@erzbergerlab.bsky.social
Studying ribosomes at UT Southwestern
Reposted
In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...
#plantscience
#plantscience
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 13, 2026 at 9:43 AM
In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...
#plantscience
#plantscience
Reposted
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...
www.science.org
February 6, 2026 at 10:07 AM
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Online Now: Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Online now:
Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus
Lawrence et al. examine how ribosome production in the eukaryotic nucleolus is coordinated by cytoplasmic processes to maintain appropriate ribosome numbers. The authors highlight regulatory inputs from cytoplasmic signaling, mitosis, and cytoplasmic organelles that converge on nucleolar function, and they discuss how disruption of these pathways contributes to human disease.
dlvr.it
January 28, 2026 at 11:57 PM
Online Now: Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Online now:
Reposted
🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬
Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing
Apply here by 11 Feb
www.nature.com/naturecareer...
Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing
Apply here by 11 Feb
www.nature.com/naturecareer...
Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761 - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12852642
Postdoctoral Researcher Salary £42,694 per annum MRC Laboratory of Molecular Biology, Cambridge, UK We are recruiting a Postdoctoral Researcher to...
www.nature.com
January 23, 2026 at 12:20 PM
🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬
Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing
Apply here by 11 Feb
www.nature.com/naturecareer...
Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing
Apply here by 11 Feb
www.nature.com/naturecareer...
Reposted
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
January 6, 2026 at 8:05 AM
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
Reposted
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Huntingtin-interacting protein K (HYPK) promotes the activity of N-terminal acetyltransferase A (NatA), which cotranslationally acetylates 40% of the eukaryotic proteome. Kinetic and in-cell measurements revealed that HYPK acts as a ribosome exchange factor for NatA, enabling its access to and acetylation of the translatome.
dlvr.it
December 19, 2025 at 11:58 PM
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Reposted
Last X-Mas, the ribosome gave you methionine,
but the very next day, MetAP took it away.
This year, to save histones from tears,
NatD gives you an acetyl group. ⭐️
Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu!
www.science.org/doi/10.1126/...
but the very next day, MetAP took it away.
This year, to save histones from tears,
NatD gives you an acetyl group. ⭐️
Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu!
www.science.org/doi/10.1126/...
Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD
NAC enables cotranslational N-terminal processing of histones H2A and H4 by recruiting MetAP1 and NatD at the ribosomal tunnel.
tinyurl.com
December 20, 2025 at 12:34 AM
Last X-Mas, the ribosome gave you methionine,
but the very next day, MetAP took it away.
This year, to save histones from tears,
NatD gives you an acetyl group. ⭐️
Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu!
www.science.org/doi/10.1126/...
but the very next day, MetAP took it away.
This year, to save histones from tears,
NatD gives you an acetyl group. ⭐️
Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu!
www.science.org/doi/10.1126/...
Reposted
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 4:29 PM
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
December 5, 2025 at 6:30 PM
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Reposted
Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry an extended set of proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. www.biorxiv.org/content/10.1...
November 30, 2025 at 9:11 PM
Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry an extended set of proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. www.biorxiv.org/content/10.1...
Reposted
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 24, 2025 at 9:12 PM
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
Reposted
Ribosome remodeling drives translation adaptation during viral infection and cellular stress https://www.biorxiv.org/content/10.1101/2025.10.24.684008v1
October 25, 2025 at 5:19 AM
Ribosome remodeling drives translation adaptation during viral infection and cellular stress https://www.biorxiv.org/content/10.1101/2025.10.24.684008v1
Reposted
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Reposted
☕Pan, David, Chevrier & co show that the microbial #metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows #tumor growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER #ribosome.
👉https://rdcu.be/eJqFc
bit.ly/46BPXtJ
👉https://rdcu.be/eJqFc
bit.ly/46BPXtJ
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control - Nature Cell Biology
Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER ribosome.
bit.ly
October 4, 2025 at 2:21 PM
☕Pan, David, Chevrier & co show that the microbial #metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows #tumor growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER #ribosome.
👉https://rdcu.be/eJqFc
bit.ly/46BPXtJ
👉https://rdcu.be/eJqFc
bit.ly/46BPXtJ
Reposted
Nothing like a coffee break to fuel great conversations ☕✨ Our #EMBLProtein participants are connecting and recharging after the first half of session 1 'Ribosome, elongation, and termination'.
September 4, 2025 at 8:58 AM
Nothing like a coffee break to fuel great conversations ☕✨ Our #EMBLProtein participants are connecting and recharging after the first half of session 1 'Ribosome, elongation, and termination'.
Reposted
Starting Session 2 'Quality control' strong!
🎙️Oliver Mühlemann opens with 'Deciphering the role of the deubiquitinase USP9X in ribosome-associated quality control' at #EMBLProtein.
🎙️Oliver Mühlemann opens with 'Deciphering the role of the deubiquitinase USP9X in ribosome-associated quality control' at #EMBLProtein.
September 4, 2025 at 12:42 PM
Starting Session 2 'Quality control' strong!
🎙️Oliver Mühlemann opens with 'Deciphering the role of the deubiquitinase USP9X in ribosome-associated quality control' at #EMBLProtein.
🎙️Oliver Mühlemann opens with 'Deciphering the role of the deubiquitinase USP9X in ribosome-associated quality control' at #EMBLProtein.
Reposted
We’re back! 🥳
Kicking off our first conference after the summer break: 'Protein synthesis and translational control'.
🌟Today’s highlights include keynote lectures from Lori Passmore, Reuven Agami, and Marina Rodnina.
Welcome to #EMBLProtein! 🎉
Kicking off our first conference after the summer break: 'Protein synthesis and translational control'.
🌟Today’s highlights include keynote lectures from Lori Passmore, Reuven Agami, and Marina Rodnina.
Welcome to #EMBLProtein! 🎉
September 3, 2025 at 2:56 PM
We’re back! 🥳
Kicking off our first conference after the summer break: 'Protein synthesis and translational control'.
🌟Today’s highlights include keynote lectures from Lori Passmore, Reuven Agami, and Marina Rodnina.
Welcome to #EMBLProtein! 🎉
Kicking off our first conference after the summer break: 'Protein synthesis and translational control'.
🌟Today’s highlights include keynote lectures from Lori Passmore, Reuven Agami, and Marina Rodnina.
Welcome to #EMBLProtein! 🎉
Reposted
Finally out!
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
I’m thrilled to share our new paper (Wolin et al., Cell 2025).
This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.
By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.
July 22, 2025 at 5:12 PM
Reposted
m6A-induced ribosome stalling and collision trigger mRNA decay
m6A-induced ribosome stalling and collision trigger mRNA decay
How m6A in different transcript regions regulates mRNA decay remains an intriguing question. Three studies from the labs of König, Jaffrey, and Steinmetz uncovered translation-dependent CDS-m6A decay: m6A in the coding sequence (CDS) induces ribosome stalling and collision to trigger mRNA decay, while tRNA modification alleviates the effects.
dlvr.it
July 22, 2025 at 11:33 AM
m6A-induced ribosome stalling and collision trigger mRNA decay
Reposted
📣 Online now - the Review "The ribosome ubiquitination code: fine-tuning translation under stress" from
Haleigh Wooters, Neil Nimmagadda, Alicia Darnell, and @thesilvalab.bsky.social .
#Ubiquitination #TranslationalReprogramming #StressResponse
Read it here: authors.elsevier.com/a/1lPPS3S6Gf...
Haleigh Wooters, Neil Nimmagadda, Alicia Darnell, and @thesilvalab.bsky.social .
#Ubiquitination #TranslationalReprogramming #StressResponse
Read it here: authors.elsevier.com/a/1lPPS3S6Gf...
July 14, 2025 at 2:08 PM
📣 Online now - the Review "The ribosome ubiquitination code: fine-tuning translation under stress" from
Haleigh Wooters, Neil Nimmagadda, Alicia Darnell, and @thesilvalab.bsky.social .
#Ubiquitination #TranslationalReprogramming #StressResponse
Read it here: authors.elsevier.com/a/1lPPS3S6Gf...
Haleigh Wooters, Neil Nimmagadda, Alicia Darnell, and @thesilvalab.bsky.social .
#Ubiquitination #TranslationalReprogramming #StressResponse
Read it here: authors.elsevier.com/a/1lPPS3S6Gf...
Reposted
New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome!
Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu
@snsf.ch @ethz.ch
www.cell.com/molecular-ce...
Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu
@snsf.ch @ethz.ch
www.cell.com/molecular-ce...
July 12, 2025 at 12:10 AM
New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome!
Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu
@snsf.ch @ethz.ch
www.cell.com/molecular-ce...
Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu
@snsf.ch @ethz.ch
www.cell.com/molecular-ce...
Reposted
With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF
Pan-viral ORFs discovery using massively parallel ribosome profiling
Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...
scim.ag
June 20, 2025 at 6:20 PM
With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF
Reposted
Reposted
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
May 26, 2025 at 9:29 AM
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇