hatzakislab
@hatzakislab.bsky.social
Professor of single protein and single cell biophysics . Utilizing machine learning for quantitative analysis of live cell imaging and single particle tracking
https://www.hatzakislab.com
orcid.org/0000-0003-4202-0328
https://www.hatzakislab.com
orcid.org/0000-0003-4202-0328
Reposted by hatzakislab
What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...
The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent
Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA
academic.oup.com
September 16, 2025 at 9:40 PM
What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...
Reposted by hatzakislab
Check out the PyCon Au talk from my team member: @ishratz25.bsky.social on the challenges and solutions(?) of cell counting in whole-brain light sheet images! Also give her a follow, she's new here.
www.youtube.com/watch?v=ccLn...
www.youtube.com/watch?v=ccLn...
"Big Brains, Small Targets: Whole-Brain Image Analysis with Python" - Ishrat Zaman (PyCon AU 2025)
YouTube video by PyCon AU
www.youtube.com
September 16, 2025 at 11:04 PM
Check out the PyCon Au talk from my team member: @ishratz25.bsky.social on the challenges and solutions(?) of cell counting in whole-brain light sheet images! Also give her a follow, she's new here.
www.youtube.com/watch?v=ccLn...
www.youtube.com/watch?v=ccLn...
Reposted by hatzakislab
Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging
@uniregensburg.bsky.social @uni-wuerzburg.de
@uniregensburg.bsky.social @uni-wuerzburg.de
June 12, 2025 at 1:31 PM
Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging
@uniregensburg.bsky.social @uni-wuerzburg.de
@uniregensburg.bsky.social @uni-wuerzburg.de
What a fantastic (TED ) talk by @krishnanyamuna.bsky.social explain her trifecta of dna nanotech, chemistry and electrophysiology for ion transport in organelles You know a conference discussion is excellent when #keynote speaker actually uses the white board to explain . @isbuc.bsky.social
June 12, 2025 at 1:43 PM
What a fantastic (TED ) talk by @krishnanyamuna.bsky.social explain her trifecta of dna nanotech, chemistry and electrophysiology for ion transport in organelles You know a conference discussion is excellent when #keynote speaker actually uses the white board to explain . @isbuc.bsky.social
1st keynote talk of chemical solution to structural biology by #Nobel laureate Brian Kobilka. Fantastic conference organised by @isbuc.bsky.social and department of chemistry UCPH
June 12, 2025 at 7:05 AM
1st keynote talk of chemical solution to structural biology by #Nobel laureate Brian Kobilka. Fantastic conference organised by @isbuc.bsky.social and department of chemistry UCPH
Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event
Check the amazing line up of speakers
isbuc.ku.dk/documents/CS...
Check the amazing line up of speakers
isbuc.ku.dk/documents/CS...
June 12, 2025 at 6:54 AM
Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event
Check the amazing line up of speakers
isbuc.ku.dk/documents/CS...
Check the amazing line up of speakers
isbuc.ku.dk/documents/CS...
Very excited to attend the Mediterranean neuroscience meeting in chania, and present in the special event what we do in my lab in the #COE center of @novo-nordisk.bsky.social and the #nanopans project funded by @lundbeckfonden.bsky.social
#hatzakislab #machinelearning #singlemolecule
#hatzakislab #machinelearning #singlemolecule
June 10, 2025 at 1:37 PM
Very excited to attend the Mediterranean neuroscience meeting in chania, and present in the special event what we do in my lab in the #COE center of @novo-nordisk.bsky.social and the #nanopans project funded by @lundbeckfonden.bsky.social
#hatzakislab #machinelearning #singlemolecule
#hatzakislab #machinelearning #singlemolecule
Very excited to attend the #embo #febs lecture course and have a plenary on 4D microscopy and machine learning analysis of delivery of biologicals. A central part of the @coecenter.bsky.social funded by @novo-nordisk.bsky.social .
meetings.embo.org/event/25-phy...
meetings.embo.org/event/25-phy...
Physical Virology: across length scales
!! Spam/phishing e-mails have been reported from some FEBS Advanced lecture courses. Please be alert and watch out for fraudulent emails offering to arrange registration, accommodation, or other ser…
meetings.embo.org
June 2, 2025 at 12:55 PM
Very excited to attend the #embo #febs lecture course and have a plenary on 4D microscopy and machine learning analysis of delivery of biologicals. A central part of the @coecenter.bsky.social funded by @novo-nordisk.bsky.social .
meetings.embo.org/event/25-phy...
meetings.embo.org/event/25-phy...
Reposted by hatzakislab
One more monthly COE meeting funded by the NNF Challenge Programme was held.
We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.
We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.
May 28, 2025 at 4:19 PM
One more monthly COE meeting funded by the NNF Challenge Programme was held.
We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.
We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.
See our recent article in @natmethods.nature.com on a machine learning model #DeepSPT to rapidly precisely and automatically analyze anomalous diffusion. The model predicted biological identity from diffusion alone indicating that motion beside structure defines function.
Excited to announce this new paper from the Kirchhausen and Hatzakis labs on DeepSPT, a deep learning framework for single-particle/vesicle tracking. www.nature.com/articles/s41...
May 26, 2025 at 10:02 AM
See our recent article in @natmethods.nature.com on a machine learning model #DeepSPT to rapidly precisely and automatically analyze anomalous diffusion. The model predicted biological identity from diffusion alone indicating that motion beside structure defines function.
Reposted by hatzakislab
For readers interested in siRNA drugs such as Alnylam's just-approved ATTR therapy vutrisiran, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eewvj
www.nature.com/articles/s41...
rdcu.be/eewvj
March 21, 2025 at 2:59 PM
For readers interested in siRNA drugs such as Alnylam's just-approved ATTR therapy vutrisiran, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eewvj
www.nature.com/articles/s41...
rdcu.be/eewvj
Reposted by hatzakislab
Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care?
Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k
#Biomarkers #Dementia #Diagnostics
Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k
#Biomarkers #Dementia #Diagnostics
The Urgent and Global Need for Democratized Blood-Based Biomarker Diagnostics in Alzheimer’s Disease
Alzheimer’s disease (AD) represents one of the most pressing healthcare challenges
of the 21st century. As a leading cause of dementia, AD impacts over 55 million people
worldwide, with this number pr...
tinyurl.com
March 19, 2025 at 11:53 AM
Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care?
Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k
#Biomarkers #Dementia #Diagnostics
Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k
#Biomarkers #Dementia #Diagnostics
Excited to attend #bps2025 with multiple of my group members. Interested in #machinelearning single particle tracking ? Quantification of lipid nanoparticles heterogeneity in dimensions and mRNA loading ? Direct observation of #lnp entering cell ? Or single enzyme activity ? Just reach out
February 15, 2025 at 7:54 PM
Excited to attend #bps2025 with multiple of my group members. Interested in #machinelearning single particle tracking ? Quantification of lipid nanoparticles heterogeneity in dimensions and mRNA loading ? Direct observation of #lnp entering cell ? Or single enzyme activity ? Just reach out
The registration Chemical solutions to structural biology symposium . Join us for 2 days and 30 speakers exploring state of the art science at the intersection of chemical and structural biology
Chemical Solutions to Structural Biology symposium.
Registration and abstract submission now open:
isbuc.ku.dk/chemical-sol...
Registration and abstract submission now open:
isbuc.ku.dk/chemical-sol...
February 12, 2025 at 1:29 PM
The registration Chemical solutions to structural biology symposium . Join us for 2 days and 30 speakers exploring state of the art science at the intersection of chemical and structural biology
Reposted by hatzakislab
Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025!
December 12, 2024 at 9:16 PM
Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025!
Reposted by hatzakislab
We have 4 fully funded #PhD positions available in York! Interested in single molecule biophysics, structural biology, biochemistry and/or physical chemistry? Get in touch! We have state-of-the-art labs in a fun-filled city! Come join us! DM for more or check out:
sites.google.com/york.ac.uk/q...
sites.google.com/york.ac.uk/q...
December 2, 2024 at 8:17 PM
We have 4 fully funded #PhD positions available in York! Interested in single molecule biophysics, structural biology, biochemistry and/or physical chemistry? Get in touch! We have state-of-the-art labs in a fun-filled city! Come join us! DM for more or check out:
sites.google.com/york.ac.uk/q...
sites.google.com/york.ac.uk/q...
Reposted by hatzakislab
First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5
November 13, 2024 at 8:23 AM
First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5