David Llères
@davidlleres.bsky.social
CNRS researcher in Marcelo Nollmann's team at Centre de Biologie Structurale (CBS) in Montpellier, France. Microscopist interested in using advanced imaging techniques (Hi-M, FRET, etc) to study 3D genome organization, gene regulation and epigenetics.
Reposted by David Llères
Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
October 31, 2025 at 1:24 PM
Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
Reposted by David Llères
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by David Llères
En ce début d’automne 2025, le CNRS continue de mettre à l’honneur les #FemmesEnScience. Tandis que "La Science taille XX elles" lance sa 8e édition, CNRS Ingénierie inaugure avec "Ingénieuses" une nouvelle exposition itinérante. Et le 15/10 paraît "Les filles sont parfaites pour les sciences".
Au CNRS, les femmes en science sur le devant de la scène
Au CNRS, les femmes en science sur le devant de la scène
www.cnrs.fr
October 14, 2025 at 5:02 AM
En ce début d’automne 2025, le CNRS continue de mettre à l’honneur les #FemmesEnScience. Tandis que "La Science taille XX elles" lance sa 8e édition, CNRS Ingénierie inaugure avec "Ingénieuses" une nouvelle exposition itinérante. Et le 15/10 paraît "Les filles sont parfaites pour les sciences".
Reposted by David Llères
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
Reposted by David Llères
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by David Llères
Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!
August 20, 2025 at 1:53 AM
Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!
Reposted by David Llères
How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
July 26, 2025 at 9:36 PM
How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
Reposted by David Llères
🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
shorturl.at
May 20, 2025 at 10:20 AM
🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!
Reposted by David Llères
Reposted by David Llères
You can read about TurboCas here: www.sciencedirect.com/science/arti....
TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
Regulation of gene expression during development and stress response requires the concerted action of transcription factors and chromatin-binding prot…
www.sciencedirect.com
April 29, 2025 at 8:24 PM
You can read about TurboCas here: www.sciencedirect.com/science/arti....
Reposted by David Llères
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
March 31, 2025 at 1:26 PM
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by David Llères
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
March 29, 2025 at 12:46 PM
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
Reposted by David Llères
36 slots for selected talks from abstracts! Join us and share your latest research!
Deadline for early registration coming up next week
Deadline for early registration coming up next week
📣Exciting meeting ahead!
Join us next June in beautiful Cassis for #ShapingLife3!
www.atoutcom.com/shaping-life/
@justinmcrocker.bsky.social @mhverlhac.bsky.social @guignardlab.bsky.social @bulutkarslioglu.bsky.social @dudinlab.bsky.social @flowerwhatelse.bsky.social @sfbd.bsky.social
Join us next June in beautiful Cassis for #ShapingLife3!
www.atoutcom.com/shaping-life/
@justinmcrocker.bsky.social @mhverlhac.bsky.social @guignardlab.bsky.social @bulutkarslioglu.bsky.social @dudinlab.bsky.social @flowerwhatelse.bsky.social @sfbd.bsky.social
March 28, 2025 at 8:58 AM
36 slots for selected talks from abstracts! Join us and share your latest research!
Deadline for early registration coming up next week
Deadline for early registration coming up next week
Reposted by David Llères
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602
The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.
www.nature.com
March 22, 2025 at 1:50 PM
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
Reposted by David Llères
Excellent keynote lecture by Susan Gasser at EpiGene3Sys @institutcurie.bsky.social.
A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.
In addition Susan has a track record as excellent mentor.
'People is all what it is about.'
A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.
In addition Susan has a track record as excellent mentor.
'People is all what it is about.'
March 12, 2025 at 9:27 AM
Excellent keynote lecture by Susan Gasser at EpiGene3Sys @institutcurie.bsky.social.
A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.
In addition Susan has a track record as excellent mentor.
'People is all what it is about.'
A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.
In addition Susan has a track record as excellent mentor.
'People is all what it is about.'
Reposted by David Llères
The U.S. Department of Defense is ending all of its funding for social science research, stopping 91 ongoing studies related to threats such as climate change, extremism, and disinformation. scim.ag/4hqu6HA
Pentagon abruptly ends all funding for social science research
More than 90 studies on threats such as climate change, extremism, and disinformation are halted
scim.ag
March 10, 2025 at 8:50 PM
The U.S. Department of Defense is ending all of its funding for social science research, stopping 91 ongoing studies related to threats such as climate change, extremism, and disinformation. scim.ag/4hqu6HA
Reposted by David Llères
Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/...
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
March 10, 2025 at 10:07 PM
Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/...
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
Reposted by David Llères
#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.
February 26, 2025 at 6:23 AM
#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.
Reposted by David Llères
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
February 21, 2025 at 3:50 PM
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Reposted by David Llères
We highlighted new research from the past two years on examples of long-range gene regulation - within large TADs, across TADs, and across chromosomes - comparing mechanisms in flies and mammals 🪰❤️🐁.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 13, 2025 at 12:22 PM
We highlighted new research from the past two years on examples of long-range gene regulation - within large TADs, across TADs, and across chromosomes - comparing mechanisms in flies and mammals 🪰❤️🐁.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by David Llères
Un amendement pour pomper 100 millions d'euros sur la trésorerie (fonds de roulement) du #CNRS qui, c'est bien connu, roule sur l'or #ESR #budget2025
www.publicsenat.fr/actualites/e...
www.publicsenat.fr/actualites/e...
Enseignement supérieur et recherche : le Sénat vote 630 millions d’euros d’économies, la gauche dénonce un « coup de rabot monumental » - Public Sénat
La majorité sénatoriale de droite et du centre a adopté 630 millions d’économies sur les crédits de l’enseignement supérieur et de la recherche, via un amendement de dernière minute du gouvernement. L...
www.publicsenat.fr
January 22, 2025 at 2:21 PM
Un amendement pour pomper 100 millions d'euros sur la trésorerie (fonds de roulement) du #CNRS qui, c'est bien connu, roule sur l'or #ESR #budget2025
www.publicsenat.fr/actualites/e...
www.publicsenat.fr/actualites/e...
Reposted by David Llères
Reposted by David Llères
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
January 16, 2025 at 1:35 PM
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
Reposted by David Llères
L’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
L’Institut Pasteur a décidé de quitter X
L’Institut Pasteur, organisme de recherche engagé depuis plus de 130 ans dans la lutte contre les maladies infectieuses, le partage des connaissances et la défense de la science, a décidé de quitter l...
www.pasteur.fr
January 16, 2025 at 9:18 AM
L’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
Reposted by David Llères
Highly recommended (I am co-organizing this exciting meeting)! Please come and join us!
The GfG is delighted to reconnect with everyone here on Bluesky!
We're excited to announce our upcoming symposium, "Epigenetics & Chromatin", taking place September 24–26 in Giessen, Germany.
Stay tuned for more details!
(... and become a member of the GfG...!)
We're excited to announce our upcoming symposium, "Epigenetics & Chromatin", taking place September 24–26 in Giessen, Germany.
Stay tuned for more details!
(... and become a member of the GfG...!)
January 14, 2025 at 1:08 PM
Highly recommended (I am co-organizing this exciting meeting)! Please come and join us!