Derek J Wilson
@derekjwilson.bsky.social
Professor: Mass spectrometry, protein dynamics, (millisecond) hydrogen deuterium exchange, conformational disorder... and more! All at York University in Toronto, Canada.
I should add - because I have been known to complain about peer review lately - that the peer review on this particular work was excellent, resulting substantial improvement. Our thanks to 'reviewer #2' in particular... ...
May 14, 2025 at 11:29 PM
I should add - because I have been known to complain about peer review lately - that the peer review on this particular work was excellent, resulting substantial improvement. Our thanks to 'reviewer #2' in particular... ...
Ok folks, here it is: Joe Anacleto (with some help from his friends) demonstrates zero sensitivity loss, zero scrambling site specific HDX. Next up: Site specific HDX-MS profiles of drug candidates in *real-world* drug development... And after that? High throughput!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Efficient, Zero Scrambling Fragmentation of Deuterium Labeled Peptides on the ZenoToF 7600 Electron Activated Dissociation Platform
Hydrogen–deuterium exchange (HDX) mass spectrometry (MS) has become an increasingly important tool in protein research, with large-scale applications in biopharmaceutical development and manufacturing...
pubs.acs.org
April 24, 2025 at 5:30 PM
Ok folks, here it is: Joe Anacleto (with some help from his friends) demonstrates zero sensitivity loss, zero scrambling site specific HDX. Next up: Site specific HDX-MS profiles of drug candidates in *real-world* drug development... And after that? High throughput!
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Alright it's been a while, I know, but just in case you were *really* curious about what ms Hydrogen Deuterium Exchange can tell you about cytochrome c membrane interactions, I present to you this work by Vimanda Chow: pubs.acs.org/doi/10.1021/...
Probing the Interactions of Cytochrome c with Anionic Phospholipid Nanodiscs Using Millisecond Hydrogen–Deuterium Exchange Mass Spectrometry
The interplay between the anionic phospholipid cardiolipin (CL) and cytochrome c (cyt c) holds significance in the early stages of apoptosis. Despite identification of up to four potential sites of in...
pubs.acs.org
April 2, 2025 at 3:21 PM
Alright it's been a while, I know, but just in case you were *really* curious about what ms Hydrogen Deuterium Exchange can tell you about cytochrome c membrane interactions, I present to you this work by Vimanda Chow: pubs.acs.org/doi/10.1021/...
Reposted by Derek J Wilson
Excited to be giving this webinar soon. Hope to see you then!
March 14, 2025 at 6:49 AM
Excited to be giving this webinar soon. Hope to see you then!
Rare political repost from me, but this one deserves it for so eloquently exhibiting the moral power of being *moderate*.
With his permission, I'm sharing Dean Treanor's response to Ed Martin's letter:
March 6, 2025 at 11:23 PM
Rare political repost from me, but this one deserves it for so eloquently exhibiting the moral power of being *moderate*.
Was it York? That sounds like something our 'advancement' office would do...
February 11, 2025 at 2:08 PM
Was it York? That sounds like something our 'advancement' office would do...
Yep, and here's why :)... journals.plos.org/plosone/arti...
Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble
Tau is an intrinsically disordered protein (IDP) whose primary physiological role is to stabilize microtubules in neuronal axons at all stages of development. In Alzheimer's and other tauopathies, tau...
journals.plos.org
December 29, 2024 at 1:28 PM
Yep, and here's why :)... journals.plos.org/plosone/arti...
The Wilson group and collaborators bids you all a Merry Xmas and Happy Holidays!
December 14, 2024 at 12:48 PM
The Wilson group and collaborators bids you all a Merry Xmas and Happy Holidays!
Sharks with frickin lazers on their heads! :)
December 13, 2024 at 12:54 PM
Sharks with frickin lazers on their heads! :)
What would this animation look like if reviewers were *paid* I wonder?
December 11, 2024 at 7:18 PM
What would this animation look like if reviewers were *paid* I wonder?
Not the shortest trek for you, but... Next time!!
December 9, 2024 at 3:31 AM
Not the shortest trek for you, but... Next time!!
December 8, 2024 at 11:15 PM
yESI is on his way to his new home in Ontario. He will no doubt find some comfort in the arms of a 13 year old boy who still loves stuffies, but I think he will be deeply disappointed by the lack of mountains... As everyone knows, Ontario is NOT the natural habitat for any species of YETI.
December 8, 2024 at 11:15 PM
yESI is on his way to his new home in Ontario. He will no doubt find some comfort in the arms of a 13 year old boy who still loves stuffies, but I think he will be deeply disappointed by the lack of mountains... As everyone knows, Ontario is NOT the natural habitat for any species of YETI.
Quick #videogames thought: It seems to me that the current situation on Google's "Play Store" is rather like the situation of #Atari in the mid 1980's. Here's hoping it causes the same sort of crash, and maybe then some marketplace competition.
December 8, 2024 at 9:15 PM
Quick #videogames thought: It seems to me that the current situation on Google's "Play Store" is rather like the situation of #Atari in the mid 1980's. Here's hoping it causes the same sort of crash, and maybe then some marketplace competition.
Time to once again close out the scientific program of the Lake Louise conference on mass spectrometry. To do that, Gary Glish is telling us why what we have all been observing can depend really quite a lot on the particular settings of our instruments. #LakeLouise2024
December 7, 2024 at 7:01 PM
Time to once again close out the scientific program of the Lake Louise conference on mass spectrometry. To do that, Gary Glish is telling us why what we have all been observing can depend really quite a lot on the particular settings of our instruments. #LakeLouise2024
More seriously, there have been many great talks, but one that stood out for me was Elvin Cabrera (Barran group) coming up with ways to do fast, high resolution IMS + FT Charge detection MS on HUGE protein complexes. Super amazing stuff!
December 6, 2024 at 5:29 PM
More seriously, there have been many great talks, but one that stood out for me was Elvin Cabrera (Barran group) coming up with ways to do fast, high resolution IMS + FT Charge detection MS on HUGE protein complexes. Super amazing stuff!
There was one Tal where I learned that my drinking water may be contaminated with the remnants of poop. It would be a depressing thought except... ... ...
December 6, 2024 at 3:48 PM
There was one Tal where I learned that my drinking water may be contaminated with the remnants of poop. It would be a depressing thought except... ... ...
I think some might appreciate this spectacular view of the majestic and timeless scenery at the Lake Louise mass spectrometry conference. #LakeLouise2024
December 6, 2024 at 1:54 PM
I think some might appreciate this spectacular view of the majestic and timeless scenery at the Lake Louise mass spectrometry conference. #LakeLouise2024
December 6, 2024 at 1:52 PM
December 5, 2024 at 10:22 PM
Don't know... But I think it has something to do with Facebook not crashing...
December 5, 2024 at 7:20 PM
Don't know... But I think it has something to do with Facebook not crashing...
Just got a 'request to review' where the editor sent me a *table* of papers they can't find reviewers for and asked me to please select one or two that I'd be willing to do. For these (hours) of work they offer 100 points that can be used to purchase services from the publisher. #peerreviewcrisis
December 2, 2024 at 4:50 PM
Just got a 'request to review' where the editor sent me a *table* of papers they can't find reviewers for and asked me to please select one or two that I'd be willing to do. For these (hours) of work they offer 100 points that can be used to purchase services from the publisher. #peerreviewcrisis
...And another critical point. For pedagogy not to subsidize research (which I agree, it shouldn't), tricouncil needs to *substantially increase the indirect cost %* that they pay when profs get funded. In the US, overhead % is *much* higher, driving unis to actually compete for research grants.
December 1, 2024 at 4:46 PM
...And another critical point. For pedagogy not to subsidize research (which I agree, it shouldn't), tricouncil needs to *substantially increase the indirect cost %* that they pay when profs get funded. In the US, overhead % is *much* higher, driving unis to actually compete for research grants.
I think this is already happening (or has already happened) at many institutions. Even at my relatively 'research light' institution, genuinely research oriented profs rarely teach below 3rd year now. This accompanies the rise of 'alt stream' professors whose job explicitly focuses on pedagogy.
December 1, 2024 at 4:42 PM
I think this is already happening (or has already happened) at many institutions. Even at my relatively 'research light' institution, genuinely research oriented profs rarely teach below 3rd year now. This accompanies the rise of 'alt stream' professors whose job explicitly focuses on pedagogy.