Antonio Ariza
@drantonioariza.bsky.social
University Teaching Associate at the University of Sheffield. Lots of structural biology, in the realm of microbiology, with a big dash of ADP-ribosylation.
Pinned
Antonio Ariza
@drantonioariza.bsky.social
· Dec 17
Zinc-Dependent Proteins Could Hold Key to Cancer and Viral Therapies
The molecular mechanism has been uncovered by which zinc-dependent proteins, known as macrodomains, reverse ADP-ribosylation—a key regulatory process in cells linked to cancer and viral infections.
www.technologynetworks.com
Interested in ADP-ribosylation? Technology Networks has published a short news article I wrote to describe the results and implications from my latest published research.
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
My former lab at the University of Oxford is looking for a postdoc to study ADP-ribosylation and ubiquitination signalling in DNA damage using biochemistry and structural biology.
my.corehr.com/pls/uoxrecru...
Informal inquiries can be sent to Prof Ivan Ahel via email: ivan.ahel@path.ox.ac.uk.
my.corehr.com/pls/uoxrecru...
Informal inquiries can be sent to Prof Ivan Ahel via email: ivan.ahel@path.ox.ac.uk.
'
my.corehr.com
June 4, 2025 at 1:02 PM
My former lab at the University of Oxford is looking for a postdoc to study ADP-ribosylation and ubiquitination signalling in DNA damage using biochemistry and structural biology.
my.corehr.com/pls/uoxrecru...
Informal inquiries can be sent to Prof Ivan Ahel via email: ivan.ahel@path.ox.ac.uk.
my.corehr.com/pls/uoxrecru...
Informal inquiries can be sent to Prof Ivan Ahel via email: ivan.ahel@path.ox.ac.uk.
After a very "dry" January and a long day in a curriculum development workshop, it was nice to go to the pub last night and celebrate our OER book launch with the librarians who helped us publish.
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
www.sheffield.ac.uk/library/news...
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
www.sheffield.ac.uk/library/news...
Cat burglars, yeast races, and other hypothesis-driven bioscience practicals, edited by Dr Rebecca Barnes
We are pleased to announce the publication of a new Open Educational Resource (OER) on the Sheffield Pressbooks Network.
www.sheffield.ac.uk
February 6, 2025 at 2:21 PM
After a very "dry" January and a long day in a curriculum development workshop, it was nice to go to the pub last night and celebrate our OER book launch with the librarians who helped us publish.
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
www.sheffield.ac.uk/library/news...
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
www.sheffield.ac.uk/library/news...
Check out this short book I've co-authored. It's aimed at University staff seeking lab practicals for biosciences students. It contains eight projects with a molecular focus, student-facing materials, and resources for teachers.
sheffield.pressbooks.pub/hypothesisba...
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
doi.org/10.15131/she...
Cat burglars, yeast races, and other hypothesis-driven bioscience practicals – Simple Book PublishingShare on XShare on LinkedInShare via Email
sheffield.pressbooks.pub
January 15, 2025 at 4:38 PM
Check out this short book I've co-authored. It's aimed at University staff seeking lab practicals for biosciences students. It contains eight projects with a molecular focus, student-facing materials, and resources for teachers.
sheffield.pressbooks.pub/hypothesisba...
doi.org/10.15131/she...
sheffield.pressbooks.pub/hypothesisba...
doi.org/10.15131/she...
Shameless self promotion 😊
Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
www.cell.com/structure/fu...
Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
www.cell.com/structure/fu...
Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
The intracellular subtilisin proteases (ISPs) are the only known members of the important and ubiquitous subtilisin family that function exclusively within the cell, constituting a major component of the degradome in many Gram-positive bacteria. The first ISP structure reported herein at a spacing of 1.56 Å reveals features unique among subtilisins that has enabled potential functional and physiological roles to be assigned to sequence elements exclusive to the ISPs. Unlike all other subtilisins, ISP from B.
www.cell.com
January 8, 2025 at 11:32 PM
Shameless self promotion 😊
Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
www.cell.com/structure/fu...
Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family
www.cell.com/structure/fu...
Happy New Year from snowy Sheffield! 🍾🥂
I hope you enjoyed the festivities and got some nice pressies (I asked Santa for a winning lottery ticket, but alas, he did not oblige ... I guess I must have been a naughty boy 😨).
I hope you enjoyed the festivities and got some nice pressies (I asked Santa for a winning lottery ticket, but alas, he did not oblige ... I guess I must have been a naughty boy 😨).
January 7, 2025 at 3:53 PM
Happy New Year from snowy Sheffield! 🍾🥂
I hope you enjoyed the festivities and got some nice pressies (I asked Santa for a winning lottery ticket, but alas, he did not oblige ... I guess I must have been a naughty boy 😨).
I hope you enjoyed the festivities and got some nice pressies (I asked Santa for a winning lottery ticket, but alas, he did not oblige ... I guess I must have been a naughty boy 😨).
Reposted by Antonio Ariza
Deadline today, January 6th! Two PhD studentships with us - fully funded and open to students worldwide. Come help us learn more about our favourite #Cdiff #phage
Just a few days left to apply for a fully funded PhD studentship with us - Jan 6th deadline. Funded through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on
#phage that infect #Cdifficile
#microsky #phage #evolution #cryoEM #AFM
#phage that infect #Cdifficile
#microsky #phage #evolution #cryoEM #AFM
January 6, 2025 at 8:34 AM
Reposted by Antonio Ariza
There is ONE WEEK left to apply for the #PlantScience #PhD position in my lab! This will use the latest #microscopy, #biosensor and #ecophysiology techniques!
The Rowe lab is recruiting a #PlantScience PhD student for 2025! You'll use our new ABACUS FRET biosensors to map the dynamic leaf #AbscisicAcid accumulations at low humidity in Arabidopsis, wheat and rice. #PhDposition
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
January 6, 2025 at 9:46 AM
There is ONE WEEK left to apply for the #PlantScience #PhD position in my lab! This will use the latest #microscopy, #biosensor and #ecophysiology techniques!
Interested in ADP-ribosylation? Technology Networks has published a short news article I wrote to describe the results and implications from my latest published research.
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
Zinc-Dependent Proteins Could Hold Key to Cancer and Viral Therapies
The molecular mechanism has been uncovered by which zinc-dependent proteins, known as macrodomains, reverse ADP-ribosylation—a key regulatory process in cells linked to cancer and viral infections.
www.technologynetworks.com
December 17, 2024 at 11:27 AM
Interested in ADP-ribosylation? Technology Networks has published a short news article I wrote to describe the results and implications from my latest published research.
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
www.technologynetworks.com/tn/articles/...
doi.org/10.1016/j.jb...
Reposted by Antonio Ariza
We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...
Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield on FindAPhD.com
PhD Project - Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
December 5, 2024 at 7:24 AM
We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...
Reposted by Antonio Ariza
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
December 13, 2024 at 4:21 PM
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
Reposted by Antonio Ariza
Unlocking the secrets of metastasis: Cancer cells' 'eating' ability could lead to new treatments medicalxpress.com/news/2024-12... via
#medical_xpress
#medical_xpress
Unlocking the secrets of metastasis: Cancer cells' 'eating' ability could lead to new treatments
Cancer is one of the most formidable health challenges of our time, affecting nearly half of us during our lives. While treatments have significantly improved in recent decades, the biggest challenge ...
medicalxpress.com
December 16, 2024 at 2:59 PM
Unlocking the secrets of metastasis: Cancer cells' 'eating' ability could lead to new treatments medicalxpress.com/news/2024-12... via
#medical_xpress
#medical_xpress
Shameless self promotion 😊
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
www.sciencedirect.com/science/arti...
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
www.sciencedirect.com/science/arti...
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanoso…
www.sciencedirect.com
December 16, 2024 at 11:47 AM
Shameless self promotion 😊
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
www.sciencedirect.com/science/arti...
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
www.sciencedirect.com/science/arti...
Shameless attempt of self-promotion 😊
Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
onlinelibrary.wiley.com/doi/10.1111/...
Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
onlinelibrary.wiley.com/doi/10.1111/...
Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
Trypanothione replaces glutathione in defence against cellular damage caused by oxidants, xenobiotics and methylglyoxal in the trypanosomatid parasites, which cause trypanosomiasis and leishmaniasis....
onlinelibrary.wiley.com
December 15, 2024 at 2:33 PM
Shameless attempt of self-promotion 😊
Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
onlinelibrary.wiley.com/doi/10.1111/...
Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Antonio Ariza
Excited to see our paper in press today at HGG Advances!!! We described a new variant in #ADPRS gene in individuals with CONDSIAS, disrupting its #ARH3 protein function leading to increased #ADP-ribosylation in cells.
bit.ly/3OmvwqH
bit.ly/3OmvwqH
November 25, 2024 at 7:11 PM
Excited to see our paper in press today at HGG Advances!!! We described a new variant in #ADPRS gene in individuals with CONDSIAS, disrupting its #ARH3 protein function leading to increased #ADP-ribosylation in cells.
bit.ly/3OmvwqH
bit.ly/3OmvwqH
Reposted by Antonio Ariza
A viral ADP-ribosyltransferase attaches RNA chains to host proteins (2023).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 10, 2023 at 1:42 PM
A viral ADP-ribosyltransferase attaches RNA chains to host proteins (2023).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Antonio Ariza
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation of proteins and nucleic acids regulates various cellular functions in all kingdoms of life, and its manipulation holds potential for human therapeutics. 60 years after the discovery of ADP-ribosylation, this review provides state-of-the-art insights on structural biology, biochemistry, cell biology, and clinical aspects.
www.cell.com
October 12, 2023 at 2:57 PM
ADP-ribosylation from molecular mechanisms to therapeutic implications
Reposted by Antonio Ariza
New paper published! 😊
Nucleosomes, ADP-ribosylation, a chromatin remodeler, smFRET, cryoEM. And the best of all: it confirmed a hypothesis we posited in our previous paper in 2021! Super nice to finally see this new paper out. 🤩 🧬🧶
doi.org/10.1038/s414...
Nucleosomes, ADP-ribosylation, a chromatin remodeler, smFRET, cryoEM. And the best of all: it confirmed a hypothesis we posited in our previous paper in 2021! Super nice to finally see this new paper out. 🤩 🧬🧶
doi.org/10.1038/s414...
Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1 - Nat...
Bacic et al. demonstrate that PARP1/HPF1 preferentially modify histone tails closest to the DNA break, directing ALC1-catalyzed nucleosome sliding. These findings suggest a mechanism for rendering DNA...
doi.org
February 5, 2024 at 9:49 PM
New paper published! 😊
Nucleosomes, ADP-ribosylation, a chromatin remodeler, smFRET, cryoEM. And the best of all: it confirmed a hypothesis we posited in our previous paper in 2021! Super nice to finally see this new paper out. 🤩 🧬🧶
doi.org/10.1038/s414...
Nucleosomes, ADP-ribosylation, a chromatin remodeler, smFRET, cryoEM. And the best of all: it confirmed a hypothesis we posited in our previous paper in 2021! Super nice to finally see this new paper out. 🤩 🧬🧶
doi.org/10.1038/s414...
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I
onlinelibrary.wiley.com/iucr/doi/10....
onlinelibrary.wiley.com/iucr/doi/10....
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I
onlinelibrary.wiley.com
December 13, 2024 at 6:47 PM
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I
onlinelibrary.wiley.com/iucr/doi/10....
onlinelibrary.wiley.com/iucr/doi/10....
Ignore this, it's a test to see if metric sites can pick up this mention or not (my earlier post seems to have been ignored by them)
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue)
academic.oup.com/nar/article/...
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue)
academic.oup.com/nar/article/...
December 13, 2024 at 6:02 PM
Ignore this, it's a test to see if metric sites can pick up this mention or not (my earlier post seems to have been ignored by them)
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue)
academic.oup.com/nar/article/...
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue)
academic.oup.com/nar/article/...
#OpenAccess Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue): t.co/fpbNDxUTeS
http://nar.oxfordjournals.org/cgi/content/long/33/5/1465
t.co
December 13, 2024 at 12:26 PM
#OpenAccess Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue): t.co/fpbNDxUTeS