Diego García González
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diegoconcalma.bsky.social
Diego García González
@diegoconcalma.bsky.social
170 followers 280 following 23 posts
Developmental neurobiologist.
Neurogenesis, neurodevelopmental disorders & evolution.
Group leader in a hotel named IBIS. I'm serious.
Posts Replies Media Videos
Reposted by Diego García González
johannajoyce.bsky.social
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬

An amazing set of resources for all scientists working on the brain!

🧠 Immersive feature:
www.nature.com/immersive/d4...

🧠 Perspective:
www.nature.com/articles/s41...
Cover of this week's Nature showing a brain rendering Cover caption from the journal: Brain development: Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues
November 5, 2025 at 6:53 PM
Reposted by Diego García González
christophertape.bsky.social
Paul Nurse describing the main job of a PI

(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Reposted by Diego García González
nathaliejuya.bsky.social
🤔 Is motile #cilia dysfunction a cause of #hydrocephalus ?
The answer depends on who you ask and which species you study. 🤔😕🧐
In mice, motile cilia dysfunction almost always leads to hydrocephalus. In humans, however, the link is far less clear. So why the difference?
Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans—Similarities and Differences from Animal Models - Journal of Molecular Neuroscience
Hydrocephalus is a condition defined by excessive cerebrospinal fluid (CSF) relative to the brain volume. Congenital and infantile forms of hydrocephalus are both genetically and physiologically heter...
doi.org
October 30, 2025 at 8:43 PM
Reposted by Diego García González
profsimonfisher.bsky.social
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
A depiction of expression patterns of the FOXP1, FOXP2, and FOXP4 genes in the brain, based on the developmental human RNA sequencing dataset of BrainSpan (http://www.brainspan.org/). Data cover different prenatal timepoints starting at 8-to-10 weeks postconception (abbreviated as pcs), postnatal timepoints from 0-to-12 months (abbreviated as mos), and expression measured in adulthood. A dashed vertical line represents time of birth. Individual dots are shown each representing one brain sample, and lines show loess curves fitted through the datapoints. The analyzed brain regions are A1C, primary auditory cortex; CB, cerebellum; CBC, cerebellar cortex; DFC, dorsolateral prefrontal cortex; DTH, dorsal thalamic nucleus; HIP, hippocampus; IPC, inferior parietal cortex; ITC, inferior temporal cortex; M1C, primary motor cortex; MD, mediodorsal thalamic nucleus; MFC, medial frontal cortex; OFC, orbitofrontal; S1C, primary sensory cortex; STR, striatum; TC, superior temporal cortex; V1C, primary visual cortex; VFC, ventromedial prefrontal cortex. This image comes from Figure 1 of a paper entitled “Molecular networks of the FOXP2 transcription factor in the brain” written by den Hoed, Devaraju and Fisher, published in the journal EMBO Reports in August 2021 (Volume 22, article e58203).
October 29, 2025 at 5:09 PM
Reposted by Diego García González
margaridamcm.bsky.social
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
crick.ac.uk The Francis Crick Institute @crick.ac.uk · Oct 7
2026 PhD recruitment is now open.

As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:

www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 4:43 PM
Reposted by Diego García González
aruizherrera.bsky.social
RIP John Gurdon
October 7, 2025 at 6:06 PM
Reposted by Diego García González
denisduboule.bsky.social
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Reposted by Diego García González
hassanbraindevlab.bsky.social
👇🏽
October 3, 2025 at 3:07 PM
Reposted by Diego García González
vw1234.bsky.social
I add that earlier and later diagnosed autism are not valid diagnostic terms and what we are looking at is (one) gradient. Also genetics explains only a fraction of the variance, with most studied factors explaining < 10%. We have FAQs in the Supplementary where we address common questions.
October 1, 2025 at 4:05 PM
Reposted by Diego García González
zoltan-molnar.bsky.social
CORTICAL EVOLUTION - 15-17th June 2026 - Bilbao Spain
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social
September 27, 2025 at 9:12 AM
Reposted by Diego García González
mirimiam.bsky.social
Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)
mirimiam.bsky.social Manuel Irimia @mirimiam.bsky.social · Jul 23
🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇
www.upf.edu
September 22, 2025 at 7:04 AM
diegoconcalma.bsky.social
What a beautiful story, Idoia.
Congratulations!
idoiaeu.bsky.social Idoia Quintana-Urzainqui @idoiaeu.bsky.social · Sep 2
🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.
September 9, 2025 at 3:53 PM
Reposted by Diego García González
csic.es
🦟 Mosquitos invasores

👩‍🔬👨‍🔬 El @ceabcsic.bsky.social y @mosquitoalert.bsky.social presentan el primer mapa municipal de la distribución de tres especies invasoras en España: mosquito tigre, de la fiebre amarilla y del Japón

🔎Más de 1.800 municipios han sido colonizados 

👉 http://tiny.cc/ia5s001
September 6, 2025 at 2:01 PM
Reposted by Diego García González
tdcapellini.bsky.social
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
www.nature.com
August 27, 2025 at 3:13 PM
Reposted by Diego García González
raciencias.bsky.social
Lamentamos profundamente el fallecimiento del académico José Manuel García Verdugo, catedrático de la Universitat de Valencia. Referente internacional en Neurocencia y Microscopía Electrónica.
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...
July 7, 2025 at 10:20 AM
Reposted by Diego García González
nat-prunet.bsky.social
Incredible diversity of #pollen grains!

Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth

#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday
June 27, 2025 at 4:40 PM
Reposted by Diego García González
vasadlab.bsky.social
Really happy to see our work on Alzheimer’s disease (AD) microglia published in @science.org www.science.org/doi/10.1126/.... A great work at IBiS from Manuel Sanchez-Garcia, Nieves Lara-Ureña, Rosana March-Diaz, @alicielena.bsky.social , and all our collaborators.
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression
PHD3 inhibition slows down the pathology and behavioral decline of an Alzheimer’s disease mouse model.
www.science.org
May 29, 2025 at 12:40 PM
Reposted by Diego García González
ec.europa.eu
Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF
A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”
May 8, 2025 at 10:12 AM
Reposted by Diego García González
sustainable2050.bsky.social
Amazing differences within the EU.

Via prof. Marco te Brömmelstroet on LinkedIn.
NB: 2019 data.
May 22, 2025 at 7:12 PM
Reposted by Diego García González
bassemh.bsky.social
Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...
rdcu.be
May 7, 2025 at 11:26 AM
Reposted by Diego García González
dattalab.bsky.social
Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...
www.biorxiv.org
May 9, 2025 at 8:44 PM
Reposted by Diego García González
djabaudon.bsky.social
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
May 5, 2025 at 4:52 PM
Reposted by Diego García González
institutocajal.bsky.social
El próximo Viernes 9 de Mayo, a las 12:30 hrs. en la Sala Washington Buño del #InstitutoCajal, seminario presencial del Dr. Diego García González, @ibis_sevilla @CSIC, con el título: "How to make a newron".
Organizado por: Dra. Aixa V. Morales
May 5, 2025 at 9:28 AM
Reposted by Diego García González
aberron.bsky.social
🔴 ENTREVISTA | Óscar Marín, neurocientífico: “Están en marcha los primeros trasplantes de neuronas 'viajeras' para tratar el cerebro” www.eldiario.es/128_bace79?u...
Óscar Marín, neurocientífico: “Están en marcha los primeros trasplantes de neuronas 'viajeras' para tratar el cerebro”
El investigador español es pionero en el estudio de trastornos del neurodesarrollo como el autismo, la epilepsia y la esquizofrenia, que considera posibles efectos colaterales de la increíble capacida...
www.eldiario.es
May 4, 2025 at 5:54 AM