I am incredibly proud to share that our team's work has been selected for the upcoming @eanoassociation.bsky.social congress in Prague! We'll be giving two oral presentations and presenting two posters.

#EANO2025 #NeuroOncology #BrainTumors #CancerResearch

🚀 Here's the exciting part: we can target this vulnerability.
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)

🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor

Intravital microscopy: glioblastoma cells that interact with brain blood vessels. SciVis #DataViz (10/11)

We are grateful to ERC StG , Institut Curie , Institut National du Cancer, CNRS, and University Paris Saclay for their support (8/11)

This research wouldn't have been possible w/o the hard work of 3 co-first authors Cathy Pichol-Thievend, Oceane Anezo, Aafrin M. Pettiwala, and many collaborators (7/11)

Interestingly, also angiocrine factors from brain blood vessels were able to induce transition to VC-Resist cell state, thus creating a vicious loop that induces infiltration of the surrounding brain tissue and even more resistance to therapy (4/11)

We first found that both radio-and chemotherapy induce a transition towards a cell state that we named VC-Resist. This senescent-like cell state is highly resistant to therapy and actively attracted by blood vessels, ie. vessel co-opting. #senescence #vesselcooption (3/11)

Intriguingly, we observed that conventional therapy induces vessel co-option in glioblastoma cells, thus “encouraging” cells to go where therapy can hurt less. This could potentially lead to future anti-vessel co-option therapies to sensitize glioblastoma to therapy. #vesselcooption (2/11)