Hugo Damstra
@damstra.bsky.social
Optical connectomics scientist at E11 Bio | Expansion microscopy tool developer
Reposted by Hugo Damstra
The E11 Bio team is headed to Society for Neuroscience #Sfn2025! Come talk circuit mapping, protein barcodes, expansion microscopy, and optical connectomics at our booth (#4015) and posters!
More info: e11.bio/sfn
Ask us about our reception!
More info: e11.bio/sfn
Ask us about our reception!
November 14, 2025 at 5:49 PM
The E11 Bio team is headed to Society for Neuroscience #Sfn2025! Come talk circuit mapping, protein barcodes, expansion microscopy, and optical connectomics at our booth (#4015) and posters!
More info: e11.bio/sfn
Ask us about our reception!
More info: e11.bio/sfn
Ask us about our reception!
Fantastic, very beautiful work! Great to see it out in the world, congrats!
Our new preprint is about the airway epithelium microtubule network, cilia, basal body protein composition, averaging of volumetric fluorescence data, and expansion microscopy.
Four years of very hard work from our very talented Emma van Grinsven. www.biorxiv.org/content/10.1... (1/N)
Four years of very hard work from our very talented Emma van Grinsven. www.biorxiv.org/content/10.1... (1/N)
September 5, 2025 at 4:43 PM
Fantastic, very beautiful work! Great to see it out in the world, congrats!
A new probe for actin compatible with ExM! Great work, congrats to all.
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
August 28, 2025 at 2:27 PM
A new probe for actin compatible with ExM! Great work, congrats to all.
Reposted by Hugo Damstra
E11 seeks a research associate with experience in fluorescence microscopy and tissue sectioning for our sample processing team. Work at a Focused Research Organization with great people, solid benefits, and tons of energy to complete the first mammalian connectome.
jobs.lever.co/convergentre...
jobs.lever.co/convergentre...
Convergent Research - E11 Bio - Research Assistant, Biological Sample Processing
E11 Bio is on a mission to reach a whole-brain human connectome. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a r...
jobs.lever.co
August 18, 2025 at 7:56 PM
E11 seeks a research associate with experience in fluorescence microscopy and tissue sectioning for our sample processing team. Work at a Focused Research Organization with great people, solid benefits, and tons of energy to complete the first mammalian connectome.
jobs.lever.co/convergentre...
jobs.lever.co/convergentre...
Reposted by Hugo Damstra
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
May 29, 2025 at 3:29 PM
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Reposted by Hugo Damstra
"Organizations like @hhmijanelia.bsky.social, the @arcinstitute.org, and a whole class of nonprofit start-ups called focused research organizations are instead using philanthropic dollars to build tools that could accelerate scientific progress."
www.nytimes.com/2025/03/19/o...
www.nytimes.com/2025/03/19/o...
Opinion | DOGE Needs a Different Playbook for Science
We need less administrative bloat in science.
www.nytimes.com
March 19, 2025 at 4:27 PM
"Organizations like @hhmijanelia.bsky.social, the @arcinstitute.org, and a whole class of nonprofit start-ups called focused research organizations are instead using philanthropic dollars to build tools that could accelerate scientific progress."
www.nytimes.com/2025/03/19/o...
www.nytimes.com/2025/03/19/o...
Reposted by Hugo Damstra
Can we treat brain disorders by restoring neural connections?
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
February 9, 2025 at 6:32 PM
Can we treat brain disorders by restoring neural connections?
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
Reposted by Hugo Damstra
Our work in connectomics is featured in @asimovpress.bsky.social! We’re building new tools to map the brain with greater precision and scale!
Can we treat brain disorders by restoring neural connections?
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
For centuries, neuroscientists could only guess. But connectomics—a method seeking to create a 3D model of every neural connection in the brain—is moving closer to providing answers.
E11 Bio is at the forefront...🧵
February 9, 2025 at 7:02 PM
Our work in connectomics is featured in @asimovpress.bsky.social! We’re building new tools to map the brain with greater precision and scale!
Reposted by Hugo Damstra
🚀 We are looking for Image Data Scientists to join our mission to advance connectomics towards whole brain scale for humans and other mammals (1/3) 🚀
February 5, 2025 at 9:34 PM
🚀 We are looking for Image Data Scientists to join our mission to advance connectomics towards whole brain scale for humans and other mammals (1/3) 🚀
Reposted by Hugo Damstra
‘Expansion microscopy’ turns ten: how a tissue-swelling method brought super-resolution imaging to the masses
@nature.com
@natureportfolio.bsky.social
🧪
www.nature.com/articles/d41...
@nature.com
@natureportfolio.bsky.social
🧪
www.nature.com/articles/d41...
‘Expansion microscopy’ turns ten: how a tissue-swelling method brought super-resolution imaging to the masses
A decade in, expansion microscopy is unlocking insights across biology and medicine.
www.nature.com
January 14, 2025 at 7:29 AM
‘Expansion microscopy’ turns ten: how a tissue-swelling method brought super-resolution imaging to the masses
@nature.com
@natureportfolio.bsky.social
🧪
www.nature.com/articles/d41...
@nature.com
@natureportfolio.bsky.social
🧪
www.nature.com/articles/d41...
Beautiful work @jpassmore.bsky.social!
For more details, check out the preprint www.biorxiv.org/content/10.1... - or ask anything here! (+here's a bonus movie that didn't quite make the cut) 🌀
December 17, 2024 at 9:00 PM
Beautiful work @jpassmore.bsky.social!
Reposted by Hugo Damstra
Expansion Microscopy is always amazing to me - here is a dividing U2OS cell expanded ~10X and imaged using a 25X objective! 🔬 A total protein stain using maleimide gives further context. #FluorescenceFriday
December 13, 2024 at 4:30 PM
Expansion Microscopy is always amazing to me - here is a dividing U2OS cell expanded ~10X and imaged using a 25X objective! 🔬 A total protein stain using maleimide gives further context. #FluorescenceFriday
Reposted by Hugo Damstra
Today we are sharing the progress we have made towards dramatically reducing the cost of whole-brain connectomes! We believe this is vital for unlocking new disease treatments and human-like AI. Extremely proud of the team we have built at E11 Bio🔥!
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 3, 2024 at 4:41 PM
Today we are sharing the progress we have made towards dramatically reducing the cost of whole-brain connectomes! We believe this is vital for unlocking new disease treatments and human-like AI. Extremely proud of the team we have built at E11 Bio🔥!
Reposted by Hugo Damstra
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 3, 2024 at 2:58 PM
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
Reposted by Hugo Damstra
Mapping and understanding the human brain is the path to AI safety! Check out @patrickmineault.bsky.social & Amaranth Foundation's roadmap, which includes our work at @e11bio.bsky.social
Excited to release what we’ve been working on at Amaranth Foundation, our latest whitepaper, NeuroAI for AI safety! A detailed, ambitious roadmap for how neuroscience research can help build safer AI systems while accelerating both virtual neuroscience and neurotech. 1/N
December 2, 2024 at 6:40 PM
Mapping and understanding the human brain is the path to AI safety! Check out @patrickmineault.bsky.social & Amaranth Foundation's roadmap, which includes our work at @e11bio.bsky.social