain and Spanish colleagues in NYC to discuss the future of cancer research. Thanks to @ContraCancerEs @CasaReal @IC_NewYork @comunidadECUSA for hosting this event. #WorldCancerResearchDay
@CSHL @cshlmeetings @MarioniLab kicked us off last night. Great presentations and lots of energy during the first session on functional genomics.
December 29, 2024 at 11:49 PM
@CSHL @cshlmeetings @MarioniLab kicked us off last night. Great presentations and lots of energy during the first session on functional genomics.
@adamcweiner is developing new tools to study DNA replication dynamics at single-cell resolution. Elegant method to understand the interplay of replication stress, genomic instability and tumor evolution.
December 30, 2024 at 12:15 AM
@adamcweiner is developing new tools to study DNA replication dynamics at single-cell resolution. Elegant method to understand the interplay of replication stress, genomic instability and tumor evolution.
@atulpdeshpande from @FertigLab presents the SpaceMarkers method for latent space analysis of tumor-immune interactions with spatial transcriptomics
December 30, 2024 at 12:10 AM
@atulpdeshpande from @FertigLab presents the SpaceMarkers method for latent space analysis of tumor-immune interactions with spatial transcriptomics
Runmin Wei from @nicholas_navin lab presents the CellTrek method to spatially resolve tumor clones and immune cell states in DCIS at single-cell resolution
December 30, 2024 at 12:05 AM
Runmin Wei from @nicholas_navin lab presents the CellTrek method to spatially resolve tumor clones and immune cell states in DCIS at single-cell resolution
@MaryamPourm walks us through her study of the spatial determinants of IL2 response in melanoma, recently published in @CIR_AACR
December 30, 2024 at 12:00 AM
@MaryamPourm walks us through her study of the spatial determinants of IL2 response in melanoma, recently published in @CIR_AACR
#AACR22="/hashtag/AACR22" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#AACR22 minisymposium on single-cell and spatial profiling of tumor cells and the immune microenvironment, chaired by @IamLinghua and @SohrabShah
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
December 29, 2024 at 11:54 PM
#AACR22="/hashtag/AACR22" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#AACR22 minisymposium on single-cell and spatial profiling of tumor cells and the immune microenvironment, chaired by @IamLinghua and @SohrabShah
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441 #AACR22
It was great to meet the exceptional awardees of the @AACR Scholar in Training Award last night. Great to see talented colleagues @danielkbronder @katherineemasih and many others recognised. Thanks to the Margaret Foti @AACR_CEO Foundation for supporting my attendance! #AACR22
December 30, 2024 at 12:15 AM
It was great to meet the exceptional awardees of the @AACR Scholar in Training Award last night. Great to see talented colleagues @danielkbronder @katherineemasih and many others recognised. Thanks to the Margaret Foti @AACR_CEO Foundation for supporting my attendance! #AACR22
