Intracellular Ion Channel Laboratory (Singh lab)
@hsingh7.bsky.social
The Singh lab focuses on intracellular ion channels and their roles in cardiac physiology.
https://u.osu.edu/singhresarchlab/
https://u.osu.edu/singhresarchlab/
Pinned
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity - Nature Communications
Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in ...
www.nature.com
Catch our recent study on BK channels in extracellular vesicles @naturecomms.bsky.social funded by NHLBI. The manuscript reports the functional BK channel in EVs and its role in regulation of EV integrity. EV BK provides protection from IR injury. #extracellularvesicle
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLICs are important. Just published as a part of our excellent collaboration.
New research demonstrates that the chloride intracellular channel 1 protein governs both their morphodynamic properties and inflammatory potential in mouse and human brains.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3L0cbNv
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3L0cbNv
October 30, 2025 at 1:45 PM
CLICs are important. Just published as a part of our excellent collaboration.
How many anion channels are present in mitochondrial associated membranes? Check out here
www.cell.com/biophysj/ful...
Undergrads (Denis and Mayukha) performed initial experiments, and manuscript was shaped by Shridhar and Satish (postdocs)
@BiophysJ
www.cell.com/biophysj/ful...
Undergrads (Denis and Mayukha) performed initial experiments, and manuscript was shaped by Shridhar and Satish (postdocs)
@BiophysJ
https://cell.com/biophysj/fullt…
April 8, 2025 at 2:51 PM
How many anion channels are present in mitochondrial associated membranes? Check out here
www.cell.com/biophysj/ful...
Undergrads (Denis and Mayukha) performed initial experiments, and manuscript was shaped by Shridhar and Satish (postdocs)
@BiophysJ
www.cell.com/biophysj/ful...
Undergrads (Denis and Mayukha) performed initial experiments, and manuscript was shaped by Shridhar and Satish (postdocs)
@BiophysJ
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Tenthorey et al. compare the effects of missense and indel mutations on the acquisition
of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find
that single indel mutations al...
www.cell.com
March 27, 2025 at 9:36 PM
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Pick your fav ion. Editorial with @rrbaliga.bsky.social and Narula labs. academic.oup.com/eurjpc/artic...
Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt?
Ragavendra R Baliga, Harpreet Singh, Jagat Narula; Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt?, European Journal
academic.oup.com
March 21, 2025 at 1:42 PM
Pick your fav ion. Editorial with @rrbaliga.bsky.social and Narula labs. academic.oup.com/eurjpc/artic...
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications
#ionchannels
www.nature.com/articles/s41...
#ionchannels
www.nature.com/articles/s41...
March 18, 2025 at 11:39 AM
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications
#ionchannels
www.nature.com/articles/s41...
#ionchannels
www.nature.com/articles/s41...
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Have you started thinking about your next career step? Join us for Careers Beyond the Bench: Moving to a World Outside the Lab to explore career options in consulting, industry, and academia
March 25, 2 PM Eastern
March 25, 2 PM Eastern
Welcome! You are invited to join a webinar: Careers Beyond the Bench: Moving to a World Outside the Lab. After registering, you will receive a confirmation email about joining the webinar.
Have you started thinking about your next career step? Are you wondering if you can apply your academic skills in industry? Or what skills outside of academia you may bring to the lab? Join us to…
us02web.zoom.us
March 13, 2025 at 12:59 PM
Have you started thinking about your next career step? Join us for Careers Beyond the Bench: Moving to a World Outside the Lab to explore career options in consulting, industry, and academia
March 25, 2 PM Eastern
March 25, 2 PM Eastern
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Join us March 24 for an inspiring event: “Women in Biophysics: Journeys and Challenges”! Four prominent women biophysicists, representing diverse career paths from the biotech industry to academia, will share their experiences navigating the field. buff.ly/uQY2gL2
#BiophysicsWeek
#BiophysicsWeek
Welcome! You are invited to join a meeting: Women in Biophysics: Journeys and Challenges. After registering, you will receive a confirmation email about joining the meeting.
Join us for an inspiring event: “Women in Biophysics: Journeys and Challenges”! Four prominent women biophysicists, representing diverse career paths from the biotech industry to academia, will share…
buff.ly
March 8, 2025 at 6:53 PM
Join us March 24 for an inspiring event: “Women in Biophysics: Journeys and Challenges”! Four prominent women biophysicists, representing diverse career paths from the biotech industry to academia, will share their experiences navigating the field. buff.ly/uQY2gL2
#BiophysicsWeek
#BiophysicsWeek
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Functional large-conductance calcium and voltage-gated potassium #ionchannels in extracellular vesicles act as gatekeepers of structural and functional integrity | Nature Communications #openaccess https://buff.ly/3PmJ5qx
January 4, 2025 at 11:39 AM
Functional large-conductance calcium and voltage-gated potassium #ionchannels in extracellular vesicles act as gatekeepers of structural and functional integrity | Nature Communications #openaccess https://buff.ly/3PmJ5qx
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Extracellular vesicles utilize ion channels to maintain membrane integrity and effectively transport cargo between cells, potentially enhancing their use in therapeutic applications. doi.org/g8z3mc
Extracellular vesicles contain ion channels that make cell-to-cell cargo transport possible
Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell through blood vessels and bodily fluids: special proteins that keep their membranes intact as they negotiate shifting electrical impulses in different biological environments.
phys.org
January 15, 2025 at 8:47 PM
Extracellular vesicles utilize ion channels to maintain membrane integrity and effectively transport cargo between cells, potentially enhancing their use in therapeutic applications. doi.org/g8z3mc
BMM subgroup at the 2025 Biophysical Society Meeting.
February 21, 2025 at 11:34 PM
BMM subgroup at the 2025 Biophysical Society Meeting.
Catch our recent study on BK channels in extracellular vesicles @naturecomms.bsky.social funded by NHLBI. The manuscript reports the functional BK channel in EVs and its role in regulation of EV integrity. EV BK provides protection from IR injury. #extracellularvesicle
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity - Nature Communications
Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in ...
www.nature.com
February 21, 2025 at 11:31 PM
Catch our recent study on BK channels in extracellular vesicles @naturecomms.bsky.social funded by NHLBI. The manuscript reports the functional BK channel in EVs and its role in regulation of EV integrity. EV BK provides protection from IR injury. #extracellularvesicle
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Intracellular Ion Channel Laboratory (Singh lab)
Gururaja Rao, S., Lam, A., Seeley, S., Park, J., Aruva, S., Singh, H. (2024). . The BK(Ca) (slo) channel regulates the cardiac function of #Drosophila. Physiological reports, 12(7):e15996 physoc.onlinelibrary.wiley.com/doi/10.14814...
November 26, 2024 at 3:51 PM
Gururaja Rao, S., Lam, A., Seeley, S., Park, J., Aruva, S., Singh, H. (2024). . The BK(Ca) (slo) channel regulates the cardiac function of #Drosophila. Physiological reports, 12(7):e15996 physoc.onlinelibrary.wiley.com/doi/10.14814...