Claudia Hemsley
@chemsley.bsky.social
Molecular Biologist | Microbiologist with an interest in gene-regulation and pathogenesis. Currently in Dundee 🏴 Favourite bugs are #Pseudomonas #Coxiella #Burkholderia #UPEC
Views are my own.
Views are my own.
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters from @jkimmey.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Letters from @jkimmey.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacter...
febs.onlinelibrary.wiley.com
November 12, 2025 at 10:36 AM
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters from @jkimmey.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Letters from @jkimmey.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
Our new paper maps the tRNA modification landscape in Vibrio cholerae! 💫
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae
Author summary This study charts the first genome-wide map of transfer RNA (tRNA) modifications in the cholera pathogen, Vibrio cholerae, revealing how chemical marks on tRNAs shape translation and st...
journals.plos.org
November 3, 2025 at 11:58 PM
Our new paper maps the tRNA modification landscape in Vibrio cholerae! 💫
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
Reposted by Claudia Hemsley
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
One transcript, two functions: the emerging roles of dual-function RNAs
Abstract. Bacteria use small regulatory RNAs (sRNAs) and small proteins to change gene expression and modulate cellular processes in response to changing e
academic.oup.com
October 27, 2025 at 6:15 PM
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
Reposted by Claudia Hemsley
MazF endoribonuclease promotes resolution of transcription–replication conflicts at ribosomal RNA genes in Escherichia coli url: academic.oup.com/nar/article/...
MazF endoribonuclease promotes resolution of transcription–replication conflicts at ribosomal RNA genes in Escherichia coli
Abstract. Toxins from toxin–antitoxin (TA) systems, widely distributed genetic elements in prokaryotic genomes, are traditionally viewed as growth inhibito
academic.oup.com
October 25, 2025 at 12:04 PM
MazF endoribonuclease promotes resolution of transcription–replication conflicts at ribosomal RNA genes in Escherichia coli url: academic.oup.com/nar/article/...
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
JB Editor's Choice: Waller, Ribardo & Hendrixson show that flagellar length impacts function, with short flagella slowing swimming and reducing host colonization, indicating the important of regulating the lenght of the filament.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 22, 2025 at 1:31 PM
JB Editor's Choice: Waller, Ribardo & Hendrixson show that flagellar length impacts function, with short flagella slowing swimming and reducing host colonization, indicating the important of regulating the lenght of the filament.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Claudia Hemsley
Thrilled to share our multidisiplinary work on how genome-wide DNA bridging by H-NS reshapes the stationary phase bacterial nucleoid and affects the transcriptional landscape. With Xindan Wang and @meyerroc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 10:01 AM
Thrilled to share our multidisiplinary work on how genome-wide DNA bridging by H-NS reshapes the stationary phase bacterial nucleoid and affects the transcriptional landscape. With Xindan Wang and @meyerroc.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Claudia Hemsley
Pls share:
A postdoctoral research position is available in the group of Prof. Dr. Kirsten Jung at Ludwig-Maximilians-Universität München, Germany focusing on SRBs (www.bio.lmu.de/en/research/...)
A postdoctoral research position is available in the group of Prof. Dr. Kirsten Jung at Ludwig-Maximilians-Universität München, Germany focusing on SRBs (www.bio.lmu.de/en/research/...)
Molecular Microbiology Group
Information about research topics and publications about the group around Kirsten Jung
www.bio.lmu.de
October 21, 2025 at 7:49 PM
Pls share:
A postdoctoral research position is available in the group of Prof. Dr. Kirsten Jung at Ludwig-Maximilians-Universität München, Germany focusing on SRBs (www.bio.lmu.de/en/research/...)
A postdoctoral research position is available in the group of Prof. Dr. Kirsten Jung at Ludwig-Maximilians-Universität München, Germany focusing on SRBs (www.bio.lmu.de/en/research/...)
Reposted by Claudia Hemsley
Our first effort exploring gut bacteria-extracellular ATP interactions is published! We show that eATP rewires gene expression and physiology in harmless and pathogenic bacteria, impacting production of bioactive metabolites, antimicrobial sensitivity, and virulence. A 🧵
www.cell.com/cell-reports...
www.cell.com/cell-reports...
October 14, 2025 at 5:20 PM
Our first effort exploring gut bacteria-extracellular ATP interactions is published! We show that eATP rewires gene expression and physiology in harmless and pathogenic bacteria, impacting production of bioactive metabolites, antimicrobial sensitivity, and virulence. A 🧵
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Claudia Hemsley
Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 14, 2025 at 6:19 PM
Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...
Reposted by Claudia Hemsley
QUESTION: anyone knows of a published example of a gene/operon which is toxic in Pseudomonas aeruginosa if in high copy plasmids, but ok in low copy? Got plenty of examples of my own for E. coli (esp of membrane protein genes), but struggling to find for Pae… Cheers!
#microsky #synbio
#microsky #synbio
October 13, 2025 at 12:48 PM
Reposted by Claudia Hemsley
Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes https://www.biorxiv.org/content/10.1101/2025.10.10.681568v1
October 12, 2025 at 6:16 AM
Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes https://www.biorxiv.org/content/10.1101/2025.10.10.681568v1
Reposted by Claudia Hemsley
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Extracellular ATP is an environmental cue in bacteria
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes
and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular
ATP reprograms the tra...
www.cell.com
October 11, 2025 at 11:59 AM
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Calling all #sustainability champions: does anybody know of any grants that can be used for sustainability projects? We used to participate in a #gloverecycling scheme, but we now lost funding for shipping the gloves to the recycling facility. Any suggestions are very welcome (this is in the UK)
October 10, 2025 at 10:07 AM
Calling all #sustainability champions: does anybody know of any grants that can be used for sustainability projects? We used to participate in a #gloverecycling scheme, but we now lost funding for shipping the gloves to the recycling facility. Any suggestions are very welcome (this is in the UK)
Reposted by Claudia Hemsley
Genome-wide dual CRISPRi-seq! Knocking down every gene with every other gene in the pneumococcus, identifying > 4000 genetic interactions (GIs), most of which have never been reported. www.biorxiv.org/content/10.1...
Dual CRISPRi-Seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 17, 2024 at 5:04 AM
Genome-wide dual CRISPRi-seq! Knocking down every gene with every other gene in the pneumococcus, identifying > 4000 genetic interactions (GIs), most of which have never been reported. www.biorxiv.org/content/10.1...
Reposted by Claudia Hemsley
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
October 4, 2025 at 10:01 AM
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
Reposted by Claudia Hemsley
Reposted by Claudia Hemsley
New in JB: Déraspe, Roy et al. perform a comparative genomics study of the PA7-clade of P. aeruginosa - now recognized as a distinct species, Pseudomonas paraeruginosa. This analysis revealed 2 sub-clades, the lack of T3SS & multiresistance.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 3, 2025 at 2:04 PM
New in JB: Déraspe, Roy et al. perform a comparative genomics study of the PA7-clade of P. aeruginosa - now recognized as a distinct species, Pseudomonas paraeruginosa. This analysis revealed 2 sub-clades, the lack of T3SS & multiresistance.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Claudia Hemsley
New in JB: Fleitas, Rebollar & Bustamante explore the strategies that bacteria use to combat antimicrobial peptides - here they focus on "releasome" mechanisms that are the first line of defense.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 2, 2025 at 11:45 AM
New in JB: Fleitas, Rebollar & Bustamante explore the strategies that bacteria use to combat antimicrobial peptides - here they focus on "releasome" mechanisms that are the first line of defense.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Claudia Hemsley
New preprint from the lab! @findunmun1.bsky.social @chemsley.bsky.social We looked at new protein synthesis and genetic fitness during starvation in P. aeruginosa. Resources are dynamically redistributed to support ongoing activity, even over days of total starvation: www.biorxiv.org/content/10.1...
Analyses of protein expression and genetic fitness determinants reveal dynamic pathways active in starved Pseudomonas aeruginosa
Heterotrophic bacteria rapidly deplete essential macronutrients during growth and must navigate subsequent periods of growth arrest imposed by starvation. Nutrient limitations can be dynamic in nature...
www.biorxiv.org
September 29, 2025 at 7:23 PM
New preprint from the lab! @findunmun1.bsky.social @chemsley.bsky.social We looked at new protein synthesis and genetic fitness during starvation in P. aeruginosa. Resources are dynamically redistributed to support ongoing activity, even over days of total starvation: www.biorxiv.org/content/10.1...