David Jones
@davidjonesbrain.bsky.social
Behavioral neurologist and AI director working to end degeneration of mental function and use technology to transform the practice of neurology.
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Pinned
David Jones
@davidjonesbrain.bsky.social
· Nov 20
So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
Pretty amazing to give this lecture here! Thank you University of Iowa Department of Neurology!
January 7, 2026 at 1:40 AM
Pretty amazing to give this lecture here! Thank you University of Iowa Department of Neurology!
Excited to head out to Iowa City @universityofiowa.bsky.social for the Baden Lecture Neurology Grand Rounds on 01/06/26: "Dementia as a Disorder of Generative Human Intelligence" #endalz #neuro #AI @mayoclinic.org
January 5, 2026 at 4:21 PM
Excited to head out to Iowa City @universityofiowa.bsky.social for the Baden Lecture Neurology Grand Rounds on 01/06/26: "Dementia as a Disorder of Generative Human Intelligence" #endalz #neuro #AI @mayoclinic.org
Reposted by David Jones
As we are having a discussion on neural codes: @earlkmiller.bsky.social is entirely right that the "only spike rates matter" idea that is so prominent in neuroscience has no credible evidence. We simply do not currently know how neurons code relevant information. Oscillations are likely part of it.
November 20, 2025 at 9:19 PM
As we are having a discussion on neural codes: @earlkmiller.bsky.social is entirely right that the "only spike rates matter" idea that is so prominent in neuroscience has no credible evidence. We simply do not currently know how neurons code relevant information. Oscillations are likely part of it.
Listen to "AI Precision and Breakthrough in Diagnosing Dementia Types" by Boomers Today via #spreaker www.spreaker.com/episode/ai-p...
AI Precision and Breakthrough in Diagnosing Dementia Types - Boomers Today
www.spreaker.com
November 18, 2025 at 6:27 PM
Listen to "AI Precision and Breakthrough in Diagnosing Dementia Types" by Boomers Today via #spreaker www.spreaker.com/episode/ai-p...
September 16, 2025 at 6:45 PM
NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....
Idiopathic Normal Pressure Hydrocephalus | Neurology Open Access
Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is an underdiagnosed but potentially
treatable condition in older adults. Population-based data on incidence and progression
re...
doi.org
September 9, 2025 at 2:11 AM
NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....
This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM
FDG-PET-Based Machine Learning Framework to Support Neurologic Decision-Making
YouTube video by Neurology Journal
youtu.be
August 22, 2025 at 10:12 PM
This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM
Reposted by David Jones
Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too.
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures - Nature Communications
This study introduces and validates a reconfigurable metastructure that uses electromagnetic waves to perform analog complex-valued mathematical computations. This device executes both stationary and ...
www.nature.com
August 13, 2025 at 4:01 PM
Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too.
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Reposted by David Jones
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
August 5, 2025 at 12:32 PM
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Focusing on AD only, out of context of all degenerative disease of intelligence is one of the major errors IMO. Intelligence is energetically expensive and FDG-PET provides a landscape for all dementias, and connects to the clinic to computational neuroscience: bsky.app/profile/davi...
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
July 3, 2025 at 7:20 PM
Focusing on AD only, out of context of all degenerative disease of intelligence is one of the major errors IMO. Intelligence is energetically expensive and FDG-PET provides a landscape for all dementias, and connects to the clinic to computational neuroscience: bsky.app/profile/davi...
18/
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
June 29, 2025 at 5:11 PM
18/
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
June 29, 2025 at 5:11 PM
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
16/
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
June 29, 2025 at 5:11 PM
16/
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
15/
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
June 29, 2025 at 5:11 PM
15/
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
14/
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
June 29, 2025 at 5:11 PM
14/
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
13/
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
June 29, 2025 at 5:11 PM
13/
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
12/
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
June 29, 2025 at 5:11 PM
12/
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare