Coloff Lab
@colofflab.com
We study cancer and metabolism at the University of Illinois College of Medicine and University of Illinois Cancer Center.
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Coloff Lab
@colofflab.com
· Apr 26
Hi everyone! My name is Lina Lietuvninkas and I’m a second year graduate student in the Coloff lab 👩🔬 Jon gave me access to this account so many of the posts will be from me. Let’s see how long it takes for him to regret this!!
Had a lovely time talking science with our peers at #MidwestMetabolism - until next year!! @palpurab.bsky.social @vipinrawat482.bsky.social @meteozgurses.bsky.social
November 12, 2025 at 6:02 PM
Had a lovely time talking science with our peers at #MidwestMetabolism - until next year!! @palpurab.bsky.social @vipinrawat482.bsky.social @meteozgurses.bsky.social
If you’re at the Midwest Metabolism Meeting, make sure you stop by our posters! We have 6 lab members presenting today @meteozgurses.bsky.social @vipinrawat482.bsky.social @palpurab.bsky.social @juliannasupplee.bsky.social @linalietuv.bsky.social
November 10, 2025 at 2:10 PM
If you’re at the Midwest Metabolism Meeting, make sure you stop by our posters! We have 6 lab members presenting today @meteozgurses.bsky.social @vipinrawat482.bsky.social @palpurab.bsky.social @juliannasupplee.bsky.social @linalietuv.bsky.social
Reposted by Coloff Lab
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
www.nature.com
November 5, 2025 at 4:11 PM
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Coloff Lab
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 28, 2025 at 4:25 PM
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Working on some very important, very serious experimental procedures…
October 23, 2025 at 5:59 PM
Working on some very important, very serious experimental procedures…
@thermofishersci.bsky.social vendor show today 🤪 can you guess who unwillingly stood for the picture????
September 25, 2025 at 6:07 PM
@thermofishersci.bsky.social vendor show today 🤪 can you guess who unwillingly stood for the picture????
Latest lab photo from celebrating Dr. Coloff’s birthday earlier this month!!!! 🥳
September 25, 2025 at 6:03 PM
Latest lab photo from celebrating Dr. Coloff’s birthday earlier this month!!!! 🥳
Congrats to @meteozgurses.bsky.social for being selected to present his work at Chicago Mass Spec Day last month!!
September 20, 2025 at 8:51 PM
Congrats to @meteozgurses.bsky.social for being selected to present his work at Chicago Mass Spec Day last month!!
Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.18.670862v1
August 22, 2025 at 4:54 PM
Reposted by Coloff Lab
Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.18.670862v1
August 22, 2025 at 4:48 PM
Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.18.670862v1
The Hormone Dependent Cancer Gordon Research Conference got a sneak peak at Purab’s new work before it hits the journals - watch this space, publication dropping soon!!!! 👀 @palpurab.bsky.social
August 15, 2025 at 12:34 AM
The Hormone Dependent Cancer Gordon Research Conference got a sneak peak at Purab’s new work before it hits the journals - watch this space, publication dropping soon!!!! 👀 @palpurab.bsky.social
Even MORE exciting Coloff lab news!!! 🥳 after graduating with her PhD from Penn, @juliannasupplee.bsky.social has moved to Chicago to continue her work in cancer lipid metabolism with us as a postdoc!!! Welcome Julianna!!! 🤩
August 13, 2025 at 7:13 PM
Even MORE exciting Coloff lab news!!! 🥳 after graduating with her PhD from Penn, @juliannasupplee.bsky.social has moved to Chicago to continue her work in cancer lipid metabolism with us as a postdoc!!! Welcome Julianna!!! 🤩
Reposted by Coloff Lab
Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
moffitt-cancer-center-careers.hctsportals.com
August 12, 2025 at 1:11 PM
Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
We also have to give a shoutout to @linalietuv.bsky.social for completing her preliminary exam!! She will now enter the next phase of her program: PhD candidacy 😱
August 10, 2025 at 4:37 PM
We also have to give a shoutout to @linalietuv.bsky.social for completing her preliminary exam!! She will now enter the next phase of her program: PhD candidacy 😱
EXCITING COLOFF LAB NEWS: Philippa successfully defended her thesis, “Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins,” last month and is officially Dr. Burns!!! Congratulations Philippa!! 🍾
August 10, 2025 at 4:24 PM
EXCITING COLOFF LAB NEWS: Philippa successfully defended her thesis, “Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins,” last month and is officially Dr. Burns!!! Congratulations Philippa!! 🍾
We had the pleasure of hosting Christian Guerrero, a high school student part of @uicancercenter.bsky.social CHESS program, for several weeks this summer. Thank you Christian for your curiosity and hard work, and we can’t wait to see what you do in your future!!
August 6, 2025 at 8:50 PM
We had the pleasure of hosting Christian Guerrero, a high school student part of @uicancercenter.bsky.social CHESS program, for several weeks this summer. Thank you Christian for your curiosity and hard work, and we can’t wait to see what you do in your future!!
Reposted by Coloff Lab
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
July 14, 2025 at 10:21 AM
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Reposted by Coloff Lab
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was
told that if you wanted to go to medical school, you should learn to speak German.
This was because in the late 19th ...
www.amjmed.com
April 18, 2025 at 10:54 AM
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Congrats to Rushika and Gilles on this really cool work!
Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41...
full text available here 👉 rdcu.be/em0VG and thread 👇
full text available here 👉 rdcu.be/em0VG and thread 👇
May 21, 2025 at 9:14 PM
Congrats to Rushika and Gilles on this really cool work!
Reposted by Coloff Lab
1/3
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
May 6, 2025 at 11:22 PM
1/3
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
Reposted by Coloff Lab
Coloff lab 🤝 AACR
May 1, 2025 at 4:18 PM
Coloff lab 🤝 AACR
Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social
April 29, 2025 at 5:35 PM
Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social
Make sure to stop by our resident ceramide nerd’s poster tomorrow between 9-12!
April 28, 2025 at 11:19 PM
Make sure to stop by our resident ceramide nerd’s poster tomorrow between 9-12!
