Giorgio Seano
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giorgioseano.bsky.social
Giorgio Seano
@giorgioseano.bsky.social
1.5K followers 920 following 110 posts
Head of the Tumor Microenvironment Laboratory at Institut Curie. #CancerResearch, #Neuro-oncology, #BrainTumor, #GBM, #Glioblastoma, #ResistanceMechanism, #TumorMicroenrironment, #TME, #Mechanobiology, #CellPlasticity

https://institut-curie.org/team/seano
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giorgioseano.bsky.social
Giorgio Seano @giorgioseano.bsky.social · Jul 17
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
giorgioseano.bsky.social
Wonderful achievement, Vale! Proud of you and your colleagues!
valentino-ribecco.bsky.social Valentino Ribecco @valentino-ribecco.bsky.social · 26d
I’m truly honoured to has been selected for the EANO Young Investigator Scholarship by the EANO Scientific Committee for the 20th Meeting of the European Association of Neuro-Oncology in Prague.

A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏
October 16, 2025 at 3:45 PM
giorgioseano.bsky.social
I am incredibly proud to share that our team's work has been selected for the upcoming @eanoassociation.bsky.social congress in Prague! We'll be giving two oral presentations and presenting two posters.

#EANO2025 #NeuroOncology #BrainTumors #CancerResearch
October 16, 2025 at 7:44 AM
Reposted by Giorgio Seano
sunrise-network.bsky.social
Amazing job! Well done guys! Funny how conventional therapies enrich for hybrid GBM cells🤩
giorgioseano.bsky.social Giorgio Seano @giorgioseano.bsky.social · Jul 17
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
July 18, 2025 at 9:24 PM
Reposted by Giorgio Seano
oncodaily.bsky.social
Why Does Glioblastoma Always Outsmart Treatment? - Giorgio Seano
@giorgioseano.bsky.social
@institutcurie.bsky.social
@valentino-ribecco.bsky.social
@ggargiul.bsky.social

oncodaily.com/science/glio...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Glioblastoma #NeuroOnc
Giorgio Seano: Why Does Glioblastoma Always Outsmart Treatment? - OncoDaily
Giorgio Seano: Why Does Glioblastoma Always Outsmart Treatment? / Adrien Thomas, Alberto Ballestín, cancer, Cathy Pichol-Thievend, Celine Vallot, Curie
oncodaily.com
July 18, 2025 at 1:52 PM
giorgioseano.bsky.social
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
July 17, 2025 at 9:08 AM
Reposted by Giorgio Seano
annaclemens.com
🎧 I made this list in 2021, but these podcasts are still in my rotation!

If you're a researcher looking for relevant and useful information for academics, check out these top podcast suggestions and learn something new this week. -> https://rpst.page.link/rxCs

#AcademicWriting #PhDSky #PhDchat
Academic Podcasts for Researchers & Scientists
Looking for the best academic podcasts? I have recommendations for academic writing podcasts, podcasts for PhD students and other podcasts on academia – from leadership and academic life to teaching.
rpst.page.link
July 13, 2025 at 11:06 AM
Reposted by Giorgio Seano
eanoassociation.bsky.social
📣 Have you heard? Registration for #EANO2025, taking place Oct 16-19, 2025 in #Prague (CZ) is open! Don’t miss out on this fantastic experience to meet experts in the field of #NeuroOncology. Early Bird fees available until July 31, 2025. 👉 eano.eu/eano2025/reg... #braincancer #medsky
June 18, 2025 at 12:50 PM
Reposted by Giorgio Seano
elizsmckenna.bsky.social
Congratulations to the 2025 Cancer Discovery Early Career Award winner: Sandra Misale! @sandramisale.bsky.social #AACR25
April 27, 2025 at 1:00 AM
giorgioseano.bsky.social
Well deserved!! Congrats Dr. Jain!!
theaacr.bsky.social American Association for Cancer Research (AACR) @theaacr.bsky.social · Apr 3
The AACR congratulates Rakesh K. Jain, PhD, FAACR, who will be honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research at #AACR25. www.aacr.org/about-the-aa... #AACRFellows @harvardmed.bsky.social
April 7, 2025 at 6:24 PM
Reposted by Giorgio Seano
theaacr.bsky.social
The AACR congratulates Rakesh K. Jain, PhD, FAACR, who will be honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research at #AACR25. www.aacr.org/about-the-aa... #AACRFellows @harvardmed.bsky.social
April 3, 2025 at 6:04 PM
Reposted by Giorgio Seano
eanoassociation.bsky.social
📢 Call for Applications
EANO & @neuroonc.bsky.social are seeking a new Editor-in-Chief for Neuro-Oncology Advances!

✅ Strong background in #NeuroOncology
✅ Editorial leadership experience

🗓️ Deadline: May 31, 2025
🔗 More info: bit.ly/4j9AqV7

#EANO #SNO #NeuroOncologyAdvances #CallForApplications
April 3, 2025 at 8:05 AM
Reposted by Giorgio Seano
biorxiv-cancer.bsky.social
Methylation-Based Deconvolution Unveils Glioblastoma Heterogeneity and Cell-Type Composition Linked to Patient Survival https://www.biorxiv.org/content/10.1101/2025.02.27.640603v1
March 4, 2025 at 6:00 AM
giorgioseano.bsky.social
Congrats @thomasdaubon.bsky.social... Cool story!!
February 17, 2025 at 12:41 PM
Reposted by Giorgio Seano
erictopol.bsky.social
A new paper on microplastics accumulating in the brain was just published in Nature Medicine. I've reviewed the background and main findings in a new Ground Truths post erictopol.substack.com/p/the-microp...
February 3, 2025 at 4:06 PM
giorgioseano.bsky.social
Looking forward to meeting a lot of good international and French friends at the Brain Tumor Microenvironment Symposium organized by the Institut du Cerveau... Super cool lineup!! #GBM #TME
curamus-cancer.fr/brain-tumor-...
SAVE THE DATE: Brain Tumor Microenvironment Symposium, 30th & 31st January 2025, Paris - Siric Cancer - Curamus - Site de Recherche Intégrée sur le Cancer
Dans le cadre de son programme de recherche intégrée « Cerveau, cancer et immunité – dialogue cellulaire dans les tumeurs cérébrales », […]
curamus-cancer.fr
January 30, 2025 at 8:02 AM
Reposted by Giorgio Seano
profharley.bsky.social
Wanted to stat today with some new #harleylab science.

ChiaWen Chang is leading efforts to understand immune cell patterning in the brain in glioblastoma. He started w/ the inverse question: how do GBM cells influence microglia (brain-resident immune cells)?

www.sciencedirect.com/science/arti...
Glioblastoma drives protease-independent extracellular matrix invasion of microglia
Glioblastoma (GBM) is the most common and lethal form of primary brain cancer. Microglia infiltration into the tumor microenvironment is associated wi…
www.sciencedirect.com
January 21, 2025 at 4:20 PM
Reposted by Giorgio Seano
valeramponi.bsky.social
I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity:
aacrjournals.org/cancerres/ar...
H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
Cell persistence and senescence are distinct states of proliferative arrest induced by cancer therapy, with persister cells being characterized by the silencing of inflammatory genes through the heter...
aacrjournals.org
January 8, 2025 at 12:08 PM
Reposted by Giorgio Seano
erictopol.bsky.social
A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com
For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...
A foundation model of transcription across human cell types - Nature
A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...
www.nature.com
January 8, 2025 at 4:27 PM
giorgioseano.bsky.social
Here again the Neuro-Oncology Starter Pack for those interested in brain tumor research and therapy.
go.bsky.app/VgzHLtt
January 8, 2025 at 11:23 AM
giorgioseano.bsky.social
Here again the Tumor Microenvironment Starter Pack for those diving deep into cancer research.

#TumorMicroenvironment, #CancerResearch, #ScientificCommunity, #TME
giorgioseano.bsky.social Giorgio Seano @giorgioseano.bsky.social · Nov 19
Among the Cancer-related Starter Packs currently available, I didn’t find one on Tumor Microenvironment.

Here, the list of who I found until now… If you want to be added, please reply below!
go.bsky.app/CtQMJyW
January 8, 2025 at 11:20 AM
Reposted by Giorgio Seano
thefuchslab.bsky.social
Cancers may arise in tissues with a low mutational burden. It’s up to the microenvironment! We discussed this in @natrevcancer.bsky.social
www.nature.com/articles/s41...
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer
In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...
www.nature.com
December 31, 2024 at 1:44 PM
Reposted by Giorgio Seano
blacoste.bsky.social
New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...
Blood–brain barrier disruption and microglial activation during hypoxia and post-hypoxic recovery in aged mice
Sapkota et al. show that hypoxia triggers vascular breakdown and microglial activation in the brain. While return to normoxia results in vascular repair, m
academic.oup.com
January 4, 2025 at 3:14 PM
Reposted by Giorgio Seano
ggargiul.bsky.social
End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?
December 31, 2024 at 1:12 PM
Reposted by Giorgio Seano
maitrejl.bsky.social
🎉@institutcurie.bsky.social is on @bsky.app
Find scientists at Curie in this pack!
go.bsky.app/UJjz275
December 12, 2024 at 11:38 AM
Reposted by Giorgio Seano
bunnech.bsky.social
How can we build an Al virtual cell that simulates all functions and interactions of a cell? How will it transform research and drive breakthroughs in programmable biology, drug discovery and personalized medicine?

Take a look at our paper in @cellpress.bsky.social!
www.cell.com/cell/fulltex...
December 12, 2024 at 8:09 PM