Silvia De Rubeis
@derubeislab.bsky.social
Neuroscientist & geneticist studying neurodev, autism, and DDX3X | PREP Director | Immigrant | 2x mom | #firstgen | #Humboldtian (she/her)
Born and raised in 🇮🇹, had fun in 🇧🇪, transplanted in 🇺🇸
Views my own
https://labs.icahn.mssm.edu/derubeislab/
Born and raised in 🇮🇹, had fun in 🇧🇪, transplanted in 🇺🇸
Views my own
https://labs.icahn.mssm.edu/derubeislab/
Pinned
Silvia De Rubeis
@derubeislab.bsky.social
· May 18
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X - Nature Communications
Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...
www.nature.com
🧪 New paper alert!
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
Reposted by Silvia De Rubeis
NIH Study Sections are on hold...again. drugmonkey.wordpress.com/2025/10/13/n...
NIH Study Sections are on hold…again.
The primary input to deciding on the merit of proposals submitted to the NIH for potential funding, as most of my remaining blog audience well knows, is the outcome of the initial peer-review proce…
drugmonkey.wordpress.com
October 13, 2025 at 9:20 PM
NIH Study Sections are on hold...again. drugmonkey.wordpress.com/2025/10/13/n...
Reposted by Silvia De Rubeis
Last year, we helped 100 students save $31K in grad school app fees, giving students from underserved communities the freedom to apply widely.
This year we lost 16 partners = $8.2K setback = 110 fewer dreams.
🎓 You can change that.
💸 Donate to open 110 new doors.
givebutter.com/supportCL
This year we lost 16 partners = $8.2K setback = 110 fewer dreams.
🎓 You can change that.
💸 Donate to open 110 new doors.
givebutter.com/supportCL
October 13, 2025 at 7:17 PM
Last year, we helped 100 students save $31K in grad school app fees, giving students from underserved communities the freedom to apply widely.
This year we lost 16 partners = $8.2K setback = 110 fewer dreams.
🎓 You can change that.
💸 Donate to open 110 new doors.
givebutter.com/supportCL
This year we lost 16 partners = $8.2K setback = 110 fewer dreams.
🎓 You can change that.
💸 Donate to open 110 new doors.
givebutter.com/supportCL
Reposted by Silvia De Rubeis
DDX3X can cause a neurodevelopmental disorder in males. 🧬
📢 A new cohort of affected males broadens the spectrum. ⬇️
www.nature.com/articles/s41...
📢 A new cohort of affected males broadens the spectrum. ⬇️
www.nature.com/articles/s41...
DDX3X-related neurodevelopmental disorder in males – presenting a new cohort of 19 males and a literature review - European Journal of Human Genetics
European Journal of Human Genetics - DDX3X-related neurodevelopmental disorder in males – presenting a new cohort of 19 males and a literature review
www.nature.com
August 26, 2025 at 10:25 AM
DDX3X can cause a neurodevelopmental disorder in males. 🧬
📢 A new cohort of affected males broadens the spectrum. ⬇️
www.nature.com/articles/s41...
📢 A new cohort of affected males broadens the spectrum. ⬇️
www.nature.com/articles/s41...
Reposted by Silvia De Rubeis
✨ Applying for fellowships?
Check out 40+ successful sample applications from:
NSF-GRFP, PD Soros, HHMI Gilliam, Ford, NIH F31 …and more!
Get inspired and strengthen your own application by learning from winners in your field.
🔗 cientificolatino.com/writing-center
Check out 40+ successful sample applications from:
NSF-GRFP, PD Soros, HHMI Gilliam, Ford, NIH F31 …and more!
Get inspired and strengthen your own application by learning from winners in your field.
🔗 cientificolatino.com/writing-center
September 2, 2025 at 4:47 PM
✨ Applying for fellowships?
Check out 40+ successful sample applications from:
NSF-GRFP, PD Soros, HHMI Gilliam, Ford, NIH F31 …and more!
Get inspired and strengthen your own application by learning from winners in your field.
🔗 cientificolatino.com/writing-center
Check out 40+ successful sample applications from:
NSF-GRFP, PD Soros, HHMI Gilliam, Ford, NIH F31 …and more!
Get inspired and strengthen your own application by learning from winners in your field.
🔗 cientificolatino.com/writing-center
Reposted by Silvia De Rubeis
“How does a brain take shape?” Neurobiologist @bassemh.bsky.social on the embryonic cells that fold into the neural tube and become the brain.
Discover more in The Brain’s Secret.
#Biology #Neuroscience #Brain #Education #ReliableKnowledge #PublicEngagement
Discover more in The Brain’s Secret.
#Biology #Neuroscience #Brain #Education #ReliableKnowledge #PublicEngagement
August 26, 2025 at 2:05 PM
“How does a brain take shape?” Neurobiologist @bassemh.bsky.social on the embryonic cells that fold into the neural tube and become the brain.
Discover more in The Brain’s Secret.
#Biology #Neuroscience #Brain #Education #ReliableKnowledge #PublicEngagement
Discover more in The Brain’s Secret.
#Biology #Neuroscience #Brain #Education #ReliableKnowledge #PublicEngagement
Reposted by Silvia De Rubeis
HAPPENING NOW! Visit the Icahn School of medicine #SURP4US Poster Session as @wellesley.edu's Kayla Quinlan, mentored by the DeRubeis Lab, presents her summer research project on “Characterizing olfactory bulb development in a mouse model of DDX3X syndrome”. @mountsinainyc.bsky.social NOT TO MISS!
August 8, 2025 at 5:02 PM
HAPPENING NOW! Visit the Icahn School of medicine #SURP4US Poster Session as @wellesley.edu's Kayla Quinlan, mentored by the DeRubeis Lab, presents her summer research project on “Characterizing olfactory bulb development in a mouse model of DDX3X syndrome”. @mountsinainyc.bsky.social NOT TO MISS!
Reposted by Silvia De Rubeis
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Silvia De Rubeis
🎉 Big congratulations to GSMI-NYC 2022 scholar, @michae1flores.bsky.social, on being awarded the prestigious HHMI Gilliam Fellowship! 🌟 We are so proud of you leading the way for the next generation of scientists!
August 11, 2025 at 8:25 PM
🎉 Big congratulations to GSMI-NYC 2022 scholar, @michae1flores.bsky.social, on being awarded the prestigious HHMI Gilliam Fellowship! 🌟 We are so proud of you leading the way for the next generation of scientists!
Reposted by Silvia De Rubeis
A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine
August 10, 2025 at 12:26 AM
A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine
Incredibly proud to see our alumnus Michael Flores among the 2025 Gilliam Fellows 🥹
Congratulations to Michael and all other Fellows!
Congratulations to Michael and all other Fellows!
Congratulations 2025 Gilliam Fellows and Advisors! 🎉
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
August 7, 2025 at 1:49 PM
Incredibly proud to see our alumnus Michael Flores among the 2025 Gilliam Fellows 🥹
Congratulations to Michael and all other Fellows!
Congratulations to Michael and all other Fellows!
Reposted by Silvia De Rubeis
Reposted by Silvia De Rubeis
Today, SfN joins communities across the nation in celebrating #Juneteenth — a day that honors freedom, resilience, and progress.
We celebrate the remarkable contributions of Black neuroscientists whose research has expanded our understanding of the brain and improved lives worldwide.
#neurosky
We celebrate the remarkable contributions of Black neuroscientists whose research has expanded our understanding of the brain and improved lives worldwide.
#neurosky
June 19, 2025 at 12:27 PM
Today, SfN joins communities across the nation in celebrating #Juneteenth — a day that honors freedom, resilience, and progress.
We celebrate the remarkable contributions of Black neuroscientists whose research has expanded our understanding of the brain and improved lives worldwide.
#neurosky
We celebrate the remarkable contributions of Black neuroscientists whose research has expanded our understanding of the brain and improved lives worldwide.
#neurosky
Reposted by Silvia De Rubeis
What? Some good news on a Friday?
Parent Fellowship Notices of Funding Opportunities are up!
F30, F31, F32, F33
grants.nih.gov/grants/guide...
Parent Fellowship Notices of Funding Opportunities are up!
F30, F31, F32, F33
grants.nih.gov/grants/guide...
PA-25-422: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) PA-25-422. NI...
grants.nih.gov
June 13, 2025 at 11:06 PM
What? Some good news on a Friday?
Parent Fellowship Notices of Funding Opportunities are up!
F30, F31, F32, F33
grants.nih.gov/grants/guide...
Parent Fellowship Notices of Funding Opportunities are up!
F30, F31, F32, F33
grants.nih.gov/grants/guide...
Reposted by Silvia De Rubeis
Today is DDX3X Awareness Day!
12th June marks the fifth annual International DDX3X Day!
Share our expert-written guide, freely available online at bit.ly/3VlQ0D5
#DDX3X #RareChromo #GeneDisorder #ChromosomeX #AwarenessDay #Unique #FamilySupport
12th June marks the fifth annual International DDX3X Day!
Share our expert-written guide, freely available online at bit.ly/3VlQ0D5
#DDX3X #RareChromo #GeneDisorder #ChromosomeX #AwarenessDay #Unique #FamilySupport
June 12, 2025 at 11:22 AM
Today is DDX3X Awareness Day!
12th June marks the fifth annual International DDX3X Day!
Share our expert-written guide, freely available online at bit.ly/3VlQ0D5
#DDX3X #RareChromo #GeneDisorder #ChromosomeX #AwarenessDay #Unique #FamilySupport
12th June marks the fifth annual International DDX3X Day!
Share our expert-written guide, freely available online at bit.ly/3VlQ0D5
#DDX3X #RareChromo #GeneDisorder #ChromosomeX #AwarenessDay #Unique #FamilySupport
Reposted by Silvia De Rubeis
the reissued NOFO for theRuth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) is finally published! grants.nih.gov/grants/guide...
PA-25-425: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Par...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without N...
grants.nih.gov
June 13, 2025 at 6:23 PM
the reissued NOFO for theRuth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) is finally published! grants.nih.gov/grants/guide...
Reposted by Silvia De Rubeis
Padilla: If this is how DHS responds to a senator with a question you can only imagine what they're doing to farm workers, to cooks, to day laborers out in the Los Angeles community and throughout California.
June 12, 2025 at 7:33 PM
Padilla: If this is how DHS responds to a senator with a question you can only imagine what they're doing to farm workers, to cooks, to day laborers out in the Los Angeles community and throughout California.
Reposted by Silvia De Rubeis
"Tanner, a chemist at the Univ. of Mississippi working to develop a novel approach for treating glioblastoma, was notified in April that the grant was terminated.
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
The Gutting of America’s Medical Research: Here Is Every Canceled or Delayed N.I.H. Grant
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 8, 2025 at 6:12 PM
"Tanner, a chemist at the Univ. of Mississippi working to develop a novel approach for treating glioblastoma, was notified in April that the grant was terminated.
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
“I would like to cure brain cancer,” Dr. Tanner said. “I think that's not particularly controversial.”
www.nytimes.com/interactive/...
Reposted by Silvia De Rubeis
NEW STUDY from Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Silvia De Rubeis, et al. unveils sex-specific molecular signatures when Ddx3x is missing, impacting the neuronal proteome, protein synthesis machinery & nucleoli structure. Learn More @natcomms.nature.com 👉 www.nature.com/articles/s41...
June 2, 2025 at 12:00 AM
NEW STUDY from Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Silvia De Rubeis, et al. unveils sex-specific molecular signatures when Ddx3x is missing, impacting the neuronal proteome, protein synthesis machinery & nucleoli structure. Learn More @natcomms.nature.com 👉 www.nature.com/articles/s41...
Reposted by Silvia De Rubeis
Excited to be in Milan for #eshg2025! If you’re interested in leading analysis of large, diverse cohorts with WGS and cellular genomic data in Australia, I’d be keen to chat - we’re looking to fill a variety of senior comp bio roles: populationgenomics.org.au/careers/ #eshg25
Careers - Centre for Population Genomics
populationgenomics.org.au
May 24, 2025 at 8:41 AM
Excited to be in Milan for #eshg2025! If you’re interested in leading analysis of large, diverse cohorts with WGS and cellular genomic data in Australia, I’d be keen to chat - we’re looking to fill a variety of senior comp bio roles: populationgenomics.org.au/careers/ #eshg25
Thanks Giannina for organizing this at @canacn.bsky.social. It was so much fun!
It was great seeing you and @arrudacarvalho.bsky.social again and meeting so many new friends!
@kundakoviclab.bsky.social @ivazovkic.bsky.social @walkerde.bsky.social @iordanova.bsky.social @deryasargin.bsky.social
It was great seeing you and @arrudacarvalho.bsky.social again and meeting so many new friends!
@kundakoviclab.bsky.social @ivazovkic.bsky.social @walkerde.bsky.social @iordanova.bsky.social @deryasargin.bsky.social
Join us at CAN for genomic fun!
If you are at @canacn.bsky.social , don't miss our symposium on Thurs 1:30 pm:
A genomics approach towards understanding sex differences in cognition, mental health, and neurodevelopment.
w @descalzi.bsky.social @ivazovkic.bsky.social @derubeislab.bsky.social @walkerde.bsky.social
See you there!
A genomics approach towards understanding sex differences in cognition, mental health, and neurodevelopment.
w @descalzi.bsky.social @ivazovkic.bsky.social @derubeislab.bsky.social @walkerde.bsky.social
See you there!
May 24, 2025 at 8:49 PM
Thanks Giannina for organizing this at @canacn.bsky.social. It was so much fun!
It was great seeing you and @arrudacarvalho.bsky.social again and meeting so many new friends!
@kundakoviclab.bsky.social @ivazovkic.bsky.social @walkerde.bsky.social @iordanova.bsky.social @deryasargin.bsky.social
It was great seeing you and @arrudacarvalho.bsky.social again and meeting so many new friends!
@kundakoviclab.bsky.social @ivazovkic.bsky.social @walkerde.bsky.social @iordanova.bsky.social @deryasargin.bsky.social
Reposted by Silvia De Rubeis
To all those descending onto Toronto for the @canacn.bsky.social annual meeting, as program chair I hope you have an exciting meeting and enjoy our featured speakers @franklandlab.bsky.social
@yulonglilab.bsky.social @neurovoice.bsky.social @turrigiano.bsky.social and Kerry Ressler #CAN2025
@yulonglilab.bsky.social @neurovoice.bsky.social @turrigiano.bsky.social and Kerry Ressler #CAN2025
May 20, 2025 at 5:39 PM
To all those descending onto Toronto for the @canacn.bsky.social annual meeting, as program chair I hope you have an exciting meeting and enjoy our featured speakers @franklandlab.bsky.social
@yulonglilab.bsky.social @neurovoice.bsky.social @turrigiano.bsky.social and Kerry Ressler #CAN2025
@yulonglilab.bsky.social @neurovoice.bsky.social @turrigiano.bsky.social and Kerry Ressler #CAN2025
Reposted by Silvia De Rubeis
Join us at CAN for genomic fun!
If you are at @canacn.bsky.social , don't miss our symposium on Thurs 1:30 pm:
A genomics approach towards understanding sex differences in cognition, mental health, and neurodevelopment.
w @descalzi.bsky.social @ivazovkic.bsky.social @derubeislab.bsky.social @walkerde.bsky.social
See you there!
A genomics approach towards understanding sex differences in cognition, mental health, and neurodevelopment.
w @descalzi.bsky.social @ivazovkic.bsky.social @derubeislab.bsky.social @walkerde.bsky.social
See you there!
May 21, 2025 at 9:37 PM
Join us at CAN for genomic fun!
Reposted by Silvia De Rubeis
OPT is the program that allows foreign students graduating with STEM degrees stay and work for up to three years. Because of the oversubscribed H-1B lottery, OPT is one of the main ways that foreign students manage to transition to jobs in the US.
Ending it would destroy a major STEM pipeline.
Ending it would destroy a major STEM pipeline.
They're terminating OPT.
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US
The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...
www.piie.com
May 21, 2025 at 9:43 PM
OPT is the program that allows foreign students graduating with STEM degrees stay and work for up to three years. Because of the oversubscribed H-1B lottery, OPT is one of the main ways that foreign students manage to transition to jobs in the US.
Ending it would destroy a major STEM pipeline.
Ending it would destroy a major STEM pipeline.