Ignacio Saez, PhD
@ignaciosaezphd.bsky.social
Associate Professor at Icahn School of Medicine at Mount Sinai. | Harnessing neurotechnology to explore human brain states & advance neurotherapies for mental health. thesaezlab.com
What does "Human-centered neural engineering and AI" mean?
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
November 5, 2025 at 3:15 PM
What does "Human-centered neural engineering and AI" mean?
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.
Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social
What does it take to move neuroengineering breakthroughs into real-world impact?
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
October 16, 2025 at 4:53 PM
What does it take to move neuroengineering breakthroughs into real-world impact?
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.
neuro.embs.org/2025/satellite-workshops/
"It takes a village!" and I'm incredibly grateful to be a part of this one.
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
October 9, 2025 at 5:46 PM
"It takes a village!" and I'm incredibly grateful to be a part of this one.
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25
Here’s to building the future of #neurotechnology, together. 🧠⚡
I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
September 29, 2025 at 7:01 PM
I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!
What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
September 2, 2025 at 5:58 PM
What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.
Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com
#BCIs #BrainComputerInterface
How is prefrontal neural activity refined as we age?
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
July 21, 2025 at 7:13 PM
How is prefrontal neural activity refined as we age?
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
Out today in @nathumbehav.nature.com! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.
Proud to have contributed!
www.nature.com/articles/s41...
As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.
July 9, 2025 at 9:05 PM
As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.
Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.
www.des-show.com/agenda-sessi...
www.des-show.com/agenda-sessi...
June 2, 2025 at 4:27 PM
Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.
www.des-show.com/agenda-sessi...
www.des-show.com/agenda-sessi...
What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
May 30, 2025 at 10:50 PM
What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social
Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
May 19, 2025 at 4:57 PM
Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...
OFC stimulation was also associated with faster reaction times.
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
May 12, 2025 at 4:48 PM
OFC stimulation was also associated with faster reaction times.
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
May 12, 2025 at 4:48 PM
Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
The oscillatory phase of delta-theta OFC activity modulates high-frequency activity (gamma/high-gamma), which we previously showed encodes the level of risk presented, via phase-amplitude cross-frequency coupling (CFC).
(6/11)
(6/11)
May 12, 2025 at 4:48 PM
The oscillatory phase of delta-theta OFC activity modulates high-frequency activity (gamma/high-gamma), which we previously showed encodes the level of risk presented, via phase-amplitude cross-frequency coupling (CFC).
(6/11)
(6/11)
Individuals with stronger synchronization of low-frequency (delta-theta) oscillatory activity within the OFC showed riskier behavior.
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
May 12, 2025 at 4:48 PM
Individuals with stronger synchronization of low-frequency (delta-theta) oscillatory activity within the OFC showed riskier behavior.
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
We investigated activity in the orbitofrontal cortex (OFC) during gambling tasks where patients chose a safe prize or risky gamble to determine reward.
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
May 12, 2025 at 4:48 PM
We investigated activity in the orbitofrontal cortex (OFC) during gambling tasks where patients chose a safe prize or risky gamble to determine reward.
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
In the new preprint 🚀 from the Saez Lab, we uncover a neurobiological basis for heterogeneity in risky decision making 🎲 in humans and show that it can be altered through targeted neuromodulation!
Full preprint here:
doi.org/10.1101/2025...
(3/11)
Full preprint here:
doi.org/10.1101/2025...
(3/11)
May 12, 2025 at 4:48 PM
In the new preprint 🚀 from the Saez Lab, we uncover a neurobiological basis for heterogeneity in risky decision making 🎲 in humans and show that it can be altered through targeted neuromodulation!
Full preprint here:
doi.org/10.1101/2025...
(3/11)
Full preprint here:
doi.org/10.1101/2025...
(3/11)
OFC stimulation was also associated with faster reaction times.
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
May 12, 2025 at 3:55 PM
OFC stimulation was also associated with faster reaction times.
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.
(8/11)
Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
May 12, 2025 at 3:55 PM
Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.
(7/11)
The oscillatory phase of delta-theta OFC activity modulates high-frequency activity (gamma/high-gamma), which we previously showed encodes the level of risk presented, via phase-amplitude cross-frequency coupling (CFC).
(6/11)
(6/11)
May 12, 2025 at 3:55 PM
The oscillatory phase of delta-theta OFC activity modulates high-frequency activity (gamma/high-gamma), which we previously showed encodes the level of risk presented, via phase-amplitude cross-frequency coupling (CFC).
(6/11)
(6/11)
Individuals with stronger synchronization of low-frequency (delta-theta) oscillatory activity within the OFC showed riskier behavior.
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
May 12, 2025 at 3:55 PM
Individuals with stronger synchronization of low-frequency (delta-theta) oscillatory activity within the OFC showed riskier behavior.
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
This link was location & frequency specific, suggesting that coordinated timing of OFC activity plays a central role in decision making.
(5/11)
We investigated activity in the orbitofrontal cortex (OFC) during gambling tasks where patients chose a safe prize or risky gamble to determine reward.
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
May 12, 2025 at 3:55 PM
We investigated activity in the orbitofrontal cortex (OFC) during gambling tasks where patients chose a safe prize or risky gamble to determine reward.
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
Using intracranial recordings, we examined neural activity differences in risk-seeking, neutral & averse participants.
(4/11)
Congratulations to Christina Maher on a successful talk at the @sinaibrain.bsky.social retreat! Thank you for sharing insights on how we are leveraging intracranial recordings to advance our understanding of the brain.
Job well done! 🎉
Learn more www.thesaezlab.com
Job well done! 🎉
Learn more www.thesaezlab.com
May 9, 2025 at 1:50 PM
Congratulations to Christina Maher on a successful talk at the @sinaibrain.bsky.social retreat! Thank you for sharing insights on how we are leveraging intracranial recordings to advance our understanding of the brain.
Job well done! 🎉
Learn more www.thesaezlab.com
Job well done! 🎉
Learn more www.thesaezlab.com
Enjoyed very stimulating ⚡ conversations alongside @urutisha.bsky.social & @suthanalab.bsky.social at #COSYNE2025 about the future of systems & computational human neuroscience using intracranial techniques! Thanks to everyone who attended the panel and visited the Saez lab posters.
April 11, 2025 at 7:47 PM
Enjoyed very stimulating ⚡ conversations alongside @urutisha.bsky.social & @suthanalab.bsky.social at #COSYNE2025 about the future of systems & computational human neuroscience using intracranial techniques! Thanks to everyone who attended the panel and visited the Saez lab posters.
Deeply grateful for my recent visits to @riceneuro.bsky.social, @bcmhouston.bsky.social, and @motifneuro.bsky.social! The passion for innovation and collaboration in the neuroscience research community is truly inspiring.
Thanks for the opportunity to share the ongoing projects from our lab!
Thanks for the opportunity to share the ongoing projects from our lab!
March 28, 2025 at 5:09 PM
Deeply grateful for my recent visits to @riceneuro.bsky.social, @bcmhouston.bsky.social, and @motifneuro.bsky.social! The passion for innovation and collaboration in the neuroscience research community is truly inspiring.
Thanks for the opportunity to share the ongoing projects from our lab!
Thanks for the opportunity to share the ongoing projects from our lab!
High frequency activity also reflected other calculations important for choices (risk or win probability), but these were more regionally specific with more predominance in some regions (e.g. orbitofrontal cortex reflects risk)
(5/7)
(5/7)
March 6, 2025 at 10:08 PM
High frequency activity also reflected other calculations important for choices (risk or win probability), but these were more regionally specific with more predominance in some regions (e.g. orbitofrontal cortex reflects risk)
(5/7)
(5/7)