Chiara Falcomatà
@chiarafalcomata.bsky.social
Postdoc in Brown lab (Mount Sinai) | Pancreatic cancer researcher - passionate about tumor microenvironment and immunology
Reposted by Chiara Falcomatà
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level
Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...
rdcu.be
October 17, 2025 at 5:16 PM
Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs
🚨 Our new #preprint is out!
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org
June 18, 2025 at 1:29 PM
🚨 Our new #preprint is out!
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
doi.org/10.1101/2025...
We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
Reposted by Chiara Falcomatà
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
February 18, 2025 at 9:37 AM
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
Reposted by Chiara Falcomatà
Immunology will be for everyone, everywhere, everyday, from driving foundational research to reaping the benefits for health.
🌎 Immunoschool 2025 is open for anyone looking to learn more about key immunotherapy advances over the last decade.
FREE TO REGISTER: www.eventbrite.com/e/internatio...
🌎 Immunoschool 2025 is open for anyone looking to learn more about key immunotherapy advances over the last decade.
FREE TO REGISTER: www.eventbrite.com/e/internatio...
International Course of Immunotherapy March 10-12, 2025
Eventbrite - Precision Immunology Institute at the Icahn School of Medicine presents International Course of Immunotherapy March 10-12, 2025 - Monday, March 10, 2025 | Wednesday, March 12, 2025 - Find...
www.eventbrite.com
January 28, 2025 at 7:32 PM
Immunology will be for everyone, everywhere, everyday, from driving foundational research to reaping the benefits for health.
🌎 Immunoschool 2025 is open for anyone looking to learn more about key immunotherapy advances over the last decade.
FREE TO REGISTER: www.eventbrite.com/e/internatio...
🌎 Immunoschool 2025 is open for anyone looking to learn more about key immunotherapy advances over the last decade.
FREE TO REGISTER: www.eventbrite.com/e/internatio...
Reposted by Chiara Falcomatà
The incidence of early-onset colorectal #cancer is surging
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
February 6, 2025 at 8:26 PM
The incidence of early-onset colorectal #cancer is surging
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
By 2030, 1/3 of all CRCs will occur before the typical recommended screening age of 50 years
In this #Cell commentary, Mauri et al. discuss the potential causes 🧪- and the importance of determining "tumor age"
www.cell.com/cell/fulltex...
Reposted by Chiara Falcomatà
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Ovarian cancer-derived IL-4 promotes immunotherapy resistance
Cancer-derived paracrine factors create distinct “neighborhoods” in the tumor microenvironment,
promoting clonal selection and tumor heterogeneity. In ovarian cancer, IL-4 originating
from a minority ...
www.cell.com
January 15, 2025 at 5:34 PM
First lab Bluesky post! Happy to share new papers:
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
PRINT: Using Perturb-map, we show in @cellpress.bsky.social how ovarian tumors resist immunotherapy > www.cell.com/cell/abstrac...
PREPRINT We developed a new technology to easily generate cell-targeted LNP-RNA > www.biorxiv.org/content/10.1...
Reposted by Chiara Falcomatà
I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma - Nature Biomedical Engineering
Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.
www.nature.com
December 10, 2024 at 3:28 PM
I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
Reposted by Chiara Falcomatà
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
Reposted by Chiara Falcomatà
#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
November 27, 2024 at 5:38 PM
#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...
Reposted by Chiara Falcomatà
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
November 23, 2024 at 9:52 PM
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW