Conan MacDougall
@conanmacdougall.bsky.social
Professor of Clinical Pharmacy @UCSFPharmacy, Infectious Diseases Pharmacist | Evidence-informed Instructional Design, Infectious Diseases Pharmacotherapy | Hiking, Backpacking, Boston Celtics Basketball
Reposted by Conan MacDougall
Excited to see the “Advances in Influenza Therapeutics” supplement out in @jidjournal.bsky.social - led by Fred Hayden and Rich Whitley, this supplement reviews what we know about antivirals and how they should be used for influenza.
academic.oup.com/jid/issue/23...
academic.oup.com/jid/issue/23...
Volume 232 Issue Supplement_3 | The Journal of Infectious Diseases | Oxford Academic
An official journal of the Infectious Diseases Society of America. Publishes research results on microbiology, immunology, and epidemiology; pathogenesis, diagnosis, and treatment of infectious diseas...
academic.oup.com
October 20, 2025 at 6:26 PM
Excited to see the “Advances in Influenza Therapeutics” supplement out in @jidjournal.bsky.social - led by Fred Hayden and Rich Whitley, this supplement reviews what we know about antivirals and how they should be used for influenza.
academic.oup.com/jid/issue/23...
academic.oup.com/jid/issue/23...
Come work as an ID pharmacist at @ucsfhealth.bsky.social! See the craziest cases, collaborate with the coolest pharmacists and physicians, teach trainees from pharmacy students to ID fellows!
sjobs.brassring.com/TGnewUI/Sear...
sjobs.brassring.com/TGnewUI/Sear...
Infectious Diseases Pharmacotherapy Specialist - University of California San Francisco - Job Details
Job Details: The Department of Pharmaceutical Services provides a full range of services for patients cared for by the Medi
sjobs.brassring.com
October 10, 2025 at 2:20 PM
Come work as an ID pharmacist at @ucsfhealth.bsky.social! See the craziest cases, collaborate with the coolest pharmacists and physicians, teach trainees from pharmacy students to ID fellows!
sjobs.brassring.com/TGnewUI/Sear...
sjobs.brassring.com/TGnewUI/Sear...
Reposted by Conan MacDougall
In OFID, Yuki Nakano and colleagues investigate the signals and characterize the clinical features of optic nerve disorders related to oxazolidinones using the FAERS database. https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaf520/8242009
Linezolid-related Optic Nerve Disorders: Insight from a Pharmacovigilance Analysis of the U.S. FDA Adverse Event Reporting System
AbstractObjective. Linezolid is a crucial oxazolidinone used to treat multidrug-resistant gram-positive infections; however, it is associated with optic ne
academic.oup.com
September 9, 2025 at 6:45 PM
In OFID, Yuki Nakano and colleagues investigate the signals and characterize the clinical features of optic nerve disorders related to oxazolidinones using the FAERS database. https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaf520/8242009
Reposted by Conan MacDougall
September 8, 2025 at 10:23 PM
Reposted by Conan MacDougall
feels significant that mass-market LLMs like ChatGPT are now capable of generating extensive natural-language dossiers about a given user's interests, location, preferences, identifying information, and more
simonwillison.net/2025/May/21/...
simonwillison.net/2025/May/21/...
I really don’t like ChatGPT’s new memory dossier
Last month ChatGPT got a major upgrade. As far as I can tell the closest to an official announcement was this tweet from @OpenAI: Starting today [April 10th 2025], memory …
simonwillison.net
September 4, 2025 at 7:50 PM
feels significant that mass-market LLMs like ChatGPT are now capable of generating extensive natural-language dossiers about a given user's interests, location, preferences, identifying information, and more
simonwillison.net/2025/May/21/...
simonwillison.net/2025/May/21/...
Reposted by Conan MacDougall
This paper has had such a journey that I feel compelled to share it. It started when our ID PharmD resident gave an in-service to @templeid.bsky.social as a 'how-to' use oral beta-lactams for systemic Gram-negative infections, then was submitted, turned down, 1/ academic.oup.com/ofid/article...
Navigating the Muddled Middle: A Case-Based Exploration of Oral β-Lactams for Systemic Gram-Negative Infections
We describe 3 common scenarios where oral β-lactams may be used for systemic gram-negative infections, and through a coupling of patient cases, we provide
academic.oup.com
September 3, 2025 at 5:55 PM
This paper has had such a journey that I feel compelled to share it. It started when our ID PharmD resident gave an in-service to @templeid.bsky.social as a 'how-to' use oral beta-lactams for systemic Gram-negative infections, then was submitted, turned down, 1/ academic.oup.com/ofid/article...
Normally a paper that concludes “Should you do X? It depends.” wouldn’t be at the top of my reading list but I think our (@jgpharmd.bsky.social, @emilylheil.bsky.social) new case-based paper on PO beta-lactams for GNRs highlights nuances & challenges generalizations academic.oup.com/ofid/article...
Navigating the Muddled Middle: A Case-Based Exploration of Oral β-Lactams for Systemic Gram-Negative Infections
We describe 3 common scenarios where oral β-lactams may be used for systemic gram-negative infections, and through a coupling of patient cases, we provide
academic.oup.com
September 3, 2025 at 5:49 PM
Normally a paper that concludes “Should you do X? It depends.” wouldn’t be at the top of my reading list but I think our (@jgpharmd.bsky.social, @emilylheil.bsky.social) new case-based paper on PO beta-lactams for GNRs highlights nuances & challenges generalizations academic.oup.com/ofid/article...
Reposted by Conan MacDougall
I wrote about the era of Mass Intelligence.
GPT-5 and Nano Banana are examples of how advanced AI is now making their way to many users, at scale, as both performance & efficiency keep improving. We are going to see a lot of weird things happening, all at once www.oneusefulthing.org/p/mass-intel...
GPT-5 and Nano Banana are examples of how advanced AI is now making their way to many users, at scale, as both performance & efficiency keep improving. We are going to see a lot of weird things happening, all at once www.oneusefulthing.org/p/mass-intel...
Mass Intelligence
From GPT-5 to nano banana: everyone is getting access to powerful AI
www.oneusefulthing.org
August 28, 2025 at 9:17 PM
I wrote about the era of Mass Intelligence.
GPT-5 and Nano Banana are examples of how advanced AI is now making their way to many users, at scale, as both performance & efficiency keep improving. We are going to see a lot of weird things happening, all at once www.oneusefulthing.org/p/mass-intel...
GPT-5 and Nano Banana are examples of how advanced AI is now making their way to many users, at scale, as both performance & efficiency keep improving. We are going to see a lot of weird things happening, all at once www.oneusefulthing.org/p/mass-intel...
Reposted by Conan MacDougall
Today, FDA approved seasonal covid vaccines for people 65+ and people with health conditions. I have updated my FAQ with more questions and answers from readers. www.forceofinfection.com/faq-on-fall-...
FAQ on Fall Vaccines
💡Looking for my 2025-2026 vaccine guide? Find it on Substack here. This page answers follow-up questions from readers.
Can doctors still prescribe the Covid-19 vaccine "off-label" to other patients w...
www.forceofinfection.com
August 28, 2025 at 12:34 AM
Today, FDA approved seasonal covid vaccines for people 65+ and people with health conditions. I have updated my FAQ with more questions and answers from readers. www.forceofinfection.com/faq-on-fall-...
Reposted by Conan MacDougall
CDC list of medical conditions associated w higher risk for severe COVID-19, you need 1 to to qualify for vaccines now:
-Cancer (solid or blood cancers)
-Cerebrovascular disease (e.g., stroke)
-Chronic kidney disease (any stage)
-Chronic liver disease (fatty liver, cirrhosis, autoimmune hepatitis)
-Cancer (solid or blood cancers)
-Cerebrovascular disease (e.g., stroke)
-Chronic kidney disease (any stage)
-Chronic liver disease (fatty liver, cirrhosis, autoimmune hepatitis)
The FDA has overhauled COVID-19 vaccine access. for 2025 updated Pfizer-BioNTech shots are approved only for:
– Adults 65+
– Ages 5–64 with at least one high-risk condition for severe COVID.
If you’re healthy and under 65, you’re no longer automatically eligible.
finance.yahoo.com/news/pfizer-...
– Adults 65+
– Ages 5–64 with at least one high-risk condition for severe COVID.
If you’re healthy and under 65, you’re no longer automatically eligible.
finance.yahoo.com/news/pfizer-...
Pfizer and BioNTech’s COMIRNATY® Receives U.S. FDA Approval for Adults 65 and Older and Individuals Ages 5 through 64 at Increased Risk for Severe COVID-19
The 2025-2026 COVID-19 vaccine formulation targets the SARS-CoV-2 sublineage LP.8.1, in line with FDA guidance to more closely match circulating strains1Shipping of the LP.8.1-adapted vaccine will beg...
finance.yahoo.com
August 27, 2025 at 6:59 PM
CDC list of medical conditions associated w higher risk for severe COVID-19, you need 1 to to qualify for vaccines now:
-Cancer (solid or blood cancers)
-Cerebrovascular disease (e.g., stroke)
-Chronic kidney disease (any stage)
-Chronic liver disease (fatty liver, cirrhosis, autoimmune hepatitis)
-Cancer (solid or blood cancers)
-Cerebrovascular disease (e.g., stroke)
-Chronic kidney disease (any stage)
-Chronic liver disease (fatty liver, cirrhosis, autoimmune hepatitis)
Finally a healthy reason for a second helping at Thanksgiving! Grab those Friday vaccine appointments while they last!
74% of Americans are overweight. That is a risk factor for severe COVID and thus qualifies you to get the now approved COVID vaccine booster shot this fall if you want it.
I figured I'd drop this pearl, for no reason at all.
I figured I'd drop this pearl, for no reason at all.
a close up of a man 's face with his eyes closed and his mouth open .
ALT: a close up of a man 's face with his eyes closed and his mouth open .
media.tenor.com
August 27, 2025 at 7:51 PM
Finally a healthy reason for a second helping at Thanksgiving! Grab those Friday vaccine appointments while they last!
Reposted by Conan MacDougall
𝗡𝗲𝘄 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗘𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻 𝗔𝗿𝘁𝗶𝗰𝗹𝗲!
Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and amplify the promise of AI. nej.md/47okmwr
Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and amplify the promise of AI. nej.md/47okmwr
August 20, 2025 at 10:01 PM
𝗡𝗲𝘄 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗘𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻 𝗔𝗿𝘁𝗶𝗰𝗹𝗲!
Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and amplify the promise of AI. nej.md/47okmwr
Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and amplify the promise of AI. nej.md/47okmwr
@jgpharmd.bsky.social we are definitely missing a good crossover opportunity for cover art for the next edition. I’ve attached a mockup here. I can’t help it who the readers will assume is whom.
August 2, 2025 at 10:29 PM
@jgpharmd.bsky.social we are definitely missing a good crossover opportunity for cover art for the next edition. I’ve attached a mockup here. I can’t help it who the readers will assume is whom.
Reposted by Conan MacDougall
OpenAI's study mode isn't perfect, but it is a step forward for a few reasons:
1) Shows labs taking educational use & misuse more seriously (Google also has LearnLM)
2) Addresses a key issue with trying to use AI in education - that AI gives answers rather than tutoring and helping
3) Easy to access
1) Shows labs taking educational use & misuse more seriously (Google also has LearnLM)
2) Addresses a key issue with trying to use AI in education - that AI gives answers rather than tutoring and helping
3) Easy to access
July 30, 2025 at 5:27 AM
OpenAI's study mode isn't perfect, but it is a step forward for a few reasons:
1) Shows labs taking educational use & misuse more seriously (Google also has LearnLM)
2) Addresses a key issue with trying to use AI in education - that AI gives answers rather than tutoring and helping
3) Easy to access
1) Shows labs taking educational use & misuse more seriously (Google also has LearnLM)
2) Addresses a key issue with trying to use AI in education - that AI gives answers rather than tutoring and helping
3) Easy to access
Reposted by Conan MacDougall
🔬 New study: Olorofim shows promise for patients with invasive fungal disease who have limited treatment options. The first antifungal in its class, it demonstrated good tolerability and encouraging outcomes.
Read more 👉 pubmed.ncbi.nlm.nih.gov/40541222/
#IFD #Olorofim #Antifungal
Read more 👉 pubmed.ncbi.nlm.nih.gov/40541222/
#IFD #Olorofim #Antifungal
Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study - PubMed
F2G.
pubmed.ncbi.nlm.nih.gov
July 16, 2025 at 12:30 PM
🔬 New study: Olorofim shows promise for patients with invasive fungal disease who have limited treatment options. The first antifungal in its class, it demonstrated good tolerability and encouraging outcomes.
Read more 👉 pubmed.ncbi.nlm.nih.gov/40541222/
#IFD #Olorofim #Antifungal
Read more 👉 pubmed.ncbi.nlm.nih.gov/40541222/
#IFD #Olorofim #Antifungal
Reposted by Conan MacDougall
It’s out! IDSA #cUTI guidelines 7/17/25. Now the fun begins….😌 #IDsky #AMSsky @idsainfo.bsky.social @sidpharm.bsky.social
www.idsociety.org/practice-gui...
www.idsociety.org/practice-gui...
complicated Urinary Tract Infection (cUTI) Guideline on Treatment and Management
www.idsociety.org
July 17, 2025 at 7:12 PM
It’s out! IDSA #cUTI guidelines 7/17/25. Now the fun begins….😌 #IDsky #AMSsky @idsainfo.bsky.social @sidpharm.bsky.social
www.idsociety.org/practice-gui...
www.idsociety.org/practice-gui...
Reposted by Conan MacDougall
The Challenges of Nocardia Susceptibility Testing and Inter-Species Susceptibility Patterns
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
The Challenges of Nocardia Susceptibility Testing and Inter-Species Susceptibility Patterns
doi.org
July 16, 2025 at 6:59 PM
The Challenges of Nocardia Susceptibility Testing and Inter-Species Susceptibility Patterns
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Conan MacDougall
It was a pleasure to work on this project with our ID pharmacist colleagues. AI has a lot of potential in this space, especially with the basic interpretation of data, but still needs human guidance to work through the complexities of patient management. Looking forward to doing more of this!
Evaluating chain-of-thought prompting in a GPT chatbot for BCID2 interpretation and stewardship: how does AI compare to human experts? | Antimicrobial Stewardship & Healthcare Epidemiology | Cambr...
Evaluating chain-of-thought prompting in a GPT chatbot for BCID2 interpretation and stewardship: how does AI compare to human experts? - Volume 5 Issue 1
www.cambridge.org
July 11, 2025 at 4:15 PM
It was a pleasure to work on this project with our ID pharmacist colleagues. AI has a lot of potential in this space, especially with the basic interpretation of data, but still needs human guidance to work through the complexities of patient management. Looking forward to doing more of this!
Reposted by Conan MacDougall
I wrote about "brain damage" from AI. Despite scary headlines, AI won't hurt you brain, but it can undermine your thinking and learning. Increasingly, however we are finding ways it can help us think and learn instead (some included prompt examples as well). www.oneusefulthing.org/p/against-br...
Against "Brain Damage"
AI can help, or hurt, our thinking
www.oneusefulthing.org
July 7, 2025 at 7:15 PM
I wrote about "brain damage" from AI. Despite scary headlines, AI won't hurt you brain, but it can undermine your thinking and learning. Increasingly, however we are finding ways it can help us think and learn instead (some included prompt examples as well). www.oneusefulthing.org/p/against-br...
Reposted by Conan MacDougall
🚨BREAKING: IDSA, along with AAP, APHA, ACP and others, has filed a lawsuit against HHS/Secretary Kennedy to stop unlawful changes to vaccine policy and defend public health.
We refuse to stand by while America’s public health safeguards are torn apart. bit.ly/4lm7UkW
We refuse to stand by while America’s public health safeguards are torn apart. bit.ly/4lm7UkW
July 7, 2025 at 5:19 PM
🚨BREAKING: IDSA, along with AAP, APHA, ACP and others, has filed a lawsuit against HHS/Secretary Kennedy to stop unlawful changes to vaccine policy and defend public health.
We refuse to stand by while America’s public health safeguards are torn apart. bit.ly/4lm7UkW
We refuse to stand by while America’s public health safeguards are torn apart. bit.ly/4lm7UkW
Reposted by Conan MacDougall
I've often wondered about this question--does a shorter duration of antibiotics spare the microbiome, or are any antibiotics bad for the microbiome
www.idsociety.org/science-spea...
www.idsociety.org/science-spea...
Shorter may be better, but how (and how much better)?
A study in OFID examined the impact of antibiotic duration on gut microbiome composition and antimicrobial resistance.
www.idsociety.org
July 5, 2025 at 9:12 PM
I've often wondered about this question--does a shorter duration of antibiotics spare the microbiome, or are any antibiotics bad for the microbiome
www.idsociety.org/science-spea...
www.idsociety.org/science-spea...
Reposted by Conan MacDougall
These recommended pediatric and adult vaccine schedules reflect ACIP guidance, and were archived on Feb 18, 2025.
🚨 If you- or your kids are behind for any reason, get caught up now.
Parents: cancer-preventing HPV vax is approved for all kids 9 yrs and up. Please don’t miss out on this protection.
🚨 If you- or your kids are behind for any reason, get caught up now.
Parents: cancer-preventing HPV vax is approved for all kids 9 yrs and up. Please don’t miss out on this protection.
June 10, 2025 at 9:50 PM
These recommended pediatric and adult vaccine schedules reflect ACIP guidance, and were archived on Feb 18, 2025.
🚨 If you- or your kids are behind for any reason, get caught up now.
Parents: cancer-preventing HPV vax is approved for all kids 9 yrs and up. Please don’t miss out on this protection.
🚨 If you- or your kids are behind for any reason, get caught up now.
Parents: cancer-preventing HPV vax is approved for all kids 9 yrs and up. Please don’t miss out on this protection.
Reposted by Conan MacDougall
The next #Communicable episode drops Monday, 19 May! CMI Comms editors @marcbonten.bsky.social @gurujosh.bsky.social @erinmccreary.bsky.social & @dremilymcd.bsky.social discuss key latebreaker trials presented at #ESCMIDGlobal & whether they should change your practice 🔍
#IDSky #MedSky #clinmicro
#IDSky #MedSky #clinmicro
May 15, 2025 at 10:45 AM
The next #Communicable episode drops Monday, 19 May! CMI Comms editors @marcbonten.bsky.social @gurujosh.bsky.social @erinmccreary.bsky.social & @dremilymcd.bsky.social discuss key latebreaker trials presented at #ESCMIDGlobal & whether they should change your practice 🔍
#IDSky #MedSky #clinmicro
#IDSky #MedSky #clinmicro
Reposted by Conan MacDougall
🆕🔥Systematic review and consensus guidelines for dose adjustments with many 🌟 Prof. Jason Roberts & Prof Manjunath P Pai
The pharmacokinetics of antibiotics in patients with obesity. #IDsky #EMIMCC
www.thelancet.com/journals/lan...
The pharmacokinetics of antibiotics in patients with obesity. #IDsky #EMIMCC
www.thelancet.com/journals/lan...
May 16, 2025 at 2:48 AM
🆕🔥Systematic review and consensus guidelines for dose adjustments with many 🌟 Prof. Jason Roberts & Prof Manjunath P Pai
The pharmacokinetics of antibiotics in patients with obesity. #IDsky #EMIMCC
www.thelancet.com/journals/lan...
The pharmacokinetics of antibiotics in patients with obesity. #IDsky #EMIMCC
www.thelancet.com/journals/lan...
Reposted by Conan MacDougall
such a joy to discuss PSSA/MSSA domains of SNAP. incredible work led by @gurujosh.bsky.social @steventong.bsky.social conversation w/ the fabulous @angelahuttner.bsky.social
joint effort @escmid.bsky.social Communicable & @sidpharm.bsky.social Breakpoints podcast
podcasts.apple.com/us/podcast/s...
joint effort @escmid.bsky.social Communicable & @sidpharm.bsky.social Breakpoints podcast
podcasts.apple.com/us/podcast/s...
SNAP Out of It: Rethinking Antistaphylococcal Penicillins for S. Aureus Bacteremia – The SNAP Trial PSSA/MSSA Results
Podcast Episode · Breakpoints · 05/04/2025 · 1h 11m
podcasts.apple.com
May 5, 2025 at 4:08 PM
such a joy to discuss PSSA/MSSA domains of SNAP. incredible work led by @gurujosh.bsky.social @steventong.bsky.social conversation w/ the fabulous @angelahuttner.bsky.social
joint effort @escmid.bsky.social Communicable & @sidpharm.bsky.social Breakpoints podcast
podcasts.apple.com/us/podcast/s...
joint effort @escmid.bsky.social Communicable & @sidpharm.bsky.social Breakpoints podcast
podcasts.apple.com/us/podcast/s...