Claudia Hemsley
@chemsley.bsky.social
Molecular Biologist | Microbiologist with an interest in gene-regulation and pathogenesis. Currently in Dundee 🏴 Favourite bugs are #Pseudomonas #Coxiella #Burkholderia #UPEC
Views are my own.
Views are my own.
Reposted by Claudia Hemsley
MRC instructs grant review boards to slash funding rates.
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls.
www.researchprofessionalnews.com/rr-news-uk-r...
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls.
www.researchprofessionalnews.com/rr-news-uk-r...
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
www.researchprofessionalnews.com
January 30, 2026 at 7:53 AM
MRC instructs grant review boards to slash funding rates.
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls.
www.researchprofessionalnews.com/rr-news-uk-r...
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls.
www.researchprofessionalnews.com/rr-news-uk-r...
Reposted by Claudia Hemsley
A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
January 28, 2026 at 11:29 PM
A paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
Reposted by Claudia Hemsley
#NatMicroPicks
A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠
by Yoshitomo Kikuchi & co @natcomms.nature.com
www.nature.com/articles/s41...
A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠
by Yoshitomo Kikuchi & co @natcomms.nature.com
www.nature.com/articles/s41...
Bacteria break through one-micrometer-square passages by flagellar wrapping - Nature Communications
Yoshioka et al. show that bacteria wrap their flagella to squeeze through near cell-width confinements, which allows symbiotic microbes to navigate constricted gut regions within insect hosts.
www.nature.com
January 26, 2026 at 2:56 PM
#NatMicroPicks
A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠
by Yoshitomo Kikuchi & co @natcomms.nature.com
www.nature.com/articles/s41...
A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠
by Yoshitomo Kikuchi & co @natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria
(=Pseudomonas fluorescens)
Advanced Science, perspective by @taylorlabgroup.bsky.social & @alanrice.ie
Uni Bath's 60th anniversary special issue
advanced.onlinelibrary.wiley.com/doi/10.1002/...
(=Pseudomonas fluorescens)
Advanced Science, perspective by @taylorlabgroup.bsky.social & @alanrice.ie
Uni Bath's 60th anniversary special issue
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria
This special issue marking the University of Bath's 60th anniversary offers an opportunity to reflect on nearly a decade of research into the evolution of gene regulatory networks (GRNs) from members....
advanced.onlinelibrary.wiley.com
January 24, 2026 at 11:35 AM
Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria
(=Pseudomonas fluorescens)
Advanced Science, perspective by @taylorlabgroup.bsky.social & @alanrice.ie
Uni Bath's 60th anniversary special issue
advanced.onlinelibrary.wiley.com/doi/10.1002/...
(=Pseudomonas fluorescens)
Advanced Science, perspective by @taylorlabgroup.bsky.social & @alanrice.ie
Uni Bath's 60th anniversary special issue
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Claudia Hemsley
A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen
-in PNAS from @anukharelab.bsky.social
www.pnas.org/doi/10.1073/...
-in PNAS from @anukharelab.bsky.social
www.pnas.org/doi/10.1073/...
A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen | PNAS
Microorganisms commonly exist in polymicrobial communities, where they can respond
to interspecies secreted molecules by altering behaviors and phy...
www.pnas.org
January 24, 2026 at 11:38 AM
A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen
-in PNAS from @anukharelab.bsky.social
www.pnas.org/doi/10.1073/...
-in PNAS from @anukharelab.bsky.social
www.pnas.org/doi/10.1073/...
Reposted by Claudia Hemsley
Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa - Nature Communications
Here, the authors identify DspII, a functionally equivalent and indispensable partner of DspI in mediating the chronic-to-acute virulence switch in Pseudomonas aeruginosa, which is a key adaptive stra...
www.nature.com
January 23, 2026 at 12:49 PM
Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Claudia Hemsley
Salmonella relies on siderophore exploitation at low pH
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
Salmonella relies on siderophore exploitation at low pH
Abstract. Salmonella enterica, a prominent enteric pathogen, employs sophisticated iron acquisition mechanisms to overcome host-imposed iron limitation, no
academic.oup.com
January 18, 2026 at 1:18 PM
Salmonella relies on siderophore exploitation at low pH
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
Reposted by Claudia Hemsley
Bacteria are amazing! The abundant Dps protein binds and protects DNA in stationary-phase cells with minimal effect on chromosome accessibility, dynamics, and organization. Now in NAR doi.org/10.1093/nar/...; I'm really proud of our multidisciplinary team led by Lauren, Lindsay, and Xiaofeng, et al.
January 16, 2026 at 11:16 PM
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
Bacteria sense the antibiotic rifampicin through a widespread dual-promoter based alarm system
@narjournal.bsky.social from Libor Krasny
academic.oup.com/nar/article/...
@narjournal.bsky.social from Libor Krasny
academic.oup.com/nar/article/...
Bacteria sense the antibiotic rifampicin through a widespread dual-promoter based alarm system
Abstract. Most antibiotics are natural compounds or their derivatives, and bacteria have evolved defensive mechanisms to resist them. Many of these mechani
academic.oup.com
January 16, 2026 at 2:00 PM
Bacteria sense the antibiotic rifampicin through a widespread dual-promoter based alarm system
@narjournal.bsky.social from Libor Krasny
academic.oup.com/nar/article/...
@narjournal.bsky.social from Libor Krasny
academic.oup.com/nar/article/...
Reposted by Claudia Hemsley
Impact of databases on genomic survey of Salmonella antimicrobial resistance and virulence factor functional genes across the African continent https://www.biorxiv.org/content/10.64898/2026.01.14.699574v1
January 15, 2026 at 9:17 PM
Impact of databases on genomic survey of Salmonella antimicrobial resistance and virulence factor functional genes across the African continent https://www.biorxiv.org/content/10.64898/2026.01.14.699574v1
Reposted by Claudia Hemsley
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
January 13, 2026 at 9:12 PM
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
Reposted by Claudia Hemsley
Valuable data sets are often overlooked because they are difficult to locate. The NIAID Data Ecosystem Discovery Portal provides a centralized, searchable interface that empowers users with varying technical expertise to find and reuse data. #mSystems: asm.social/2Lo
January 12, 2026 at 7:10 PM
Valuable data sets are often overlooked because they are difficult to locate. The NIAID Data Ecosystem Discovery Portal provides a centralized, searchable interface that empowers users with varying technical expertise to find and reuse data. #mSystems: asm.social/2Lo
Reposted by Claudia Hemsley
JB Editor's Choice: Bhattarai, Harshey et al. propose a new model for YcgR::c-di-GMP regulation of flagellar motility in Salmonella/E. coli. They provide evidence for the first part of their model.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
January 9, 2026 at 1:18 PM
JB Editor's Choice: Bhattarai, Harshey et al. propose a new model for YcgR::c-di-GMP regulation of flagellar motility in Salmonella/E. coli. They provide evidence for the first part of their model.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Claudia Hemsley
Ever wondered if your favorite bacteria 🧫🦠 produce exopolysaccharides? You can now easily check that with epsSMASH, our new bioinformatic tool built on the antiSMASH framework. It detects both known and novel exoPS BGCs. Check out and share the preprint! www.biorxiv.org/content/10.6...
epsSMASH uncovers exopolysaccharide biosynthetic gene clusters in environmental and human microbiomes
Biofilms represent the default mode of bacterial life in natural and built environments, with extracellular polysaccharides (exoPS) serving as essential structural and functional components of the bio...
www.biorxiv.org
January 5, 2026 at 10:26 AM
Ever wondered if your favorite bacteria 🧫🦠 produce exopolysaccharides? You can now easily check that with epsSMASH, our new bioinformatic tool built on the antiSMASH framework. It detects both known and novel exoPS BGCs. Check out and share the preprint! www.biorxiv.org/content/10.6...
Reposted by Claudia Hemsley
NLR-like immunity in bacteria
A new study from the Alex Gao lab. The scope of this work is incredible!!!
www.biorxiv.org/content/10.6...
A new study from the Alex Gao lab. The scope of this work is incredible!!!
www.biorxiv.org/content/10.6...
Diverse bacterial pattern recognition receptors sense the conserved phage proteome
Recognition of foreign molecules inside cells is critical for immunity in all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic nucleotide-binding oligomerization domain ...
www.biorxiv.org
January 5, 2026 at 1:59 PM
NLR-like immunity in bacteria
A new study from the Alex Gao lab. The scope of this work is incredible!!!
www.biorxiv.org/content/10.6...
A new study from the Alex Gao lab. The scope of this work is incredible!!!
www.biorxiv.org/content/10.6...
Reposted by Claudia Hemsley
JB Editor's Choice: Ratnikava, Lamprecht & Sourjik explore the complex regulation of curli in Escherichia coli.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
January 5, 2026 at 3:43 PM
JB Editor's Choice: Ratnikava, Lamprecht & Sourjik explore the complex regulation of curli in Escherichia coli.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Claudia Hemsley
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
Author summary Prophages—viral genomes integrated into bacterial chromosomes—are common in enteric bacteria and can profoundly influence bacterial physiology and ecological fitness. Here we show that ...
journals.plos.org
January 3, 2026 at 11:18 AM
A prophage-encoded sRNA limits phage infection of adherent-invasive E. coli
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
#PLoSPathogen from @prsecor.bsky.social
journals.plos.org/plospathogen...
Reposted by Claudia Hemsley
Characterizing Cell-Free Transcription and Translation Dynamics with Nucleic Acid–Based Assays
doi.org/10.1021/acss...
doi.org/10.1021/acss...
Characterizing Cell-Free Transcription and Translation Dynamics with Nucleic Acid–Based Assays
Characterization of cell-free expression (CFE) systems must expand beyond single spectrophotometric measurements of a green fluorescent protein to provide meaningful metrics of system performance duri...
doi.org
December 26, 2025 at 10:37 PM
Characterizing Cell-Free Transcription and Translation Dynamics with Nucleic Acid–Based Assays
doi.org/10.1021/acss...
doi.org/10.1021/acss...
Reposted by Claudia Hemsley
1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...
How medically important antimicrobials bind to the 30S ribosomal subunit in a bacterial pathogen
Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions ne...
doi.org
December 26, 2025 at 3:27 AM
1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...
Reposted by Claudia Hemsley
A scalable transposon mutagenesis system for non-model bacteria https://www.biorxiv.org/content/10.64898/2025.12.22.696024v1
December 24, 2025 at 4:02 AM
A scalable transposon mutagenesis system for non-model bacteria https://www.biorxiv.org/content/10.64898/2025.12.22.696024v1
Reposted by Claudia Hemsley
We believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
Supporting early-career researchers
On these pages we highlight the range of resources that we offer to early-career researchers.
www.biologists.com
December 19, 2025 at 4:59 PM
We believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
Reposted by Claudia Hemsley
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Reposted by Claudia Hemsley
Our recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Predicting drug inactivation by changes in bacterial growth dynamics - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Predicting drug inactivation by changes in bacterial growth dynamics
www.nature.com
December 22, 2025 at 3:25 PM
Our recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪
www.nature.com/articles/s44...
www.nature.com/articles/s44...