Dave Truong
@davidmtruong.bsky.social
Assistant Professor of Biomedical Engineering @NYU Tandon School of Engineering | Synthetic Biology lab | Genome re-writing in human iPSCs | Programmable off-the-shelf myeloid cell therapies | Regenerative tissue engineering.
www.truonglab.com
www.truonglab.com
Pinned
Dave Truong
@davidmtruong.bsky.social
· Aug 21
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The Truong lab @nyuniversity (Programmable Regenerative Immunity) has an opening for a Postdoctoral Fellow to work in Mammalian Synthetic Biology in human iPSCs:
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
🚨 Preprint Alert!
The era of human genome writing begins…
We developed REWRITE for human iPSCs, enabling 100–209 kb rewriting of all 3 HLA genes - or anywhere.
➡️ On-demand HLA hiPSCs
➡️ Off-the-shelf cells
➡️ Extensible cell engineering
🧵⬇️
www.biorxiv.org/content/10.1...
The era of human genome writing begins…
We developed REWRITE for human iPSCs, enabling 100–209 kb rewriting of all 3 HLA genes - or anywhere.
➡️ On-demand HLA hiPSCs
➡️ Off-the-shelf cells
➡️ Extensible cell engineering
🧵⬇️
www.biorxiv.org/content/10.1...
Genomic REWRITE of Immune Interfaces Reveals Heritable Epigenetic Memory in Human Stem Cells
Human leukocyte antigen (HLA) polymorphism hinders allogeneic therapies. We developed REWRITE, a modular platform for iterative, scar-minimized genome writing of synthetic constructs >100 kb in human ...
www.biorxiv.org
September 17, 2025 at 2:03 PM
🚨 Preprint Alert!
The era of human genome writing begins…
We developed REWRITE for human iPSCs, enabling 100–209 kb rewriting of all 3 HLA genes - or anywhere.
➡️ On-demand HLA hiPSCs
➡️ Off-the-shelf cells
➡️ Extensible cell engineering
🧵⬇️
www.biorxiv.org/content/10.1...
The era of human genome writing begins…
We developed REWRITE for human iPSCs, enabling 100–209 kb rewriting of all 3 HLA genes - or anywhere.
➡️ On-demand HLA hiPSCs
➡️ Off-the-shelf cells
➡️ Extensible cell engineering
🧵⬇️
www.biorxiv.org/content/10.1...
The Truong lab @nyuniversity (Programmable Regenerative Immunity) has an opening for a Postdoctoral Fellow to work in Mammalian Synthetic Biology in human iPSCs:
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
August 21, 2025 at 2:30 PM
The Truong lab @nyuniversity (Programmable Regenerative Immunity) has an opening for a Postdoctoral Fellow to work in Mammalian Synthetic Biology in human iPSCs:
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
apply.interfolio.com/172424
This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.
This a really killer resource.
Led by Fia Larsen in @rhp-lab.bsky.social, we mapped degrons in all ~1600 human transcription factors
We find overlap between degrons and TADs, and show how negatively charged residues contribute to function by helping prevent degradation
See preprint for much more:
doi.org/10.1101/2025...
We find overlap between degrons and TADs, and show how negatively charged residues contribute to function by helping prevent degradation
See preprint for much more:
doi.org/10.1101/2025...
May 18, 2025 at 5:37 PM
This a really killer resource.
Abstract deadline (April 28) coming up for for the best mammalian synthetic biology conference!
Join us at #mSBW2025
www.aiche.org/sbe/conferen...
Join us at #mSBW2025
www.aiche.org/sbe/conferen...
2025 International Mammalian Synthetic Biology Workshop (mSBW)
The International Mammalian Synthetic Biology Workshop (mSBW) brings together leaders in synthetic biology with experts from other relevant fields to highlight and inspire cutting-edge synthetic biolo...
www.aiche.org
April 22, 2025 at 12:04 PM
Abstract deadline (April 28) coming up for for the best mammalian synthetic biology conference!
Join us at #mSBW2025
www.aiche.org/sbe/conferen...
Join us at #mSBW2025
www.aiche.org/sbe/conferen...
Need a site-specific, dox-inducible system for human cells?
Low leakage, silencing-resistant, and modular?
It’s here in the first paper from my lab, led by Tomoki Yanagi MD, PhD.
Bonus: forward programming of TEC-like cells from hiPSCs.
tinyurl.com/trunod01
Low leakage, silencing-resistant, and modular?
It’s here in the first paper from my lab, led by Tomoki Yanagi MD, PhD.
Bonus: forward programming of TEC-like cells from hiPSCs.
tinyurl.com/trunod01
Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing - Journal of Biological Engineering
Background Inducible gene expression circuits enable precise control over target gene activation and are widely used in direct reprogramming. However, their usability is often compromised by DNA methy...
tinyurl.com
April 11, 2025 at 2:23 PM
Need a site-specific, dox-inducible system for human cells?
Low leakage, silencing-resistant, and modular?
It’s here in the first paper from my lab, led by Tomoki Yanagi MD, PhD.
Bonus: forward programming of TEC-like cells from hiPSCs.
tinyurl.com/trunod01
Low leakage, silencing-resistant, and modular?
It’s here in the first paper from my lab, led by Tomoki Yanagi MD, PhD.
Bonus: forward programming of TEC-like cells from hiPSCs.
tinyurl.com/trunod01
Reposted by Dave Truong
Many of us in academic science will default to “business as usual” as our response. We will feel that our power should be used to maintain a semblance of normalcy. To live to fight another day.
February 18, 2025 at 4:24 PM
Many of us in academic science will default to “business as usual” as our response. We will feel that our power should be used to maintain a semblance of normalcy. To live to fight another day.
Reposted by Dave Truong
Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing https://www.biorxiv.org/content/10.1101/2024.12.18.629244v1
December 21, 2024 at 5:04 AM
Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing https://www.biorxiv.org/content/10.1101/2024.12.18.629244v1
Reposted by Dave Truong
Snapdragons are my favorite flower to grow. They do however produce seed pods that look like the screaming skulls of the damned.
December 12, 2024 at 9:01 PM
Snapdragons are my favorite flower to grow. They do however produce seed pods that look like the screaming skulls of the damned.
We are looking for two new colleagues (open rank tenure-track) in neuro-engineering for the Dept of Biomedical Engineering @nyutandon.bsky.social! Priority applications due Dec 8th, rolling till January.
Neuro-Cell/Tissue
apply.interfolio.com/159312
Neuro-Devices
apply.interfolio.com/159320
Neuro-Cell/Tissue
apply.interfolio.com/159312
Neuro-Devices
apply.interfolio.com/159320
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November 25, 2024 at 7:59 PM
We are looking for two new colleagues (open rank tenure-track) in neuro-engineering for the Dept of Biomedical Engineering @nyutandon.bsky.social! Priority applications due Dec 8th, rolling till January.
Neuro-Cell/Tissue
apply.interfolio.com/159312
Neuro-Devices
apply.interfolio.com/159320
Neuro-Cell/Tissue
apply.interfolio.com/159312
Neuro-Devices
apply.interfolio.com/159320
Reposted by Dave Truong
Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
November 22, 2024 at 4:05 AM
Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
Bluesky, new beginnings. Let's hope this place is about positive science developments and not rage bait!
November 16, 2024 at 6:09 PM
Bluesky, new beginnings. Let's hope this place is about positive science developments and not rage bait!