Ian McGough 🇪🇺🇮🇪🪰
@ianmcgough.bsky.social
Group Leader @BabrahamInst Cambridge. Interested in #MorphogenSignalling #CellBio #Wnt #Hedgehog #BMP #Drosophila 🪰
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Closing the chapter: Goodbye from Joyce
Our (former) Community Manager @joyceyu.bsky.social bids farewell 👋 to the Node community. Check out her (almost) final post:
thenode.biologists.com/closing-the-...
Our (former) Community Manager @joyceyu.bsky.social bids farewell 👋 to the Node community. Check out her (almost) final post:
thenode.biologists.com/closing-the-...
Closing the chapter: Goodbye from Joyce - the Node
Today marks the end of the chapter for my time at the Node and Development. What a ride it has been! I don’t think you can find many jobs like this one:
thenode.biologists.com
July 18, 2025 at 9:06 AM
Closing the chapter: Goodbye from Joyce
Our (former) Community Manager @joyceyu.bsky.social bids farewell 👋 to the Node community. Check out her (almost) final post:
thenode.biologists.com/closing-the-...
Our (former) Community Manager @joyceyu.bsky.social bids farewell 👋 to the Node community. Check out her (almost) final post:
thenode.biologists.com/closing-the-...
So frustrating... the site is down more often than not in the last week. You only fully realize what a wonderful/crucial resource it is when you cannot access it.
Once more with feeling!
Hey!
Are you using a script to scrape FlyBase?
Just stop.
NOW.
You're crashing the site for everyone.
Yes, we mean YOU.
Hey!
Are you using a script to scrape FlyBase?
Just stop.
NOW.
You're crashing the site for everyone.
Yes, we mean YOU.
January 28, 2025 at 9:31 AM
So frustrating... the site is down more often than not in the last week. You only fully realize what a wonderful/crucial resource it is when you cannot access it.
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Our 2024 Sir Michael Berridge Prize winner Alyssa Silva-Cayetano, a former postdoc with @linterman.bsky.social, spills the beans on the work recognised by the Prize, and wider aspects of her career and life outside science. #ImmunoSky
www.babraham.ac.uk/news/2024/12...
www.babraham.ac.uk/news/2024/12...
December 18, 2024 at 2:07 PM
Our 2024 Sir Michael Berridge Prize winner Alyssa Silva-Cayetano, a former postdoc with @linterman.bsky.social, spills the beans on the work recognised by the Prize, and wider aspects of her career and life outside science. #ImmunoSky
www.babraham.ac.uk/news/2024/12...
www.babraham.ac.uk/news/2024/12...
Looking forward to an exciting meeting and congrats to Yeonjoo from @babrahaminst.bsky.social on being selected to speak in the ECR slot.
Registration and abstract submission is now open for the #WNT2025 meeting at @ox.ac.uk in Mar 2025 sponsored by @oxfordcancer.bsky.social and @cambridgebio.bsky.social. Join links below and lets showcase the best Wnt research the UK has to offer!
www.oxforduniversitystores.co.uk/conferences-...
www.oxforduniversitystores.co.uk/conferences-...
December 13, 2024 at 9:36 AM
Looking forward to an exciting meeting and congrats to Yeonjoo from @babrahaminst.bsky.social on being selected to speak in the ECR slot.
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Excited about our pre-print on AXIN1 mutations in HCC!
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
In healthy cells, AXIN1 organizes assembly of a large destruction complex that mediates proteolysis
www.biorxiv.org
December 8, 2024 at 4:17 PM
Excited about our pre-print on AXIN1 mutations in HCC!
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
December 4, 2024 at 9:37 AM
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Please welcome us to BlueSky and give us a follow!
We are newly formed UK scientific society with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
We are represented by all four corners of the UK and cover all aspects of Wnt signalling!
We are newly formed UK scientific society with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
We are represented by all four corners of the UK and cover all aspects of Wnt signalling!
December 4, 2024 at 3:53 PM
Please welcome us to BlueSky and give us a follow!
We are newly formed UK scientific society with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
We are represented by all four corners of the UK and cover all aspects of Wnt signalling!
We are newly formed UK scientific society with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
We are represented by all four corners of the UK and cover all aspects of Wnt signalling!
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Delighted to announce a new call for applications for our Pathway to Independence programme. Now entering its third year, this scheme supports postdocs going on the job market in 2025 - with training, mentorship, profile-raising and networking opportunities. Application deadline 31 Jan 2025. 1/3
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
December 2, 2024 at 3:43 PM
Delighted to announce a new call for applications for our Pathway to Independence programme. Now entering its third year, this scheme supports postdocs going on the job market in 2025 - with training, mentorship, profile-raising and networking opportunities. Application deadline 31 Jan 2025. 1/3
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Are you aware of our collection of #Drosophila #history articles? Feel free to suggest more!!!!!!!! droso4public.wordpress.com/history/
December 2, 2024 at 7:16 PM
Are you aware of our collection of #Drosophila #history articles? Feel free to suggest more!!!!!!!! droso4public.wordpress.com/history/
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Our new preprint is out - please share!
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
December 2, 2024 at 3:16 PM
Our new preprint is out - please share!
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals.
Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR #geneediting
Reposted by Ian McGough 🇪🇺🇮🇪🪰
Just under 2 weeks to get your abstracts in!
Abstracts are due in one month for Biologists @ 100, a unique conference to celebrate our 100-year anniversary and bring together our different communities. We hope you can join us.
Abstract deadline is 13 December. Submit yours at 100yearsconference.biologists.com/abstracts/
#biologists100
Abstract deadline is 13 December. Submit yours at 100yearsconference.biologists.com/abstracts/
#biologists100
December 2, 2024 at 9:19 AM
Just under 2 weeks to get your abstracts in!
Reposted by Ian McGough 🇪🇺🇮🇪🪰
We love that #MicroscopyMonday is still a thing! Let us introduce our Imaging facility team, led by @smonw.bsky.social, together they make these beautiful images possible! 👇 Here are our favourite images but can you match them to our research programmes - #Epigenetics, #Immunology and #Signalling ?🧪
November 20, 2024 at 6:28 PM
We love that #MicroscopyMonday is still a thing! Let us introduce our Imaging facility team, led by @smonw.bsky.social, together they make these beautiful images possible! 👇 Here are our favourite images but can you match them to our research programmes - #Epigenetics, #Immunology and #Signalling ?🧪