Hiroshi Yano, PhD
@hirothehero.bsky.social
Postdoc/NIAID K99 fellow at Weill Cornell Medicine. Artis Lab. Interested in dissecting mechanisms regulating inflammation. Neuro-immune interactions/ILC2/microbiome/helminth/barrier immunity/tumor immunology, etc.
Reposted by Hiroshi Yano, PhD
🎉 Registration is NOW OPEN! 🎉
We’re excited to welcome you to next year’s International Conference on Innate Lymphoid Cells, where leading experts, innovators, and researchers will come together to share insights, spark collaborations, and shape the future of ILCs and beyond.
#ILC6
(1/3)
We’re excited to welcome you to next year’s International Conference on Innate Lymphoid Cells, where leading experts, innovators, and researchers will come together to share insights, spark collaborations, and shape the future of ILCs and beyond.
#ILC6
(1/3)
November 22, 2025 at 9:35 PM
🎉 Registration is NOW OPEN! 🎉
We’re excited to welcome you to next year’s International Conference on Innate Lymphoid Cells, where leading experts, innovators, and researchers will come together to share insights, spark collaborations, and shape the future of ILCs and beyond.
#ILC6
(1/3)
We’re excited to welcome you to next year’s International Conference on Innate Lymphoid Cells, where leading experts, innovators, and researchers will come together to share insights, spark collaborations, and shape the future of ILCs and beyond.
#ILC6
(1/3)
Reposted by Hiroshi Yano, PhD
BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
November 3, 2025 at 5:58 PM
BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
Reposted by Hiroshi Yano, PhD
“You can’t discover what you don’t study.” @jennifergarrison.bsky.social highlights the need for more focus on women’s health at the Merkin Symposium at Caltech. Hard for anti-diversity folks to argue against addressing health issues that impact half the population…
February 6, 2025 at 6:13 PM
“You can’t discover what you don’t study.” @jennifergarrison.bsky.social highlights the need for more focus on women’s health at the Merkin Symposium at Caltech. Hard for anti-diversity folks to argue against addressing health issues that impact half the population…
#ILC2 as an inducer of tertiary lymphoid structures (#TLS) in cancer!
Beautiful study by Balachandran group at MSK.
I'm so happy to have been able to contribute to this exciting story!
www.nature.com/articles/s41...
x.com/thevinodlab/...
Beautiful study by Balachandran group at MSK.
I'm so happy to have been able to contribute to this exciting story!
www.nature.com/articles/s41...
x.com/thevinodlab/...
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature
IL-33 induces tertiary lymphoid structures.
www.nature.com
January 15, 2025 at 4:51 PM
#ILC2 as an inducer of tertiary lymphoid structures (#TLS) in cancer!
Beautiful study by Balachandran group at MSK.
I'm so happy to have been able to contribute to this exciting story!
www.nature.com/articles/s41...
x.com/thevinodlab/...
Beautiful study by Balachandran group at MSK.
I'm so happy to have been able to contribute to this exciting story!
www.nature.com/articles/s41...
x.com/thevinodlab/...
Reposted by Hiroshi Yano, PhD
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology
Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.
www.nature.com
January 6, 2025 at 12:29 AM
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
Another inhibitory receptor regulating ILC2s.
VISTA, upregulated upon activation, negatively regulates ILC2 proliferation and effector functions through AKT-FOXO1 axis both in mice and humans.
VISTA-AKT-FOXO1 axis suppresses OXPHOS and FAO in ILC2s.
www.jci.org/articles/vie...
VISTA, upregulated upon activation, negatively regulates ILC2 proliferation and effector functions through AKT-FOXO1 axis both in mice and humans.
VISTA-AKT-FOXO1 axis suppresses OXPHOS and FAO in ILC2s.
www.jci.org/articles/vie...
JCI -
FOXO1 pathway activation by VISTA immune checkpoint restrains pulmonary ILC2 functions
www.jci.org
January 6, 2025 at 1:33 AM
Another inhibitory receptor regulating ILC2s.
VISTA, upregulated upon activation, negatively regulates ILC2 proliferation and effector functions through AKT-FOXO1 axis both in mice and humans.
VISTA-AKT-FOXO1 axis suppresses OXPHOS and FAO in ILC2s.
www.jci.org/articles/vie...
VISTA, upregulated upon activation, negatively regulates ILC2 proliferation and effector functions through AKT-FOXO1 axis both in mice and humans.
VISTA-AKT-FOXO1 axis suppresses OXPHOS and FAO in ILC2s.
www.jci.org/articles/vie...
🤩 Feimin, a new cytokine encoded by a gene with a previously unknown function, was identified as a synergistic regulator of blood glucose dynamics in concert with insulin.
Insulin = Potent but short action
Feimin = Modest but long-lasting
Interesting
www.nature.com/articles/s42...
Insulin = Potent but short action
Feimin = Modest but long-lasting
Interesting
www.nature.com/articles/s42...
A feeding-induced myokine modulates glucose homeostasis - Nature Metabolism
The authors identify feimin as a feeding-induced myokine that regulates glucose homeostasis via the MERTK–AKT signalling axis in mice and humans.
www.nature.com
January 6, 2025 at 12:58 AM
🤩 Feimin, a new cytokine encoded by a gene with a previously unknown function, was identified as a synergistic regulator of blood glucose dynamics in concert with insulin.
Insulin = Potent but short action
Feimin = Modest but long-lasting
Interesting
www.nature.com/articles/s42...
Insulin = Potent but short action
Feimin = Modest but long-lasting
Interesting
www.nature.com/articles/s42...
😂
January 2, 2025 at 5:53 PM
😂
Reposted by Hiroshi Yano, PhD
Hot off the press 🔥
Very proud of this collaboration! 💫
@Harvard
@JohnsHopkins
@UChicago
@UniHeidelberg
Interested in immunotherapy-induced toxicity? 🤓
This is a must-read 🤩
#immunology #science #cancer #research
@nct-heidelberg.bsky.social @dkfz.bsky.social
www.cell.com/trends/immun...
Very proud of this collaboration! 💫
@Harvard
@JohnsHopkins
@UChicago
@UniHeidelberg
Interested in immunotherapy-induced toxicity? 🤓
This is a must-read 🤩
#immunology #science #cancer #research
@nct-heidelberg.bsky.social @dkfz.bsky.social
www.cell.com/trends/immun...
December 28, 2024 at 8:02 AM
Hot off the press 🔥
Very proud of this collaboration! 💫
@Harvard
@JohnsHopkins
@UChicago
@UniHeidelberg
Interested in immunotherapy-induced toxicity? 🤓
This is a must-read 🤩
#immunology #science #cancer #research
@nct-heidelberg.bsky.social @dkfz.bsky.social
www.cell.com/trends/immun...
Very proud of this collaboration! 💫
@Harvard
@JohnsHopkins
@UChicago
@UniHeidelberg
Interested in immunotherapy-induced toxicity? 🤓
This is a must-read 🤩
#immunology #science #cancer #research
@nct-heidelberg.bsky.social @dkfz.bsky.social
www.cell.com/trends/immun...
Wow…🤯 Nitrogen-fixing organelle “nitroplast”!
We may be witnessing an active evolutionary process of organelle acquisition endosymbiosis in an eukaryote marine alga, like what is considered to be the process that led to mitochondria and chloroplast.
www.science.org/doi/10.1126/...
We may be witnessing an active evolutionary process of organelle acquisition endosymbiosis in an eukaryote marine alga, like what is considered to be the process that led to mitochondria and chloroplast.
www.science.org/doi/10.1126/...
Nitrogen-fixing organelle in a marine alga
Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles, which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the reduction of ab...
www.science.org
December 26, 2024 at 2:08 PM
Wow…🤯 Nitrogen-fixing organelle “nitroplast”!
We may be witnessing an active evolutionary process of organelle acquisition endosymbiosis in an eukaryote marine alga, like what is considered to be the process that led to mitochondria and chloroplast.
www.science.org/doi/10.1126/...
We may be witnessing an active evolutionary process of organelle acquisition endosymbiosis in an eukaryote marine alga, like what is considered to be the process that led to mitochondria and chloroplast.
www.science.org/doi/10.1126/...
Merry festive time🍗🎄
Speaking of festivity and since we’re all thinking about same ole new year resolutions, this study might be a good read to learn about what differentiates metabolically “healthy” vs “unhealthy” obese individuals.
www.cell.com/cell-metabol...
Speaking of festivity and since we’re all thinking about same ole new year resolutions, this study might be a good read to learn about what differentiates metabolically “healthy” vs “unhealthy” obese individuals.
www.cell.com/cell-metabol...
Unveiling adipose populations linked to metabolic health in obesity
Metabolic disease risk in individuals with obesity is variable and influenced by so-far-unknown factors. Reinisch and Ghosh et al. uncovered distinct cell populations and transcriptional programs in adipose tissue that are strongly linked to metabolic disease. The findings suggest that visceral adipose tissue plasticity is key to maintaining metabolic health despite excess adiposity.
www.cell.com
December 26, 2024 at 2:10 AM
Merry festive time🍗🎄
Speaking of festivity and since we’re all thinking about same ole new year resolutions, this study might be a good read to learn about what differentiates metabolically “healthy” vs “unhealthy” obese individuals.
www.cell.com/cell-metabol...
Speaking of festivity and since we’re all thinking about same ole new year resolutions, this study might be a good read to learn about what differentiates metabolically “healthy” vs “unhealthy” obese individuals.
www.cell.com/cell-metabol...
🤯
Human study demonstrating long-lasting desynchronization and potential mechanism of neuroplasticity induced by psychedelic Psilocybin.
www.nature.com/articles/s41...
Human study demonstrating long-lasting desynchronization and potential mechanism of neuroplasticity induced by psychedelic Psilocybin.
www.nature.com/articles/s41...
Psilocybin desynchronizes the human brain - Nature
Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disr...
www.nature.com
December 23, 2024 at 8:36 PM
🤯
Human study demonstrating long-lasting desynchronization and potential mechanism of neuroplasticity induced by psychedelic Psilocybin.
www.nature.com/articles/s41...
Human study demonstrating long-lasting desynchronization and potential mechanism of neuroplasticity induced by psychedelic Psilocybin.
www.nature.com/articles/s41...
Long-chain fatty acid oxidation (FAO) is dispensable for hematopoietic stem cells in young mice, while crucial for HSCs in old mice. But then too much FAO is detrimental for HSCs.
Fatty diet makes us unhealthy to the core...literally, our bone marrow…
www.cell.com/cell-stem-ce...
Fatty diet makes us unhealthy to the core...literally, our bone marrow…
www.cell.com/cell-stem-ce...
Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet
Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.
www.cell.com
December 23, 2024 at 8:00 PM
Long-chain fatty acid oxidation (FAO) is dispensable for hematopoietic stem cells in young mice, while crucial for HSCs in old mice. But then too much FAO is detrimental for HSCs.
Fatty diet makes us unhealthy to the core...literally, our bone marrow…
www.cell.com/cell-stem-ce...
Fatty diet makes us unhealthy to the core...literally, our bone marrow…
www.cell.com/cell-stem-ce...
Reposted by Hiroshi Yano, PhD
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
December 19, 2024 at 9:30 PM
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Reposted by Hiroshi Yano, PhD
When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!
When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!
December 18, 2024 at 10:37 PM
When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!
When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!
🍄🟫 Shiitake mushroom is delicious and good for health. 🍄🟫
Shiitake-derived functional food shows suppression of liver fibrosis progression
"Prevention of the progression of liver fibrosis through lifestyle habits such as diet and exercise is crucial."
Open Access
journals.physiology.org/doi/full/10....
"Prevention of the progression of liver fibrosis through lifestyle habits such as diet and exercise is crucial."
Open Access
journals.physiology.org/doi/full/10....
AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway | American Journal of Physiology-Gastroi...
Cirrhosis, which represents the end stage of liver fibrosis, remains a life-threatening condition without effective treatment. Therefore, prevention of the progression of liver fibrosis through lifest...
journals.physiology.org
December 19, 2024 at 2:34 PM
🍄🟫 Shiitake mushroom is delicious and good for health. 🍄🟫
Reposted by Hiroshi Yano, PhD
Tissue-specific ILC progenitors governing distribution, developmental kinetics, and gene expression exist in human fetal development, including CD34+RORγt+Eomes- & CD34+RORγt+Eomes+ progenitors in fetal intestine
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social
December 17, 2024 at 2:33 PM
Tissue-specific ILC progenitors governing distribution, developmental kinetics, and gene expression exist in human fetal development, including CD34+RORγt+Eomes- & CD34+RORγt+Eomes+ progenitors in fetal intestine
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social
Reposted by Hiroshi Yano, PhD
And here is my condensed guide on how to science: top 5 Rules
December 15, 2024 at 3:49 PM
And here is my condensed guide on how to science: top 5 Rules
Reposted by Hiroshi Yano, PhD
Rare sighting of wild G-protein in Virginia
December 12, 2024 at 11:10 AM
Rare sighting of wild G-protein in Virginia
Reposted by Hiroshi Yano, PhD
I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:
Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036
Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036
December 12, 2024 at 7:05 PM
I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:
Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036
Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036
Reposted by Hiroshi Yano, PhD
The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nutrient-driven histone code determines exhausted CD8+ T cell fates
ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...
www.science.org
December 12, 2024 at 10:36 PM
The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🤯😍
How can we build an Al virtual cell that simulates all functions and interactions of a cell? How will it transform research and drive breakthroughs in programmable biology, drug discovery and personalized medicine?
Take a look at our paper in @cellpress.bsky.social!
www.cell.com/cell/fulltex...
Take a look at our paper in @cellpress.bsky.social!
www.cell.com/cell/fulltex...
December 13, 2024 at 12:37 AM
🤯😍
Reposted by Hiroshi Yano, PhD
🔥 Microbial colonisation in early life shapes mast cell NGF production and nociceptor sensitivity later in life. Beautiful new #MucosalImmunology study from the Altier lab out online #OpenAccess: www.mucosalimmunology.org/article/S193...
December 12, 2024 at 9:40 PM
🔥 Microbial colonisation in early life shapes mast cell NGF production and nociceptor sensitivity later in life. Beautiful new #MucosalImmunology study from the Altier lab out online #OpenAccess: www.mucosalimmunology.org/article/S193...
Reposted by Hiroshi Yano, PhD
PYROPTOSIS is a type of programmed cell death characterized by inflammatory cell lysis when gasdermin forms pores in the cell membrane
December 12, 2024 at 3:57 PM
PYROPTOSIS is a type of programmed cell death characterized by inflammatory cell lysis when gasdermin forms pores in the cell membrane
Reposted by Hiroshi Yano, PhD
A gut fungus protects mice against parasitic worms but increases allergies
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
December 12, 2024 at 2:47 AM
A gut fungus protects mice against parasitic worms but increases allergies
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...