Hasanga Manikpurage
@hasanga.bsky.social
Genetics of cardiovascular diseases
Post-Doc @cam.ac.uk @dphpc.bsky.social https://www.inouyelab.org/home/people 🇬🇧
PhD @ulaval.ca @IUCPQ 🇨🇦
MSc @upcite.bsky.social @lvts 🇫🇷
From 🇫🇷/🇱🇰
Post-Doc @cam.ac.uk @dphpc.bsky.social https://www.inouyelab.org/home/people 🇬🇧
PhD @ulaval.ca @IUCPQ 🇨🇦
MSc @upcite.bsky.social @lvts 🇫🇷
From 🇫🇷/🇱🇰
Reposted by Hasanga Manikpurage
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Reposted by Hasanga Manikpurage
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:20 PM
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
Reposted by Hasanga Manikpurage
Well done @eliasallara.bsky.social! Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data. www.thelancet.com/journals/lan...
Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data
Our study offers new insights into recent cardiovascular disease patterns and reveals
important health inequalities at a whole-population scale for multiple cardiovascular
diseases, during and after t...
www.thelancet.com
October 28, 2025 at 4:46 PM
Well done @eliasallara.bsky.social! Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data. www.thelancet.com/journals/lan...
Reposted by Hasanga Manikpurage
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Reposted by Hasanga Manikpurage
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
July 25, 2025 at 7:24 AM
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
Reposted by Hasanga Manikpurage
Wish we could've cited this highly relevant (and consistent) study, published nearly the same time: Psychological & emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&I www.sciencedirect.com/science/arti...
July 22, 2025 at 9:18 AM
Wish we could've cited this highly relevant (and consistent) study, published nearly the same time: Psychological & emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&I www.sciencedirect.com/science/arti...
Reposted by Hasanga Manikpurage
The concept of personalised health is at the centre of a renewed NHS and its 10 Year Health Plan says Prof Mike Inouye (thank you @mikeinouye.bsky.social)as we put 'Making personalised health work for population health' in the spotlight.
Read it here: lnkd.in/eRDY5q2j
#personalisedhealth
Read it here: lnkd.in/eRDY5q2j
#personalisedhealth
July 15, 2025 at 10:03 AM
The concept of personalised health is at the centre of a renewed NHS and its 10 Year Health Plan says Prof Mike Inouye (thank you @mikeinouye.bsky.social)as we put 'Making personalised health work for population health' in the spotlight.
Read it here: lnkd.in/eRDY5q2j
#personalisedhealth
Read it here: lnkd.in/eRDY5q2j
#personalisedhealth
Reposted by Hasanga Manikpurage
Variation and prognostic potential of the gut antibiotic resistome in a population-based cohort www.nature.com/articles/s41...
We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.
We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.
July 5, 2025 at 9:43 AM
Variation and prognostic potential of the gut antibiotic resistome in a population-based cohort www.nature.com/articles/s41...
We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.
We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.
Reposted by Hasanga Manikpurage
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 12:29 PM
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @commsmed.nature.com. We benchmarked a set of PGS for cardiovascular traits available from the pgscatalog.org resource in different Canadian cohorts🍁.
See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...
(1/4)
See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...
(1/4)
Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions - Communications Medicine
Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The co...
www.nature.com
July 2, 2025 at 11:02 AM
📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @commsmed.nature.com. We benchmarked a set of PGS for cardiovascular traits available from the pgscatalog.org resource in different Canadian cohorts🍁.
See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...
(1/4)
See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...
(1/4)
Reposted by Hasanga Manikpurage
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
June 16, 2025 at 10:33 AM
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
Reposted by Hasanga Manikpurage
📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
June 12, 2025 at 6:00 AM
📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Reposted by Hasanga Manikpurage
Its been an absolute pleasure to have @gmeric.bsky.social in the lab for the last 7 years (omg has it been that long)
Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!
Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!
Looks like I’ve got another move across the world in me! 🌏✈️📦 I'll be starting at @uniofbath.bsky.social in a few weeks as senior lecturer/associate prof in human microbiome. Excited to be back in Europe + for new collabs (alongside ongoing 🇦🇺🇬🇧🇫🇮🇸🇪🇦🇹 ones). Thanks to everyone who helped; more soon!
June 3, 2025 at 6:45 AM
Its been an absolute pleasure to have @gmeric.bsky.social in the lab for the last 7 years (omg has it been that long)
Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!
Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!
Reposted by Hasanga Manikpurage
@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025
May 24, 2025 at 9:38 AM
@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025
Reposted by Hasanga Manikpurage
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
May 12, 2025 at 3:49 PM
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Reposted by Hasanga Manikpurage
📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱
🚨Closing June 5th
www.jobs.cam.ac.uk/job/51255/
Topics below 👇
#AcademicSky #GreenSky
🚨Closing June 5th
www.jobs.cam.ac.uk/job/51255/
Topics below 👇
#AcademicSky #GreenSky
May 9, 2025 at 12:36 PM
📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱
🚨Closing June 5th
www.jobs.cam.ac.uk/job/51255/
Topics below 👇
#AcademicSky #GreenSky
🚨Closing June 5th
www.jobs.cam.ac.uk/job/51255/
Topics below 👇
#AcademicSky #GreenSky
Reposted by Hasanga Manikpurage
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
April 23, 2025 at 11:35 AM
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
Reposted by Hasanga Manikpurage
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
April 23, 2025 at 2:19 PM
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
📣 Feeling extremely lucky to have modestly contributed to this masterpiece, investigating the impact of loss-of-function mutations in APOC3 gene on aortic valve disease risk reduction.
See more in JACC 👇🏽
www.jacc.org/doi/10.1016/...
See more in JACC 👇🏽
www.jacc.org/doi/10.1016/...
Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease:
Discover why JACC is the ultimate publishing partner for your cardiovascular research.
www.jacc.org
April 15, 2025 at 12:58 PM
📣 Feeling extremely lucky to have modestly contributed to this masterpiece, investigating the impact of loss-of-function mutations in APOC3 gene on aortic valve disease risk reduction.
See more in JACC 👇🏽
www.jacc.org/doi/10.1016/...
See more in JACC 👇🏽
www.jacc.org/doi/10.1016/...
📣 Thrilled to share this paper. We leveraged transcriptomic data from one of the largest existing aortic valve collection. We identified genes/pathways involved in disease progression/severity, with distinct transcriptomic signatures in TAV vs BAV. Perspectives for potential therapeutics?
See more👇🏽
See more👇🏽
Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves
There is currently no medical therapy for calcific aortic valve stenosis. We aimed to identify transcriptomic signatures of the disease severity. We p…
www.sciencedirect.com
April 10, 2025 at 10:23 AM
📣 Thrilled to share this paper. We leveraged transcriptomic data from one of the largest existing aortic valve collection. We identified genes/pathways involved in disease progression/severity, with distinct transcriptomic signatures in TAV vs BAV. Perspectives for potential therapeutics?
See more👇🏽
See more👇🏽
Reposted by Hasanga Manikpurage
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
April 9, 2025 at 9:09 PM
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Can testify to this -> awesome research environment, with access to great ressources, sharing space and time with incredible colleagues and renowned experts...
📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
April 9, 2025 at 10:16 PM
Can testify to this -> awesome research environment, with access to great ressources, sharing space and time with incredible colleagues and renowned experts...
Reposted by Hasanga Manikpurage
Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org !
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease | Molecular Systems Biology
imageimageUsing genetically predicted metabolic reaction fluxes, the authors identify reactions
that can amplify or buffer the effect of coronary artery disease (CAD) risk alleles
on disease susceptib...
www.embopress.org
April 3, 2025 at 4:57 PM
Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org !
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
Reposted by Hasanga Manikpurage
Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!
Running the PGS Catalog Calculator via the All of Us workbench — Polygenic Score (PGS) Catalog Calculator documentation
pgsc-calc.readthedocs.io
April 1, 2025 at 3:20 PM
Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!
Reposted by Hasanga Manikpurage
Pleased to have been able to make a modest contribution to this piece about the genetic contributors to and consequences of socioeconomic status, initiated and led by @dr-appie.bsky.social . Share with your social science friends!
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓
Link: rdcu.be/efacK
Thread below 👇🏽
Link: rdcu.be/efacK
Thread below 👇🏽
March 26, 2025 at 8:42 PM
Pleased to have been able to make a modest contribution to this piece about the genetic contributors to and consequences of socioeconomic status, initiated and led by @dr-appie.bsky.social . Share with your social science friends!