Ferran Muiños
@fmuinos.bsky.social
Scientist working on computational genomics, looking into mutational heterogeneity and somatic evolution. Maths, Stats, ML, Bioinfo. Staff scientist, BBGLab, IRB Barcelona.
Shell-shocked by the passing of Danya. Incredibly talented person, brilliant chess player and educator. He epitomized the love for the game of chess.
The Charlotte Chess Center, where Naroditsky trained and worked as a coach, announced his death, calling him "a talented chess player, educator, and beloved member of the chess community." n.pr/472VQjQ
American chess grandmaster Daniel Naroditsky dies at 29
The Charlotte Chess Center, where Naroditsky trained and worked as a coach, announced his death, calling him "a talented chess player, educator, and beloved member of the chess community."
n.pr
October 21, 2025 at 3:27 PM
Shell-shocked by the passing of Danya. Incredibly talented person, brilliant chess player and educator. He epitomized the love for the game of chess.
Reposted by Ferran Muiños
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Reposted by Ferran Muiños
🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
October 8, 2025 at 3:01 PM
🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
Stop the genocide!
www.ohchr.org/en/press-rel...
www.ohchr.org/en/press-rel...
Israel has committed genocide in the Gaza Strip, UN Commission finds
GENEVA – Israel has committed genocide against Palestinians in the Gaza Strip, the UN Independent International Commission of Inquiry on the Occupied Palestinian Territory, including East Jerusalem, a...
www.ohchr.org
September 16, 2025 at 10:11 AM
Stop the genocide!
www.ohchr.org/en/press-rel...
www.ohchr.org/en/press-rel...
Reposted by Ferran Muiños
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods
academic.oup.com
August 14, 2025 at 1:10 PM
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Reposted by Ferran Muiños
I wrote about the debate with the Jubilee fascists, the overall idea of the utility of debate and the alleged need for it in order to arrive at truth, and the malicious and corrosive effect this false idea actually has upon the discourse and society.
www.the-reframe.com/boiling-water/
www.the-reframe.com/boiling-water/
Boiling Water
The corrosive damage cause by forcing people to defend their own lives by debating ideas that have already been defeated.
www.the-reframe.com
August 2, 2025 at 3:07 PM
I wrote about the debate with the Jubilee fascists, the overall idea of the utility of debate and the alleged need for it in order to arrive at truth, and the malicious and corrosive effect this false idea actually has upon the discourse and society.
www.the-reframe.com/boiling-water/
www.the-reframe.com/boiling-water/
Reposted by Ferran Muiños
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
July 26, 2025 at 2:11 PM
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
Reposted by Ferran Muiños
On my country's 249th birthday, I wrote about the problem of sharing a nation with millions of evil people, and how to live a human life in the face of overwhelming inhumanity.
Oh and the Beastie Boys make an appearance.
www.the-reframe.com/so-shines-a-...
Oh and the Beastie Boys make an appearance.
www.the-reframe.com/so-shines-a-...
So Shines A Good Deed In A Weary World
Dark isn't the opposite of light, it's the absence of light.
www.the-reframe.com
July 4, 2025 at 5:03 PM
On my country's 249th birthday, I wrote about the problem of sharing a nation with millions of evil people, and how to live a human life in the face of overwhelming inhumanity.
Oh and the Beastie Boys make an appearance.
www.the-reframe.com/so-shines-a-...
Oh and the Beastie Boys make an appearance.
www.the-reframe.com/so-shines-a-...
Reposted by Ferran Muiños
Our colleagues Olivia Dove, Raquel Blanco and Ferriol Calvet are attending the #EACR2025. They are sharing their research results with their respective posters and are for sure learning a lot in an excellent Congress with an outstanding list of speakers. @ferriol.bsky.social @raquelbmi.bsky.social
June 18, 2025 at 1:58 PM
Our colleagues Olivia Dove, Raquel Blanco and Ferriol Calvet are attending the #EACR2025. They are sharing their research results with their respective posters and are for sure learning a lot in an excellent Congress with an outstanding list of speakers. @ferriol.bsky.social @raquelbmi.bsky.social
Reposted by Ferran Muiños
Oh goodness, @dereklowe.bsky.social's response to Hassabis is so on the mark and full of quotable things. 1/n
www.science.org/content/blog...
www.science.org/content/blog...
June 17, 2025 at 9:52 PM
Oh goodness, @dereklowe.bsky.social's response to Hassabis is so on the mark and full of quotable things. 1/n
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Ferran Muiños
I read this cool piece by @owlposting1.bsky.social on endometriosis on @scientificdiscovery.dev's recommendation
www.owlposting.com/p/endometrio...
One point is that endometriosis is very common, 10% of women according to the WHO. Which makes the paltry research (funding) even more galling.
www.owlposting.com/p/endometrio...
One point is that endometriosis is very common, 10% of women according to the WHO. Which makes the paltry research (funding) even more galling.
Endometriosis is an incredibly interesting disease
5k words, 23 minutes reading time
www.owlposting.com
June 16, 2025 at 9:08 AM
I read this cool piece by @owlposting1.bsky.social on endometriosis on @scientificdiscovery.dev's recommendation
www.owlposting.com/p/endometrio...
One point is that endometriosis is very common, 10% of women according to the WHO. Which makes the paltry research (funding) even more galling.
www.owlposting.com/p/endometrio...
One point is that endometriosis is very common, 10% of women according to the WHO. Which makes the paltry research (funding) even more galling.
Reposted by Ferran Muiños
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored
an AI researcher going back to school for immunology
rachel.fast.ai
June 4, 2025 at 3:53 PM
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Reposted by Ferran Muiños
We're thrilled to introduce PromoterAI — a tool for accurately identifying promoter variants that impact gene expression. 🧵 (1/)
May 29, 2025 at 6:29 PM
We're thrilled to introduce PromoterAI — a tool for accurately identifying promoter variants that impact gene expression. 🧵 (1/)
I came across this really compressed, yet understandable explanation of Gödel's incompleteness blog.plover.com/math/Gdl-Smu...
World's shortest explanation of Gödel's theorem
From the highly eclectic blog of Mark Dominus
blog.plover.com
May 23, 2025 at 7:33 AM
I came across this really compressed, yet understandable explanation of Gödel's incompleteness blog.plover.com/math/Gdl-Smu...
Heading to day 2 #VariantEffect25
Come by poster 129 to know more about our recent @bbglab.bsky.social joint study with Risques lab at UW Medicine: somatic variation (and selection!) in the normal bladder urothelium.
Come by poster 129 to know more about our recent @bbglab.bsky.social joint study with Risques lab at UW Medicine: somatic variation (and selection!) in the normal bladder urothelium.
May 22, 2025 at 6:04 AM
Heading to day 2 #VariantEffect25
Come by poster 129 to know more about our recent @bbglab.bsky.social joint study with Risques lab at UW Medicine: somatic variation (and selection!) in the normal bladder urothelium.
Come by poster 129 to know more about our recent @bbglab.bsky.social joint study with Risques lab at UW Medicine: somatic variation (and selection!) in the normal bladder urothelium.
Reposted by Ferran Muiños
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
www.nejm.org
April 23, 2025 at 10:22 PM
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Just learned that pandas and numpy do not provide the same default calculation of the variance: pandas gives the unbiased sample variance estimator whilst numpy gives the MLE estimator 😱
To get the pandas behaviour with numpy, use the kwarg ddof=1 👌
To get the pandas behaviour with numpy, use the kwarg ddof=1 👌
April 17, 2025 at 8:48 PM
Just learned that pandas and numpy do not provide the same default calculation of the variance: pandas gives the unbiased sample variance estimator whilst numpy gives the MLE estimator 😱
To get the pandas behaviour with numpy, use the kwarg ddof=1 👌
To get the pandas behaviour with numpy, use the kwarg ddof=1 👌
Reposted by Ferran Muiños
Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️
The complexity of tobacco smoke-induced mutagenesis in head and neck cancer
Nature Genetics - Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution...
rdcu.be
March 31, 2025 at 10:48 AM
Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️
Reposted by Ferran Muiños
During apartheid, South African armed forces killed 69 civilians in the Sharpeville Massacre. The world was shocked. This event is still taught in history classes.
On average, Israel has massacred more than 70 Palestinian civilians *every day* for the past 18 months.
On average, Israel has massacred more than 70 Palestinian civilians *every day* for the past 18 months.
March 30, 2025 at 9:35 AM
During apartheid, South African armed forces killed 69 civilians in the Sharpeville Massacre. The world was shocked. This event is still taught in history classes.
On average, Israel has massacred more than 70 Palestinian civilians *every day* for the past 18 months.
On average, Israel has massacred more than 70 Palestinian civilians *every day* for the past 18 months.
Reposted by Ferran Muiños
Let's talk about this Nature piece in more detail.
I've rarely read something so anti-scientific anywhere short of the National Review.
www.nature.com/articles/d41...
I've rarely read something so anti-scientific anywhere short of the National Review.
www.nature.com/articles/d41...
Three AI-powered steps to faster, smarter peer review
Tired of spending countless hours on peer reviews? An AI-assisted workflow could help.
www.nature.com
March 6, 2025 at 5:34 AM
Let's talk about this Nature piece in more detail.
I've rarely read something so anti-scientific anywhere short of the National Review.
www.nature.com/articles/d41...
I've rarely read something so anti-scientific anywhere short of the National Review.
www.nature.com/articles/d41...
Reposted by Ferran Muiños
Modern-Day Oracles or Bullshit Machines?
Jevin West (@jevinwest.bsky.social) and I have spent the last eight months developing the course on large language models (LLMs) that we think every college freshman needs to take.
thebullshitmachines.com
Jevin West (@jevinwest.bsky.social) and I have spent the last eight months developing the course on large language models (LLMs) that we think every college freshman needs to take.
thebullshitmachines.com
INTRODUCTION
thebullshitmachines.com
February 4, 2025 at 4:12 PM
Modern-Day Oracles or Bullshit Machines?
Jevin West (@jevinwest.bsky.social) and I have spent the last eight months developing the course on large language models (LLMs) that we think every college freshman needs to take.
thebullshitmachines.com
Jevin West (@jevinwest.bsky.social) and I have spent the last eight months developing the course on large language models (LLMs) that we think every college freshman needs to take.
thebullshitmachines.com
Reposted by Ferran Muiños
“‘Science can and should as a community organise itself to maximise its ability to act collectively, ethically and – when necessary – politically.’ The scientific community needs to speak up – not just for the sake of science, but of human decency, dignity and morality.”
February 7, 2025 at 3:20 PM
“‘Science can and should as a community organise itself to maximise its ability to act collectively, ethically and – when necessary – politically.’ The scientific community needs to speak up – not just for the sake of science, but of human decency, dignity and morality.”
Reposted by Ferran Muiños
"The most abundant nanoplastic was tyre particles (41%), then polystyrene (28%) and polyethylene (12%). Each tyre on the world’s 1.6bn vehicles can lose 4kg during its lifetimes and may be the largest source of tiny plastic pollution."
Vehicle tyres found to be biggest source of nanoplastics in the high Alps
Mountaineers now scaling more peaks for first global study of nanoplastics, which can enter lungs and bloodstream
www.theguardian.com
February 5, 2025 at 12:23 AM
"The most abundant nanoplastic was tyre particles (41%), then polystyrene (28%) and polyethylene (12%). Each tyre on the world’s 1.6bn vehicles can lose 4kg during its lifetimes and may be the largest source of tiny plastic pollution."
Reposted by Ferran Muiños
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
OpenVariant: a toolkit to parse and operate multiple input file formats
AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc
academic.oup.com
December 12, 2024 at 10:11 AM
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...