Doc Edge
@docedge.bsky.social
Assistant professor in quantitative and computational biology @USC. Genetics, evolution, statistics. https://edgepopgen.github.io/edgelab/
Reposted by Doc Edge
Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests.
We describe a critical concept that we call *specificity*.
Led by Jeff Spence and Hakhamanesh Mostafavi:
We describe a critical concept that we call *specificity*.
Led by Jeff Spence and Hakhamanesh Mostafavi:
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 4:08 AM
Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests.
We describe a critical concept that we call *specificity*.
Led by Jeff Spence and Hakhamanesh Mostafavi:
We describe a critical concept that we call *specificity*.
Led by Jeff Spence and Hakhamanesh Mostafavi:
Reposted by Doc Edge
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
October 24, 2025 at 1:51 AM
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
October 16, 2025 at 11:46 PM
Reposted by Doc Edge
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In most species within the walnut family, two genetically determined morphs alternate
between male and female flowering phases in time. Groh et al. identify a distinct
locus for this dimorphism in two...
www.cell.com
October 16, 2025 at 3:43 PM
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Reposted by Doc Edge
Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…
www.sciencedirect.com
October 16, 2025 at 3:42 PM
Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Doc Edge
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
The "You gotta keep 'em separated" line in "Come Out and Play" was inspired by his bench work (for real) www.facebook.com/watch/?v=113...
October 15, 2025 at 1:51 PM
The "You gotta keep 'em separated" line in "Come Out and Play" was inspired by his bench work (for real) www.facebook.com/watch/?v=113...
This is a great opportunity!
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!
October 15, 2025 at 1:48 PM
This is a great opportunity!
Reposted by Doc Edge
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!
October 15, 2025 at 12:52 PM
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
Reposted by Doc Edge
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Doc Edge
Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.
August 6, 2025 at 5:18 PM
Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.
Reposted by Doc Edge
The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.
June 7, 2025 at 12:03 AM
The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.
Reposted by Doc Edge
I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
June 2, 2025 at 5:45 PM
I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
Reposted by Doc Edge
Jennifer Blanc and @jeremyjberg.bsky.social use theory and simulations to study the process of testing for an association between polygenic scores and axes of ancestry variation when confounding factors are present.
Learn more about their findings in #GENETICS: buff.ly/EmKpXyP
Learn more about their findings in #GENETICS: buff.ly/EmKpXyP
June 3, 2025 at 10:02 PM
Jennifer Blanc and @jeremyjberg.bsky.social use theory and simulations to study the process of testing for an association between polygenic scores and axes of ancestry variation when confounding factors are present.
Learn more about their findings in #GENETICS: buff.ly/EmKpXyP
Learn more about their findings in #GENETICS: buff.ly/EmKpXyP
Reposted by Doc Edge
Welcome to the Modeling and Theory in Population Biology workshop!
We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...
We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...
June 2, 2025 at 1:21 PM
Welcome to the Modeling and Theory in Population Biology workshop!
We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...
We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...
Reposted by Doc Edge
Harvard has just under 6,800 foreign students enrolled. Every one of them would have to give up their dreams of an education in the US or transfer elsewhere, if Noem's attack on Harvard is upheld.
None of them have done anything wrong, they're just collateral damage to Trump.
None of them have done anything wrong, they're just collateral damage to Trump.
May 22, 2025 at 6:21 PM
Harvard has just under 6,800 foreign students enrolled. Every one of them would have to give up their dreams of an education in the US or transfer elsewhere, if Noem's attack on Harvard is upheld.
None of them have done anything wrong, they're just collateral damage to Trump.
None of them have done anything wrong, they're just collateral damage to Trump.
Reposted by Doc Edge
Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...
May 22, 2025 at 3:09 PM
Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...
Reposted by Doc Edge
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Reposted by Doc Edge
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
April 29, 2025 at 8:52 PM
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
Reposted by Doc Edge
In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and @docedge.bsky.social, show the effect of various choices made while computing Q-ST.
Read more: buff.ly/OwrU9oB
Read more: buff.ly/OwrU9oB
April 29, 2025 at 6:03 PM
In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and @docedge.bsky.social, show the effect of various choices made while computing Q-ST.
Read more: buff.ly/OwrU9oB
Read more: buff.ly/OwrU9oB
Reposted by Doc Edge
In a new #GENETICS research, @dandanpeng.bsky.social, Mulder, and @docedge.bsky.social evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score.
Read more: buff.ly/ztrRU83
Read more: buff.ly/ztrRU83
April 28, 2025 at 8:02 PM
In a new #GENETICS research, @dandanpeng.bsky.social, Mulder, and @docedge.bsky.social evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score.
Read more: buff.ly/ztrRU83
Read more: buff.ly/ztrRU83
Reposted by Doc Edge
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
April 28, 2025 at 4:18 PM
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
Reposted by Doc Edge
I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.
April 24, 2025 at 5:48 PM
I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.
Reposted by Doc Edge
My paper about type I error rates in Qst/Fst comparisons is now published in @genetics-gsa.bsky.social. Check it out here: academic.oup.com/genetics/adv...
April 18, 2025 at 12:19 AM
My paper about type I error rates in Qst/Fst comparisons is now published in @genetics-gsa.bsky.social. Check it out here: academic.oup.com/genetics/adv...