Chengyuan Wu | Lightnews

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Sep 18

🚨 New preprint! Great work lead by @neuroanup.bsky.social: insular traveling waves that shape memory. 🧠🌊
The insula isn’t just along for the ride—it helps direct the flow.

🧵Check out the thread below for more details 👇

#Neuroscience #Memory

Anup Das, PhD @neuroanup.bsky.social · Sep 18

1/7 New preprint on the role of insular traveling waves in memory and behavior, using depth recordings from neurosurgical patients, with @chenwumd.bsky.social, Sameer Sheth, and Josh Jacobs.

www.biorxiv.org/content/10.1...

Insular Traveling Waves Link Distributed Neural Dynamics to Human Memory Performance

The insula is a critical brain region that plays a foundational role in adaptive human behaviors, with diverse subregions performing distinct functional roles. However, explaining how these insular su...

www.biorxiv.org

Anup Das, PhD @neuroanup.bsky.social · Sep 18

1/7 New preprint on the role of insular traveling waves in memory and behavior, using depth recordings from neurosurgical patients, with @chenwumd.bsky.social, Sameer Sheth, and Josh Jacobs.

www.biorxiv.org/content/10.1...

Insular Traveling Waves Link Distributed Neural Dynamics to Human Memory Performance

The insula is a critical brain region that plays a foundational role in adaptive human behaviors, with diverse subregions performing distinct functional roles. However, explaining how these insular su...

www.biorxiv.org

max tani @maxtani.bsky.social · Sep 18

The union representing the musicians from Jimmy Kimmel’s band releases a statement calling the FCC’s pressure on Disney “state censorship.”

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Sep 16

Even with perfect targeting, #DBS electrodes can bend.

On the CNS Journal Club Podcast, Dr. Kim Burchiel interviewed me about my research on how brain tissue mechanics shape electrode paths + deviation.
🎧 www.cns.org/publications...

🎧 podcasts.apple.com/us/podcast/d...

#Neurosurgery #Stereotaxy

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Sep 5

Could brain stimulation help restore movement after #stroke?

The RESTORE DBS trial, led by Dr. André Machado and Cleveland Clinic, is now enrolling at Jefferson!

CNN recently covered this innovative approach: amp.cnn.com/cnn/2023/08/...

More details here: restorestrokestudy.com/jefferson

#DBS

RESTORE Stroke Study

restorestrokestudy.com

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Sep 5

Where do you draw the line? 🧠✏️
Literally.

We’re asking epilepsy surgeons to sketch their ATL resection. It takes ~10 min on a desktop computer
👉 redcap.uhhospitals.org/redcap/surve...

So…where do you draw the line?

@amepilepsysoc.bsky.social
@ilae-epilepsy.bsky.social

#Epilepsy #Neurosurgery

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · May 15

Back from my first @ismrm.bsky.social —great science, thoughtful conversations, and a chance to present our work on how MRE helps explain DBS electrode bending! Grateful to collaborate with teams at UDelaware and Villanova. Definitely not my last ISMRM. And it didn't hurt that it was in Honolulu.

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Mar 15

Warmer weather means more of this! IMO spare ribs >>> than baby back ribs

Apple wood smoked spare ribs using the 2:1:0.5 method

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Mar 10

Highlights from #AES2024 Temporal Lobe Club 🧠

Temporal lobe epilepsy surgery review: ATL = best seizure control; LITT = balanced risk; Neuromodulation = lower risk, modest outcomes.

🔗 Check out the suummary article here: www.ncbi.nlm.nih.gov/pmc/articles...

#Epilepsy #Neurosurgery

J. Offir, PhD @joffirphd.bsky.social · Feb 28

What the FDA will likely do is produce *something* - just not a vax that includes strains chosen based on the committee & WHO's reasoned input.

🔹️They'll throw darts at a board, & the vax won't be a good match (it's tough to get it right even *with* annual input), but folks will think "see,...

1/5

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Feb 26

Intracranial electrode bending is underrecognized but not random—it correlates with brain stiffness interfaces. Our study shows MR elastography can predict deviations, challenging the idea that bending is inevitable.

🔗 Read the full article here: journals.lww.com/onsonline/ab...

#DBS #stereotaxy

Deep Brain Stimulation Electrode Deviations are Associated... : Operative Neurosurgery

tion, an estimated 3% to 8% of patients still require revision surgery to address suboptimal electrode placement. DBS electrode deviation may occur at mechanical tissue interfaces, with denser interna...

journals.lww.com

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Feb 9

NIH’s new policy capping indirect cost funding at 15% is a gut punch to academic research. Cutting support for lab upkeep & admin costs means fewer resources for scientists & slower progress. This could seriously hurt innovation...

www.npr.org/sections/sho....

NIH announces new funding policy that rattles medical researchers

The National Institutes of Health has dramatically changed its grant-making terms by limiting how much it will disperse for costs such as equipment and administration.

www.npr.org

Michael Okun @michaelokun.bsky.social · Jan 27

How is it that Parkinson's name has been perpetuated in our language, but the man himself has been forgotten? What do you know about the man himself? Nadeem Toodayan and Andy Lees have written a brilliant new article sharing the details and the history not only of the memorial, but of the man.

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Jan 21

🚨 Upcoming ASSFN Webinar: How to Optimize DBS Targeting 🚨

Join us tomorrow for the first DBS Targeting webinar, where experts will share insights on optimizing deep brain stimulation (DBS) targeting to improve patient outcomes.

Register now: zoom.us/meeting/regi...

https://zoom.us/meeting/register/tJEkf–upzIuH9yez2hPXRdg3rzXnQERKELy

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Jan 3

"... alcohol directly contributes to 100,000 cancer cases and 20,000 related deaths each year...[but] fewer than half of Americans identified alcohol use as a risk factor for cancer"

www.nytimes.com/2025/01/03/h...

U.S. Surgeon General Calls for Cancer Warnings on Alcohol

Dr. Vivek Murthy’s report cites studies linking alcoholic beverages to at least seven malignancies, including breast cancer. But to add warning labels, Congress would have to act.

www.nytimes.com

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 26

This is what happens when a surgeon puts together a 'bouquet garni'...😬

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 26

Huge prime rib for Christmas dinner🎄🤤

Dry brined overnight, injected with garlic, rosemary, & thyme infused wagyu tallow. Smoked for 4 hours with a rosemary, sage, & thyme 'bouquet garni' tossed in every hour. Finally seared to develop a nice crust before a long rest.

Happy holidays everybody!!!

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 20

😳

Mother Jones @motherjones.com · Dec 20

3. Insurance profits outpace health care spending

Title: Insurance profits outpace health care spending
Subtitle: Increase in combined earnings of UnitedHealth Group, Evelance, and Cigna

Photo: A line graph that shows the increase in combined earnings of UnitedHealth Group, Elevance, and Cigna (shown as "Cumulative earnings") compared to the increase in national health care expenditures over time from 2012 to 2022. “Cumulative earnings” moves from 8.35% in 2012 to 261.56% in 2022. “National” moves from 4% in 2012 to 67% in 2022.

Chart credit: Michael Mechanic/Mother Jones. Source: Commonwealth Fund

Mother Jones @motherjones.com · Dec 20

3. Insurance profits outpace health care spending

Parkinson's Europe @parkinsonseurope.bsky.social · Dec 19

Fact: #DeepBrainStimulation can't improve every Parkinson's symptom. Here's some info on what DBS can and can't help.

👉 Discover more expert info in our interview: https://t.co/enDba26zhm

#DemystifyingDBS
In partnership with @AbbottNews, @bostonsci and @Medtronic #parkinson #parkinsons

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 14

"...for each 10 min increase in time engaged in strength training per week, the mean telomere length was about 6.7 base pairs longer, on average, compared with non-lifters...equivalent to almost 4 years less biological aging for adults participating in about 90 min of strength training per week."

Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women

Telomere length is an index of cellular aging. Healthy lifestyles are associated with reduced oxidative stress and longer telomeres, whereas unhealthy behaviors are related to shorter telomeres and gr...

www.mdpi.com

Parkinson's Europe @parkinsonseurope.bsky.social · Dec 13

A key part of researching #DeepBrainStimulation for Parkinson's is finding out the benefits. Here are 5️⃣ examples from DBS experts.

👉 Discover lots more expert info in our interview: https://buff.ly/3MMrS8M

🧵 1/7

#DemystifyingDBS
In partnership with @AbbottNews, @bostonsci and @Medtronic

Kyle Swanson, MD, FAANS, FCNS @kiswanson.medsky.social · Dec 11

youtube.com/shorts/VGgQD...

My Thoughts On The United Healthcare CEO Murder

YouTube video by Dr. Glaucomflecken

youtube.com

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 9

Very cool demonstration of what Renishaw does with robotics outside of #Neurosurgery at #AES2024

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 8

Our very own Michael Sperling on the big stage at #AES2024 for the Annual Course

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 8

Another year in the books for the AES-ASSFN joint course on #Epilepsy Surgery for #Neurology & #Neurosurgery residents

Many thanks to all the amazing faculty who have dedicated their time and effort to education! And thank you to all the residents who made the trip out to #AES2024!

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 8

Neena Marupudi from the University of Michigan continues to push the boundaries of minimally invasive disconnection surgery for #epilepsy with endoscopic approaches

#AES2024

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 8

A simply fantastic presentation by Marc Guenot from the University Hospital of Lyon about thermo-SEEG!

Approximately 30% seizure free at 2 months & 10% at 1 year.

But greater utility may be diagnostic value: 92% PPV & 45% NPV of outcome after resection if >2 months of seizure freedom after RF

Chengyuan Wu, MD, MSBmE @chenwumd.bsky.social · Dec 8

Great summary of #LITT for mesial temporal lobe #epilepsy by Brett Youngerman @columbiauniversity.bsky.social!

TLDR: Long term outcomes ~50% seizure freedom rate with early experience. But we have learned much about how to perform the procedure & will likely see improved outcomes in years to come.

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