Emma Hamilton-WIlliams
@emmahwlab.bsky.social
Type 1 diabetes | Immunology | Microbiome | Professor at University of Queensland | She/her
Pinned
SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome - Nature Communications
In a previous clinical trial, the authors reported that SCFA-yielding biotherapy in adults with type 1 diabetes remodels the gut proteome and metabolome. Here, the show that colonization of the post-t...
www.nature.com
My lab's latest research out now published with @springernature.com in Nature Communications.
www.nature.com/articles/s41...
We show that a short-chain fatty acid delivering biotherapy given to adults with #type1diabetes remodeled the gut barrier and #microbiome function.
www.nature.com/articles/s41...
We show that a short-chain fatty acid delivering biotherapy given to adults with #type1diabetes remodeled the gut barrier and #microbiome function.
Reposted by Emma Hamilton-WIlliams
Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology
An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.
www.nature.com
October 22, 2025 at 1:36 PM
Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Reposted by Emma Hamilton-WIlliams
▪️ “There was a time when politicians did not use defamation laws. Most believed they had platform enough to defend their reputations... You & the govt you served in played a big role in changing that. Imagine the consequences.”
- Sat Paper Editorial ⤵️
www.thesaturdaypaper.com.au/share/21849/...
- Sat Paper Editorial ⤵️
www.thesaturdaypaper.com.au/share/21849/...
October 17, 2025 at 10:53 PM
▪️ “There was a time when politicians did not use defamation laws. Most believed they had platform enough to defend their reputations... You & the govt you served in played a big role in changing that. Imagine the consequences.”
- Sat Paper Editorial ⤵️
www.thesaturdaypaper.com.au/share/21849/...
- Sat Paper Editorial ⤵️
www.thesaturdaypaper.com.au/share/21849/...
Reposted by Emma Hamilton-WIlliams
As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D
October 7, 2025 at 7:51 AM
As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D
Reposted by Emma Hamilton-WIlliams
A new soft plastics recycling scheme is replacing Australia’s failed REDcycle. Will it mean consumers have to pay more?
A new soft plastics recycling scheme is replacing Australia’s failed REDcycle. Will it mean consumers have to pay more?
A consortium of manufacturers aims to fund the sorting and processing of soft plastics for reuse – but critics say it will pass costs on to consumers
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Almost three years after the collapse of the national soft plastics collection and recycling program REDCycle, the consumer regulator is set to greenlight an industry-led replacement scheme.
But there are concerns product manufacturers and the major supermarkets will shift the program’s costs onto consumers rather than change their own behaviour of producing and stocking vast quantities of soft plastics that mostly end up in landfill. Continue reading...
www.theguardian.com
October 4, 2025 at 7:02 PM
A new soft plastics recycling scheme is replacing Australia’s failed REDcycle. Will it mean consumers have to pay more?
Reposted by Emma Hamilton-WIlliams
🚨 The US government has stopped the funding PubMed, one of the most comprehensive databased of biomedical literature.
Try using Europe PMC (europepmc.org) — the European alternative to PubMed with 46M+ articles.
Try using Europe PMC (europepmc.org) — the European alternative to PubMed with 46M+ articles.
October 2, 2025 at 8:36 AM
🚨 The US government has stopped the funding PubMed, one of the most comprehensive databased of biomedical literature.
Try using Europe PMC (europepmc.org) — the European alternative to PubMed with 46M+ articles.
Try using Europe PMC (europepmc.org) — the European alternative to PubMed with 46M+ articles.
Reposted by Emma Hamilton-WIlliams
#JaneCaro comments on the absurdity that sees all taxpayers fund private schools while underfunding public schools
@janecaro.bsky.social
Gift article
#Auspol failure #AusLabor fail
www.thesaturdaypaper.com.au/share/21678/...
@janecaro.bsky.social
Gift article
#Auspol failure #AusLabor fail
www.thesaturdaypaper.com.au/share/21678/...
The segregation crisis in schools funding
In the Albanese government’s first term, Education Minister Jason Clare observed that Australia has one of the most segregated education systems in the OECD. What is deeply shocking – though not surpr...
www.thesaturdaypaper.com.au
September 27, 2025 at 3:50 AM
#JaneCaro comments on the absurdity that sees all taxpayers fund private schools while underfunding public schools
@janecaro.bsky.social
Gift article
#Auspol failure #AusLabor fail
www.thesaturdaypaper.com.au/share/21678/...
@janecaro.bsky.social
Gift article
#Auspol failure #AusLabor fail
www.thesaturdaypaper.com.au/share/21678/...
Reposted by Emma Hamilton-WIlliams
In The Lancet @thelancet.com:
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 #diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial www.thelancet.com/journals/lan... #T1D
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 #diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial www.thelancet.com/journals/lan... #T1D
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle...
In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg
ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed
agent, ATG, in a low and sa...
www.thelancet.com
September 20, 2025 at 3:38 PM
In The Lancet @thelancet.com:
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 #diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial www.thelancet.com/journals/lan... #T1D
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 #diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial www.thelancet.com/journals/lan... #T1D
Reposted by Emma Hamilton-WIlliams
Prediction of progression to type 1 #diabetes with dynamic biomarkers and risk scores thelancet.com/journals/lan...
#T1D
#MedSky #EndoSky
#T1D
#MedSky #EndoSky
Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores
Identifying biomarkers of functional β-cell loss is an important step in the risk
stratification of type 1 diabetes. Genetic risk scores (GRS), generated by profiling
an array of single nucleotide pol...
thelancet.com
September 18, 2025 at 8:13 PM
Prediction of progression to type 1 #diabetes with dynamic biomarkers and risk scores thelancet.com/journals/lan...
#T1D
#MedSky #EndoSky
#T1D
#MedSky #EndoSky
Reposted by Emma Hamilton-WIlliams
Want to hear all the latest #type1diabetes research? Registration has now opened for the 2026 Immunology of Diabetes Society Congress
@ids-t1d.bsky.social www.ids2026.com.au
@ids-t1d.bsky.social www.ids2026.com.au
September 17, 2025 at 2:54 AM
Want to hear all the latest #type1diabetes research? Registration has now opened for the 2026 Immunology of Diabetes Society Congress
@ids-t1d.bsky.social www.ids2026.com.au
@ids-t1d.bsky.social www.ids2026.com.au
Reposted by Emma Hamilton-WIlliams
Disasters are multiplying & the costs are set to skyrocket.
The ADF is already stretched, & shouldn't be asked to carry this burden.
We need to decide who pays for disaster relief: ordinary Australians, or the fossil fuel industry fuelling the damage?
www.abc.net.au/news/2025-09...
The ADF is already stretched, & shouldn't be asked to carry this burden.
We need to decide who pays for disaster relief: ordinary Australians, or the fossil fuel industry fuelling the damage?
www.abc.net.au/news/2025-09...
Dedicated disaster force needed to prevent ADF being overwhelmed: report
A dedicated disaster recovery force is needed, or else responders and defence forces could be "overwhelmed" by multiple concurrent natural disasters, the National Climate Risk Assessment warns.
www.abc.net.au
September 16, 2025 at 10:37 PM
Disasters are multiplying & the costs are set to skyrocket.
The ADF is already stretched, & shouldn't be asked to carry this burden.
We need to decide who pays for disaster relief: ordinary Australians, or the fossil fuel industry fuelling the damage?
www.abc.net.au/news/2025-09...
The ADF is already stretched, & shouldn't be asked to carry this burden.
We need to decide who pays for disaster relief: ordinary Australians, or the fossil fuel industry fuelling the damage?
www.abc.net.au/news/2025-09...
Reposted by Emma Hamilton-WIlliams
Straight to the Pool Room.📌
Excellent explainer on immigration and housing. #auspol
www.thenewdaily.com.au/opinion/2025...
Excellent explainer on immigration and housing. #auspol
www.thenewdaily.com.au/opinion/2025...
Is population growth driving the housing crisis? Here's the reality
The usual suspects are trying to whip up a scare campaign about immigration and housing. Let’s look at the numbers and put them into context.
www.thenewdaily.com.au
August 28, 2025 at 9:58 PM
Straight to the Pool Room.📌
Excellent explainer on immigration and housing. #auspol
www.thenewdaily.com.au/opinion/2025...
Excellent explainer on immigration and housing. #auspol
www.thenewdaily.com.au/opinion/2025...
Reposted by Emma Hamilton-WIlliams
Just maybe we need a campaign to reform education. At a time when we all face a huge social upheaval to #transition the #economy, trashing the arts and social sciences and making them inaccessible will only benefit Shell, Santos and Woodside as a delaying tactic. #auspol
@jasonclaremp.bsky.social
@jasonclaremp.bsky.social
A national disgrace
“Hundreds of university courses within teaching, languages, archaeology and media are among those being slashed as the tertiary sector pushes back against “confused” government policies”
www.theguardian.com/australia-ne...
“Hundreds of university courses within teaching, languages, archaeology and media are among those being slashed as the tertiary sector pushes back against “confused” government policies”
www.theguardian.com/australia-ne...
Australian universities to cut about 2,400 jobs and hundreds of courses as sector blames ‘confused’ government policies
Vice-chancellors say they’ve been forced to restructure but critics point finger at ‘unaccountable’ university management
www.theguardian.com
August 24, 2025 at 2:12 AM
Just maybe we need a campaign to reform education. At a time when we all face a huge social upheaval to #transition the #economy, trashing the arts and social sciences and making them inaccessible will only benefit Shell, Santos and Woodside as a delaying tactic. #auspol
@jasonclaremp.bsky.social
@jasonclaremp.bsky.social
Reposted by Emma Hamilton-WIlliams
Interesting report that I missed from last year detailing just how dire R&D funding has gotten in Australia. ~15years of cuts have left us so far off the pace its embarrassing.
go8.edu.au/wp-content/u...
go8.edu.au/wp-content/u...
go8.edu.au
August 13, 2025 at 12:31 AM
Interesting report that I missed from last year detailing just how dire R&D funding has gotten in Australia. ~15years of cuts have left us so far off the pace its embarrassing.
go8.edu.au/wp-content/u...
go8.edu.au/wp-content/u...
Reposted by Emma Hamilton-WIlliams
Superb science journalism from @nature.com on a handful of bad editors driving most retractions. This was always a concern for mega journals, where editorial oversight quality varies wildly - this report puts names and numbers on the problem.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Exclusive: retraction-prone editors identified at megajournal PLoS ONE
Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.
www.nature.com
August 8, 2025 at 1:35 AM
Superb science journalism from @nature.com on a handful of bad editors driving most retractions. This was always a concern for mega journals, where editorial oversight quality varies wildly - this report puts names and numbers on the problem.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Emma Hamilton-WIlliams
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Reposted by Emma Hamilton-WIlliams
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing #NBTNV go.nature.com/43JRgno
rdcu.be/eyorl
rdcu.be/eyorl
Resurrecting a miniature Cas9 ancestor for genome and epigenome editing - Nature Biotechnology
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome edi...
go.nature.com
July 30, 2025 at 12:51 PM
The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing #NBTNV go.nature.com/43JRgno
rdcu.be/eyorl
rdcu.be/eyorl
Reposted by Emma Hamilton-WIlliams
Why working less could be better for you — and your employer
www.sbs.com.au/news/article...
www.sbs.com.au/news/article...
Why working less could be better for you — and your employer
Australian workers are feeling exhausted and burnt out and experts believe it may be time to reassess working conditions.
www.sbs.com.au
July 26, 2025 at 2:55 AM
Why working less could be better for you — and your employer
www.sbs.com.au/news/article...
www.sbs.com.au/news/article...
Reposted by Emma Hamilton-WIlliams
Good to see reports on this finally out…we need an independent science watchdog to prevent this happening again.
The cage, the camera and the con: How a superstar scientist was finally caught out - The Age
The cage, the camera and the con: How a superstar scientist was finally caught out - The Age
The cancer drug, the faked data and the superstar scientist — The Age
An investigation can reveal the secret history of one of Australia’s top scientists, whose faked data underpins a drug now being given to patients.
apple.news
July 25, 2025 at 10:03 PM
Good to see reports on this finally out…we need an independent science watchdog to prevent this happening again.
The cage, the camera and the con: How a superstar scientist was finally caught out - The Age
The cage, the camera and the con: How a superstar scientist was finally caught out - The Age
Reposted by Emma Hamilton-WIlliams
"Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis" http://dlvr.it/TM6rrb
Hiroko Nagao-Kitamoto Nobuhiko Kamada
@cp-cellreports.bsky.social
Hiroko Nagao-Kitamoto Nobuhiko Kamada
@cp-cellreports.bsky.social
July 25, 2025 at 10:07 PM
"Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis" http://dlvr.it/TM6rrb
Hiroko Nagao-Kitamoto Nobuhiko Kamada
@cp-cellreports.bsky.social
Hiroko Nagao-Kitamoto Nobuhiko Kamada
@cp-cellreports.bsky.social
Reposted by Emma Hamilton-WIlliams
I reviewed this paper a bit ago and have been waiting for it to come out. A great resource for us Bifidobacteria researchers!
New RESOURCE!
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology
A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.
www.nature.com
July 17, 2025 at 1:44 AM
I reviewed this paper a bit ago and have been waiting for it to come out. A great resource for us Bifidobacteria researchers!
Reposted by Emma Hamilton-WIlliams
If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!
www.drugdiscoverytrends.com/nih-announce...
www.drugdiscoverytrends.com/nih-announce...
NIH announces end to funding for animal-only studies - Drug Discovery and Development
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
www.drugdiscoverytrends.com
July 10, 2025 at 7:43 AM
If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!
www.drugdiscoverytrends.com/nih-announce...
www.drugdiscoverytrends.com/nih-announce...
Reposted by Emma Hamilton-WIlliams
Just out in @theconversation.com
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
theconversation.com/melting-ice-...
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
theconversation.com/melting-ice-...
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
Sediments in a lagoon near Darwin hold traces of changes to monsoonal rains over 150,000 years. Here’s what it means as Earth’s polar ice melts.
theconversation.com
July 10, 2025 at 1:21 AM
Just out in @theconversation.com
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
theconversation.com/melting-ice-...
Melting ice will strengthen the monsoon in northern Australia – but cause drier conditions north of the Equator
theconversation.com/melting-ice-...
Latest from my lab: We used CRISPR to knockout PD-1 from islet-specific CD4+ T cells, and show that bystander suppression of islet-specific CD8+ T cells is disrupted, accelerating autoimmune diabetes #type1diabetes #tolerance
doi.org/10.1111/imcb...
doi.org/10.1111/imcb...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
We investigated the requirement for programmed death 1 (PD-1) expression by CD4+ T cells in the maintenance of self-tolerance via bystander suppression of autoreactive CD8+ T cells. Using CRISPR/Cas9...
doi.org
July 8, 2025 at 12:00 PM
Latest from my lab: We used CRISPR to knockout PD-1 from islet-specific CD4+ T cells, and show that bystander suppression of islet-specific CD8+ T cells is disrupted, accelerating autoimmune diabetes #type1diabetes #tolerance
doi.org/10.1111/imcb...
doi.org/10.1111/imcb...
Reposted by Emma Hamilton-WIlliams
Earth is trapping much more heat than climate models forecast – and the rate has doubled in 20 years
theconversation.com/earth-is-tra...
theconversation.com/earth-is-tra...
Earth is trapping much more heat than climate models forecast – and the rate has doubled in 20 years
Real world measurements of how much extra heat the Earth is trapping are well beyond most climate models. That’s a real problem.
theconversation.com
June 28, 2025 at 5:52 AM
Earth is trapping much more heat than climate models forecast – and the rate has doubled in 20 years
theconversation.com/earth-is-tra...
theconversation.com/earth-is-tra...