Curtis McCloskey
@curtismccloskey.bsky.social
Assistant Professor Dept. Computational and Systems Bio, University of Pittsburgh + UPMC. Ovarian + breast cancer researcher. Views are my own. He/him 🏳️🌈
Reposted by Curtis McCloskey
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
November 10, 2025 at 6:15 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
Reposted by Curtis McCloskey
new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...
www.nature.com
November 6, 2025 at 7:42 AM
new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Curtis McCloskey
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Thrilled to see this study out today!! It was a true pleasure working on this story over the past few years led by brilliant collaborators in Manchester and Cambridge. Team science spanning clinical and basic science bringing us closer to breast cancer prevention for premenopausal women!
A MBC team has found that anti-progestin therapy could help prevent breast cancer before menopause.
The anti-progestin drug blocks progesterone’s effects, lowering breast density & reducing cells that can turn into aggressive triple-negative breast cancer.
Published in Nature doi.org/10.1038/s415...
The anti-progestin drug blocks progesterone’s effects, lowering breast density & reducing cells that can turn into aggressive triple-negative breast cancer.
Published in Nature doi.org/10.1038/s415...
Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...
doi.org
November 5, 2025 at 7:35 PM
Thrilled to see this study out today!! It was a true pleasure working on this story over the past few years led by brilliant collaborators in Manchester and Cambridge. Team science spanning clinical and basic science bringing us closer to breast cancer prevention for premenopausal women!
Reposted by Curtis McCloskey
connectomeDB2025: Quality matters!
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
October 31, 2025 at 11:21 PM
connectomeDB2025: Quality matters!
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
Reposted by Curtis McCloskey
Recent findings link participating in an exercise program with a lower risk of colon cancer returning, adding to the known benefits of physical activity, even if you are just starting now.
Physical Activity Linked to Lower Colon Cancer Recurrence | Cancer Today
Participating in an exercise program after treatment was associated with a reduced risk of recurrence in people diagnosed with colon cancer.
buff.ly
July 3, 2025 at 12:23 PM
Recent findings link participating in an exercise program with a lower risk of colon cancer returning, adding to the known benefits of physical activity, even if you are just starting now.
I'm excited to announce that my lab is looking to hire a motivated Postdoctoral Associate at the University of Pittsburgh and UPMC Hillman Cancer Center.
Interested in personalized prevention, therapeutics, and women's health research?
📢Learn more:
cfopitt.taleo.net/careersectio...
Interested in personalized prevention, therapeutics, and women's health research?
📢Learn more:
cfopitt.taleo.net/careersectio...
Post Doctoral Associate
Click the link provided to see the complete job description.
cfopitt.taleo.net
June 30, 2025 at 1:06 PM
I'm excited to announce that my lab is looking to hire a motivated Postdoctoral Associate at the University of Pittsburgh and UPMC Hillman Cancer Center.
Interested in personalized prevention, therapeutics, and women's health research?
📢Learn more:
cfopitt.taleo.net/careersectio...
Interested in personalized prevention, therapeutics, and women's health research?
📢Learn more:
cfopitt.taleo.net/careersectio...
Reposted by Curtis McCloskey
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 10:49 AM
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Reposted by Curtis McCloskey
Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....
April 23, 2025 at 10:22 PM
Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....
Reposted by Curtis McCloskey
I am excited to share our latest publication. A big thank you to all the co-authors for their invaluable contributions, and to my mentors for their guidance and support. I also appreciate the support from the #AACR
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
ERneg BCs originates from metabolic mechanisms involving the SOG and methionine pathways.
www.science.org
March 21, 2025 at 7:05 PM
I am excited to share our latest publication. A big thank you to all the co-authors for their invaluable contributions, and to my mentors for their guidance and support. I also appreciate the support from the #AACR
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...