Centre for Genome Engineering and Maintainance
@cengem.bsky.social
The Centre for #Genome Engineering and Maintenance nurtures #interdisciplinary research focused on improving the quality of life and increasing #lifespans. 👨🔬🧬
https://tinyurl.com/3wdwkasz
Brunel University of London
https://tinyurl.com/3wdwkasz
Brunel University of London
🚀 Big news! Meet the new leadership team at #CenGEM!🧬🔬
We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance.
#GenomeMaintenance #BrunelUniversity #BioScience
We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance.
#GenomeMaintenance #BrunelUniversity #BioScience
cengem.org
January 10, 2026 at 2:44 PM
🚀 Big news! Meet the new leadership team at #CenGEM!🧬🔬
We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance.
#GenomeMaintenance #BrunelUniversity #BioScience
We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance.
#GenomeMaintenance #BrunelUniversity #BioScience
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
rudolphlab.com/blog/on-narr...
Rudolph BLOG
Pages of the Rudolph laboratory at Brunel University London.
rudolphlab.com
November 28, 2025 at 2:21 PM
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
rudolphlab.com/blog/on-narr...
Reposted by Centre for Genome Engineering and Maintainance
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer
cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling,
uncovering a vuln...
www.embopress.org
November 23, 2025 at 5:10 PM
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Centre for Genome Engineering and Maintainance
Very exciting few days this week as we attended and presented our work at the 5th Crick International Cancer Conference. Well done Rebecca! @crick.ac.uk @cengem.bsky.social @cancerresearchuk.org
October 10, 2025 at 12:50 PM
Very exciting few days this week as we attended and presented our work at the 5th Crick International Cancer Conference. Well done Rebecca! @crick.ac.uk @cengem.bsky.social @cancerresearchuk.org
Reposted by Centre for Genome Engineering and Maintainance
The Authors have found that overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
August 25, 2025 at 3:04 PM
The Authors have found that overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
Reposted by Centre for Genome Engineering and Maintainance
Happy new academic year for all our students and colleagues at Brunel.
#bruneluniversity #success @cengem.bsky.social
#bruneluniversity #success @cengem.bsky.social
September 22, 2025 at 10:39 AM
Happy new academic year for all our students and colleagues at Brunel.
#bruneluniversity #success @cengem.bsky.social
#bruneluniversity #success @cengem.bsky.social
Reposted by Centre for Genome Engineering and Maintainance
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
August 18, 2025 at 3:15 PM
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
Reposted by Centre for Genome Engineering and Maintainance
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!
@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!
@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
August 18, 2025 at 3:31 PM
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!
@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!
@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology
open.spotify.com/episode/3vv8...
open.spotify.com/episode/3vv8...
E03 - CHRDL2 in Colorectal Cancer [New paper from Lewis Lab]
CenGEM | Centre for Genome Engineering and Maintenance · Episode
open.spotify.com
July 3, 2025 at 2:47 PM
We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology
open.spotify.com/episode/3vv8...
open.spotify.com/episode/3vv8...
Centre for Genome Engineering and Maintenance at Brunel University of London Research Showcase at Senate House.
June 6, 2025 at 1:17 PM
Centre for Genome Engineering and Maintenance at Brunel University of London Research Showcase at Senate House.
When the work of centre members has an impact on people. News from Dr Victor Hernandez and Axovia Therapeutics. #gentherapy #cengem
axoviatherapeutics.com/axovia-thera...
axoviatherapeutics.com/axovia-thera...
Axovia Therapeutics Presents New Preclinical Data for AXV-101 for the Treatment of Blindness Associated with BBS Mutations at ASGCT - Axovia Therapeutics
London, UK – May 13, 2025 – Axovia Therapeutics Ltd., a biotechnology company developing therapies to address the genetic causes of blindness and obesity, announced the presentation of new preclinical...
axoviatherapeutics.com
May 13, 2025 at 3:06 PM
When the work of centre members has an impact on people. News from Dr Victor Hernandez and Axovia Therapeutics. #gentherapy #cengem
axoviatherapeutics.com/axovia-thera...
axoviatherapeutics.com/axovia-thera...
Reposted by Centre for Genome Engineering and Maintainance
#Microscopills Episode 1. A brief refresher about what #FRET is and FRET #microscopy can do. A primer in a conversational podcast format.
open.spotify.com/episode/4JoK...
open.spotify.com/episode/4JoK...
Microscopills E01 - A FRET primer: the basics
Quantitative Biology: Papers and Perspectives · Episode
open.spotify.com
May 1, 2025 at 12:54 PM
#Microscopills Episode 1. A brief refresher about what #FRET is and FRET #microscopy can do. A primer in a conversational podcast format.
open.spotify.com/episode/4JoK...
open.spotify.com/episode/4JoK...
Reposted by Centre for Genome Engineering and Maintainance
Dear Colleagues,
I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.
I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.
Microsoft Forms
bit.ly
December 17, 2024 at 3:25 PM
Dear Colleagues,
I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.
I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.
Reposted by Centre for Genome Engineering and Maintainance
Single nucleic acids probe imaged by #FLIM exemplifies how #fluorescence #lifetimes can reveal physicochemical characteristics of the sample hidden within the mere brightness of the sample. Shared just for fun :) red: high lifetime; blue: low lifetime. Probe: to be announced ;) #livecellimaging
December 10, 2024 at 8:46 AM
Single nucleic acids probe imaged by #FLIM exemplifies how #fluorescence #lifetimes can reveal physicochemical characteristics of the sample hidden within the mere brightness of the sample. Shared just for fun :) red: high lifetime; blue: low lifetime. Probe: to be announced ;) #livecellimaging
Reposted by Centre for Genome Engineering and Maintainance
Very humbled and honored to share my story. Thank you @jcellsci.bsky.social and Sara Morais da Silva for the interview!
journals.biologists.com/jcs/article/...
@cengem.bsky.social
journals.biologists.com/jcs/article/...
@cengem.bsky.social
Cell scientist to watch – Barbara Tanos
ABSTRACT. Barbara Tanos is a Senior Lecturer in Biomedical Sciences in the Department of Life Sciences at Brunel University London (UK). Barbara received her undergraduate degree from the University o...
journals.biologists.com
December 4, 2024 at 12:27 PM
Very humbled and honored to share my story. Thank you @jcellsci.bsky.social and Sara Morais da Silva for the interview!
journals.biologists.com/jcs/article/...
@cengem.bsky.social
journals.biologists.com/jcs/article/...
@cengem.bsky.social
[new review] Zhang Lab. Recent advances and applications of artificial intelligence in 3D bioprinting. Biophys Rev (Melville)
http://dlvr.it/TGbPnR
http://dlvr.it/TGbPnR
Recent advances and applications of artificial intelligence in 3D bioprinting
3D bioprinting techniques enable the precise deposition of living cells, biomaterials, and biomolecules, emerging as a promising approach for engineering functi
dlvr.it
December 4, 2024 at 7:18 PM
[new review] Zhang Lab. Recent advances and applications of artificial intelligence in 3D bioprinting. Biophys Rev (Melville)
http://dlvr.it/TGbPnR
http://dlvr.it/TGbPnR
[New paper] Roberts Lab. 5-aza-2'-deoxycytidine induces #telomere dysfunction in #breast #cancer cells. Biomed Pharmacother.
http://dlvr.it/TGZ4HL
http://dlvr.it/TGZ4HL
Redirecting
dlvr.it
December 3, 2024 at 7:15 PM
[New paper] Roberts Lab. 5-aza-2'-deoxycytidine induces #telomere dysfunction in #breast #cancer cells. Biomed Pharmacother.
http://dlvr.it/TGZ4HL
http://dlvr.it/TGZ4HL
[New review] Tosi Lab. The role of #diet in #cancer: the potential of shaping public #policy and #clinical outcomes in the UK. Genes Nutr
http://dlvr.it/TGWz87
http://dlvr.it/TGWz87
The role of diet in cancer: the potential of shaping public policy and clinical outcomes in the UK - Genes & Nutrition
dlvr.it
December 2, 2024 at 8:01 AM
[New review] Tosi Lab. The role of #diet in #cancer: the potential of shaping public #policy and #clinical outcomes in the UK. Genes Nutr
http://dlvr.it/TGWz87
http://dlvr.it/TGWz87
Reposted by Centre for Genome Engineering and Maintainance
Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.
Cell cycle tracker
Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.
buff.ly
November 30, 2024 at 2:59 PM
Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.
Reposted by Centre for Genome Engineering and Maintainance
Useful orders of magnitude
December 1, 2024 at 3:00 PM
Useful orders of magnitude
[new paper ] Rudolph Lab. Repurposing Proximity-Dependent Protein Labeling (#BioID2) for Protein Interaction Mapping in E. coli. Methods Mol Biol
http://dlvr.it/TGTj3D
http://dlvr.it/TGTj3D
Repurposing Proximity-Dependent Protein Labeling (BioID2) for Protein Interaction Mapping in E. coli
Methods that identify protein-protein interactions are essential for understanding molecular mechanisms controlling biological systems. Proximity-dependent labeling has proven to be a valuable method for revealing protein-protein interaction networks in living cells....
dlvr.it
November 29, 2024 at 7:11 PM
[new paper ] Rudolph Lab. Repurposing Proximity-Dependent Protein Labeling (#BioID2) for Protein Interaction Mapping in E. coli. Methods Mol Biol
http://dlvr.it/TGTj3D
http://dlvr.it/TGTj3D
[new review] Karteris Lab. The "Road" to Malignant Transformation from #Endometriosis to Endometriosis-Associated #Ovarian #Cancers (EAOCs): An #mTOR-Centred Review. Cancers (Basel)
http://dlvr.it/TGSRX0
http://dlvr.it/TGSRX0
The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review
dlvr.it
November 28, 2024 at 7:19 PM
[new review] Karteris Lab. The "Road" to Malignant Transformation from #Endometriosis to Endometriosis-Associated #Ovarian #Cancers (EAOCs): An #mTOR-Centred Review. Cancers (Basel)
http://dlvr.it/TGSRX0
http://dlvr.it/TGSRX0
[new paper] Drenos Lab. No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle #Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis. Genes
http://dlvr.it/TGSQdz
http://dlvr.it/TGSQdz
No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis
dlvr.it
November 28, 2024 at 7:02 PM
[new paper] Drenos Lab. No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle #Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis. Genes
http://dlvr.it/TGSQdz
http://dlvr.it/TGSQdz
[New #preprint] Sisu Lab. #GENCODE: massively expanding the #lncRNA catalog through capture long-read #RNA sequencing. http://dlvr.it/TGPqVQ
GENCODE: massively expanding the lncRNA catalog through capture long-read RNA sequencing
dlvr.it
November 26, 2024 at 7:01 PM
[New #preprint] Sisu Lab. #GENCODE: massively expanding the #lncRNA catalog through capture long-read #RNA sequencing. http://dlvr.it/TGPqVQ
[new paper] Sisu lab. GENCODE 2025: reference gene annotation for human and mouse
http://dlvr.it/TGNfV3
http://dlvr.it/TGNfV3
GENCODE 2025: reference gene annotation for human and mouse
Abstract. GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as n
dlvr.it
November 25, 2024 at 7:01 PM
[new paper] Sisu lab. GENCODE 2025: reference gene annotation for human and mouse
http://dlvr.it/TGNfV3
http://dlvr.it/TGNfV3