Frédéric Blanc
@fredericblanc.bsky.social
Professor of Geriatrics, Geriatrician and Neurologist
Disease with Lewy bodies
Alzheimer's disease
Lewy body disease
University of Strasbourg
University Hospital of Strasbourg
Disease with Lewy bodies
Alzheimer's disease
Lewy body disease
University of Strasbourg
University Hospital of Strasbourg
Dementia with Lewy bodies and EEG: delta/theta excess, posterior alpha attenuation, and uniquely reduced gamma.
More EEG are needed in DLB to diagnose and better understand this disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
More EEG are needed in DLB to diagnose and better understand this disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
EEG network reorganization across Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies
INTRODUCTION Electroencephalography (EEG) provides a temporally precise index of neural dysfunction, capturing changes in oscillatory activity, connectivity, and network organization. While spectral...
alz-journals.onlinelibrary.wiley.com
February 19, 2026 at 6:07 PM
Dementia with Lewy bodies and EEG: delta/theta excess, posterior alpha attenuation, and uniquely reduced gamma.
More EEG are needed in DLB to diagnose and better understand this disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
More EEG are needed in DLB to diagnose and better understand this disease 👍
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Frédéric Blanc
Japan's dementia safety measures are urgently needed: 19,039 dementia patients went missing in 2023, with 553 found deceased. Japan is advancing safety measures for daily life through GPS trackers, store/community alerts, AI screening, and robotic caregiving. 🔗 www.bbc.com/news/article...
Japan is facing a dementia crisis – can technology help?
Elderly people aged 65 and over now make up nearly 30% of Japan's population.
www.bbc.com
February 18, 2026 at 3:15 AM
Japan's dementia safety measures are urgently needed: 19,039 dementia patients went missing in 2023, with 553 found deceased. Japan is advancing safety measures for daily life through GPS trackers, store/community alerts, AI screening, and robotic caregiving. 🔗 www.bbc.com/news/article...
Reposted by Frédéric Blanc
🧬🎙️ 👉Nouvel épisode avec le Pr David Wallon pour mieux comprendre les enjeux de la génétique dans la maladie d’Alzheimer : www.podcastics.com/episode/4029...
February 18, 2026 at 6:21 AM
🧬🎙️ 👉Nouvel épisode avec le Pr David Wallon pour mieux comprendre les enjeux de la génétique dans la maladie d’Alzheimer : www.podcastics.com/episode/4029...
Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia (dementia with Lewy bodies)
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Alpha‐synuclein quantitative seed amplification assay predicts conversion to dementia
INTRODUCTION The alpha-synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognosti...
alz-journals.onlinelibrary.wiley.com
February 14, 2026 at 2:39 PM
Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia (dementia with Lewy bodies)
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Increase HDAC class I (epigenetic for memory and inflammation) in dementia with Lewy bodies: Amygdala, Insula, anterior cingulate, Striatum and precentral gyrus.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
February 14, 2026 at 2:36 PM
Increase HDAC class I (epigenetic for memory and inflammation) in dementia with Lewy bodies: Amygdala, Insula, anterior cingulate, Striatum and precentral gyrus.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Diagnostic Performance of the α-Synuclein Seed Amplification Assay (RT-QuIC) for Dementia With Lewy Bodies: a Comparison Across 4 Laboratories.
Lower sensitivity in β-amyloid (Aβ)–positive patients with DLB (70%) compared with Aβ-negative patients with DLB (87.5%)
www.neurology.org/doi/10.1212/...
Lower sensitivity in β-amyloid (Aβ)–positive patients with DLB (70%) compared with Aβ-negative patients with DLB (87.5%)
www.neurology.org/doi/10.1212/...
Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies | Neurology
Background and ObjectivesThe α-synuclein (α-syn) seed amplification assay (SAA) has shown promising results
for diagnosing dementia with Lewy bodies (DLB) using CSF samples. A barrier to implementing
...
www.neurology.org
February 14, 2026 at 2:18 PM
Diagnostic Performance of the α-Synuclein Seed Amplification Assay (RT-QuIC) for Dementia With Lewy Bodies: a Comparison Across 4 Laboratories.
Lower sensitivity in β-amyloid (Aβ)–positive patients with DLB (70%) compared with Aβ-negative patients with DLB (87.5%)
www.neurology.org/doi/10.1212/...
Lower sensitivity in β-amyloid (Aβ)–positive patients with DLB (70%) compared with Aβ-negative patients with DLB (87.5%)
www.neurology.org/doi/10.1212/...
Despite being grouped under Lewy body dementia, Parkinson's Disease Dementia (PDD) and dementia with Lewy bodies (DLB) have distinct phenotypes: PDD more severe than DLB for parkinsonism, hallucinations, delusion, somnolence and urinary dysfunction
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
link.springer.com
February 14, 2026 at 2:12 PM
Despite being grouped under Lewy body dementia, Parkinson's Disease Dementia (PDD) and dementia with Lewy bodies (DLB) have distinct phenotypes: PDD more severe than DLB for parkinsonism, hallucinations, delusion, somnolence and urinary dysfunction
link.springer.com/content/pdf/...
link.springer.com/content/pdf/...
February 12, 2026 at 4:40 AM
Reposted by Frédéric Blanc
La protéine klotho circulante pourrait elle être un marqueur de longévité cérébrale ?
@fredericblanc.bsky.social #alzsky
@fredericblanc.bsky.social #alzsky
Serum Klotho Levels, Brain Structure, and Cognitive Performance
This cross-sectional study investigates if circulating serum klotho levels modify the negative association between age-related brain atrophy and cognitive decline in a cognitively unimpaired, older ad...
jamanetwork.com
February 9, 2026 at 7:46 AM
La protéine klotho circulante pourrait elle être un marqueur de longévité cérébrale ?
@fredericblanc.bsky.social #alzsky
@fredericblanc.bsky.social #alzsky
Un effet «neuroprotecteur» : trois tasses de café ou de thé par jour pourraient réduire le risque de démence, selon une étude de Harvard
www.lefigaro.fr/sciences/un-...
www.lefigaro.fr/sciences/un-...
Un effet «neuroprotecteur» : trois tasses de café ou de thé par jour pourraient réduire le risque de démence, selon une étude de Harvard
Pour parvenir à cette conclusion, les chercheurs ont analysé les données de 131.000 professionnels de santé aux États-Unis pendant 43 ans.
www.lefigaro.fr
February 12, 2026 at 4:36 AM
Un effet «neuroprotecteur» : trois tasses de café ou de thé par jour pourraient réduire le risque de démence, selon une étude de Harvard
www.lefigaro.fr/sciences/un-...
www.lefigaro.fr/sciences/un-...
Jeux Olympiques 2026 : le relais mixte de biathlon, première médaille d'or pour la France. L'Italie argent, l'Allemagne bronze
www.franceinfo.fr/les-jeux-oly...
www.franceinfo.fr/les-jeux-oly...
JO d'hiver 2026 : intouchable, le relais mixte de biathlon apporte à la France sa première médaille d'or
En argent à Pékin en 2022, l'équipe de France de biathlon a reconquis le trône olympique en relais mixte, dimanche, grâce à Eric Perrot, Quentin Fillon Maillet, Lou Jeanmonnot et Julia Simon.
https://www.franceinfo.fr/les-jeux-olympiques/biathlon/jo-d-hiver-2026-intouchable-le-relais-mixte-de-biathlon-apporte-a-la-france-sa-premiere-medaille-d-or_7792355.html#xtor=CS2-765-[autres]-
February 8, 2026 at 2:45 PM
Jeux Olympiques 2026 : le relais mixte de biathlon, première médaille d'or pour la France. L'Italie argent, l'Allemagne bronze
www.franceinfo.fr/les-jeux-oly...
www.franceinfo.fr/les-jeux-oly...
Maladie de Charcot et maladie frontotemporale : découverte d’un mécanisme clé d’une forme génétique (C9ORF72) de la maladie. La synthèse des protéines et son contrôle est la clef.
sante.lefigaro.fr/medecine/mal...
sante.lefigaro.fr/medecine/mal...
Maladie de Charcot : découverte d’un mécanisme clé d’une forme génétique de la maladie
Des chercheurs ont identifié un mécanisme clé d’une forme génétique de la maladie de Charcot et de la démence fronto-temporale et sont même parvenus à bloquer la neurodégénérescence dans plusieurs mod...
sante.lefigaro.fr
February 6, 2026 at 6:54 AM
Maladie de Charcot et maladie frontotemporale : découverte d’un mécanisme clé d’une forme génétique (C9ORF72) de la maladie. La synthèse des protéines et son contrôle est la clef.
sante.lefigaro.fr/medecine/mal...
sante.lefigaro.fr/medecine/mal...
Felice Varini, palais des Beaux-Arts, Lille
Impressionnant
Impressive 😳
Impressionnant
Impressive 😳
January 31, 2026 at 6:44 PM
Felice Varini, palais des Beaux-Arts, Lille
Impressionnant
Impressive 😳
Impressionnant
Impressive 😳
Palais des Beaux-Arts de Lille, France.
January 31, 2026 at 6:38 PM
Palais des Beaux-Arts de Lille, France.
"Les Vieilles" ou "Le Temps" Francisco Goya. Musée des Beaux-Arts de Lille.
January 31, 2026 at 6:31 PM
"Les Vieilles" ou "Le Temps" Francisco Goya. Musée des Beaux-Arts de Lille.
Reposted by Frédéric Blanc
We’ve been awarded a #QEdPrize for our research into Dementia with Lewy bodies (DLB).
Our experts are leading the way in DLB research and treatment, having redefined it as a distinct and common cause of dementia.
Find out more https://bit.ly/3KgEg2X
#WeAreNCL
Our experts are leading the way in DLB research and treatment, having redefined it as a distinct and common cause of dementia.
Find out more https://bit.ly/3KgEg2X
#WeAreNCL
November 26, 2025 at 8:02 AM
We’ve been awarded a #QEdPrize for our research into Dementia with Lewy bodies (DLB).
Our experts are leading the way in DLB research and treatment, having redefined it as a distinct and common cause of dementia.
Find out more https://bit.ly/3KgEg2X
#WeAreNCL
Our experts are leading the way in DLB research and treatment, having redefined it as a distinct and common cause of dementia.
Find out more https://bit.ly/3KgEg2X
#WeAreNCL
Reposted by Frédéric Blanc
We have been awarded a #QEdPrize in recognition of more than 30 years of research into Dementia with Lewy bodies, which has transformed the understanding, diagnosis and care of patients across the world.
Read more here: t.co/MRj4dzMAcD
Read more here: t.co/MRj4dzMAcD
November 26, 2025 at 9:18 AM
We have been awarded a #QEdPrize in recognition of more than 30 years of research into Dementia with Lewy bodies, which has transformed the understanding, diagnosis and care of patients across the world.
Read more here: t.co/MRj4dzMAcD
Read more here: t.co/MRj4dzMAcD
Reposted by Frédéric Blanc
Dementia with Lewy bodies (DLB) in the prodromal to mild stage: little change over 8 years. This confirms the neurofunctional status of DLB at onset, which can progress to a neurodegenerative status. The challenge is to prevent this transition from one to the other.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Long term cognitive outcome of prodromal and mild dementia with Lewy bodies: a cohort study - GeroScience
The cognitive evolution of early dementia with Lewy bodies (DLB) is less well known than that of Alzheimer’s disease (AD). During dementia, DLB progresses like AD. The aim of this study was to analyze...
link.springer.com
December 5, 2025 at 2:16 PM
Dementia with Lewy bodies (DLB) in the prodromal to mild stage: little change over 8 years. This confirms the neurofunctional status of DLB at onset, which can progress to a neurodegenerative status. The challenge is to prevent this transition from one to the other.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Frédéric Blanc
🚨 Paper Alert 🚨
💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you!
🔓 shorturl.at/b3ws2
@robindeflores.bsky.social @claireandre.bsky.social
@hcl-recherche.bsky.social @neuropresage.bsky.social
💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you!
🔓 shorturl.at/b3ws2
@robindeflores.bsky.social @claireandre.bsky.social
@hcl-recherche.bsky.social @neuropresage.bsky.social
January 17, 2026 at 1:03 PM
🚨 Paper Alert 🚨
💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you!
🔓 shorturl.at/b3ws2
@robindeflores.bsky.social @claireandre.bsky.social
@hcl-recherche.bsky.social @neuropresage.bsky.social
💡If you are interested in the locus coeruleus and dementia with Lewy bodies, this systematic review, led by @sophiedautricourt.bsky.social 👏, is for you!
🔓 shorturl.at/b3ws2
@robindeflores.bsky.social @claireandre.bsky.social
@hcl-recherche.bsky.social @neuropresage.bsky.social
Reposted by Frédéric Blanc
Research role at Newcastle University exploring biomarkers in Parkinsons and dementia with Lewy bodies using patient samples and advanced chemistry tools. Closing date: 9th February
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Assistant/Associate: Neurodegenerative Disease Proteins
Newcastle University seeks a Research Assistant or Associate to study biomarkers in Lewy body disorders using biochemical and analytical chemistry methods.
www.dementiaresearcher.nihr.ac.uk
January 27, 2026 at 8:59 AM
Research role at Newcastle University exploring biomarkers in Parkinsons and dementia with Lewy bodies using patient samples and advanced chemistry tools. Closing date: 9th February
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by Frédéric Blanc
LBDA: What are Lewy Bodies?
Lewy body dementia (LBD) is the second most common type of progressive dementia, accounting for 5 to 10 percent of cases and affecting 1.4 million people in the US.
Read more: www.lbda.org/blog/what-ar...
Lewy body dementia (LBD) is the second most common type of progressive dementia, accounting for 5 to 10 percent of cases and affecting 1.4 million people in the US.
Read more: www.lbda.org/blog/what-ar...
January 28, 2026 at 10:22 PM
LBDA: What are Lewy Bodies?
Lewy body dementia (LBD) is the second most common type of progressive dementia, accounting for 5 to 10 percent of cases and affecting 1.4 million people in the US.
Read more: www.lbda.org/blog/what-ar...
Lewy body dementia (LBD) is the second most common type of progressive dementia, accounting for 5 to 10 percent of cases and affecting 1.4 million people in the US.
Read more: www.lbda.org/blog/what-ar...
Reposted by Frédéric Blanc
A comparison of 4 labs, assessing the performance of the α-Synuclein seed amplification assay for Dementia With Lewy Bodies, "highlights challenges for the reproducibility of α-syn SAA results across different protocols applied by different laboratories"
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
January 29, 2026 at 10:59 AM
A comparison of 4 labs, assessing the performance of the α-Synuclein seed amplification assay for Dementia With Lewy Bodies, "highlights challenges for the reproducibility of α-syn SAA results across different protocols applied by different laboratories"
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Reposted by Frédéric Blanc
On World Lewy Body Day earlier this week, we were incredibly honoured to host the premiere of our new short film about life with Lewy bodies at an iconic London landmark.
#lbaw2026 #lewybodyawaresnessweek #lewybodydementia
youtu.be/I2p9XQM5VLc?...
#lbaw2026 #lewybodyawaresnessweek #lewybodydementia
youtu.be/I2p9XQM5VLc?...
What is life with Lewy body dementia really like?
YouTube video by The Lewy Body Society
youtu.be
January 30, 2026 at 12:43 PM
On World Lewy Body Day earlier this week, we were incredibly honoured to host the premiere of our new short film about life with Lewy bodies at an iconic London landmark.
#lbaw2026 #lewybodyawaresnessweek #lewybodydementia
youtu.be/I2p9XQM5VLc?...
#lbaw2026 #lewybodyawaresnessweek #lewybodydementia
youtu.be/I2p9XQM5VLc?...