Florian Kämpf
@flofightscience.bsky.social
Behaviour • Circuit neuroscience • Connectomics • Microscopy • Drosophila • Zebrafish • PhD • MRC-LMB • Cambridge • Konstanz • Go • Aquaria • Art • Film • He/Him •
Pinned
We are proud to present our new preprint “Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish”, just posted on bioRxiv (www.biorxiv.org/content/10.1...). (1/10)
Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish
Accumulating information is a critical component of most circuit computations in the brain across species, yet its precise implementation at the synaptic level remains poorly understood. Dissecting su...
www.biorxiv.org
Our new paper on the circuit implementation of evidence integration in larval zebrafish is now on bioRxiv!
Reposted by Florian Kämpf
Earlier today, I was notified that someone was at my door.
This is who it was:
This is who it was:
November 21, 2025 at 12:59 AM
Earlier today, I was notified that someone was at my door.
This is who it was:
This is who it was:
November 13, 2025 at 4:15 PM
Reposted by Florian Kämpf
Congratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner.
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
October 24, 2025 at 8:52 AM
Congratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner.
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
Reposted by Florian Kämpf
Some fly neurons are “dimorphic”, existing in both males and females but connecting to different neighboring neurons. Neighbors may be “isomorphic”, the same in both male and female; or sex specific; or dimorphic themselves. Here's an example, the type AOTU012, present in left and right instances.
October 8, 2025 at 9:11 AM
Some fly neurons are “dimorphic”, existing in both males and females but connecting to different neighboring neurons. Neighbors may be “isomorphic”, the same in both male and female; or sex specific; or dimorphic themselves. Here's an example, the type AOTU012, present in left and right instances.
Reposted by Florian Kämpf
We provide the most detailed picture yet of the result of sexually dimorphic development of the nervous system. The dataset should be a game-changer for researchers exploring behaviour, circuits & brain wiring! Check out male-cns.janelia.org.
Huge thanks to our amazing team of co-authors! 10/10
Huge thanks to our amazing team of co-authors! 10/10
October 15, 2025 at 4:29 PM
We provide the most detailed picture yet of the result of sexually dimorphic development of the nervous system. The dataset should be a game-changer for researchers exploring behaviour, circuits & brain wiring! Check out male-cns.janelia.org.
Huge thanks to our amazing team of co-authors! 10/10
Huge thanks to our amazing team of co-authors! 10/10
Reposted by Florian Kämpf
Statistical analysis of connectivity within the central brain shows that around 6.5% of synaptic connections in the male and 1.3% of connections in the female are dimorphic. In the male, sex-specific circuit elements form highly interconnected clusters with similar connectivity. 9/10
October 15, 2025 at 4:24 PM
Statistical analysis of connectivity within the central brain shows that around 6.5% of synaptic connections in the male and 1.3% of connections in the female are dimorphic. In the male, sex-specific circuit elements form highly interconnected clusters with similar connectivity. 9/10
Reposted by Florian Kämpf
We explore #dimorphism across sensory modalities (visual and auditory systems, gustation and olfaction) and find, for example, a putative functional “love spot” involving male-specific neurons. 8/10
October 15, 2025 at 4:23 PM
We explore #dimorphism across sensory modalities (visual and auditory systems, gustation and olfaction) and find, for example, a putative functional “love spot” involving male-specific neurons. 8/10
Reposted by Florian Kämpf
Comparing the EM neurons to light microscopy datasets of fruitless and doublesex expression, we annotated the putative expression pattern of these genes for both the male and female connectomes. 7/10
October 15, 2025 at 4:23 PM
Comparing the EM neurons to light microscopy datasets of fruitless and doublesex expression, we annotated the putative expression pattern of these genes for both the male and female connectomes. 7/10
Reposted by Florian Kämpf
We cross-matched neurons and identified over 7k isomorphic, 114 sexually dimorphic, 262 male- and 69 female-specific cell types. In total, these neurons make up 4.8% and 2.4% of the male and female brain, respectively. 6/10
October 15, 2025 at 4:22 PM
We cross-matched neurons and identified over 7k isomorphic, 114 sexually dimorphic, 262 male- and 69 female-specific cell types. In total, these neurons make up 4.8% and 2.4% of the male and female brain, respectively. 6/10
Reposted by Florian Kämpf
Using these annotations we ran end-to-end analyses going from sensory inputs all the way to motor outputs. This showed, for instance, that ascending and descending neurons are not passive relays but likely perform complex transformations of information flowing between brain and nerve cord. 4/10
October 15, 2025 at 4:20 PM
Using these annotations we ran end-to-end analyses going from sensory inputs all the way to motor outputs. This showed, for instance, that ascending and descending neurons are not passive relays but likely perform complex transformations of information flowing between brain and nerve cord. 4/10
Reposted by Florian Kämpf
This is the first completely proofread connectome of a nervous system (brain + nerve cord) for an adult animal with complex behaviour: 167k neurons with rich annotations (classes, cell types, developmental lineages, …) to help explore the dataset and 125M synaptic connections between them. 3/10
October 15, 2025 at 4:20 PM
This is the first completely proofread connectome of a nervous system (brain + nerve cord) for an adult animal with complex behaviour: 167k neurons with rich annotations (classes, cell types, developmental lineages, …) to help explore the dataset and 125M synaptic connections between them. 3/10
Reposted by Florian Kämpf
A hugely successful collaboration between @janelia-flyem.bsky.social @camzoology.bsky.social @mrclmb.bsky.social with @beckett14.bsky.social @mmcosta.bsky.social Philipp Schlegel (not on Bluesky) and many others. Major funding from @wellcometrust.bsky.social and @hhmijanelia.bsky.social. 2/10
October 15, 2025 at 4:19 PM
A hugely successful collaboration between @janelia-flyem.bsky.social @camzoology.bsky.social @mrclmb.bsky.social with @beckett14.bsky.social @mmcosta.bsky.social Philipp Schlegel (not on Bluesky) and many others. Major funding from @wellcometrust.bsky.social and @hhmijanelia.bsky.social. 2/10
Reposted by Florian Kämpf
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Florian Kämpf
WELCOME BACK! Join us for an aptly themed Let's Get Social Neurotalks next week to kick off the new year.
Social robots, and how flies use touch to make social decisions with Alva Markelius and @flofightscience.bsky.social
🗓️Tues 14 October
🕓7pm-9pm
🗺️ Cambridge Tap
Social robots, and how flies use touch to make social decisions with Alva Markelius and @flofightscience.bsky.social
🗓️Tues 14 October
🕓7pm-9pm
🗺️ Cambridge Tap
October 7, 2025 at 2:48 PM
WELCOME BACK! Join us for an aptly themed Let's Get Social Neurotalks next week to kick off the new year.
Social robots, and how flies use touch to make social decisions with Alva Markelius and @flofightscience.bsky.social
🗓️Tues 14 October
🕓7pm-9pm
🗺️ Cambridge Tap
Social robots, and how flies use touch to make social decisions with Alva Markelius and @flofightscience.bsky.social
🗓️Tues 14 October
🕓7pm-9pm
🗺️ Cambridge Tap
Reposted by Florian Kämpf
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 3:40 PM
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Reposted by Florian Kämpf
🪰 A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system—a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the millions of connections between them.
🔗 https://hhmi.news/4o3EJnk
🔗 https://hhmi.news/4o3EJnk
October 6, 2025 at 2:16 PM
🪰 A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system—a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the millions of connections between them.
🔗 https://hhmi.news/4o3EJnk
🔗 https://hhmi.news/4o3EJnk
Reposted by Florian Kämpf
We're very proud to be releasing the complete male fly CNS connectome!
It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators.
More soon...
www.janelia.org/project-team...
It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators.
More soon...
www.janelia.org/project-team...
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 6:02 PM
We're very proud to be releasing the complete male fly CNS connectome!
It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators.
More soon...
www.janelia.org/project-team...
It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators.
More soon...
www.janelia.org/project-team...
Reposted by Florian Kämpf
Save the Date
📍 Where: MRC-LMB, Cambridge or Online (Zoom)
🗓️ When: 10th and 11th of July
🧪 Themes: Cell Biology, Structural Biology, Immunology, Nucleic Acids and Neuroscience.
🤝 In collaboration with students at Institut Pasteur
📍 Where: MRC-LMB, Cambridge or Online (Zoom)
🗓️ When: 10th and 11th of July
🧪 Themes: Cell Biology, Structural Biology, Immunology, Nucleic Acids and Neuroscience.
🤝 In collaboration with students at Institut Pasteur
May 21, 2025 at 7:50 PM
Save the Date
📍 Where: MRC-LMB, Cambridge or Online (Zoom)
🗓️ When: 10th and 11th of July
🧪 Themes: Cell Biology, Structural Biology, Immunology, Nucleic Acids and Neuroscience.
🤝 In collaboration with students at Institut Pasteur
📍 Where: MRC-LMB, Cambridge or Online (Zoom)
🗓️ When: 10th and 11th of July
🧪 Themes: Cell Biology, Structural Biology, Immunology, Nucleic Acids and Neuroscience.
🤝 In collaboration with students at Institut Pasteur
Reposted by Florian Kämpf
The first paper from the lab is out on biorxiv - enjoy reading! Social context and interactions influence our behavioral decisions - the same is true for the little fly larva!
March 24, 2025 at 8:28 PM
The first paper from the lab is out on biorxiv - enjoy reading! Social context and interactions influence our behavioral decisions - the same is true for the little fly larva!
Our new paper on the circuit implementation of evidence integration in larval zebrafish is now on bioRxiv!
We are proud to present our new preprint “Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish”, just posted on bioRxiv (www.biorxiv.org/content/10.1...). (1/10)
Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish
Accumulating information is a critical component of most circuit computations in the brain across species, yet its precise implementation at the synaptic level remains poorly understood. Dissecting su...
www.biorxiv.org
March 17, 2025 at 7:09 PM
Our new paper on the circuit implementation of evidence integration in larval zebrafish is now on bioRxiv!
Reposted by Florian Kämpf
Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish https://www.biorxiv.org/content/10.1101/2025.03.14.643363v1
March 16, 2025 at 3:16 AM
Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish https://www.biorxiv.org/content/10.1101/2025.03.14.643363v1
Reposted by Florian Kämpf
Such biophysically realistic network modeling provides the foundation for precise hypothesis-driven circuit manipulations, electrophysiology, and transcriptomic analysis in the future. So stay tuned😄(10/10)
March 17, 2025 at 10:36 AM
Such biophysically realistic network modeling provides the foundation for precise hypothesis-driven circuit manipulations, electrophysiology, and transcriptomic analysis in the future. So stay tuned😄(10/10)
Reposted by Florian Kämpf
Our anterior hindbrain circuit model, based on ground-truth connectivity, reproduces experimentally observed neural dynamics and predicts new mechanisms for flexible decision-making. (9/10)
March 17, 2025 at 10:35 AM
Our anterior hindbrain circuit model, based on ground-truth connectivity, reproduces experimentally observed neural dynamics and predicts new mechanisms for flexible decision-making. (9/10)
Reposted by Florian Kämpf
Using 2P photo-activations and a ML classifier, we assigned functional labels to neurons based solely on morphology, enhancing our EM dataset. Our classifier also provides a basis to assign functional labels to other cell library resources for which calcium imaging had not been performed. (8/10)
March 17, 2025 at 10:33 AM
Using 2P photo-activations and a ML classifier, we assigned functional labels to neurons based solely on morphology, enhancing our EM dataset. Our classifier also provides a basis to assign functional labels to other cell library resources for which calcium imaging had not been performed. (8/10)