Yardena Samuels
@yardenasamuels.bsky.social
Professor, Weizmann Institute
Director, Moross Integrated Cancer Center
President, European Association for Cancer Research
Director, Moross Integrated Cancer Center
President, European Association for Cancer Research
Thanks Johanna
Opening of the EACR congress in Lisbon by our wonderful president, Yardena Samuels
#EACR2025
@helloeacr.bsky.social
@yardenasamuels.bsky.social
#EACR2025
@helloeacr.bsky.social
@yardenasamuels.bsky.social
June 16, 2025 at 11:07 PM
Thanks Johanna
Reposted by Yardena Samuels
EACR President @yardenasamuels.bsky.social delivers the #EACR2025 Opening Address!
June 16, 2025 at 3:11 PM
EACR President @yardenasamuels.bsky.social delivers the #EACR2025 Opening Address!
Reposted by Yardena Samuels
@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!
June 16, 2025 at 4:08 PM
@yardenasamuels.bsky.social opening #EACR2025! Amazing grace! @eacr.org is very lucky to have Yardena as its president!
Reposted by Yardena Samuels
Targeting the Cancer Ecosystem: Presenters addressed microenvironmental and host-level changes that accompany tumor progression during an #AACR25 Plenary Session. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/fourth-... @yardenasamuels.bsky.social
May 14, 2025 at 11:24 AM
Targeting the Cancer Ecosystem: Presenters addressed microenvironmental and host-level changes that accompany tumor progression during an #AACR25 Plenary Session. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/fourth-... @yardenasamuels.bsky.social
Thanks #AACR25 for the huge honor!
Proud of @yardenasamuels.bsky.social for her fascinating plenary session at the @theaacr.bsky.social annual meeting in Chicago! A great thank you to the program committee chairs, Drs. Matthew Vander Heiden and Lillian Siu for this opportunity. @mvhlab.bsky.social @lilliansiu.bsky.social #AACR25
April 29, 2025 at 3:47 PM
Thanks #AACR25 for the huge honor!
Thanks AACR25 this has been an amazing honor
April 29, 2025 at 3:36 PM
Thanks AACR25 this has been an amazing honor
Reposted by Yardena Samuels
Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Translation dysregulation in cancer as a source for targetable antigens
Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized…
www.sciencedirect.com
April 29, 2025 at 8:25 AM
Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!
April 29, 2025 at 3:24 PM
Thank you AACR25 for inviting me to give a plenary talk this morning! An absolute honor!
Reposted by Yardena Samuels
Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social @yardenasamuels.bsky.social
April 2, 2025 at 3:55 PM
Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social @yardenasamuels.bsky.social
Reposted by Yardena Samuels
With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!
March 29, 2025 at 1:18 AM
With great collaborators @wellerchen.bsky.social @yardenasamuels.bsky.social and many others!
Reposted by Yardena Samuels
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor
immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide
MHC presentation, increasin...
www.cell.com
March 27, 2025 at 11:45 PM
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Thanks Chris! @cmcginnis.bsky.social
great working with you-looking forward to many more collaborations!
great working with you-looking forward to many more collaborations!
Thrilled to see our paper out today in @cp-cancercell.bsky.social — in collaboration with @yardenasamuels.bsky.social @wellerchen.bsky.social and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here
March 27, 2025 at 7:20 PM
Thanks Chris! @cmcginnis.bsky.social
great working with you-looking forward to many more collaborations!
great working with you-looking forward to many more collaborations!
thanks Panos!
Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
March 27, 2025 at 7:18 PM
thanks Panos!
and all our amazing collaborators H. Palashati, D. Malko, M.D. Shmueli, P. Poulis, M.J. Zemanek, M.M. Nielsen, A. Khatib, Y. Levin, Y. Pilpel, M. Rodnina, J. Cox, Y. Merbl, F. Erhard, T. Suzuki, A.R. Buskirk and whole team!
March 27, 2025 at 3:50 PM
and all our amazing collaborators H. Palashati, D. Malko, M.D. Shmueli, P. Poulis, M.J. Zemanek, M.M. Nielsen, A. Khatib, Y. Levin, Y. Pilpel, M. Rodnina, J. Cox, Y. Merbl, F. Erhard, T. Suzuki, A.R. Buskirk and whole team!
✨ We are thankful to the @CancerCell editorial team and the reviewers for their constructive comments, and I am grateful to have such a wonderful team. (7/7)
March 27, 2025 at 3:50 PM
✨ We are thankful to the @CancerCell editorial team and the reviewers for their constructive comments, and I am grateful to have such a wonderful team. (7/7)
🏥 Patient data completed the picture: Primary melanoma tumors with low TYW2 showed enhanced responses to ICB, even in patients with low TMB (@Tiangen). Translation fidelity defects may help predict immunotherapy responders, opening new paths for precision cancer treatment. (6/7)
March 27, 2025 at 3:50 PM
🏥 Patient data completed the picture: Primary melanoma tumors with low TYW2 showed enhanced responses to ICB, even in patients with low TMB (@Tiangen). Translation fidelity defects may help predict immunotherapy responders, opening new paths for precision cancer treatment. (6/7)
Together with Yaron Carmi, we identified FS peptides that triggered robust T cell responses. Moreover, these peptides elicited de novo T cell responses specifically in TYW2-KO tumor-bearing mice! (5/7)
March 27, 2025 at 3:49 PM
Together with Yaron Carmi, we identified FS peptides that triggered robust T cell responses. Moreover, these peptides elicited de novo T cell responses specifically in TYW2-KO tumor-bearing mice! (5/7)
🐭 In mice, TYW2 loss increased tumor immunogenicity, specifically in immunocompetent mice. scRNA-seq revealed that TYW2-KO tumors were enriched for exhausted T cells. Indeed, TYW2-KO tumor-bearing mice were sensitive to immune checkpoint blockade (ICB) therapy.
March 27, 2025 at 3:49 PM
🐭 In mice, TYW2 loss increased tumor immunogenicity, specifically in immunocompetent mice. scRNA-seq revealed that TYW2-KO tumors were enriched for exhausted T cells. Indeed, TYW2-KO tumor-bearing mice were sensitive to immune checkpoint blockade (ICB) therapy.
Furthermore, in vitro T cell stimulation assays (@Johannaolweus & team) demonstrated that these aberrant peptides are potent immune triggers! Could translation errors fuel anti-tumor immunity? (3/7)
March 27, 2025 at 3:49 PM
Furthermore, in vitro T cell stimulation assays (@Johannaolweus & team) demonstrated that these aberrant peptides are potent immune triggers! Could translation errors fuel anti-tumor immunity? (3/7)
🧬 Loss of TYW2, a tRNA modifier, disrupts translation fidelity—causing ribosomes to pause at Phe codons and increasing frameshift (FS) events. This generates out-of-frame peptides, which are presented by MHC class I molecules. (2/7)
March 27, 2025 at 3:49 PM
🧬 Loss of TYW2, a tRNA modifier, disrupts translation fidelity—causing ribosomes to pause at Phe codons and increasing frameshift (FS) events. This generates out-of-frame peptides, which are presented by MHC class I molecules. (2/7)
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
March 27, 2025 at 3:49 PM
Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)
Reposted by Yardena Samuels
Fabulous group photos from our recent conference in Athens !🎉 #MICC2025 Please feel free to share and tag :)
@peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social
@peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social
March 23, 2025 at 7:38 AM
Fabulous group photos from our recent conference in Athens !🎉 #MICC2025 Please feel free to share and tag :)
@peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social
@peeperlab.bsky.social @yardenasamuels.bsky.social @leeat-keren.bsky.social @rongfan8.bsky.social @shouval.bsky.social @yogogurt.bsky.social @eriksahailab.bsky.social
