Chiara Falcomatà
@chiarafalcomata.bsky.social
Postdoc in Brown lab (Mount Sinai) | Pancreatic cancer researcher - passionate about tumor microenvironment and immunology
Deleting Serpine1 or Serpinb2:
✓ Remodels the ECM
✓ Reduces immunosuppressive macrophage accumulation
✓ Permits T cell infiltration
✓ Synergizes with anti-PD-1 immunotherapy, increasing survival
(6/8)
✓ Remodels the ECM
✓ Reduces immunosuppressive macrophage accumulation
✓ Permits T cell infiltration
✓ Synergizes with anti-PD-1 immunotherapy, increasing survival
(6/8)
June 18, 2025 at 1:29 PM
Deleting Serpine1 or Serpinb2:
✓ Remodels the ECM
✓ Reduces immunosuppressive macrophage accumulation
✓ Permits T cell infiltration
✓ Synergizes with anti-PD-1 immunotherapy, increasing survival
(6/8)
✓ Remodels the ECM
✓ Reduces immunosuppressive macrophage accumulation
✓ Permits T cell infiltration
✓ Synergizes with anti-PD-1 immunotherapy, increasing survival
(6/8)
We applied Perturb-map (Dhainaut et al., Cell 2022) to perform a spatial CRISPR screen of extracellular factors in orthotopic PDAC models.
This let us track over space and time:
✓ Clonal selection
✓ TME remodeling
✓ Immune reprogramming
(4/8)
This let us track over space and time:
✓ Clonal selection
✓ TME remodeling
✓ Immune reprogramming
(4/8)
June 18, 2025 at 1:29 PM
We applied Perturb-map (Dhainaut et al., Cell 2022) to perform a spatial CRISPR screen of extracellular factors in orthotopic PDAC models.
This let us track over space and time:
✓ Clonal selection
✓ TME remodeling
✓ Immune reprogramming
(4/8)
This let us track over space and time:
✓ Clonal selection
✓ TME remodeling
✓ Immune reprogramming
(4/8)