Drosophilosopher
@hammedbadmos.bsky.social
PhD. AFHEA. CSO Fellow. Postdoc in @RossCagan lab @CRUK_SI @UofGlasgow #cellbiology #cancerbiology #drosophila #drug #screening #Microscopy #organoids #Python #chemistry
"Your article has been published" 🎉 We found there's a sweet spot of GSK-3β activity required to keep axonal microtubules bundled in 🪰🐀. Too much/little affect how Tau and Shot associate with microtubules leading to microtubules that loose bundling and resemble a bowl of cooked spaghetti 🍝
February 18, 2026 at 5:29 PM
Cholinergic signaling modulates intestinal pathophysiology in a drosophila model of cystic fibrosis.
Lane EA, Petsakou A, Liu Y, Chen W, Qadiri M, Hu Y, Perrimon N. PLoS Genet. 2026 Feb 17;22(2):e1012048. doi: 10.1371/journal.pgen.1012048. Online ahead of print. PMID: 41701793
Lane EA, Petsakou A, Liu Y, Chen W, Qadiri M, Hu Y, Perrimon N. PLoS Genet. 2026 Feb 17;22(2):e1012048. doi: 10.1371/journal.pgen.1012048. Online ahead of print. PMID: 41701793
February 18, 2026 at 5:29 PM
I’d like to highlight @felicityhsu.bsky.social ‘s recently publish work in @dev-journal.bsky.social ! She showed that the regeneration blastema consists of concentric zones of differential growth and translation driven by Myc and Tor. journals.biologists.com/dev/article/...
January 8, 2026 at 7:30 PM
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 8:15 PM
Reposted by Drosophilosopher
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 7:00 PM
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
Hsiao, C. T., Fu, S. J., Cheng, K. M., Lo, H., Tang, C. Y., Chan, C. C., Jeng, C. J. (2025). Restoration of Shal/K(V)4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22. Cell Mol Life Sci, 82(1):181 link.springer.com/article/10.1...
Restoration of Shal/KV4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22 - Cellular and Molecular Life Sciences
Loss-of-function mutations in the human KCND3 gene encoding KV4.3 K+ channels are linked to the autosomal dominant neurodegenerative disease spinocerebellar ataxia type 19/22 (SCA19/22). Previous biop...
link.springer.com
January 7, 2026 at 8:13 PM
Ready, D. F., Chang, H. C. (2025). Drosophila photoreceptor tethering by a laminin-Eys scaffold. iScience, 28(6):112732 www.cell.com/iscience/ful...
January 7, 2026 at 8:13 PM
Bose, A., Schuster, K., Kodali, C., Sonam, S., Smith-Bolton, R. K. (2025). The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila. Sci Adv, 11(23):eads5743 www.science.org/doi/10.1126/...
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.
www.science.org
January 7, 2026 at 8:13 PM
Song, Y., Martin, P., Sun, T., Fernandez-Herrero, J., Sanchez-Herrero, E., Pastor-Pareja, J. C. (2025). Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere. Curr Biol, 35(13):3090-3105 www.cell.com/current-biol...
Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere
Song et al. discover that the two surfaces of the Drosophila haltere display dorso-ventral
adhesion, similar to the wing, and that this is essential to sculpt its 3D globular
shape against tissue-wide...
www.cell.com
January 7, 2026 at 8:13 PM
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...
journals.plos.org
January 7, 2026 at 8:13 PM
Otsune, S., Matsuka, M., Shirakashi, C., Zhang, X., Nakagoshi, H. (2025). Polished Rice Regulates Maturation but Not Survival of Secondary Cells in Drosophila Male Accessory Gland. Genes Cells, 30(3):e70025 onlinelibrary.wiley.com/doi/10.1111/...
January 7, 2026 at 8:12 PM
Peng, J., Sun, A., Zheng, J., Zhang, N., Zhang, X., Gao, G. (2025). Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila. Commun Biol, 8(1):710 www.nature.com/articles/s42...
Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila - Communications Biology
The Drosophila Testis-Specific Serine/Threonine Kinase (dTSSK2), an ortholog of human TSSK4, coordinates sperm flagella assembly and motility. Disruption of dTSSK2 impairs sperm motility, leading to m...
www.nature.com
January 7, 2026 at 8:12 PM
Simmons, C., Williams, I. H., Bradshaw, T. W., Armstrong, A. R. (2025). Adipocyte-Derived CCHamide-1, Eiger, Growth-Blocking Peptide 3, and Unpaired 2 Regulate Drosophila melanogaster Oogenesis. Biomolecules, 15(4) www.mdpi.com/2218-273X/15...
January 7, 2026 at 8:12 PM
Ku, H. Y., Bilder, D. (2025). Basement membrane patterning by spatial deployment of a secretion-regulating protease. Proc Natl Acad Sci U S A, 122(20):e2412161122 www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 7, 2026 at 8:12 PM
Reposted by Drosophilosopher
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins | American Journal of Physiology-Cell Physiology ...
Prickle 1, an ortholog found in Drosophila, was localized at the Sertoli cell-spermatid interface consistent with its role of supporting the Vangl2 planar cell polarity (PCP), which is an integral mem...
journals.physiology.org
January 7, 2026 at 7:14 PM
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
January 7, 2026 at 8:12 PM
Reposted by Drosophilosopher
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
January 7, 2026 at 7:30 PM
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
If spending some time in the UK is of interest, my lab is advertising a PhD post presently with a deadline of Jan 8th.
For MSc enquiries, email me (see link) and see 2nd post.
mahansonresearch.weebly.com/blog/phd-stu...
1/2
For MSc enquiries, email me (see link) and see 2nd post.
mahansonresearch.weebly.com/blog/phd-stu...
1/2
PhD studentship! Deadline Jan 8th 2026
Cryptic fitness consequences of a selfish X chromosome
mahansonresearch.weebly.com
January 4, 2026 at 2:53 PM
I am proud to present my latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. Register to hear my presentation! #ISSCR2026 invt.io/1bxbzdbzjfq @isscr.org
I'm speaking at ISSCR 2026 Annual Meeting, join me
Register now
invt.io
December 23, 2025 at 3:53 PM
Now that is cool!
Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @hollyingraham.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @hollyingraham.bsky.social
December 23, 2025 at 3:53 PM
Zhang, Y., Ma, P., Wang, S., Chen, S., Deng, H. (2025). Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila. Nat Commun, 16(1):4909 www.nature.com/articles/s41...
Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila - Nature Communications
Disruption of the calcium network is associated with cellular ageing. In this study, Zhang et al. show that the breakdown of mitochondria-ER contacts causes disruption of ER-mitochondrial calcium flux...
www.nature.com
December 23, 2025 at 3:52 PM
Chen, Y., Sun, L. V. (2025). alphaSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis. Sci Rep, 15(1):18989 www.nature.com/articles/s41...
αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis - Scientific Reports
Scientific Reports - αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis
www.nature.com
December 23, 2025 at 3:52 PM
Knudsen, C., Moriya, A., Nakato, E., Gulati, R., Akiyama, T., Nakato, H. (2025). Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells. PLoS Genet, 21(5):e1011686 journals.plos.org/plosgenetics...
Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells
Author summary The control of stem cells is important to many areas of developmental and cell biology, including cancer, stem cell therapies, and tissue regeneration following injury. The Drosophila m...
journals.plos.org
December 23, 2025 at 3:52 PM
Raz, A. A., Hassan, H., Yamashita, Y. M. (2025). Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation. bioRxiv, www.biorxiv.org/content/10.1...
December 23, 2025 at 3:52 PM
Dominado, N., Ye, R., Casagranda, F., Heaney, J., Siddall, N. A., Abud, H. E., Hime, G. R. (2025). Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation. Cell Death Discov, 11(1):206 www.nature.com/articles/s41...
Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation - Cell Death Discovery
Cell Death Discovery - Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation
www.nature.com
December 23, 2025 at 3:51 PM