Cyrus Harmon
@cyrusharmon.bsky.social
CEO at Vilya @vilyatx.bsky.social where we use AI to design novel macrocycles. Founder, board member, and ex-CEO at Olema where we design and develop new drugs for breast cancer.
Earthquake! Small one, thankfully.
November 26, 2025 at 2:17 PM
Earthquake! Small one, thankfully.
Reposted by Cyrus Harmon
I don't know who this guy is (just a disclaimer, I guess), but this is a compelling and arithmetically straightforward explanation of the many predicaments the US finds itself in. Why upward mobility in America is a myth and class warfare is on the rise. Read it over your morning coffee.
Part 1: My Life Is a Lie
How a Broken Benchmark Quietly Broke America
www.yesigiveafig.com
November 26, 2025 at 12:19 PM
I don't know who this guy is (just a disclaimer, I guess), but this is a compelling and arithmetically straightforward explanation of the many predicaments the US finds itself in. Why upward mobility in America is a myth and class warfare is on the rise. Read it over your morning coffee.
Reposted by Cyrus Harmon
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
Reposted by Cyrus Harmon
Rapid De Novo Antibody Design with GeoFlow-V3 [new]
De novo antibody design: Uses a generative model that predicts structure and enables rapid, in silico design, significantly improving hit rates.
De novo antibody design: Uses a generative model that predicts structure and enables rapid, in silico design, significantly improving hit rates.
October 22, 2025 at 6:06 AM
Rapid De Novo Antibody Design with GeoFlow-V3 [new]
De novo antibody design: Uses a generative model that predicts structure and enables rapid, in silico design, significantly improving hit rates.
De novo antibody design: Uses a generative model that predicts structure and enables rapid, in silico design, significantly improving hit rates.
Reposted by Cyrus Harmon
#compchem New group preprint: "From Water Networks to Binding Affinities: Resolving Solvation Dynamics for Accurate Protein-Ligand Predictions"
👉Check it out: www.biorxiv.org/content/10.1...
Great work by M. Blazhynska.
#compbio #drugdesign
👉Check it out: www.biorxiv.org/content/10.1...
Great work by M. Blazhynska.
#compbio #drugdesign
October 22, 2025 at 5:27 AM
#compchem New group preprint: "From Water Networks to Binding Affinities: Resolving Solvation Dynamics for Accurate Protein-Ligand Predictions"
👉Check it out: www.biorxiv.org/content/10.1...
Great work by M. Blazhynska.
#compbio #drugdesign
👉Check it out: www.biorxiv.org/content/10.1...
Great work by M. Blazhynska.
#compbio #drugdesign
Reposted by Cyrus Harmon
Triangle Multiplication Is All You Need For Biomolecular Structure Representations [new]
Streamlined alternative to AlphaFold's pairwise reasoning, replacing triangle attention with Pairmixer, enabling faster, cheaper biomolecular structure prediction.
Streamlined alternative to AlphaFold's pairwise reasoning, replacing triangle attention with Pairmixer, enabling faster, cheaper biomolecular structure prediction.
October 22, 2025 at 5:31 AM
Triangle Multiplication Is All You Need For Biomolecular Structure Representations [new]
Streamlined alternative to AlphaFold's pairwise reasoning, replacing triangle attention with Pairmixer, enabling faster, cheaper biomolecular structure prediction.
Streamlined alternative to AlphaFold's pairwise reasoning, replacing triangle attention with Pairmixer, enabling faster, cheaper biomolecular structure prediction.
Spoiler alert… NYT with some minor shade.
October 11, 2025 at 6:38 PM
Spoiler alert… NYT with some minor shade.
Man, two fewer parking spots at Cal now?!?
October 8, 2025 at 3:20 PM
Man, two fewer parking spots at Cal now?!?
Reposted by Cyrus Harmon
This ought to be engraved somewhere.
September 23, 2025 at 2:56 AM
This ought to be engraved somewhere.
Yikes! That was a long one.
September 22, 2025 at 9:57 AM
Yikes! That was a long one.
Reposted by Cyrus Harmon
The New Yorker asked me “how bad” today’s Supreme Court ruling was. I boiled it down to one paragraph:
link.newyorker.com/view/5bda429...
link.newyorker.com/view/5bda429...
September 8, 2025 at 9:52 PM
The New Yorker asked me “how bad” today’s Supreme Court ruling was. I boiled it down to one paragraph:
link.newyorker.com/view/5bda429...
link.newyorker.com/view/5bda429...
I can’t wait for the day when we have a sane administration that pulls funds for all universities that don’t … switch to the metric system. I mean, why not at this point?
August 9, 2025 at 12:55 PM
I can’t wait for the day when we have a sane administration that pulls funds for all universities that don’t … switch to the metric system. I mean, why not at this point?
Reposted by Cyrus Harmon
The subway risk chart you've been waiting for (Sawyer County, Wisconsin, is where Sean Duffy is from). Gift link: www.bloomberg.com/opinion/arti...
July 21, 2025 at 1:23 PM
The subway risk chart you've been waiting for (Sawyer County, Wisconsin, is where Sean Duffy is from). Gift link: www.bloomberg.com/opinion/arti...
Reposted by Cyrus Harmon
Not only am I delighted to learn about the role of an Indigenous scholar in the creation of R, but doubly so to discover he wrote a paper arguing that a worthy successor to R should be built on top of Common Lisp! www.stat.auckland.ac.nz/%7Eihaka/dow...
July 19, 2025 at 9:18 PM
Not only am I delighted to learn about the role of an Indigenous scholar in the creation of R, but doubly so to discover he wrote a paper arguing that a worthy successor to R should be built on top of Common Lisp! www.stat.auckland.ac.nz/%7Eihaka/dow...
Perhaps this has been addressed elsewhere but my question re: grok is did they specifically tune it to go full Nazi or did they just relax the filters and let in learn from X posts? Honestly not sure which is worse.
July 10, 2025 at 11:59 AM
Perhaps this has been addressed elsewhere but my question re: grok is did they specifically tune it to go full Nazi or did they just relax the filters and let in learn from X posts? Honestly not sure which is worse.
Reposted by Cyrus Harmon
Punk rock kid buskers (‘The Whops’, tiktok) near the Edgware Rd. They run into Paul Simonon, play Death or Glory for him. He asks if they know The Guns of Brixton. They do -
June 15, 2025 at 1:13 PM
Punk rock kid buskers (‘The Whops’, tiktok) near the Edgware Rd. They run into Paul Simonon, play Death or Glory for him. He asks if they know The Guns of Brixton. They do -
Reposted by Cyrus Harmon
Seriously. You know who has *great* messaging? Cancer researchers! Literally curing cancer! Sells itself!
Still got fed to the DOGE woodchipper.
FEMA and the National Weather Service got fed to the DOGE woodchipper, too. Nobody thought poorly of them until the right did the thing they always do.
Still got fed to the DOGE woodchipper.
FEMA and the National Weather Service got fed to the DOGE woodchipper, too. Nobody thought poorly of them until the right did the thing they always do.
You hear this a lot on the left but it isn't true. USAID did not "fail to tell its story to Americans," the right targeted the agency with lies and misinformation.
Ultimately this narrative turns conservative attacks into even more calls for the left to reform.
www.nytimes.com/2025/06/29/o...
Ultimately this narrative turns conservative attacks into even more calls for the left to reform.
www.nytimes.com/2025/06/29/o...
June 30, 2025 at 4:39 PM
Seriously. You know who has *great* messaging? Cancer researchers! Literally curing cancer! Sells itself!
Still got fed to the DOGE woodchipper.
FEMA and the National Weather Service got fed to the DOGE woodchipper, too. Nobody thought poorly of them until the right did the thing they always do.
Still got fed to the DOGE woodchipper.
FEMA and the National Weather Service got fed to the DOGE woodchipper, too. Nobody thought poorly of them until the right did the thing they always do.
Reposted by Cyrus Harmon
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 5:20 PM
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Reposted by Cyrus Harmon
"Through the lens of his camera, Sebastião tirelessly fought for a more just, humane and ecological world"
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
‘I photographed the world’: the career of Sebastião Salgado – in pictures
The Brazilian photographer has died at 81, leaving behind a career filled with striking images taken around the world. ‘Through the lens of his camera, Sebastião tirelessly fought for a more just, hum...
www.theguardian.com
May 26, 2025 at 2:11 PM
"Through the lens of his camera, Sebastião tirelessly fought for a more just, humane and ecological world"
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
Reposted by Cyrus Harmon
Time to catch up on the past week’s news about science and medicine in the US. Whew. 1/10
May 1, 2025 at 11:50 PM
Time to catch up on the past week’s news about science and medicine in the US. Whew. 1/10
I was today years old when I learned what the collateral-bar rule is and what contumacious means.
April 16, 2025 at 9:37 PM
I was today years old when I learned what the collateral-bar rule is and what contumacious means.
Reposted by Cyrus Harmon
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design by @yehlincho.bsky.social @martinpacesa.bsky.social @sokrypton.org 🧶🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 7, 2025 at 7:01 AM
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design by @yehlincho.bsky.social @martinpacesa.bsky.social @sokrypton.org 🧶🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Cyrus Harmon
Thank you to the @proteinsociety.bsky.social for this honour and recognition of my contributions to protein science research, education, and service! The intersection of the three is why I love academia and how we make science better in the long term.
Party in SF in June!
Party in SF in June!
Our March newsletter is hot off the press and FULL of great information: our 2025 Award winners, our 2024 Best Paper winners, the introduction of our new Protein Society Fellows program, PS39 Symposium information, and MORE!
mailchi.mp/092ac32c4994...
mailchi.mp/092ac32c4994...
March 26, 2025 at 10:30 PM
Thank you to the @proteinsociety.bsky.social for this honour and recognition of my contributions to protein science research, education, and service! The intersection of the three is why I love academia and how we make science better in the long term.
Party in SF in June!
Party in SF in June!
Reposted by Cyrus Harmon
DHS Begins National Registry Of Duolingo Users
theonion.com/dhs-beg...
theonion.com/dhs-beg...
DHS Begins National Registry Of Duolingo Users
WASHINGTON—Warning that the highly suspicious individuals constituted a threat to the country’s safety and cultural unity, the U.S. Department of Homeland Security announced plans Monday to create a national registry of Duolingo users. “For unknown reasons, there are people in this country attempting to learn foreign languages ranging from Italian to Japanese, and we need […]
theonion.com
March 16, 2025 at 4:00 PM
DHS Begins National Registry Of Duolingo Users
theonion.com/dhs-beg...
theonion.com/dhs-beg...
Reposted by Cyrus Harmon
I think some in the Senate have convinced themselves that the backlash to folding will be limited to “the left” and therefore ignorable.
Those people are deeply and profoundly misreading the moment and the stakes.
Virtually every swing district House Dem walked the plank to vote NO for a reason.
Those people are deeply and profoundly misreading the moment and the stakes.
Virtually every swing district House Dem walked the plank to vote NO for a reason.
March 14, 2025 at 2:46 AM
I think some in the Senate have convinced themselves that the backlash to folding will be limited to “the left” and therefore ignorable.
Those people are deeply and profoundly misreading the moment and the stakes.
Virtually every swing district House Dem walked the plank to vote NO for a reason.
Those people are deeply and profoundly misreading the moment and the stakes.
Virtually every swing district House Dem walked the plank to vote NO for a reason.