Florencia Pratto
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florpratto.bsky.social
Florencia Pratto
@florpratto.bsky.social
520 followers 880 following 18 posts
Tenure-track Stadtman Investigator at NIH/NIDDK. Studying meiotic replication and recombination while rolling those R's! Views are my own.
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Reposted by Florencia Pratto
piotraz.bsky.social
Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...
Protecting double Holliday junctions ensures crossing over during meiosis - Nature
Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.
www.nature.com
September 25, 2025 at 12:32 PM
Reposted by Florencia Pratto
maxperutzlabs.ac.at
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu

@univie.ac.at
@meduniwien.ac.at
September 25, 2025 at 7:04 AM
Reposted by Florencia Pratto
aphillippy.bsky.social
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
Reposted by Florencia Pratto
aphillippy.bsky.social
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
www.biorxiv.org
September 22, 2025 at 5:01 PM
Reposted by Florencia Pratto
aurelepiazza.bsky.social
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
August 27, 2025 at 12:00 PM
Reposted by Florencia Pratto
aphillippy.bsky.social
A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...
A phylogeny of the 7 ape genomes that have now been completed from "T2T", with Homer Simpson representing mankind.
April 9, 2025 at 9:31 PM
florpratto.bsky.social
Check this out if you ever wondered what intercellular bridges might be doing during meiosis! Happy to have played a small role! Congrats!!! @thejainlab.bsky.social
April 8, 2025 at 11:17 PM
Reposted by Florencia Pratto
ewanbirney.bsky.social
This is an important shift - the long awaited new Ensembl web site is ready for beta testing - is smooth, scrollable genome loveliness +clean views of the complex information - but @ensembl.bsky.social needs your help to get all the use cases out. Come to the webinar, and check out beta.ensembl.org
January 14, 2025 at 10:29 AM
Reposted by Florencia Pratto
katemiro.bsky.social
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
January 8, 2025 at 12:14 PM
Reposted by Florencia Pratto
cohenlab.bsky.social
Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA

biorxiv.org/cgi/content/...
Argonaute proteins regulate the timing of the spermatogenic transcriptional program
Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...
biorxiv.org
January 1, 2025 at 10:54 PM
florpratto.bsky.social
Home sweet home... New Year in the summer! #puntadeleste #uruguay
View of the Playa Mansa in Punta del Este, crystal clear water with Isla Gorriti in the background
December 31, 2024 at 1:33 PM
Reposted by Florencia Pratto
jweir.bsky.social
New preprint! How does meiosis work in non-model organisms? Together with Susana Coelho at the MPI for Biology Tübingen @mpi-bio-fml.bsky.social , we took a look at the proteins of the meiotic axis in the brown alga Ectocarpus www.biorxiv.org/content/10.1...
Exploring Meiosis in Brown Algae: Meiotic Axis Proteins in the model brown alga Ectocarpus
Most extant eukaryotic systems share core meiosis-specific genes, suggesting meiosis evolved only once in the last eukaryotic common ancestor (LECA). These genes have been characterized as master regu...
www.biorxiv.org
December 22, 2024 at 4:38 PM
florpratto.bsky.social
Uff Botafogo! 1 player down, 2 goals up!
#CopaLibertadores
Pic of the game showing Botafogo up by two goals, playing with 10 players since minute 1
November 30, 2024 at 8:51 PM
Reposted by Florencia Pratto
takashiakeralab.bsky.social
2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭🪱🪰🧬🦠Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIs🎉 #meiosis4eva
November 16, 2024 at 4:16 PM
Reposted by Florencia Pratto
jsantoyo.bsky.social
Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries. #CrossoverRecombination #Chromosomes #Meiosis #TrendsInGenetics
www.cell.com/trends/genet...
Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries
Crossing over between homologous chromosomes in meiosis is essential in most eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically evenly spaced, with each homolog pa...
www.cell.com
November 13, 2024 at 4:23 PM
Reposted by Florencia Pratto
somssich.bsky.social
The Chromosome Biology Department of @raphmercier.bsky.social here at the Max Planck Institute for Plant Breeding Research Cologne (@maxplanck.bsky.social) is looking for a new group leader!

jobs.mpipz.mpg.de/jobposting/8...

#PlantScience #PlantSciJobs #GroupLeader #NewPI #PlantChromosomalBiology
Group Leader Position in Plant Chromosome Biology (m/f/d)
jobs.mpipz.mpg.de
November 5, 2024 at 8:20 AM
Reposted by Florencia Pratto
biotobi.bsky.social
Fantastic resource for bio icons: NIH Bioart Source

Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov
October 29, 2024 at 7:19 AM
Reposted by Florencia Pratto
compoundchem.com
It's #InternationalNachoDay!

This graphic on kitchen chemistry hacks in @cenmag.bsky.social features tips on making a creamy nacho sauce as well as a guac that doesn't brown: cen.acs.org/food/food-sc...
Infographic detailing the chemistry behind four kitchen chemistry hacks. The first is slowing fruit browning. Fruits brown due to oxidation and polymerization of phenols. Adding acids, such as lemon juice, wrapping fruit in cling film or otherwise blocking oxygen slows browning, reducing the activity of the polyphenol oxidase enzyme. You can brown onions more quickly by increasing the pH with baking soda, deprotonating amines so they react with sugars faster. Onions make your eyes water when chopped due to the production of propanethial S-oxide. A sharp knife damages onion cells less, reducing eye-watering reactions. Chilling onions before chopping reduces the rate of the reaction and the volatility of propanethial S-oxide. Warming cheese, water, milk, and sodium citrate makes a stable, smooth cheese sauce. Sodium ions replace calcium ions that hold casein proteins in cheese together. This allows the casein proteins to separate and act as emulsifiers, binding fat and water together
October 21, 2024 at 1:04 PM
Reposted by Florencia Pratto
lumipie.com
🧪What a beautiful work has just been published.

This study reveals the mechanisms behind egg release during ovulation.

Looking at those images and videos is like visiting a museum. Pure art!
🔗 www.nature.com/articles/s41...
October 17, 2024 at 7:55 AM
florpratto.bsky.social
Picaña al gancho! Not many grilling days left this year...
October 19, 2024 at 8:58 PM
Reposted by Florencia Pratto
rebeccasear.bsky.social
“I quickly learned most undergraduates in my classes still hold the pre-Lewontin belief that human genetic variation predominately sorts geographically. Many students also thought race was based in genetic differences & that single mutations could explain complex traits in humans”
People Are Not Peas—Why Genetics Education Needs an Overhaul
The dated genetics taught in U.S. schools stokes misconceptions about race and human diversity. A biological anthropologist calls for change.
www.sapiens.org
October 3, 2024 at 1:00 PM
Reposted by Florencia Pratto
jkpritch.bsky.social
Two new chapters from my free online book in human genetics out this weekend!
These complete Part 3 of the book, on human population structure and history:
3.3: Human prehistory [separate thread]
3.4: Ancient DNA: a genetic time capsule [this thread]
web.stanford.edu/group/pritch...
September 23, 2024 at 9:48 PM
Reposted by Florencia Pratto
mollyprz.bsky.social
The final program for the conference is now up: events.columbia.edu/cal/event/ev...
September 28, 2024 at 6:30 PM
florpratto.bsky.social
So cool!
aphillippy.bsky.social Adam Phillippy @aphillippy.bsky.social · Sep 16
"Epigenetic control and inheritance of rDNA arrays" New preprint from the T2T acrocentrics team! We find a tight link between methylation and transcription of the rDNAs, including the occasional silencing of entire arrays www.biorxiv.org/content/10.1...
September 16, 2024 at 11:59 PM
Reposted by Florencia Pratto
biorxivpreprint.bsky.social
A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1
A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1
Using five complementary short- and long-read sequencing technologies, we phased and assembled >95%
www.biorxiv.org
August 6, 2024 at 6:32 AM