David Jones
@davidjonesbrain.bsky.social
Behavioral neurologist and AI director working to end degeneration of mental function and use technology to transform the practice of neurology.
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Pinned
David Jones
@davidjonesbrain.bsky.social
· Nov 20
So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
September 16, 2025 at 6:45 PM
NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....
Idiopathic Normal Pressure Hydrocephalus | Neurology Open Access
Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is an underdiagnosed but potentially
treatable condition in older adults. Population-based data on incidence and progression
re...
doi.org
September 9, 2025 at 2:11 AM
NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....
This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM
FDG-PET-Based Machine Learning Framework to Support Neurologic Decision-Making
YouTube video by Neurology Journal
youtu.be
August 22, 2025 at 10:12 PM
This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM
Reposted by David Jones
Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too.
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures - Nature Communications
This study introduces and validates a reconfigurable metastructure that uses electromagnetic waves to perform analog complex-valued mathematical computations. This device executes both stationary and ...
www.nature.com
August 13, 2025 at 4:01 PM
Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too.
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Programmable wave-based analog computing machine: a metastructure that designs metastructures
www.nature.com/articles/s41...
#neuroscience
Reposted by David Jones
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
August 5, 2025 at 12:32 PM
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
June 29, 2025 at 5:11 PM
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Reposted by David Jones
A new AI tool can identify nine types of dementia from a single FDG-PET brain scan, supporting faster and more accurate diagnosis, even in clinics without neurology specialists. doi.org/g9rnhp
AI tool detects 9 types of dementia from a single brain scan
Mayo Clinic researchers have developed a new artificial intelligence (AI) tool that helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single, widely available scan—a transformative advance in early, accurate diagnosis.
medicalxpress.com
June 28, 2025 at 8:32 AM
A new AI tool can identify nine types of dementia from a single FDG-PET brain scan, supporting faster and more accurate diagnosis, even in clinics without neurology specialists. doi.org/g9rnhp
Reposted by David Jones
"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A unifying perspective on neural manifolds and circuits for cognition - Nature Reviews Neuroscience
Neural manifolds can shed light on how heterogeneous neuronal population activity drives neural computations, but linking these insights to the underlying neuronal connectivity is challenging. Engel a...
www.nature.com
April 13, 2025 at 2:40 PM
"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚨 Video alert: I was able to share our @mayoclinic.org work on #NeuroAI at #GoogleCloudNext, including how we hope to scale expert interpretation of brain scans to improve dementia care.
🧠 Watch here: youtu.be/lJ1SVeeFWZQ?...
#DigitalHealth #AI #endalz
🧠 Watch here: youtu.be/lJ1SVeeFWZQ?...
#DigitalHealth #AI #endalz
Gopal Srinivasan, Deloitte Consulting LLP & Dr. David Jones, Mayo Clinic | Google Cloud Next 2025
YouTube video by SiliconANGLE theCUBE
youtu.be
April 13, 2025 at 5:28 PM
🚨 Video alert: I was able to share our @mayoclinic.org work on #NeuroAI at #GoogleCloudNext, including how we hope to scale expert interpretation of brain scans to improve dementia care.
🧠 Watch here: youtu.be/lJ1SVeeFWZQ?...
#DigitalHealth #AI #endalz
🧠 Watch here: youtu.be/lJ1SVeeFWZQ?...
#DigitalHealth #AI #endalz
Reposted by David Jones
Discovery funded by 3 NIH grants:
"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/...
Bonus: My son Luca's first pub
Bonus: My son Luca's first pub
Synaptic architecture of a memory engram in the mouse hippocampus
Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...
www.science.org
March 22, 2025 at 8:34 PM
Discovery funded by 3 NIH grants:
Reposted by David Jones
Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity - Acta N...
Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...
link.springer.com
March 17, 2025 at 4:32 PM
Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
Reposted by David Jones
Amazing group
@maggieflanagan.bsky.social @gokcegroup.bsky.social @leatgrinberg.bsky.social @hillmanlab.bsky.social @davidjonesbrain.bsky.social @alifiyakapasi.bsky.social @karchlab.bsky.social @tammarynlashley.bsky.social @tnrlab.bsky.social @tspiresjones.bsky.social @ionicwoman.bsky.social
@maggieflanagan.bsky.social @gokcegroup.bsky.social @leatgrinberg.bsky.social @hillmanlab.bsky.social @davidjonesbrain.bsky.social @alifiyakapasi.bsky.social @karchlab.bsky.social @tammarynlashley.bsky.social @tnrlab.bsky.social @tspiresjones.bsky.social @ionicwoman.bsky.social
March 13, 2025 at 12:26 PM
Reposted by David Jones
A big thank you to all those who have been so positive about my new book. It's about how neurological patients can tell us so much about our selves, how personal and social identities are forged by different cognitive functions, and what it means to belong.
February 23, 2025 at 3:33 PM
A big thank you to all those who have been so positive about my new book. It's about how neurological patients can tell us so much about our selves, how personal and social identities are forged by different cognitive functions, and what it means to belong.
Multiple pathological processes appear to have contributed to the hippocampal atrophy and hypometabolism in a patient that has taught me so much about limbic-predominant amnestic neurodegeneration: doi.org/10.1111/neup...
Multiple Neuropathologies Underly Hippocampal Subfield Atrophy in a Case With a Slowly Progressive Amnestic Syndrome: Challenging the Notion of Pure LATE‐NC
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, marked by abnormal protein buildup (beta-amyloid and tau) resulting in neuronal loss, especially in the medial temporal lobe ...
doi.org
February 20, 2025 at 12:46 PM
Multiple pathological processes appear to have contributed to the hippocampal atrophy and hypometabolism in a patient that has taught me so much about limbic-predominant amnestic neurodegeneration: doi.org/10.1111/neup...
Reposted by David Jones
The agents are coming! ‘Digital humans’ in a virtual world www.thetransmitter.org/neuroai/digi... cc @thetransmitter.bsky.social
‘Digital humans’ in a virtual world
Robert Yang and his collaborators have built agents that are capable of grounded reasoning at a linguistic level. Striking collective behaviors have emerged.
www.thetransmitter.org
February 10, 2025 at 12:31 PM
The agents are coming! ‘Digital humans’ in a virtual world www.thetransmitter.org/neuroai/digi... cc @thetransmitter.bsky.social
Epistemic failure of the current paradigm is an epistemic pump that drives the next paradigm!
February 13, 2025 at 2:00 PM
Epistemic failure of the current paradigm is an epistemic pump that drives the next paradigm!
“The connection between amyloid-β and tau pathology appears to be disrupted in this individual…”
The connection is functional, and the function is preserved in this case. www.nature.com/articles/s41...
The connection is functional, and the function is preserved in this case. www.nature.com/articles/s41...
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine
A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.
www.nature.com
February 13, 2025 at 11:31 AM
“The connection between amyloid-β and tau pathology appears to be disrupted in this individual…”
The connection is functional, and the function is preserved in this case. www.nature.com/articles/s41...
The connection is functional, and the function is preserved in this case. www.nature.com/articles/s41...
I made some edits for people who think behavioral neurology should focus more on proteins then behavior:
January 29, 2025 at 3:12 PM
I made some edits for people who think behavioral neurology should focus more on proteins then behavior:
Reposted by David Jones
Episodic and associative memory from spatial scaffolds in the hippocampus rdcu.be/d7UYu - such cool work going on in computational neuroscience, connecting circuit designs to cognitive operations 👍
Episodic and associative memory from spatial scaffolds in the hippocampus
Nature - A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory...
rdcu.be
January 29, 2025 at 12:07 PM
Episodic and associative memory from spatial scaffolds in the hippocampus rdcu.be/d7UYu - such cool work going on in computational neuroscience, connecting circuit designs to cognitive operations 👍
