Diogo Maia-Silva
@diogomaiasilva.bsky.social
Pathology resident @ Mass General Brigham. Cancer lineage from transcription to tissue architecture.
Reposted by Diogo Maia-Silva
Reposted by Diogo Maia-Silva
#PathSky 45 with a forearm skin tumor. Highly cellular, monomorphic spindle cell tumor with a “packeted” pattern and deep, nodular lymphoid aggregates.
May 8, 2025 at 4:36 PM
#PathSky 45 with a forearm skin tumor. Highly cellular, monomorphic spindle cell tumor with a “packeted” pattern and deep, nodular lymphoid aggregates.
This is the guy who CRISPRed human embryos despite lack of appropriate safety studies. Why yes, comparing your technology to the atomic bomb really sounds promising and not ominous
March 12, 2025 at 3:00 AM
This is the guy who CRISPRed human embryos despite lack of appropriate safety studies. Why yes, comparing your technology to the atomic bomb really sounds promising and not ominous
Reposted by Diogo Maia-Silva
#PathSky I’ve been bad about posting, my apologies. Ok, 86M with destructive T12 lesion. Sent in to subclassify the malignant spindle cell lesion. Keratins, melanocytic markers, muscle markers, SATB2 negative.
March 10, 2025 at 7:09 PM
#PathSky I’ve been bad about posting, my apologies. Ok, 86M with destructive T12 lesion. Sent in to subclassify the malignant spindle cell lesion. Keratins, melanocytic markers, muscle markers, SATB2 negative.
*chuckles in tears*
Poll Finds Most Americans Would Swap Democracy For $100 Best Buy Gift Card
theonion.com/poll-fi...
theonion.com/poll-fi...
March 8, 2025 at 4:36 PM
*chuckles in tears*
Reposted by Diogo Maia-Silva
Slightly terrifying case (not mine).
Biopsy full of LCIS and this, with negative E-cadherin staining.
I think on the basis of H&E I would’ve initially called this invasive lobular
1/2
#PathSky
Biopsy full of LCIS and this, with negative E-cadherin staining.
I think on the basis of H&E I would’ve initially called this invasive lobular
1/2
#PathSky
March 6, 2025 at 5:44 AM
Slightly terrifying case (not mine).
Biopsy full of LCIS and this, with negative E-cadherin staining.
I think on the basis of H&E I would’ve initially called this invasive lobular
1/2
#PathSky
Biopsy full of LCIS and this, with negative E-cadherin staining.
I think on the basis of H&E I would’ve initially called this invasive lobular
1/2
#PathSky
Having a blast at the International Society for Dermatopathology joint meeting in Orlando #ISDP2025 with Mass General Brigham residents and faculty!
March 6, 2025 at 6:28 PM
Having a blast at the International Society for Dermatopathology joint meeting in Orlando #ISDP2025 with Mass General Brigham residents and faculty!
March 4, 2025 at 2:36 AM
Incredible work from Stu Orkin’s lab showing BCL11A functions as a tetramer and can be destabilized by breaking its quaternary structure. A single zinc finger domain mediates tetramerization - a promising drug discovery blueprint.
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing
Down-regulation of BCL11A protein reverses the fetal (HbF, α2γ2) to adult (HbA, α2β2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo ...
www.science.org
December 1, 2024 at 1:17 PM
Incredible work from Stu Orkin’s lab showing BCL11A functions as a tetramer and can be destabilized by breaking its quaternary structure. A single zinc finger domain mediates tetramerization - a promising drug discovery blueprint.
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
In the United States, documents must be declassified after 50 years unless they are about weapons of mass destruction, espionage, or.. a @jama.com Dermatology first describing what we now know as Merkel cell carcinoma
November 27, 2024 at 8:41 PM
In the United States, documents must be declassified after 50 years unless they are about weapons of mass destruction, espionage, or.. a @jama.com Dermatology first describing what we now know as Merkel cell carcinoma
Reposted by Diogo Maia-Silva
new out in Nature www.nature.com/articles/s41...
Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature
Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...
www.nature.com
November 20, 2024 at 5:08 PM
new out in Nature www.nature.com/articles/s41...
Reposted by Diogo Maia-Silva
A wonderful example of CMV viral cytopathic effect. Pt was immunosuppressed. Bx showed no inflammation. Separate bx showed reactive changes leading to a re-review of this and other bxs, all of which showed CMV. Easily missed if no history is provided (which it wasn't). #PathSky
November 17, 2024 at 3:05 AM
A wonderful example of CMV viral cytopathic effect. Pt was immunosuppressed. Bx showed no inflammation. Separate bx showed reactive changes leading to a re-review of this and other bxs, all of which showed CMV. Easily missed if no history is provided (which it wasn't). #PathSky
Reposted by Diogo Maia-Silva
Distinguishing #UsualEpithelialHyperplasia from #DCIS can be tricky. Hope this helps you 😉🔬
#pathology
#BreastPath
#pathology
#BreastPath
November 16, 2024 at 10:58 AM
Distinguishing #UsualEpithelialHyperplasia from #DCIS can be tricky. Hope this helps you 😉🔬
#pathology
#BreastPath
#pathology
#BreastPath
Reposted by Diogo Maia-Silva
The forest is very exciting right now 🍄📷
September 12, 2023 at 4:32 PM
The forest is very exciting right now 🍄📷
Reposted by Diogo Maia-Silva
