David Jones
@davidjonesbrain.bsky.social
Behavioral neurologist and AI director working to end degeneration of mental function and use technology to transform the practice of neurology.
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
September 16, 2025 at 6:45 PM
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
June 29, 2025 at 5:11 PM
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
10/
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
June 29, 2025 at 5:11 PM
10/
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
5/
Not all “Alzheimer’s” is the same.
Some patients have language-predominant, visual, or dysexecutive forms — each with different symptoms, prognosis, and response to therapy.
Others seem like AD, but aren’t. (We call these cases LANS.)
Precision matters.
#AD
@alzassociation.bsky.social
Not all “Alzheimer’s” is the same.
Some patients have language-predominant, visual, or dysexecutive forms — each with different symptoms, prognosis, and response to therapy.
Others seem like AD, but aren’t. (We call these cases LANS.)
Precision matters.
#AD
@alzassociation.bsky.social
June 29, 2025 at 5:11 PM
5/
Not all “Alzheimer’s” is the same.
Some patients have language-predominant, visual, or dysexecutive forms — each with different symptoms, prognosis, and response to therapy.
Others seem like AD, but aren’t. (We call these cases LANS.)
Precision matters.
#AD
@alzassociation.bsky.social
Not all “Alzheimer’s” is the same.
Some patients have language-predominant, visual, or dysexecutive forms — each with different symptoms, prognosis, and response to therapy.
Others seem like AD, but aren’t. (We call these cases LANS.)
Precision matters.
#AD
@alzassociation.bsky.social
4/
Take DLB (Dementia with Lewy Bodies). #DLB
DLB ≠ AD ≠ Parkinson’s ≠ PSP ≠ NPH ≠ MSA. But it’s easy to mistake.
A proper diagnosis changes everything. Don’t know how to do that?
Read this:
link.springer.com/article/10.1...
Take DLB (Dementia with Lewy Bodies). #DLB
DLB ≠ AD ≠ Parkinson’s ≠ PSP ≠ NPH ≠ MSA. But it’s easy to mistake.
A proper diagnosis changes everything. Don’t know how to do that?
Read this:
link.springer.com/article/10.1...
June 29, 2025 at 5:11 PM
4/
Take DLB (Dementia with Lewy Bodies). #DLB
DLB ≠ AD ≠ Parkinson’s ≠ PSP ≠ NPH ≠ MSA. But it’s easy to mistake.
A proper diagnosis changes everything. Don’t know how to do that?
Read this:
link.springer.com/article/10.1...
Take DLB (Dementia with Lewy Bodies). #DLB
DLB ≠ AD ≠ Parkinson’s ≠ PSP ≠ NPH ≠ MSA. But it’s easy to mistake.
A proper diagnosis changes everything. Don’t know how to do that?
Read this:
link.springer.com/article/10.1...
2/
One of the most striking examples?
🧠 Normal Pressure Hydrocephalus (NPH)
– Gait trouble
– Cognitive slowing
– Incontinence
It mimics other dementias. But it’s reversible.
If you miss the diagnosis, you miss the chance to help. #NPH
continuum.aan.com/doi/10.1212/...
One of the most striking examples?
🧠 Normal Pressure Hydrocephalus (NPH)
– Gait trouble
– Cognitive slowing
– Incontinence
It mimics other dementias. But it’s reversible.
If you miss the diagnosis, you miss the chance to help. #NPH
continuum.aan.com/doi/10.1212/...
June 29, 2025 at 5:11 PM
2/
One of the most striking examples?
🧠 Normal Pressure Hydrocephalus (NPH)
– Gait trouble
– Cognitive slowing
– Incontinence
It mimics other dementias. But it’s reversible.
If you miss the diagnosis, you miss the chance to help. #NPH
continuum.aan.com/doi/10.1212/...
One of the most striking examples?
🧠 Normal Pressure Hydrocephalus (NPH)
– Gait trouble
– Cognitive slowing
– Incontinence
It mimics other dementias. But it’s reversible.
If you miss the diagnosis, you miss the chance to help. #NPH
continuum.aan.com/doi/10.1212/...
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
June 29, 2025 at 5:11 PM
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
More accurate protein mapping:
January 29, 2025 at 3:51 PM
More accurate protein mapping:
I made some edits for people who think behavioral neurology should focus more on proteins then behavior:
January 29, 2025 at 3:12 PM
I made some edits for people who think behavioral neurology should focus more on proteins then behavior:
Another day as Doc4 quaternary referral after several tertiary evaluations found "some unknown degenerative condition" without doing a simple test for those. FDG-PET:
January 22, 2025 at 2:41 PM
Another day as Doc4 quaternary referral after several tertiary evaluations found "some unknown degenerative condition" without doing a simple test for those. FDG-PET:
Even more of Behavioral Neurology explained in one figure of FDG-PET data. Brain metabolism seems to give a key readout of fundamental neurobiology related to all degenerative diseases of the mind:
January 9, 2025 at 9:07 PM
Even more of Behavioral Neurology explained in one figure of FDG-PET data. Brain metabolism seems to give a key readout of fundamental neurobiology related to all degenerative diseases of the mind:
From the perspective of FDG, one would never mistake NPH (green nodes are patients with NPH) and PSP (maroon nodes). Given that expertise in this distinction is limited and 60 million people have dementia, FDG should be more widely used.
January 1, 2025 at 3:08 PM
From the perspective of FDG, one would never mistake NPH (green nodes are patients with NPH) and PSP (maroon nodes). Given that expertise in this distinction is limited and 60 million people have dementia, FDG should be more widely used.
I have been thinking about ecological psychology a lot lately.
December 12, 2024 at 9:10 AM
I have been thinking about ecological psychology a lot lately.
This is still far and above my favorite scientific conference poster photo! We have since been blessed with a third child (now 7 yo), so I have got to update this shot!
December 4, 2024 at 1:19 PM
This is still far and above my favorite scientific conference poster photo! We have since been blessed with a third child (now 7 yo), so I have got to update this shot!
Degenerative diseases carve the mind at its joints. Understanding the information contained in this plot of similarity between brain metabolism across degenerative diseases of mind should be a heavily funded priority.
November 28, 2024 at 4:02 AM
Degenerative diseases carve the mind at its joints. Understanding the information contained in this plot of similarity between brain metabolism across degenerative diseases of mind should be a heavily funded priority.
I use investigational AI in my practice right now and it works great! It is based on this information in FDG-PET scans.
November 25, 2024 at 1:19 AM
I use investigational AI in my practice right now and it works great! It is based on this information in FDG-PET scans.
Near purple/light green
November 22, 2024 at 4:58 PM
Near purple/light green
So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
November 20, 2024 at 12:56 AM
So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz
#Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz