Ignacio Saez, PhD
@ignaciosaezphd.bsky.social
Associate Professor at Icahn School of Medicine at Mount Sinai. | Harnessing neurotechnology to explore human brain states & advance neurotherapies for mental health. thesaezlab.com
Pinned
How is prefrontal neural activity refined as we age?
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
✨ Program Manager Job Alert ✨ Join our Mount Sinai team in NYC to steer a multi-institutional neuroscience initiative aimed at understanding Bipolar Disorder.
If you’re passionate about science, data & impact we’d love to hear from you!
Learn More & Apply 👇
careers.mountsinai.org/jobs/3032351...
If you’re passionate about science, data & impact we’d love to hear from you!
Learn More & Apply 👇
careers.mountsinai.org/jobs/3032351...
Research Project Manager I (Dr Saez's Lab) - Neurosciences in New York, NY | Mount Sinai Health Systems
Mount Sinai is hiring a Research Project Manager I (Dr Saez's Lab) - Neurosciences in New York, NY. Review all of the job details and apply today!
careers.mountsinai.org
November 10, 2025 at 9:08 PM
✨ Program Manager Job Alert ✨ Join our Mount Sinai team in NYC to steer a multi-institutional neuroscience initiative aimed at understanding Bipolar Disorder.
If you’re passionate about science, data & impact we’d love to hear from you!
Learn More & Apply 👇
careers.mountsinai.org/jobs/3032351...
If you’re passionate about science, data & impact we’d love to hear from you!
Learn More & Apply 👇
careers.mountsinai.org/jobs/3032351...
What does "Human-centered neural engineering and AI" mean?
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
November 5, 2025 at 3:15 PM
What does "Human-centered neural engineering and AI" mean?
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
Reposted by Ignacio Saez, PhD
We are proud to award $18M to four new Discovery Research teams exploring neuromodulation and brain circuits in #Bipolar 🧠📈
🔗bit.ly/48M1TKP
🎙️ Hear from Daniel Pham, PhD, and the teams about their innovative projects 👇
🔗bit.ly/48M1TKP
🎙️ Hear from Daniel Pham, PhD, and the teams about their innovative projects 👇
October 28, 2025 at 2:20 PM
We are proud to award $18M to four new Discovery Research teams exploring neuromodulation and brain circuits in #Bipolar 🧠📈
🔗bit.ly/48M1TKP
🎙️ Hear from Daniel Pham, PhD, and the teams about their innovative projects 👇
🔗bit.ly/48M1TKP
🎙️ Hear from Daniel Pham, PhD, and the teams about their innovative projects 👇
How mood states shift in the brain remains one of psychiatry’s biggest mysteries.
With generous support from @bipolardiscoveries.org, our @sinaibrain.bsky.social team will apply cutting-edge techniques to map these transitions—aiming to build the most precise understanding of bipolar disorder yet.
With generous support from @bipolardiscoveries.org, our @sinaibrain.bsky.social team will apply cutting-edge techniques to map these transitions—aiming to build the most precise understanding of bipolar disorder yet.
PRESS RELEASE! @mountsinainyc.bsky.social receives $4.5 million @bipolardiscoveries.org grant! Led by @ignaciosaezphd.bsky.social, team will investigate neural mechanisms underlying #BipolarDisorder & pioneer novel neuromodulation-based treatment strategies 👉 www.mountsinai.org/about/newsro...
October 28, 2025 at 4:12 PM
How mood states shift in the brain remains one of psychiatry’s biggest mysteries.
With generous support from @bipolardiscoveries.org, our @sinaibrain.bsky.social team will apply cutting-edge techniques to map these transitions—aiming to build the most precise understanding of bipolar disorder yet.
With generous support from @bipolardiscoveries.org, our @sinaibrain.bsky.social team will apply cutting-edge techniques to map these transitions—aiming to build the most precise understanding of bipolar disorder yet.
Must-read #NYBCI25 coverage by @neurotechnology.substack.com in @forbes.com.
My key takeaway on cognitive BCI: Our biggest limiting factor isn't tech—it's fundamental scientific understanding.
We can’t advance the tech until we define the disorder. Basic research must lead the way!
My key takeaway on cognitive BCI: Our biggest limiting factor isn't tech—it's fundamental scientific understanding.
We can’t advance the tech until we define the disorder. Basic research must lead the way!
@mountsinainyc.bsky.social's #BrainComputerInterface Symposium has cemented itself as a must-attend for those interested in the nexus of brain health & implanted technologies. This is a MUST READ, in-depth summary of #NYBCI25 penned for @forbes.com by Naveen Rao 👉 www.forbes.com/sites/naveen...
October 23, 2025 at 6:18 PM
Must-read #NYBCI25 coverage by @neurotechnology.substack.com in @forbes.com.
My key takeaway on cognitive BCI: Our biggest limiting factor isn't tech—it's fundamental scientific understanding.
We can’t advance the tech until we define the disorder. Basic research must lead the way!
My key takeaway on cognitive BCI: Our biggest limiting factor isn't tech—it's fundamental scientific understanding.
We can’t advance the tech until we define the disorder. Basic research must lead the way!
What does it take to move neuroengineering breakthroughs into real-world impact?
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
October 16, 2025 at 4:53 PM
What does it take to move neuroengineering breakthroughs into real-world impact?
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
"It takes a village!" and I'm incredibly grateful to be a part of this one.
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
October 9, 2025 at 5:46 PM
"It takes a village!" and I'm incredibly grateful to be a part of this one.
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
Excited to be speaking at #NYBCI25 this weekend, alongside so many leaders in #Neurotech and #BCI.
It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.
www.nybci.com/event/2886b6...
It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.
www.nybci.com/event/2886b6...
2025 New York BCI Symposium
https://www.nybci.com/event/2886b64d-65fd-42dd-856c-57ff4a467388/program"
October 2, 2025 at 8:19 PM
Excited to be speaking at #NYBCI25 this weekend, alongside so many leaders in #Neurotech and #BCI.
It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.
www.nybci.com/event/2886b6...
It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.
www.nybci.com/event/2886b6...
I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
September 29, 2025 at 7:01 PM
I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
Reposted by Ignacio Saez, PhD
❤️Thank you to all of Mount Sinai’s past, present and future #PostdoctoralScholars whose hard work and dedication play a vital role in advancing biomedical research. Here, we celebrate the #SchillerLab’s Dr. @paruljain.bsky.social! #NPAW2025 Learn More about her work👉 www.teenmiso.org/post/intervi...
September 16, 2025 at 3:01 PM
❤️Thank you to all of Mount Sinai’s past, present and future #PostdoctoralScholars whose hard work and dedication play a vital role in advancing biomedical research. Here, we celebrate the #SchillerLab’s Dr. @paruljain.bsky.social! #NPAW2025 Learn More about her work👉 www.teenmiso.org/post/intervi...
Big congrats to @intlbrainlab.bsky.social on two groundbreaking new papers!
Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.
Read more: www.thetransmitter.org/decision-mak...
Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.
Read more: www.thetransmitter.org/decision-mak...
Everything everywhere all at once: Decision-making signals engage entire brain
The findings, gleaned from the most comprehensive map yet of brain activity during decision-making in mice, show that the process is even more distributed than previously thought.
www.thetransmitter.org
September 17, 2025 at 6:16 PM
Big congrats to @intlbrainlab.bsky.social on two groundbreaking new papers!
Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.
Read more: www.thetransmitter.org/decision-mak...
Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.
Read more: www.thetransmitter.org/decision-mak...
What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
September 2, 2025 at 5:58 PM
What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
Data from participants with treatment-resistant depression is revolutionizing our understanding of network disorders 🧠💻
Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️
Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️
In the latest episode of Brain Inspired, @crozell.bsky.social describes how his team is combining deep brain stimulation and explainable artificial intelligence to develop tools to help people with treatment-resistant depression.
www.thetransmitter.org/brain-inspir...
#neuroskyence
www.thetransmitter.org/brain-inspir...
#neuroskyence
Chris Rozell on brain stimulation and AI to treat depression
Rozell and his colleagues, using deep brain stimulation and explainable AI, have developed tools to help people with treatment-resistant depression.
www.thetransmitter.org
August 19, 2025 at 5:39 PM
Data from participants with treatment-resistant depression is revolutionizing our understanding of network disorders 🧠💻
Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️
Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️
Reposted by Ignacio Saez, PhD
NOT TO MISS! On Sept 22, 2025, Dr. Peter Rudebeck & The Lipschultz Center for Cognitive Neuroscience invite cognitive neuroscientists to a free symposium showcasing cutting-edge research being conducted across NYC & the surrounding area. Learn More | RSVP friedmanbrain.icahn.mssm.edu/lipschultz-s...
August 13, 2025 at 2:17 PM
NOT TO MISS! On Sept 22, 2025, Dr. Peter Rudebeck & The Lipschultz Center for Cognitive Neuroscience invite cognitive neuroscientists to a free symposium showcasing cutting-edge research being conducted across NYC & the surrounding area. Learn More | RSVP friedmanbrain.icahn.mssm.edu/lipschultz-s...
Need reality check on where brain-computer interface technology stands today? 🧠💻
This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.
This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.
On this episode of "Uncanny Valley," we dive into the heated race between two companies to build a commercial brain-computer interface. www.wired.com/story/uncann...
The Very Real Case for Brain-Computer Implants
On this episode of "Uncanny Valley," we dive into the heated race between two companies to build a commercial brain-computer interface.
www.wired.com
August 6, 2025 at 4:27 PM
Need reality check on where brain-computer interface technology stands today? 🧠💻
This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.
This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.
Reposted by Ignacio Saez, PhD
This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.
The development of aperiodic neural activity in the human brain - Nature Human Behaviour
This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.
www.nature.com
July 21, 2025 at 7:49 PM
This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.
How is prefrontal neural activity refined as we age?
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
July 21, 2025 at 7:13 PM
How is prefrontal neural activity refined as we age?
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.
July 9, 2025 at 9:05 PM
As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.
Huge news for Paradromics! 🎉 Their first human implant is a major milestone. Excited to see the Connexus Brain-Computer Interface enter clinical trials, bringing us closer to restoring motor and speech function for people with disabilities. Great coverage from @ashleycapoot.cnbc.com
It’s a major milestone for the nearly 10-year-old startup, as it marks the beginning of its next chapter as a clinical-stage company.
Neuralink competitor Paradromics completes first human implant
The procedure took place at the University of Michigan with a patient who was already undergoing neurosurgery to treat epilepsy.
cnb.cx
June 11, 2025 at 2:40 PM
Huge news for Paradromics! 🎉 Their first human implant is a major milestone. Excited to see the Connexus Brain-Computer Interface enter clinical trials, bringing us closer to restoring motor and speech function for people with disabilities. Great coverage from @ashleycapoot.cnbc.com
Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.
www.des-show.com/agenda-sessi...
www.des-show.com/agenda-sessi...
June 2, 2025 at 4:27 PM
Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.
www.des-show.com/agenda-sessi...
www.des-show.com/agenda-sessi...
What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
May 30, 2025 at 10:50 PM
What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
Thanks to @psypost.bsky.social for the thoughtful coverage of our work exploring the neural basis of human decision-making!
Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...
Learn more about our work: thesaezlab.com
Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...
Learn more about our work: thesaezlab.com
Surprisingly widespread brain activity supports economic decision-making, new study finds
Surprisingly widespread brain activity supports economic decision-making, new study finds
A new study using direct brain recordings reveals that human economic decision-making is not localized to a single brain region. Instead, multiple areas work together, with high-frequency activity encoding risk, reward probability, and the final choice itself.
www.psypost.org
May 22, 2025 at 6:21 PM
Thanks to @psypost.bsky.social for the thoughtful coverage of our work exploring the neural basis of human decision-making!
Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...
Learn more about our work: thesaezlab.com
Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...
Learn more about our work: thesaezlab.com
Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
May 19, 2025 at 4:57 PM
Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
Unlocking the brain's potential 🔐
Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.
Thanks to Yoga Journal for highlighting this work.
www.yogajournal.com/meditation/n...
Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.
Thanks to Yoga Journal for highlighting this work.
www.yogajournal.com/meditation/n...
What the Latest Research in Neuroscience Tells Us About Meditation
An exploration of the neuroscience of meditation, including recent research as well as future potential for its application.
www.yogajournal.com
May 15, 2025 at 5:48 PM
Unlocking the brain's potential 🔐
Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.
Thanks to Yoga Journal for highlighting this work.
www.yogajournal.com/meditation/n...
Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.
Thanks to Yoga Journal for highlighting this work.
www.yogajournal.com/meditation/n...
🤔 Imagine this scenario: you are happy at your job but learn of a professional opportunity with a great salary and benefits, but at a company that you don’t know well. What would you do?
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May 12, 2025 at 4:48 PM
🤔 Imagine this scenario: you are happy at your job but learn of a professional opportunity with a great salary and benefits, but at a company that you don’t know well. What would you do?
(1/11)
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