Ethan Burghardt
@eburghardt.bsky.social
PhD student in the Taylor lab at Notre Dame.
Total synthesis, med chem, natural products.
Lifelong learner & multi-sport nerd
Total synthesis, med chem, natural products.
Lifelong learner & multi-sport nerd
Reposted by Ethan Burghardt
November 8, 2025 at 11:06 AM
Reposted by Ethan Burghardt
I’ve spent a good chunk of my career relying on American science and engineering to keep me alive. Yesterday, RFK Jr. testified at the U.S. Senate Finance Committee. It was sad to see him try to destroy the life’s work of so many American scientists. He shouldn’t be in this job.
September 5, 2025 at 10:17 PM
I’ve spent a good chunk of my career relying on American science and engineering to keep me alive. Yesterday, RFK Jr. testified at the U.S. Senate Finance Committee. It was sad to see him try to destroy the life’s work of so many American scientists. He shouldn’t be in this job.
A picture worth a thousand words. I’m holding the manuscript (in prep) for my paper detailing the optimization of a natural product for treating FLT3-ITD AML. The bag below it holds my stem cells, collected for transplant into a non-related leukemia patient. Truly a full circle moment #chemsky
August 4, 2025 at 3:08 PM
A picture worth a thousand words. I’m holding the manuscript (in prep) for my paper detailing the optimization of a natural product for treating FLT3-ITD AML. The bag below it holds my stem cells, collected for transplant into a non-related leukemia patient. Truly a full circle moment #chemsky
Reposted by Ethan Burghardt
Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You. www.propublica.org/getinvolved/...
Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You.
The National Institutes of Health is canceling grants that are seen as conflicting with the Trump administration’s priorities. We want to hear from researchers who have been affected.
www.propublica.org
June 23, 2025 at 10:03 PM
Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You. www.propublica.org/getinvolved/...
Reposted by Ethan Burghardt
@sellathechemist.mastodon.social.ap.brid.gy, a @ucl.ac.uk chemistry professor, has returned his 2014 Michael Faraday Prize to protest the @royalsociety.org's failure to take more decisive (or any) action against Elon Musk for his attack on science. 👏
Royal Society prize winner returns award in protest over Elon Musk
[FREE TO READ] Andrea Sella is latest scientist to express dismay over UK science academy’s refusal to criticise tech billionaire
www.ft.com
June 10, 2025 at 7:55 AM
@sellathechemist.mastodon.social.ap.brid.gy, a @ucl.ac.uk chemistry professor, has returned his 2014 Michael Faraday Prize to protest the @royalsociety.org's failure to take more decisive (or any) action against Elon Musk for his attack on science. 👏
Reposted by Ethan Burghardt
"Generally, I don’t like to sign things, but ... the future of our research enterprise .... is at stake here." NIH staff spoke frankly to @laureloldach.bsky.social at @cenmag.bsky.social about their decision to sign an open letter asking for a reversal of funding cuts. cen.acs.org/policy/resea...
NIH staff break ranks in open letter to Director Jay Bhattacharya
Bethesda Declaration urges reversal of recent policies, including funding cuts
cen.acs.org
June 9, 2025 at 3:34 PM
"Generally, I don’t like to sign things, but ... the future of our research enterprise .... is at stake here." NIH staff spoke frankly to @laureloldach.bsky.social at @cenmag.bsky.social about their decision to sign an open letter asking for a reversal of funding cuts. cen.acs.org/policy/resea...
Reposted by Ethan Burghardt
Jimmy Carter for The Onion: You People Made Me Give Up My Peanut Farm Before I Got To Be President. “Maybe I’m just a sucker. Apparently, all I needed to do was hand off control of the farm to my family.” [theonion.com]
You People Made Me Give Up My Peanut Farm Before I Got To Be President
For generations, U.S. presidents have gone to great lengths to avoid potential conflicts of interest. When I was elected, I followed suit by placing my small business in a blind trust to assure our citizens that I would always put the country’s interests ahead of my own. It’s a vital presidential tr
theonion.com
May 12, 2025 at 3:52 PM
Jimmy Carter for The Onion: You People Made Me Give Up My Peanut Farm Before I Got To Be President. “Maybe I’m just a sucker. Apparently, all I needed to do was hand off control of the farm to my family.” [theonion.com]
Reposted by Ethan Burghardt
Via @gorskon.bsky.social : “Lysenkoism 2.0. It’s all there: ideology trumping science, scientists not buying into the new scientific dogma losing favor, being fired, or even otherwise punished, while scientists who do are rewarded, sometimes richly.”
sciencebasedmedicine.org/lysenkoism-2...
sciencebasedmedicine.org/lysenkoism-2...
Lysenkoism 2.0 and the dismantling of the NIH
Robert F. Kennedy Jr.'s "make America healthy again" is basically Lysenko 2.0. It's come to the NIH and is destroying the crown jewel of US biomedical research with ideology and cronyism.
sciencebasedmedicine.org
May 12, 2025 at 12:23 PM
Via @gorskon.bsky.social : “Lysenkoism 2.0. It’s all there: ideology trumping science, scientists not buying into the new scientific dogma losing favor, being fired, or even otherwise punished, while scientists who do are rewarded, sometimes richly.”
sciencebasedmedicine.org/lysenkoism-2...
sciencebasedmedicine.org/lysenkoism-2...
Friends who study computer aided synth — can you please make a program that predicts ideal conditions for RCM processes based on substrate strain and olefin reactivity? The expanse of conditions are incredibly variable and successful ones are often idiosyncratic. Would be worth its weight in gold!
May 5, 2025 at 12:38 PM
Friends who study computer aided synth — can you please make a program that predicts ideal conditions for RCM processes based on substrate strain and olefin reactivity? The expanse of conditions are incredibly variable and successful ones are often idiosyncratic. Would be worth its weight in gold!
Reposted by Ethan Burghardt
RFK Jr: "Everyone should do their own research."
NIH: "No, not you, scientists."
NIH: "No, not you, scientists."
April 30, 2025 at 2:46 AM
RFK Jr: "Everyone should do their own research."
NIH: "No, not you, scientists."
NIH: "No, not you, scientists."
Reposted by Ethan Burghardt
Reposted by Ethan Burghardt
When people ask me about chemistry, especially younger people wanting to do synthetic chemistry, I emphasise the practical elements. Not to discourage anyone, far from it, but because it is one of the wonderful things about chemistry: you get to be "good with your brain" and "good with your hands".
April 24, 2025 at 4:07 PM
When people ask me about chemistry, especially younger people wanting to do synthetic chemistry, I emphasise the practical elements. Not to discourage anyone, far from it, but because it is one of the wonderful things about chemistry: you get to be "good with your brain" and "good with your hands".
Reposted by Ethan Burghardt
reminds me of this A+ tweet, which is 100% true
April 24, 2025 at 1:43 PM
reminds me of this A+ tweet, which is 100% true
Reposted by Ethan Burghardt
The Division of Organic Chemistry (DOC) congratulates the sixteen 2025 DOC Summer Undergraduate Research Fellowship (SURF) awardees and gratefully acknowledges the generous sponsors.
zurl.co/x1kZh
zurl.co/x1kZh
April 18, 2025 at 1:35 PM
The Division of Organic Chemistry (DOC) congratulates the sixteen 2025 DOC Summer Undergraduate Research Fellowship (SURF) awardees and gratefully acknowledges the generous sponsors.
zurl.co/x1kZh
zurl.co/x1kZh
Reposted by Ethan Burghardt
Funding via the NSF GRFP grants dropped 56% for chemists this year, but all chemistry subfields were hit about the same. More on the gutting of the GRFP from @cenmag.bsky.social. Words by @bribarbu.bsky.social, data by me cen.acs.org/policy/resea...
NSF halves graduate fellowship awards
Students from all fields lose out on tens of millions of dollars in career-boosting funds this year
cen.acs.org
April 18, 2025 at 7:30 PM
Funding via the NSF GRFP grants dropped 56% for chemists this year, but all chemistry subfields were hit about the same. More on the gutting of the GRFP from @cenmag.bsky.social. Words by @bribarbu.bsky.social, data by me cen.acs.org/policy/resea...
Reposted by Ethan Burghardt
Lactate legs: Fans drew the structure of lactic acid on the road during the 2024 Il Lombardia cycle race. Tadej Pogačar, the cyclist pictured, rapidly overcomes the adverse effects of glycolysis. cen.acs.org/biological-c...
April 11, 2025 at 12:08 PM
Lactate legs: Fans drew the structure of lactic acid on the road during the 2024 Il Lombardia cycle race. Tadej Pogačar, the cyclist pictured, rapidly overcomes the adverse effects of glycolysis. cen.acs.org/biological-c...
Reposted by Ethan Burghardt
With RFK Jr. talking about de-flouridating the water it looks like it's time to resurface this post from @kkjetelina.bsky.social yourlocalepidemiologist.substack.com/p/the-fluori...
The fluoride debate
The nuance you may be looking for
yourlocalepidemiologist.substack.com
April 8, 2025 at 2:31 AM
With RFK Jr. talking about de-flouridating the water it looks like it's time to resurface this post from @kkjetelina.bsky.social yourlocalepidemiologist.substack.com/p/the-fluori...
What a lovely day to be a Wisconsinite. Voting for #susancrawford was a privilege and a pleasure
April 2, 2025 at 3:15 AM
What a lovely day to be a Wisconsinite. Voting for #susancrawford was a privilege and a pleasure
Reposted by Ethan Burghardt
Hey Elon!!!
Wisconsin is not for sale, bitch!!!
Vote for Judge Susan Crawford tomorrow.
Wisconsin is not for sale, bitch!!!
Vote for Judge Susan Crawford tomorrow.
March 31, 2025 at 10:08 PM
Hey Elon!!!
Wisconsin is not for sale, bitch!!!
Vote for Judge Susan Crawford tomorrow.
Wisconsin is not for sale, bitch!!!
Vote for Judge Susan Crawford tomorrow.
Reposted by Ethan Burghardt
Europe is advertising itself as a destination for embattled US scientists
https://go.nature.com/4cdKKcx
https://go.nature.com/4cdKKcx
A brain drain would impoverish the United States and diminish world science
Europe is advertising itself as a destination for embattled US scientists. It seems many are considering leaving.
go.nature.com
April 1, 2025 at 2:59 PM
Europe is advertising itself as a destination for embattled US scientists
https://go.nature.com/4cdKKcx
https://go.nature.com/4cdKKcx
Reposted by Ethan Burghardt
Check out this article written about our recent event at the Indiana Statehouse! publicaffairs.nd.edu/news/notre-d...
Notre Dame graduate students engage lawmakers at 6th Annual Indiana Science Communication Day
Graduate students from the University of Notre Dame joined peers from across Indiana at the Statehouse for the 2025 Indiana Science Communication Day, a...
publicaffairs.nd.edu
March 24, 2025 at 6:11 PM
Check out this article written about our recent event at the Indiana Statehouse! publicaffairs.nd.edu/news/notre-d...
Reposted by Ethan Burghardt
Researchers have independently developed ways to cleave double bonds and install nitrogen atoms in a range of simple substrates and complex bioactive molecules.
Skeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules
www.chemistryworld.com
March 14, 2025 at 10:33 AM
Researchers have independently developed ways to cleave double bonds and install nitrogen atoms in a range of simple substrates and complex bioactive molecules.
Reposted by Ethan Burghardt
Discussion from @dereklowe.bsky.social of the recent paper in Nature Chemistry from Liu, Polikanov, Myers et al. www.nature.com/articles/s41...
March 12, 2025 at 4:25 PM
Discussion from @dereklowe.bsky.social of the recent paper in Nature Chemistry from Liu, Polikanov, Myers et al. www.nature.com/articles/s41...
Reposted by Ethan Burghardt
NEW in Chemical Science!
"Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues" by Kira Weissman and Bertrand Aigle et al.
Read it here: pubs.rsc.org/doi/D4S...
#ChemSky
"Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues" by Kira Weissman and Bertrand Aigle et al.
Read it here: pubs.rsc.org/doi/D4S...
#ChemSky
Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues
The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been shown p
pubs.rsc.org
March 11, 2025 at 10:00 AM
NEW in Chemical Science!
"Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues" by Kira Weissman and Bertrand Aigle et al.
Read it here: pubs.rsc.org/doi/D4S...
#ChemSky
"Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues" by Kira Weissman and Bertrand Aigle et al.
Read it here: pubs.rsc.org/doi/D4S...
#ChemSky
South Bend shows up! #StandUpForScience
March 7, 2025 at 6:45 PM
South Bend shows up! #StandUpForScience