Dr. Mouse
@drmusmusculus.bsky.social
Happily inhabiting cage 42, rack 13, room 02.321 of the animal facility building. Will work hard for chow and publications. Generally unafraid of cats, but animal activists scare the hell out of me.
Reposted by Dr. Mouse
A “response” to their Supreme Court issuing a ruling after due process. It isn’t enough that have destroyed the integrity of our Supreme Court. Now they arrogate to themselves the power to demand that the high court in other nations subvert the rule of law as well.
This is insane.
This is insane.
Rubio vows US response following conviction of Brazil's Bolsonaro reut.rs/4piCG0f
Rubio vows US response following conviction of Brazil's Bolsonaro
U.S. Secretary of State Marco Rubio on Thursday said the United States would "respond accordingly to this witch hunt" after former Brazilian President Jair Bolsonaro was convicted of plotting a coup to remain in power after losing the 2022 election.
reut.rs
September 11, 2025 at 11:03 PM
A “response” to their Supreme Court issuing a ruling after due process. It isn’t enough that have destroyed the integrity of our Supreme Court. Now they arrogate to themselves the power to demand that the high court in other nations subvert the rule of law as well.
This is insane.
This is insane.
Typical USA. Not enough to destroy their own democracy, they gotta do it to other countries trying to get up on their feet. Crazy. We live in a world where China became the voice of reason and moderation.
Rubio vows US response following conviction of Brazil's Bolsonaro reut.rs/4piCG0f
Rubio vows US response following conviction of Brazil's Bolsonaro
U.S. Secretary of State Marco Rubio on Thursday said the United States would "respond accordingly to this witch hunt" after former Brazilian President Jair Bolsonaro was convicted of plotting a coup to remain in power after losing the 2022 election.
reut.rs
September 12, 2025 at 1:13 PM
Typical USA. Not enough to destroy their own democracy, they gotta do it to other countries trying to get up on their feet. Crazy. We live in a world where China became the voice of reason and moderation.
Reposted by Dr. Mouse
Check out the latest from Mike and I on how to be a scientist in a post-journal world
9/9
thescientistpapers.substack.com/p/how-to-be-...
9/9
thescientistpapers.substack.com/p/how-to-be-...
How to be a scientist in a post-journal world
When we created this site to write about things in science that need to be fixed, we chose not to start with publishing, even though it has been our preoccupation for decades.
thescientistpapers.substack.com
September 8, 2025 at 7:52 PM
Check out the latest from Mike and I on how to be a scientist in a post-journal world
9/9
thescientistpapers.substack.com/p/how-to-be-...
9/9
thescientistpapers.substack.com/p/how-to-be-...
Reposted by Dr. Mouse
I strongly suggest that academic publishers cease to exist.
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
December 3, 2024 at 5:53 AM
I strongly suggest that academic publishers cease to exist.
Reposted by Dr. Mouse
A paywalled article from @nature.com bemoaning the exploitation of scientists' unpaid labour. Chef's kiss. Perfection. No notes.
It can be hard to say no to service requests in academia.
We sought advice on how to ensure researchers don’t get stuck doing unpaid labour
https://go.nature.com/3FsSD1p
We sought advice on how to ensure researchers don’t get stuck doing unpaid labour
https://go.nature.com/3FsSD1p
I spent two years organizing an international conference. How do I get compensated for my work?
It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.
go.nature.com
March 17, 2025 at 6:42 PM
A paywalled article from @nature.com bemoaning the exploitation of scientists' unpaid labour. Chef's kiss. Perfection. No notes.
Reposted by Dr. Mouse
The fact that Oded is still heralded as a scientific leader says all you need to know about science IMO.
Itai Yanai is now putting together with Oded Rechavi and others the Woodstock of Biology 2 & Night Science conference to integrate some of Itai's ideas into a scientific meeting. #theconferencetoendallconferences
More info & registration here: woodstock.img.cas.cz
More info & registration here: woodstock.img.cas.cz
April 15, 2025 at 11:30 PM
The fact that Oded is still heralded as a scientific leader says all you need to know about science IMO.
Reposted by Dr. Mouse
While journal publishing has always been deeply problematic, hurting both the pace and trajectory of science, something is happening in this moment that is finally causing the system to crumble under its own weight and cost.
1/
1/
September 8, 2025 at 7:52 PM
While journal publishing has always been deeply problematic, hurting both the pace and trajectory of science, something is happening in this moment that is finally causing the system to crumble under its own weight and cost.
1/
1/
Reposted by Dr. Mouse
Pretty sure we will not know the cause for autism in September but I have a great hypothesis for the dramatic increase in morbidity due to infectious disease THAT COULD HAVE BEEN TOTALLY HANDLED BY FOLKS WHO ARE NOT BATSHIT CRAZY
MAKE AMERICA HYPERVENTILATE AGAIN
MAKE AMERICA HYPERVENTILATE AGAIN
August 27, 2025 at 2:43 AM
Pretty sure we will not know the cause for autism in September but I have a great hypothesis for the dramatic increase in morbidity due to infectious disease THAT COULD HAVE BEEN TOTALLY HANDLED BY FOLKS WHO ARE NOT BATSHIT CRAZY
MAKE AMERICA HYPERVENTILATE AGAIN
MAKE AMERICA HYPERVENTILATE AGAIN
...
America Tips Into Fascism
Today is different than before.
www.doomsdayscenario.co
August 25, 2025 at 7:27 PM
...
Reposted by Dr. Mouse
Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities
August 20, 2025 at 4:58 PM
Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities
Tragic to see the U.S. brought to its knees, as the elites either retreat into their shells or bask in the fabricated blinding sun of self-praise.
“The arc of the moral universe is long, but it bends towards justice."
—-Dr. Martin Luther King Jr.
"If slavery is not wrong, nothing is wrong."
—-Abraham Lincoln
“Those who cannot remember the past are condemned to repeat it.”
—-George Santayana
—-Dr. Martin Luther King Jr.
"If slavery is not wrong, nothing is wrong."
—-Abraham Lincoln
“Those who cannot remember the past are condemned to repeat it.”
—-George Santayana
August 21, 2025 at 7:12 AM
Tragic to see the U.S. brought to its knees, as the elites either retreat into their shells or bask in the fabricated blinding sun of self-praise.
Reposted by Dr. Mouse
Accurate and scalable multi-disease classification from adaptive immune repertoires
www.biorxiv.org/content/10....
www.biorxiv.org/content/10....
August 19, 2025 at 2:15 PM
Accurate and scalable multi-disease classification from adaptive immune repertoires
www.biorxiv.org/content/10....
www.biorxiv.org/content/10....
Repeat after me: we. do. not. need. journals.
That said: after autoclaving the printed ones, they do give some nice nesting material.
That said: after autoclaving the printed ones, they do give some nice nesting material.
Nate Silver thinks academic journals are a lost cause.
But they aren't. If anything, the real problem is that these journals are *too* profitable.
Which means no one bothers to dream up other ideas, only variations on the theme.
🧵
But they aren't. If anything, the real problem is that these journals are *too* profitable.
Which means no one bothers to dream up other ideas, only variations on the theme.
🧵
August 18, 2025 at 7:22 AM
Repeat after me: we. do. not. need. journals.
That said: after autoclaving the printed ones, they do give some nice nesting material.
That said: after autoclaving the printed ones, they do give some nice nesting material.
Reposted by Dr. Mouse
"At no other time in modern history has a country so throughly turned its back on its core national strengths."— @vermontgmg.bsky.social
Gift link
www.nytimes.com/2025/08/12/o...
Gift link
www.nytimes.com/2025/08/12/o...
August 17, 2025 at 4:29 PM
"At no other time in modern history has a country so throughly turned its back on its core national strengths."— @vermontgmg.bsky.social
Gift link
www.nytimes.com/2025/08/12/o...
Gift link
www.nytimes.com/2025/08/12/o...
The silence of opposition in the US is hard to believe.
Democrats have so failed this moment in US politics.
The fact that every congressional Dem is not out in the streets of DC leading protests, organizing mass strikes, and holding daily press conferences for the world press to rail against these new Gestapo speaks volumes as to why we also need a new Dem party should we ever get out of this mess.
August 17, 2025 at 3:18 PM
The silence of opposition in the US is hard to believe.
“These creatures you call mice you see are not quite as they appear, they are merely the protrusions into our dimension of vast, hyper-intelligent pan-dimensional beings.”
I am just going to leave this here. But what a bunch of egocentric crap huh?
I am just going to leave this here. But what a bunch of egocentric crap huh?
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
August 17, 2025 at 3:01 PM
“These creatures you call mice you see are not quite as they appear, they are merely the protrusions into our dimension of vast, hyper-intelligent pan-dimensional beings.”
I am just going to leave this here. But what a bunch of egocentric crap huh?
I am just going to leave this here. But what a bunch of egocentric crap huh?
Not a new idea, but the level of demonstration seems unparalleled thanks to the power of Drosophila genetics. Congrats on the published paper! When learning about TEs for the first time, we are all dead scarred of insertional mutagenesis in genes, but maybe that is exactly what the genome wants.
1/ How do animals develop immunity against a newly encountered transposable element from scratch? Our study reveals that the mobility of TEs is their Achilles heel, allowing hosts to develop a powerful small RNA-mediated silencing response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 17, 2025 at 2:56 PM
Not a new idea, but the level of demonstration seems unparalleled thanks to the power of Drosophila genetics. Congrats on the published paper! When learning about TEs for the first time, we are all dead scarred of insertional mutagenesis in genes, but maybe that is exactly what the genome wants.
Show me an editor with any sense of foresight, I will show you a talking mouse or a unicorn.
"But multiple journals rejected that paper at first!"
A paper could have very well been the first to suggest or hint at something that we now think is relevant, but that doesn't meant it was good or that the evidence was strong, or that it was a good fit to where it was sent. Hindsight is 20/20.
A paper could have very well been the first to suggest or hint at something that we now think is relevant, but that doesn't meant it was good or that the evidence was strong, or that it was a good fit to where it was sent. Hindsight is 20/20.
August 17, 2025 at 2:41 PM
Show me an editor with any sense of foresight, I will show you a talking mouse or a unicorn.
Well, the real surprise is why is it not 100%. Why would any one want to set foot in the USA is beyond the comprehension of even the smartest mice out there.
Watching the US wonder what possible reason there could be for the massive, precipitous drop in numbers of tourists to the USA from Canada is absolutely the gift that keeps giving.
“The weather? Exchange rates? Who can even say!”
newhampshirebulletin.com/2025/08/14/n...
“The weather? Exchange rates? Who can even say!”
newhampshirebulletin.com/2025/08/14/n...
August 17, 2025 at 2:38 PM
Well, the real surprise is why is it not 100%. Why would any one want to set foot in the USA is beyond the comprehension of even the smartest mice out there.
Reposted by Dr. Mouse
oh is tourism down across the board in the united states, that’s crazy
our new slogan “we will throw you in a fucking prison camp” doesn’t seem to be gaining traction with the tourism sector
our new slogan “we will throw you in a fucking prison camp” doesn’t seem to be gaining traction with the tourism sector
August 6, 2025 at 4:56 PM
oh is tourism down across the board in the united states, that’s crazy
our new slogan “we will throw you in a fucking prison camp” doesn’t seem to be gaining traction with the tourism sector
our new slogan “we will throw you in a fucking prison camp” doesn’t seem to be gaining traction with the tourism sector
Reposted by Dr. Mouse
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Reposted by Dr. Mouse
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Quintessential Stockholm syndrome: the relationship between scientists and scientific publishing companies.
Believe me, I would know. I mean, I love the caretakers of our facility. 100% sure I will never end in one of those black trash bags they sometimes carry out of the room.
Believe me, I would know. I mean, I love the caretakers of our facility. 100% sure I will never end in one of those black trash bags they sometimes carry out of the room.
August 6, 2025 at 7:22 PM
Quintessential Stockholm syndrome: the relationship between scientists and scientific publishing companies.
Believe me, I would know. I mean, I love the caretakers of our facility. 100% sure I will never end in one of those black trash bags they sometimes carry out of the room.
Believe me, I would know. I mean, I love the caretakers of our facility. 100% sure I will never end in one of those black trash bags they sometimes carry out of the room.
RFK Jr. wants to finally ban the mRNA poison. I did my own research to help!
I have the solution for the great MAGA people and RFK Jr.: ask your therapists for daily IV infusions of actinomycin D, or a more effective IV of α-Amanitin.
#stopmRNA #mRNA #NOmRNAinMAGA #spreadtheword #MAGA
I have the solution for the great MAGA people and RFK Jr.: ask your therapists for daily IV infusions of actinomycin D, or a more effective IV of α-Amanitin.
#stopmRNA #mRNA #NOmRNAinMAGA #spreadtheword #MAGA
August 6, 2025 at 7:35 AM
RFK Jr. wants to finally ban the mRNA poison. I did my own research to help!
I have the solution for the great MAGA people and RFK Jr.: ask your therapists for daily IV infusions of actinomycin D, or a more effective IV of α-Amanitin.
#stopmRNA #mRNA #NOmRNAinMAGA #spreadtheword #MAGA
I have the solution for the great MAGA people and RFK Jr.: ask your therapists for daily IV infusions of actinomycin D, or a more effective IV of α-Amanitin.
#stopmRNA #mRNA #NOmRNAinMAGA #spreadtheword #MAGA
I spent 6 years getting my PhD in immunology, only to be told I now need 47 forms, 3 ethics reviews, and a Zoom call with a goat to run a basic inflammation study.
At this rate, humans will cure aging after I’m dead of natural causes.
#LetMiceDoScience 🐭📉
At this rate, humans will cure aging after I’m dead of natural causes.
#LetMiceDoScience 🐭📉
August 6, 2025 at 7:09 AM
I spent 6 years getting my PhD in immunology, only to be told I now need 47 forms, 3 ethics reviews, and a Zoom call with a goat to run a basic inflammation study.
At this rate, humans will cure aging after I’m dead of natural causes.
#LetMiceDoScience 🐭📉
At this rate, humans will cure aging after I’m dead of natural causes.
#LetMiceDoScience 🐭📉