Brian Sweis
@brianmsweis.bsky.social
MD, PhD | psychiatry | neuroscience | neuroeconomics | neuromodulation | assistant professor | residency program training director @MountSinaiPsych @SinaiBrain 🧠
Pinned
Brian Sweis
@brianmsweis.bsky.social
· Oct 29
For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
Reposted by Brian Sweis
🧠📢 New preprint alert
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
December 5, 2025 at 8:42 PM
🧠📢 New preprint alert
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Reposted by Brian Sweis
(1/6) We have a new paper out in #eNeuro!
How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆
Read more: www.eneuro.org/content/12/1...
How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆
Read more: www.eneuro.org/content/12/1...
December 3, 2025 at 8:22 PM
(1/6) We have a new paper out in #eNeuro!
How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆
Read more: www.eneuro.org/content/12/1...
How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆
Read more: www.eneuro.org/content/12/1...
Reposted by Brian Sweis
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Characterizing neuronal population geometry with AI equation discovery
The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...
www.biorxiv.org
November 14, 2025 at 6:07 PM
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Brian Sweis
🚨 Reminder: Applications for #OptoGRC2026 are now OPEN!
Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠
Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠
Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
November 26, 2025 at 5:48 PM
🚨 Reminder: Applications for #OptoGRC2026 are now OPEN!
Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠
Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠
Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
Reposted by Brian Sweis
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
November 25, 2025 at 2:58 PM
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
Reposted by Brian Sweis
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
November 14, 2025 at 7:16 PM
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
November 14, 2025 at 5:37 PM
Reposted by Brian Sweis
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1... 1/13 🧵
www.biorxiv.org/content/10.1... 1/13 🧵
Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties
The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...
www.biorxiv.org
November 13, 2025 at 12:24 AM
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1... 1/13 🧵
www.biorxiv.org/content/10.1... 1/13 🧵
Reposted by Brian Sweis
Our Behavioural Brain Research special issue on Ultrasonic Communication in Rodents is growing, rapidly – and actually a lot faster than I manage to post about it. Nine new manuscripts got accepted since my last post. Quite impressive work. Check it out:
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
November 6, 2025 at 12:53 PM
Our Behavioural Brain Research special issue on Ultrasonic Communication in Rodents is growing, rapidly – and actually a lot faster than I manage to post about it. Nine new manuscripts got accepted since my last post. Quite impressive work. Check it out:
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Brian Sweis
📣We are hiring! 📣
Join us as a Postdoctoral Researcher to study brain–body interactions uncovering how neural and physiological systems regulate behavior and energy metabolism under stress!
Details are below:
📩 abha.rajbhandari@mssm.edu 🔗 careers.mountsinai.org/jobs/3032214
Details are below:
📩 abha.rajbhandari@mssm.edu 🔗 careers.mountsinai.org/jobs/3032214
Postdoctoral Fellow-MSH-13400-363 in New York, NY | Mount Sinai Health Systems
Mount Sinai is hiring a Postdoctoral Fellow-MSH-13400-363 in New York, NY. Review all of the job details and apply today!
careers.mountsinai.org
October 29, 2025 at 2:22 PM
📣We are hiring! 📣
Join us as a Postdoctoral Researcher to study brain–body interactions uncovering how neural and physiological systems regulate behavior and energy metabolism under stress!
Details are below:
📩 abha.rajbhandari@mssm.edu 🔗 careers.mountsinai.org/jobs/3032214
Details are below:
📩 abha.rajbhandari@mssm.edu 🔗 careers.mountsinai.org/jobs/3032214
For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
October 29, 2025 at 11:27 PM
For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
Reposted by Brian Sweis
"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
October 23, 2025 at 9:39 PM
"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
Reposted by Brian Sweis
When I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!
Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases
Morris et al. identify a common behavioural signature of apathy in Alzheimer’s and Parkinson’s disease: a decision bias towards rejecting the option to exe
academic.oup.com
October 21, 2025 at 2:51 PM
When I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!
Reposted by Brian Sweis
We are also considering applications from undergraduate students and Master's students in the local New York City area!
Please check out our website for more information on how to become involved: sinclaboratory.com/apply
Please check out our website for more information on how to become involved: sinclaboratory.com/apply
Apply
SOCIAL INTERACTION &<br>NEURAL COMPUTATION LAB. The SINC Lab examines the neural and computational basis of social cognition and interaction. We are particularly interested in understanding how social...
sinclaboratory.com
September 22, 2025 at 6:17 PM
We are also considering applications from undergraduate students and Master's students in the local New York City area!
Please check out our website for more information on how to become involved: sinclaboratory.com/apply
Please check out our website for more information on how to become involved: sinclaboratory.com/apply
Reposted by Brian Sweis
Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
October 16, 2025 at 3:00 PM
Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
Reposted by Brian Sweis
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
nature.com
October 15, 2025 at 8:18 PM
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Reposted by Brian Sweis
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
September 29, 2025 at 4:31 PM
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
Reposted by Brian Sweis
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
September 22, 2025 at 11:54 AM
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
Reposted by Brian Sweis
So excited for this! Can't wait to see everyone there!
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
September 24, 2025 at 8:06 PM
So excited for this! Can't wait to see everyone there!
Reposted by Brian Sweis
The amygdala helps mobilize #Stress hormones cortisol & adrenaline w/in about 15 minutes. A recent study by Icahn Mount Sinai's Dr. Sarah Stanley suggests a 2nd role for the #Amygdala in response to #Fear & #Anxiety. Dr. Stanley discusses her research @pnas.org 👉 www.pnas.org/post/journal...
September 22, 2025 at 5:46 PM
Reposted by Brian Sweis
The Sosa Lab website is now live!
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
Sosa Lab
www.sosaneurolab.com
September 22, 2025 at 9:23 PM
The Sosa Lab website is now live!
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬
September 13, 2025 at 1:59 AM
#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬
Reposted by Brian Sweis
Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 5:12 PM
Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!
Reposted by Brian Sweis
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 7:13 PM
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.