Prachi Stafford
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dodoscientist.bsky.social
Prachi Stafford
@dodoscientist.bsky.social
1.2K followers 790 following 61 posts
Senior lecturer & Researcher in #microbiology, #cellbiology #platelets at Sheffield Hallam University, Sheffield, UK.
Speaks English, Français, Mauritian Creole (from the land of the dodos) & basic Hindi. She/her #WomenInStem #EDI
Posts Replies Media Videos
Reposted by Prachi Stafford
peiferlabunc.bsky.social
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
Cell cycle duration determines oncogenic transformation capacity Danian Chen, Suying Lu, Katherine Huang, Joel D. Pearson, Marek Pacal, Phillipos Peidis, Sean McCurdy, Tao Yu, Monika Sangwan, Angela Nguyen, Philippe P. Monnier, Daniel Schramek, Liang Zhu, David Santamaria, Mariano Barbacid, Nagako Akeno, Kathryn A. Wikenheiser-Brokamp & Rod Bremner https://www.nature.com/articles/s41586-025-08935-x
July 26, 2025 at 2:14 PM
dodoscientist.bsky.social
Thrilled our proposal on 'the effects of carbon monoxide on platelets' has been funded by CO Research Trust! Excited to study this under-researched area & provide new insights.
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social
Carbon monoxide and Platelets: The role of CO in clotting | CO Research
Carbon monoxide (CO) is a colourless, odourless gas commonly encountered in urban environments due to pollution, in occupational settings, and sometimes at home from faulty appliances. At toxic levels...
www.coresearchtrust.org
July 15, 2025 at 8:45 PM
dodoscientist.bsky.social
📢 we have a fully-funded #PhDOpportunity 🎓🧬
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR
Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University on FindAPhD.com
PhD Project - Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University, listed on FindAPhD.com
www.findaphd.com
April 16, 2025 at 10:21 PM
Reposted by Prachi Stafford
frisophagy.bsky.social
In this week's #mitophagy papers, Rab GTPases take the centre stage, with a systematic study their role in autophagy, showing that multiple "Rabs" selectively mediate the degradation of mitochondria and other cellular components.

Thanks to @biomednews.bsky.social

biomed.news/bims-tofagi/...
Schematic representation of Rab GTPases acting as “eat me” signals for selective autophagy.
April 13, 2025 at 11:29 AM
dodoscientist.bsky.social
@campbellsg.bsky.social, might be of interest
April 16, 2025 at 7:56 AM
Reposted by Prachi Stafford
trishgreenhalgh.bsky.social
Our new paper!! Led by @drpauldijkstra.bsky.social with @jessrmorley.bsky.social and awesome medical student Yosra Mekki. #digitalhealth #medsky #episky

How to Read a Paper Involving AI.

bmjmedicine.bmj.com/content/4/1/...
How to read a paper involving artificial intelligence (AI)
This paper guides readers through the critical appraisal of a paper that includes the use of artificial intelligence (AI) in clinical settings for healthcare delivery. A brief introduction to the diff...
bmjmedicine.bmj.com
April 16, 2025 at 6:43 AM
Reposted by Prachi Stafford
hithlabinserm1176.bsky.social
Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
April 4, 2025 at 4:16 PM
Reposted by Prachi Stafford
pdc-lab.bsky.social
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
April 10, 2025 at 2:17 PM
Reposted by Prachi Stafford
goetzjacky.bsky.social
(1/2) Very happy to study of my friend @hps2022.bsky.social @cniostopcancer.bsky.social now out also at @naturecomms.bsky.social.

Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...
The impact of a high fat diet and platelet activation on pre-metastatic niche formation - Nature Communications
Previous work has identified a link between obesity and breast cancer metastasis. Here, using preclinical mouse models, the authors show that high-fat diet promotes platelet and endothelial cell activ...
www.nature.com
April 2, 2025 at 5:32 PM
dodoscientist.bsky.social
Interesting thread on how glycans targeting vaccines could help against coronaviruses. The possibility of a universal vaccine again them!
francisb-sciences.bsky.social Francis Beaulieu 🇨🇦 @francisb-sciences.bsky.social · Mar 29
Les enrobages de sucre ne sont pas réservés aux bonbons, ils aident également les virus, comme celui de la COVID-19, à se cacher du système immunitaire de leur hôte. Des chercheurs ont mis au point un vaccin universel qui cible les coronavirus et les sucres qu'ils
trustmyscience.com/vaccin-unive...
Vaccin universel contre les coronavirus en vue : il serait efficace contre la COVID-19, le MERS et certains rhumes
Un nouveau vaccin universel pourrait neutraliser plusieurs coronavirus, dont ceux à l’origine de la COVID-19, du MERS et de certains rhumes.
trustmyscience.com
March 30, 2025 at 12:24 PM
Reposted by Prachi Stafford
frezzalab.bsky.social
www.nature.com/articles/s41...

Plasticity of the mammalian integrated stress response
Plasticity of the mammalian integrated stress response - Nature
A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 ...
www.nature.com
March 26, 2025 at 5:55 PM
Reposted by Prachi Stafford
epimechfc.bsky.social
Bastounis, E. E., Serrano-Alcalde, F., ..., García-Aznar, J. M., & Theriot, J. A. (2021). Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. Developmental cell, 56(4), 443–460.e11. #EpithelialMechanics
buff.ly/c4eJTxW
March 24, 2025 at 7:00 AM
Reposted by Prachi Stafford
albertosanzmon1.bsky.social
New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.
Developmental mitochondrial complex I activity determines lifespan | EMBO reports
imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...
www.embopress.org
March 23, 2025 at 7:29 AM
Reposted by Prachi Stafford
apatgiri.bsky.social
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications
Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...
www.nature.com
March 23, 2025 at 3:29 PM
dodoscientist.bsky.social
Re: 23andme.com & company takeover. You might want to request deletion of your data & destruction of your sample if you used this service.
profmakris.bsky.social ProfMakris @profmakris.bsky.social · Mar 24
If you have used 23andme.com for analysis of your genome like me, you may wish to read this document from the California Attorney General about requesting deletion of your data and destruction of your sample before the company is taken over. oag.ca.gov/news/press-r...
DNA Genetic Testing For Health, Ancestry And More - 23andMe
23andMe offers DNA testing with the most comprehensive ancestry breakdown, personalized health insights and more.
23andme.com
March 24, 2025 at 9:08 PM
dodoscientist.bsky.social
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.

🎤 Speaker: Dr Pooja Goddard

📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
Dr Pooja Goddard is tomorrow’s speaker for our RSC inclusion & diversity talk. Join us online or in person at Sheffield Hallam University.
March 24, 2025 at 8:26 PM
Reposted by Prachi Stafford
rpth.bsky.social
New discovery from Fabiola Del Carpio-Cano on the role of RUNX1 regulates platelet-megakaryocyte F13A1 expression, impacting clot stabilization.

Read the full study: www.rpthjournal.org/article/S247...

#platelets #RUNX1
www.rpthjournal.org
March 18, 2025 at 6:00 PM
dodoscientist.bsky.social
🔬 Happy #InternationalWomensDay! Proud to be one of the many women in #Biosciences & #Chemistry working to make a difference in #Science and #Education through #Research and #Teaching. 🧪📚 Love working with this inspiring bunch. #IWD2025 #WomenInSTEM @hallam-biosci-chem.bsky.social
#ChemSky #BioSky
March 8, 2025 at 5:59 PM
Reposted by Prachi Stafford
dodoscientist.bsky.social
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.

🎤 Speaker: Prof Robert Mokaya, OBE, FRS

📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
Talk by Professor Robert Mokaya, OBE, FRS on March 5th at Sheffield Hallam University from 5-6 pm. Hybrid delivery see links below to register.
February 26, 2025 at 10:30 PM
Reposted by Prachi Stafford
zeynepbaharoglu.bsky.social
#rnasky #microsky
peiferlabunc.bsky.social Mark Peifer (He, him) @peiferlabunc.bsky.social · Mar 1
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
Title, authors and abstract from link
March 1, 2025 at 5:05 PM
Reposted by Prachi Stafford
ella-cinders.bsky.social
youtu.be/zPEGX8bke_o?...
Artificial intelligence can be biased against certain people. Here's how.
YouTube video by PBS NewsHour
youtu.be
March 1, 2025 at 9:29 PM
Reposted by Prachi Stafford
worldthrombosisday.bsky.social
🚨It’s #BloodClotAwarenessMonth🚨

This month, we’re on a mission to raise awareness, save lives, and take action against blood clots! Show your support by creating a Survivor Selfie using the #WorldThrombosisDay Design Hub📸: www.worldthrombosisday.org/poster-builder/
March 1, 2025 at 10:56 PM
dodoscientist.bsky.social
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.

🎤 Speaker: Prof Robert Mokaya, OBE, FRS

📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
Talk by Professor Robert Mokaya, OBE, FRS on March 5th at Sheffield Hallam University from 5-6 pm. Hybrid delivery see links below to register.
February 26, 2025 at 10:30 PM
Reposted by Prachi Stafford
jdhl18.bsky.social
Eight critical questions for the new chief executive of UKRI wonkhe.com/blogs/eight-...
Eight critical questions for the new chief executive of UKRI
With announcement of a new UKRI chief executive expected imminently, Anton Muscatelli and Miles Padgett set out the most pressing issues for the new incumbent With announcement of a new UKRI chief exe...
wonkhe.com
February 17, 2025 at 7:25 AM
Reposted by Prachi Stafford
dijiang319.bsky.social
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 8, 2025 at 11:39 PM