Chris McGinnis
@cmcginnis.bsky.social
Cancer immunology, metastasis, TME, single-cell genomics | Postdoc Satpathy Lab Stanford | PhD Gartner Lab UCSF
Reposted by Chris McGinnis
🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
August 25, 2025 at 10:00 PM
🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Reposted by Chris McGinnis
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
Protein language models reveal evolutionary constraints on synonymous codon choice
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...
www.biorxiv.org
August 7, 2025 at 8:29 AM
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
Reposted by Chris McGinnis
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host
B cells and drive B cell proliferation and differentiation. These Th17 cells require
B cells for sustained immunit...
www.cell.com
July 25, 2025 at 2:51 PM
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Reposted by Chris McGinnis
🚨🚨 We're hiring! 🚨🚨
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.
June 23, 2025 at 8:27 PM
🚨🚨 We're hiring! 🚨🚨
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.
Reposted by Chris McGinnis
❗How can a cancer exploit its environment and still resist treatment?
✅The answer: co-existing malignant subclones.
Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵
doi.org/10.1158/2159...
✅The answer: co-existing malignant subclones.
Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵
doi.org/10.1158/2159...
June 19, 2025 at 11:31 AM
❗How can a cancer exploit its environment and still resist treatment?
✅The answer: co-existing malignant subclones.
Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵
doi.org/10.1158/2159...
✅The answer: co-existing malignant subclones.
Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵
doi.org/10.1158/2159...
Reposted by Chris McGinnis
Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇
🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 2, 2025 at 9:02 AM
Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇
Reposted by Chris McGinnis
Register for our next ECLC webinar by Marco Montagner, PhD on Understanding the determinants of the invisible phase of metastasis - June 26th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - tinyurl.com/ujer8yw8
June 3, 2025 at 1:17 PM
Register for our next ECLC webinar by Marco Montagner, PhD on Understanding the determinants of the invisible phase of metastasis - June 26th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - tinyurl.com/ujer8yw8
Reposted by Chris McGinnis
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos
Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...
www.biorxiv.org
June 2, 2025 at 4:13 PM
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
Reposted by Chris McGinnis
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 3, 2025 at 12:11 AM
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chris McGinnis
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
May 23, 2025 at 8:53 PM
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
Reposted by Chris McGinnis
Meet the MRS presidents! Dr. Dihua Yu is the Hubert L. & Olive Stringer Chair of Molecular and Cellular Oncology @mdanderson.bsky.social and served as the Metastasis Research Society’s president from 2018-2020.
We interviewed Dr Yu about her research and involvement with the society 🧵…
We interviewed Dr Yu about her research and involvement with the society 🧵…
May 20, 2025 at 3:40 PM
Meet the MRS presidents! Dr. Dihua Yu is the Hubert L. & Olive Stringer Chair of Molecular and Cellular Oncology @mdanderson.bsky.social and served as the Metastasis Research Society’s president from 2018-2020.
We interviewed Dr Yu about her research and involvement with the society 🧵…
We interviewed Dr Yu about her research and involvement with the society 🧵…
Reposted by Chris McGinnis
Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨
I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature
Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...
www.nature.com
May 14, 2025 at 5:12 PM
Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨
Reposted by Chris McGinnis
Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here lnkd.in/gfJKJ_RT...
May 12, 2025 at 1:25 PM
Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here lnkd.in/gfJKJ_RT...
Reposted by Chris McGinnis
Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here us02web.zoom.us/webinar/regi...
May 2, 2025 at 6:41 PM
Don't miss the next ECLC webinar by Christine Desmedt, PhD on Opportunities of post-mortem tissue donation programs to advance metastatic cancer research - May 19th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - Register here us02web.zoom.us/webinar/regi...
Reposted by Chris McGinnis
New publication in @cp-cancercell.bsky.social from our Skin Cancer and Ageing group led by Dr Amaya Viros, with first author Shilpa Gurung explains the question of age-related #metastasis in #melanoma
For a full-write up & link to #CancerCell paper here:
www.cruk.manchester.ac.uk/news/institu...
For a full-write up & link to #CancerCell paper here:
www.cruk.manchester.ac.uk/news/institu...
May 1, 2025 at 1:53 PM
New publication in @cp-cancercell.bsky.social from our Skin Cancer and Ageing group led by Dr Amaya Viros, with first author Shilpa Gurung explains the question of age-related #metastasis in #melanoma
For a full-write up & link to #CancerCell paper here:
www.cruk.manchester.ac.uk/news/institu...
For a full-write up & link to #CancerCell paper here:
www.cruk.manchester.ac.uk/news/institu...
Reposted by Chris McGinnis
Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!
April 29, 2025 at 3:24 PM
Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!
Reposted by Chris McGinnis
Multi-cellular phenotypic dynamics during the progression of breast tumors https://www.biorxiv.org/content/10.1101/2025.04.16.649085v1
April 29, 2025 at 2:38 PM
Multi-cellular phenotypic dynamics during the progression of breast tumors https://www.biorxiv.org/content/10.1101/2025.04.16.649085v1
Reposted by Chris McGinnis
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 21, 2025 at 7:21 PM
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Reposted by Chris McGinnis
Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy https://www.biorxiv.org/content/10.1101/2025.04.16.649000v1
April 18, 2025 at 11:47 PM
Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy https://www.biorxiv.org/content/10.1101/2025.04.16.649000v1
Catch the @metastasisresearch.bsky.social webinar with Dr. Casanova-Acebes — in ~1hr!!
Don't miss out on our next webinar as Dr. Maria Casanova-Acebes @casanova-acebes.bsky.social @cniostopcancer.bsky.social discusses her work on "TREM1-ing-metastasis lung immunity" - April 8th - 10:00 EST | 16:00 CET | 00:00 AEDT
Sign-up today! us02web.zoom.us/webinar/register/WN_tVSpK...
Sign-up today! us02web.zoom.us/webinar/register/WN_tVSpK...
April 8, 2025 at 12:49 PM
Catch the @metastasisresearch.bsky.social webinar with Dr. Casanova-Acebes — in ~1hr!!
check out Daphne's (@dasuperville.bsky.social) updated DECIPHER-seq package for compatibility with Seurat v5 -- extremely useful for analyzing multi-sample sc omics datasets
Running NMF on your scRNAseq data? Check out my updates to Lyndsay Murrow's DECIPHER-seq package, now compatible with Seurat v5 objects and rliger v2! github.com/dasuperville...
GitHub - dasuperville/DECIPHER-seq-v2: Data and code to reproduce results from DECIPHER-seq paper. Updated for use with Seurat v5 objects and rLiger v2.
Data and code to reproduce results from DECIPHER-seq paper. Updated for use with Seurat v5 objects and rLiger v2. - dasuperville/DECIPHER-seq-v2
github.com
April 7, 2025 at 7:49 PM
check out Daphne's (@dasuperville.bsky.social) updated DECIPHER-seq package for compatibility with Seurat v5 -- extremely useful for analyzing multi-sample sc omics datasets
Reposted by Chris McGinnis
🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org
April 7, 2025 at 11:24 AM
🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org
Reposted by Chris McGinnis
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor
immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide
MHC presentation, increasin...
www.cell.com
March 27, 2025 at 11:45 PM
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Reposted by Chris McGinnis
Online Now: Translation dysregulation in cancer as a source for targetable antigens
Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasing both tumor immunogenicity and sensitivity to ICB therapy. TYW2 expression levels in patients with melanoma predict clinical outcomes, highlighting translation regulatory factors as immunotherapy targets.
dlvr.it
March 27, 2025 at 6:51 PM
Online Now: Translation dysregulation in cancer as a source for targetable antigens
Reposted by Chris McGinnis
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
March 27, 2025 at 3:49 PM
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)